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McKay Orthopaedic Research Laboratory

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Boerckel Laboratory

Publications

Peer-reviewed Papers

  1. Kegelman CD,  Nijsure MP, Moharrer Y, Pearson HB, Dawahare JH, Jordan KM,  Qin L,  Boerckel JD. “YAP and TAZ promote periosteal osteoblast precursor expansion and differentiation for fracture repair.” Journal of Bone and Mineral Research 2020 Aug 24. Preprint available on bioRxiv at doi: 10.1101/2020.03.17.995761.

  2. Ruehle MA, Eastburn EA, LaBelle SA, Krishnan L, Weiss JA, Boerckel JD, Wood LB, Guldberg RE, Willett NJ. “Extracellular matrix compression temporally regulates microvascular angiogenesis.” Science Advances. 2020 Aug 21; 6(34). Preprint available on bioRxiv at doi: 10.1101/2020.01.14.906354. Highlights: University of Oregon

  3. Kegelman CD*, Collins JM*, Nijsure MP*, Eastburn EA*, Boerckel JD. “Gone caving: roles of the transcriptional regulators YAP and TAZ in skeletal development.” Current Osteoporosis Reports. 2020 Jul 25; 18:526–540. doi: 10.1007/s11914-020-00605-3. *Contributed equally.

  4. Kegelman CD, Coulombe JC, Jordan KM, Horan DJ, Qin L, Robling AG, Ferguson VL, Bellido TM, Boerckel JD. “YAP and TAZ mediate osteocyte perilacunar/canalicular remodeling.” Journal of Bone and Mineral Research. 2020 Jan; 35(1):196-210. Preprint available on bioRxiv at: doi.org/10.1101/611913.

  5. Herberg S*, McDermott AM*, Dang PN, Alt DS, Tang R, Dawahare JH, Varghai D, Shin J-Y, McMillan1 A, Dikina1 AD, He F, Lee Y, Cheng Y, Umemori K, Wong PC, Park H, Boerckel JD†, Alsberg E†. "Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair." *Co-first authors. †Co-corresponding authors. Science Advances. 2019 Aug 28;5(8). Preprint available on bioRxiv at: doi.org/10.1101/561837. Highlights: Penn Medicine, UIC Today

  6. McDermott AM*, Herberg S*, Mason DE, Collins JM, Pearson HB, Dawahare JH, Tang R, Patwa AN, Grinstaff MW, Kelly DJ, Alsberg E†, Boerckel JD†. “Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration .” *Co-first authors. †Co-corresponding authors. Science Translational Medicine. 2019 Jun 5;11(495). Preprint available on bioRxiv at: doi.org/10.1101/265744. Highlights: Penn Today, Penn Medicine, Penn Bioengineering, UIC Today, F1000 Prime

  7. Pearson HB, Mason DE, Kegelman CD, Zhao L, Dawahare JH, Kacena MA, Boerckel JD. "Effects of Bone Morphogenetic Protein-2 on Neovascularization During Large Bone Defect Regeneration." Tissue Engineering Part A. 2019 Jun 14. Preprint available on bioRxiv at: doi.org/10.1101/464396.

  8. Mason DE, Collins JM, Dawahare, JH, Nguyen TD, Lin Y, Voytik-Harbin SL, Zorlutuna PZ, Yoder MC, Boerckel JD. “YAP and TAZ limit cytoskeletal and focal adhesion maturation to enable persistent cell motility.” Journal of Cell Biology. 2019 Apr 1;218(4):1369-1389. Preprint available on bioRxiv at: doi.org/10.1101/265744. Highlights: JCB The Year in Cell Biology: 2019, Prelights, Penn Engineering, JCB Spotlight, JCB Special Collection on Cell Adhesion, F1000 Prime.

  9. Wang L, Tower RJ, Chandra A, Yao L, Tong W, Xiong Z, Tang K, Zhang Y, Liu XS, Boerckel JD, Guo X, Ahn J, Qin L. "Periosteal Mesenchymal Progenitor Dysfunction and Extraskeletally-Derived Fibrosis Contribute to Atrophic Fracture Nonunion." J Bone Miner Res. 2019 Mar;34(3):520-532.

