Daria V Babushok, MD, PhD

faculty photo
Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Biomedical Research Building II/III, Room 808
421 Curie Boulevard
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 215-614-1847
Fax: 215-615-5888
Lab: 215-573-0667
Education:
BA (Biology, Chemistry)
Bryn Mawr College, 2000.
PhD (Cellular and Molecular Biology)
University of Pennsylvania, 2007.
MD (Medicine)
University of Pennsylvania, 2008.
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Description of Clinical Expertise

Bone marrow failure syndromes (inherited and acquired), acquired aplastic anemia, paroxysmal nocturnall hemoglobinuria, clonal hematopoiesis, MDS/AML predisposition syndromes, MPN predisposition syndromes, myeloproliferative neoplasms

Description of Research Expertise

RESEARCH INTERESTS:
The Babushok Lab conducts basic and translational research to understand the fundamental mechanisms of how bone marrow can fail, how the failure of bone marrow can lead to pre-malignant genetic changes and myelodysplastic syndrome and leukemia, and what is the relationship between our immune system and the development of clonal hematopoiesis.

We use state-of-the-art genome analysis, molecular biology and immunogenetic analyses, as well as in vitro and in vivo models to study the mechanisms of immune-mediated marrow failure and the factors that lead to the development of clonal hematopoiesis in bone marrow failure and aging.

KEYWORDS:
Clonal hematopoiesis, bone marrow failure, aplastic anemia, PNH, malignant predisposition to MDS and leukemia

ROTATION PROJECTS:
We are always looking for talented individuals who are passionate about science. There are opportunities to contribute at every level, and we welcome inquiries from undergraduate and graduate students, postdoctoral scientists, and medical students, residents, and fellows. Please contact Daria.Babushok at uphs.upenn.edu to discuss research opportunities.

SEE BABUSHOK LAB WEBSITE

LAB MEMBERS:
Kathy Guo – Research Specialist
Caitlin Ritz - Research Specialist
Natasha Stanley – Research Specialist

MEDICAL STUDENT RESEARCHERS:
Taylor Linaburg – Medical Student
Tristan Lim - Medical Student

UNDERGRADUATE RESEARCHERS:
Ben Frost
Jahnvi Patel

Selected Publications

27. Freyer CW, Carulli A, Gier SH, Ganetsky A, Timlin C, Schuster MJ, Babushok DV, Frey NV, Gill SI, Hexner EO, Mangan JK, Martin ME, McCurdy SR, Perl AE, Pratz KW, Smith J, Luger SM, Stadtmauer EA, Porter DL and Loren AW. : Letermovir Vs High Dose Valacyclovir for Cytomegalovirus Prophylaxis Following Haploidentical Allogeneic Hematopoietic Transplantation. Presentation submitted to 2021 Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR. 2021.

26. Sung A, Koll T, Gier SH, Lew M, Free MM, Bohannon L, Racioppi A, Babushok DV, Frey NV, Gill SI, Hexner EO, Martin ME, Perl AE, Pratz KW, Luger SM, Stadtmauer EA, Porter DL, Loren AW, Bhatt VR, Gimotty P, McCurdy SR. : Fried’s Frailty Phenotype Predicts Overall Survival for Older Hematopoietic Cell Transplantation Recipients. Presentation submitted to 2021 Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR. 2021.

23. Sklarz T, Hurwitz SN, Stanley NL, Juusola J, Bagg A, Babushok DV. : Aplastic anemia in a patient with CVID due to NFKB1 haploinsufficiency. Cold Spring Harb Mol Case Stud Sept 2020

Sun L and Babushok DV: Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria. Blood July 2020.

Sung PJ, Babushok DV: Born to RUNX1. Blood May 2020.

Ritz C, Meng W, Stanley NL, Baroja ML, Xu C, Yan P, Huang AC, Hausler R, Nicholas P, Fan JM, Lieberman D, Carreno BM, Luning Prak ET, Olson TS, Babushok DV. : Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes. Blood Adv April 2020.

24. Frost BF, Duke JL, Xie HM, Ferriola D, Oved JH, Nicholas P, Fan JM, Hausler R, Bertuch AA, Furutani E, Shimamura A, Lee SJ, Spellman SR, MOnos DS, Olson TS*, Babushok DV*, : Towards Identifying the Mechanism of Autoimmunity in Aplastic Anemia. Poster presentation at the 2020 American Society of Hematology Conference. American Society of Hematology Conference, San Diego CA 2020.

Oved JH, Babushok DV, Lambert MP, Wolfset N, Kowalska MA, Poncz M, Karczewski KJ, Olson TS.: Human mutational constraint as a tool to understand biology of rare and emerging bone marrow failure syndromes. Blood Adv. 2020.

Abella BS, Jolkovsky EL, Biney BT, Uspal JE, Hyman MC, Frank I, Hensley SE, Gill S, Vogl DT, Maillard I, Babushok DV, Huang AC, Nasta SD, Walsh JC, Wiletyo EP, Gimotty PA, Milone MC, Amaravadi RK;and the Prevention and Treatment of COVID-19 With Hydroxychloroquine (PATCH) Investigators. : Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers: A Randomized Clinical Trial. JAMA Intern Med. 2020.

25. Lim T, Lieberman DB, Davis AR, Hausler R, Bigdeli A, Li Y, Powers J, Regeneron Genetics Center, Carty SA, Nathanson KL, Bagg A, Hexner EO, Maxwell KN, Morrissette JJD, Babushok DV. : Germline POT1 variants can predispose to a variety of hematologic neoplasms. Poster presentation at the 2020 American Society of Hematology Conference, San Diego CA 2020.

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Last updated: 11/11/2020
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