Brendon M. Baker, Ph.D.
Graduate Student in Bioengineering
GAANN Fellow (2006-2007)
NSF Graduate Research Fellow (2007-2010)
University of Pennsylvania
Hometown
Bedford, Maryland
Education
B.S. Biomedical Engineering, 2005, Columbia UniversityPh.D. Bioengineering, 2010, University of Pennsylvania
Areas of Special Interest
Brendon Baker joined the group as a Bioengineering graduate student in September of 2005. An avid proponent of !Science!, Brendon's work focuses on the tissue engineering of the knee meniscus using nanofibrous biodegradable scaffolds. When not shocking himself in the closet, Brendon can be found microwaving tissue culture plastic. Like his advisor, Brendon is an advocate for warm hats, baked goods, and winter cycling.
Manuscripts
Nathan AS, Baker BM, Nerurkar NL, Mauck RL. "Mechano-Topographic Control of Nuclear Deformation," 2010, Acta Biomaterialia, PMID: 20709198.
Nerurkar NL, Sen S, Baker BM, Elliott DM, Mauck RL. "Dynamic culture enhances stem cell infiltration and modulates extracellular matrix production on aligned electrospun nanofibrous scaffolds," 2010, Acta Biomaterialia, PMID: 20728589.
Baker BM, Nathan AS, Gee AO, Mauck RL. "The Influence of an Aligned Nanofibrous Topography on Human Mesenchymal Stem Cell Fibrochondrogenesis," 2010, Biomaterials, 31(24):6190-200.
Nerurkar NL, Baker BM, Sen S, Wible EW, Elliott DM, Mauck RL. "Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus," Nature Materials doi:10.1038/nmat2558. [**Selected for cover art, December 2009**].
Baker BM, Handorf AM, Ionescu LC, Li W-J, Mauck RL. "New Directions in Nanofibrous Scaffolds for Soft Tissue Engineering and Regeneration," Expert Review of Medical Devices, 2009, Expert Review of Medical Devices, 6(5):515-32.
Baker BM, Nerurkar NL, Burdick JA, Elliott DM, and Mauck RL. "Fabrication and Modeling of Dynamic Multi-Polymer Nanofibrous Scaffolds," Journal of Biomechanical Engineering, 2009, Journal of Biomechanical Engineering, 131(10):101012 [**Selected for cover art, October 2009**].
Mauck RL, Baker BM, Nerurkar NL, Burdick JA, Li WJ, Tuan RS, Elliott DM. "Engineering on the Straight and Narrow: The Mechanics of Nanofibrous Assemblies for Fiber-Reinforced Tissue Regeneration," 2009, Tissue Engineering: Part B, 15(2):171-93.
Baker BM, Gee AO, Sheth NP, Huffman GR, Sennett BJ, Schaer TP, Mauck RL. "Meniscus Tissue Engineering on the Nanoscale: From Basic Principles to Clinical Application," 2009, Journal of Knee Surgery, 22(1):45-59.
Baker BM, Nathan AS, Huffman GR, Mauck RL. "Tissue Engineering with Meniscus Cells Derived from Surgical Debris," 2009, Osteoarthritis and Cartilage, 17(3):336-45.
Baker BM, Gee AO, Metter RB, Nathan AS, Marklein RA, Burdick JA, Mauck RL. "Selective Removal of Sacrificial Fibers Improves Cell Infiltration in Composite Fiber-Aligned Nanofibrous Scaffolds," 2008, Biomaterials, 29(15):2348-58.
Tan AR, Ifkovits JL, Baker BM, Brey DM, Mauck RL, Burdick JA. "Electrospinning of Photocrosslinked and Degradable Fibrous Scaffolds," 2008, Journal of Biomedical Materials Research A, 87(4):1034-43.
Baker BM, Mauck RL. "Alignment Enhances the Maturation of Nanofiber-Based Engineered Meniscus Constructs," 2007, Biomaterials, 28(11):1967-77.
Sheth NP, Baker BM, Huffman GR, Mauck RL, "Emerging Strategies for Meniscus Repair," 2006, University of Pennsylvania Orthopaedic Journal, 18:59-72.
Abstracts
Baker BM, Qu F, Silverstein AM, Mauck RL. "Functional Human MSC Fibrochondrogenesis on Aligned Nanofibrous Scaffolds via Combined Exposure to FGF/TGF," Transactions of the 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, CA, January 13-16, 2011, submitted.
Baker BM, Shah RP, Silverstein AM, Zachry T, Qu F, Schenker M, Esterhai J, Mauck RL. "Instruction Without Impediment: Tunable Fibrous Scaffolds for Engineering Dense Connective Tissues," Transactions of the 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, CA, January 13-16, 2011, submitted.
Heo SC, Nerurkar NL, Baker BM, Mauck RL. "Fibrochondrogenesis Attenuates Stretch-Induced Nuclear Deformation on Aligned Nanofibrous Electrospun Scaffolds," Transactions of the 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, CA, January 13-16, 2011, submitted.