  10. Zhang Y, Nallathamby PD, Vigil GD, Khan AA, Mason DE, Boerckel JD, Roeder RK, Howard SS. “Super-resolution fluorescence microscopy by stepwise optical saturation.” Biomedical Optics Express. 2018 Mar 12;9(4):1613-1629.  Preprint available on arXiv at: 10.1364/BOE.9.001613

  11. Kegelman CD, Mason DE, Dawahare JH, Horan D, Vigil G, Howard S, Robling AG, Bellido TM, Boerckel JD. “Skeletal cell YAP and TAZ combinatorially promote bone development.” FASEB J. 2018 May;32(5):2706-2721. Preprint available on bioRxiv at: doi.org/10.1101/14398 Highlights: Penn Medicine

  12. Curtis KJ, Coughlin TR, Mason DE, Boerckel JD, Niebur GL, 2018, “Bone marrow mechanotransduction in porcine explants alters kinase activation and enhances trabecular bone formation in the absence of osteocyte signaling”, Bone. 2017 107C:78-87.

  13. Marcucio RS, Qin L, Alsberg E, Boerckel JD “Reverse-engineering development: crosstalk opportunities between developmental biology and tissue engineering.” Journal of Orthopaedic Research. 2017 Nov;35(11):2356-2368. Journal of Orthopaedic Research. 2017 Nov;35(11):2356-2368.

  14. Pearson HB, Dobbs C, Grantham E, Niebur GL, Chappuis JL, Boerckel JD. “Intraoperative biomechanics of lumbar  pedicle screw loosening following successful arthrodesis” Journal of Orthopaedic Research. 2017 Dec;35(12):2673-2681. Awarded Best Poster Award, Orthopaedic Research Society Spine Section, 2016.

  15. Coughlin TR, Romero-Romeno R, Mason DE, Nystrom L, Boerckel JD, Niebur GL, Littlepage LE. “Bone: A fertile soil for cancer metastasis.” Current Drug Targets, 2018. 18 (11), 1281-1295.

  16. McDermott AM, Mason DE, Lin ASP, Guldberg RE, Boerckel JD. “Influence of structural load-bearing scaffolds on mechanical load- and BMP-2-mediated bone regeneration.” Journal of the Mechanical Behavior of Biomedical Materials, Sep 62:169-81, 2016.

  17. Meagher MJ, Weiss-Bilka HE, Best ME, Boerckel JD, Wagner DR, Roeder RK. “Acellular Hydroxyapatite-Collagen Scaffolds Support Angiogenesis and Osteogenic Gene Expression in an Ectopic Murine Model: Effects of Hydroxyapatite Volume Fraction.” Journal of Biomedical Materials Research: Part A. Sep;104(9):2178-88, 2016.

  18. Xie Y, Rustom LE, McDermott AM, Boerckel JD, Wagoner Johnson AJ, Alleyne AG, Hoelzle DJ “Net shape fabrication of calcium phosphate scaffolds with domains of different material compositions.” Biofabrication. Jan 8;8(1):015005, 2015.

  19. Griffin KS*, Davis KM*, McKinley TO, Anglen JO, Chu TMG, Boerckel JD†, Kacena MA†. “Evolution of bone grafting: Bone grafts and tissue engineering strategies for vascularized bone regeneration.” Clinical Reviews in Bone and Mineral Metabolism. 13(4),232-244, 2015. *Co-first authors. †Co-corresponding authors.

  20. Boerckel JD†, Mason DE, McDermott AM, Alsberg E. “Microcomputed Tomography: Approaches and Applications in Bioengineering.” Stem Cell Research and Therapy. 2014 Dec;5(6):144.  †Corresponding author.

  21. Boerckel JD, Chandrasekharan UM, Waitkus MS, Tillmaand EG, Bartlett R, DiCorleto PE, “MKP-1 promotes neovascularization and angiogenic gene expression.” Arteriosclerosis, Thrombosis, and Vascular Biology. 2014 May;34(5):1020-31. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014 May;34(5):1020-31.

  22. Uhrig BA, Boerckel JD, Willett NJ, Li MT, Huebsch N, Guldberg RE. “Recovery from hind limb ischemia enhances rhBMP-2-mediated segmental bone defect repair in a rat composite injury model.” Bone. 2013 Aug;55(2):410-7. Bone. 2013 Aug;55(2):410-7.

  23. Willett NJ, Li MT, Uhrig BA, Boerckel JD, Warren G, Guldberg RE, “Attenuated rhBMP-2 Mediated Bone Regeneration in a Rat Model of Composite Bone and Muscle Injury.” Tissue Engineering Part C. 2013 Apr;19(4):316-25.

