Daria V. Babushok

faculty photo
Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Biomedical Research Building II/III, Room 808
421 Curie Boulevard
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 215-614-1847
Fax: 215-615-5888
Lab: 215-573-0667
Education:
BA (Biology, Chemistry)
Bryn Mawr College, 2000.
PhD (Cellular and Molecular Biology)
University of Pennsylvania, 2007.
MD (Medicine)
University of Pennsylvania, 2008.
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Description of Clinical Expertise

Bone marrow failure syndromes (inherited and acquired), acquired aplastic anemia, paroxysmal nocturnall hemoglobinuria, clonal hematopoiesis, MDS/AML predisposition syndromes, MPN predisposition syndromes, myeloproliferative neoplasms

Description of Research Expertise

RESEARCH INTERESTS:
The Babushok Lab conducts basic and translational research to understand the fundamental mechanisms of how bone marrow can fail, how the failure of bone marrow can lead to pre-malignant genetic changes and myelodysplastic syndrome and leukemia, and what is the relationship between our immune system and the development of clonal hematopoiesis.

We use state-of-the-art genome analysis, molecular biology and immunogenetic analyses, as well as in vitro and in vivo models to study the mechanisms of immune-mediated marrow failure and the factors that lead to the development of clonal hematopoiesis in bone marrow failure and aging.

KEYWORDS:
Clonal hematopoiesis, bone marrow failure, aplastic anemia, PNH, malignant predisposition to MDS and leukemia

ROTATION PROJECTS:
We are always looking for talented individuals who are passionate about science. There are opportunities to contribute at every level, and we welcome inquiries from undergraduate and graduate students, postdoctoral scientists, and medical students, residents, and fellows. Please contact Daria.Babushok at uphs.upenn.edu to discuss research opportunities.

SEE BABUSHOK LAB WEBSITE

LAB MEMBERS:
Kathy Guo – Research Specialist
Caitlin Ritz - Research Specialist
Natasha Stanley – Research Specialist

MEDICAL STUDENT RESEARCHERS:
Taylor Linaburg – Medical Student
Tristan Lim - Medical Student

UNDERGRADUATE RESEARCHERS:
Ben Frost
Jahnvi Patel

Selected Publications

Sun L and Babushok DV: Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria10. Blood July 2020.

Sung PJ, Babushok DV: Born to RUNX1. Blood May 2020.

Ritz C, Meng W, Stanley NL, Baroja ML, Xu C, Yan P, Huang AC, Hausler R, Nicholas P, Fan JM, Lieberman D, Carreno BM, Luning Prak ET, Olson TS, Babushok DV. : Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes. Blood Adv April 2020.

Babushok D: Eltrombopag: wielding a double-edged sword? Blood June 2019.

Linaburg T, Davis AR, Frey NV, Khawaja MR, Landsburg DJ, Schuster SJ, Svoboda J, Li Y, Borovskiy Y, Olson TS, Bagg A, Hexner EO, Babushok DV. : Hodgkin lymphoma patients have an increased incidence of idiopathic acquired aplastic anemia. PLoS One April 2019.

Oved JH, Stanley N, Babushok DV, Huang Y, Duke JL, Monos DS, Teachey DT, Olson TS. : Development of hemolytic paroxysmal nocturnal hemoglobinuria without graft loss following hematopoietic stem cell transplantation for acquired aplastic anemia. Pediatric Transplant March 2019.

Babushok DV, Hsu AP, Dokal I: Bone Marrow Failure Syndromes. Chapter 15. In Stiehm's Immune Deficiencies, 2nd edition. . Edited by Kathleen E. Sullivan and E. Richard Stiehm (eds.). 2019.

Babushok DV: A Brief, But Comprehensive, Guide to Clonal Evolution in Aplastic Anemia. Hematology 2018 Dec 2018.

Babushok DV: Expert commentary on “Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment. Blood Adv October 2018.

Ganetsky A, Han JH, Hughes ME, Babushok DV, Frey NV, Gill SI, Hexner EO, Loren AW, Luger SM, Mangan JK, Martin ME, Smith J, Freyer CW, Gilmar C, Schuster M, Stadtmauer EA, Porter DL.: Oral vancomycin prophylaxis is highly effective in preventing Clostridium difficile infection in allogeneic hematopoietic cell transplant recipients. Clin Infect Dis. Sept 2018.

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Last updated: 09/01/2020
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