Heo SC, Nerurkar NL, Baker BM, Mauck RL. "Microstructure Dictates Stretch-Induced Cell and Nucleus Reorganization on Aligned Nanofibrous Scaffolds," Transactions of the 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, CA, January 13-16, 2011, submitted.
Baker BM, Shah RP, Huang AH, Mauck RL. "Dynamic Tensile Stimulation of MSC-Seeded Nanofibrous Constructs," 6th World Congress on Biomechanics, Singapore, August 1-6, 2010, podium.
Huang AH, Farrell MJ, Baker BM, Kim MW, Mauck RL. "Mechanical Stimulation Enhances Functional Mesenchymal Stem Cell Chondrogenesis," 6th World Congress on Biomechanics, Singapore, August 1-6, 2010, podium.
Baker BM, Shah RP, Mauck RL. "Dynamic Tensile Loading Improves the Mechanical Properties of MSC-Laden Aligned Nanofibrous Scaffolds," Proceedings of ASME 2010 Summer Bioengineering Conference, Naples, FL, June 16-19, paper #19447, podium.
Baker BM, Silverstein AM, Shah RP, Mauck RL. "Engineering the Functional Maturation of Nanofiber-Based Human Meniscus Tissue," Proceedings of ASME 2010 Summer Bioengineering Conference, Naples, FL, June 16-19, paper #19685, poster.
Huang AH, Baker BM, Ateshian GA, Mauck RL. "Sliding Contact Loading Improves the Tensile Properties of MSC-Based Engineered Cartilage," Proceedings of ASME 2010 Summer Bioengineering Conference, Naples, FL, June 16-19, 2010, paper#19292, podium.
Baker BM, Shah RP, Silverstein AM, Mauck RL. "Dynamic Tension Improves the Mechanical Properties of Nanofiber-Based Engineered Meniscus Constructs," Transactions of the 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 6-9, 2010, 35:179, podium.
Baker BM, Silverstein AM, Shah RP, Mauck RL. "Matrix Deposition Modulates Dynamic Mechanical Behavior of Nanofiber-Based Fibrocartilage," Transactions of the 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 6-9, 2010, 35:1312, poster.
Nathan AS, Baker BM, Nerurkar NL, Mauck RL. "Time-Dependent and Anisotropic Nuclear Deformations on Aligned Nanofibrous Scaffolds," Transactions of the 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 6-9, 2010, 35:105, podium.
Huang AH, Baker BM, Ateshian GA, Mauck RL. "Sliding Contact Enhances Mesenchymal Stem Cell Chondrogenesis in 3D Culture," Transactions of the 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 6-9, 2010, 35:315, podium.
Gee AO, Baker BM, Montero G, Silverstein AM, Mauck RL. "Fabrication and Evaluation of Biomimetic-Biosynthetic Nanofibrous Composites," Transactions of the 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 6-9, 2010, 35:1288, poster.
Nerurkar NL, Sen S, Baker BM, Zachry TL, Elliott DM, Mauck RL. "Dynamic culture enhances stem cell ingress and extracellular matrix deposition on electrospun nanofibrous scaffolds," Transactions of the 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 6-9, 2010, 35:1277, poster.
DeCoons RM, Shah RP, Gee AO, Baker BM, Guevara JL, Modesto RB, Schaer TP, Mauck RL. "In vivo Meniscus Repair with Anatomic Nanofibrous Scaffolds: A Preliminary Report," Transactions of the 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 6-9, 2010, 35:1308, poster.
Baker BM, Nathan AS, DeCoons RM, Gee AO, Mauck RL. "Human Meniscus Fibrochondrocytes Yield Superior Tissue Compared to Donor-Matched Mesenchymal Stem Cells on Nanofibrous Scaffolds," Proceedings of the 2009 BMES Annual Meeting, Pittsburgh, PA, October 7-10, 2009, podium.
Baker BM, Montero G, Mauck RL. "Removal of Sacrificial Fibers Enhances Long Term Cell and Matrix Distribution in Aligned Nanofibrous Scaffolds," Proceedings of ASME 2009 Summer Bioengineering Conference, Lake Tahoe, CA, June 17-21, paper #206856.
Nathan AS, Baker BM, Mauck RL. "Cytoskeletal Control of Mesenchymal Stem Cell Nuclear Deformation on Nanofibrous Scaffolds," Proceedings of ASME 2009 Summer Bioengineering Conference, Lake Tahoe, CA, June 17-21, paper #206855.
Baker BM, Nerurkar NL, Burdick JA, Elliott DM, Mauck RL. "Instilling Time-Dependent Behavior in Electrospun, Multi-Polymer Nanofibrous Composites," Transactions of the 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, NV, February 22-25, 2009, 34:473.
Baker BM, Gee AO, Nathan AS, Mauck RL. "Meniscus Tissue Engineering with Fibrochondrocytes and MSCs from Osteoarthritic Donors," Transactions of the 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, NV, February 22-25, 2009, 34:1293.
Nathan AS, Baker BM, Mauck RL. "Static Deformation Modulates Stem Cell Architecture and Morphology on Aligned Nanofibrous Scaffolds" Transactions of the 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, NV, February 22-25, 2009, 34:1293.