  24. Uhrig BA, Clements IP, Boerckel JD, Bellamkonda RV, Guldberg RE. “Characterization of a Composite Injury Model of Severe Lower Limb Bone and Nerve Trauma.” Journal of Tissue Engineering and Regenerative Medicine. 2014 Jun;8(6):432-41.

  25. Diab T, Pritchard EM, Uhrig BA, Boerckel JD, Kaplan DL, Guldberg RE. “A Silk Hydrogel-based Delivery System of Bone Morphogenic Protein for the Treatment of Large Bone Defects.” Journal of the Mechanical Behavior of Biomedical Materials. 2012 Jul;11:123-31.

  26. Boerckel JD, Kolambkar YM, Stevens HY, Lin ASP, Dupont KM, Guldberg RE, “Effects of in Vivo Mechanical Loading on Large Bone Defect Regeneration.” Journal of Orthopaedic Research. 2012 Jul;30(7):1067-75.

  27. Berner A*, Boerckel JD*, Saifzadeh S, Steck R, Ren J, Vaquette C, Zhang JQ, Nerlich M, Guldberg RE, Hutmacher DW, Woodruff MA. “Biomimetic tubular nanofiber mesh and platelet rich plasma-mediated delivery of BMP-7 for large bone defect regeneration.” Cell and Tissue Research. 2012 Mar;347(3):603-12. *Contributed equally.

  28. Dupont KM, Boerckel JD, Stevens HY, Diab T, Kolambkar YM, Takahata M, Schwarz EM, Guldberg RE, “Synthetic Scaffold Coating with Adeno-Associated Virus Encoding BMP2 to Promote Endogenous Bone Repair.” Cell and Tissue Research 2012 Mar;347(3):575-88.

  29. Johnson MR, Boerckel JD, Dupont KM, Guldberg RE. “Functional Restoration of Critically Sized Segmental Defects with BMP-2 and Heparin Treatment.” Clinical Orthopaedics and Related Research. 2011 Nov;469(11):3111-7.

  30. Boerckel JD, Uhrig BA, Willett, NJ, Huebsch N, Guldberg RE, “Mechanical Regulation of Vascular Growth and Tissue Regeneration in Vivo.” Proceedings of the National Academy of Sciences. 2011 Sep 13;108(37):E674-80. Proceedings of the National Academy of Sciences. 2011 Sep 13;108(37):E674-80.

  31. Kolambkar YM, Boerckel JD, Dupont KM, Bajin M, Huebsch N, Mooney DJ, Hutmacher DW, Guldberg RE, “Spatiotemporal Delivery of Bone Morphogenetic Protein Enhances Functional Repair of Segmental Bone Defects.” Bone. 2011 Sep;49(3):485-92.

  32. Boerckel JD, Kolambkar YM, Dupont KM, Uhrig BA, Phelps EA, Stevens HY, García AJ, Guldberg RE, “Effects of Protein Dose and Delivery System on BMP-Mediated Bone Regeneration. Biomaterials. 2011 Aug;32(22):5241-51.

  33. Kolambkar YM, Dupont KM, Boerckel JD, Heubsch N, Mooney DJ, Hutmacher DW, Guldberg RE, “An Alginate-based Hybrid System for Growth Factor Delivery in the Functional Repair of Large Bone Defects.” Biomaterials. 2011 Jan;32(1):65-74.

  34. Dupont KM, Sharma K, Stevens HY, Boerckel JD , García AJ , Guldberg RE,  “Human stem cell delivery for treatment of large segmental bone defects." Proceedings of the National Academy of Sciences 2010 Feb 23;107(8):3305-10.

  35. Boerckel JD, Dupont KM, Kolambkar YM, Lin ASP, Guldberg RE, “In Vivo Model for Evaluating the Effects of Mechanical Stimulation on Tissue-Engineered Bone Repair.” Journal of Biomechanical Engineering. 2009 Aug;131(8):084502.

Preprints under review

  1. McDermott AM*, Eastburn EA*, Kelly DJ†, Boerckel JD†. “Effects of chondrogenic priming duration on mechanoregulation of engineered cartilage anlagen.” bioRxiv. 2020. doi: doi.org/10.1101/2020.09.02.280115. *Co-first authors. †Co-corresponding authors.

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