Baker BM, Nerurkar NL, Burdick JA, Mauck RL. "The Temporal Behavior of Electrospun, Multi-Polymer Nanofibrous Composites," Proceedings of TERMIS-NA 2008 Conference, San Diego, CA, December 7-11, paper #574.
Baker BM, Nerurkar NL, Burdick JA, Elliott DM, Mauck RL. "Fabrication and Modeling of an Electrospun Tri-Polymer Composite for the Engineering of Fibrous Tissues," Proceedings of ASME 2008 Summer Bioengineering Conference, Marco Island, FL, June 25-29, paper #193174.
Gee AO, Baker BM, Mauck RL. "Mechanics and Cytocompatibility of Genepin Crosslinked Type I Collagen Nanofibrous Scaffolds," Proceedings of ASME 2008 Summer Bioengineering Conference, Marco Island, FL, June 25-29, paper #193220.
Baker BM, Nathan AS, Mauck RL. "Tensile Loading Modulates Collagen Gene Expression in MSC-Laden Nanofibrous Scaffolds," Transactions of the 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, March 2-5, 2008, 33:1465.
Baker BM, Gee AO, Jennings MW, Nathan AS, Huffman GR, Mauck RL. "Engineering Anatomically-Shaped Meniscus Constructs: Biologic and Mechanical Integration," Transactions of the 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, March 2-5, 2008, 33:1460.
Baker BM, Gee AO, Marklein RA, Nathan AS, Burdick JA, Mauck RL. "Tuning Nanofibrous Scaffold Mechanics and Porosity to Promote Cell Infiltration," Transactions of the 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, March 2-5, 2008, 33:132.
Baker BM, Nathan AS, Huffman GR, Mauck RL. "Structure-Function Correlations of Young and Aged Human Fibrochondrocyte-Seeded Engineered Meniscus Constructs," Transactions of the 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, March 2-5, 2008, 33:321.
Baker BM, Nathan AS, Sheth NP, Huffman GR, Mauck RL: "Autologous Human Fibrochondrocytes from Meniscectomy Debris are a Potent Cell Source for Meniscus Tissue Engineering," Proceedings of ASME 2007 Summer Bioengineering Conference, Keystone, CO, June 20-24, paper #176525.
Baker BM, O’Connell GD, Sen S, Nathan AS, Elliott DM, Mauck RL: "Multi-Lamellar and Multi-Axial Maturation of Cell-Seeded Fiber-Reinforced Tissue Engineered Constructs," Proceedings of ASME 2007 Summer Bioengineering Conference, Keystone, CO, June 20-24, paper #176434.
O’Connell GD, Sen S, Baker BM, Mauck RL, Elliott DM: "Biaxial Mechanics of Native and Engineered Fiber-Reinforced Musculoskeletal Tissues," Proceedings of ASME 2007 Summer Bioengineering Conference, Keystone, CO, June 20-24, paper #176540.
Metter RB, Baker BM, Burdick JA, Mauck RL: "Enhanced Cellular Infiltration with Removal of Sacrificial Fibers from a Dual-Polymer Nanofibrous Scaffold," Proceedings of ASME 2007 Summer Bioengineering Conference, Keystone, CO, June 20-24, paper #176487.
Tan AR, Ifkovits JL, Baker BM, Mauck RL, Burdick JA: "Electrospinning of Photopolymerizable Poly(Beta-Amino Ester) Networks for Fibrous Tissue Engineering," Proceedings of ASME 2007 Summer Bioengineering Conference, Keystone, CO, June 20-24, paper #176206.
Baker BM, Tan AR, Metter RB, Nathan AS, Mauck RL: "Nanofiber Alignment Enhances the Development of Engineered Meniscus Constructs," Transactions of the 53rd Annual Meeting of the Orthopaedic Research Society, San Diego, CA, February 11-14, 2007, 32:779.
Sheth NP, Baker BM, Nathan AS, Mauck RL: "Biologic Integration of Fiber-Aligned Nanofibrous Scaffolds with Native Meniscus," Transactions of the 53rd Annual Meeting of the Orthopaedic Research Society, San Diego, CA, February 11-14, 2007, 32:780.
Nerurkar NL, Baker BM, Chen CY, Elliott DM, Mauck RL, "Engineering of Fiber-Reinforced Tissues with Anisotropic Biodegradable Nanofibrous Scaffolds," IEEE-EMBS Meeting, New York, NY, Aug 30-Sept 3, 2006, pp. 787-790.
Baker BM, Sheth NP, Mauck RL: "Maturation of MFC- and MSC-Laden Nanofibrous Scaffolds for Meniscus Tissue Engineering," University of Pennsylvania IME Symposium, Philadelphia, PA, May 19, 2006, pp. 47.
Baker BM, Sheth NP, and Mauck RL: "Maturation of MFC- and MSC-Laden Nanofibrous Scaffolds for Meniscus Tissue Engineering," Proceedings of ASME 2006 Summer Bioengineering Conference, Amelia Island, FL, June 21-25, paper #157580.