Dakota Jones, Ph.D.
He/Him/His
Post-Doctoral Fellow
University of Pennsylvania
Hometown
Friendsville, Pennsylvania
Education
BS, Bioengineering Syracuse University, 2014
PhD, Biomedical Sciences, Mayo Clinic Graduate School of Biomedical Sciences, 2020
Areas of Special Interest
Tissue injury/repair, epigenetics, mechanobiology. Outside of the lab, Dakota enjoys listening to music, eating good food, and going on hikes.
Publications
Aravamudhan A, Haak AJ, Choi KM, Meridew JA, Caporarello N, Jones DL, Tan Q, Ligrest G, Tschumperlin DJ. TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation. AJP Lung Cellular and Molecular Physiology. 2020. PMID: 32159970
Soreide E, Denbeigh JM, Lewallen EA, Thaler R, Samsonraj RM, Jones DL, Xu W, Larson D, Nordsletten L, Kakar S, van Wijnen AJ. A Multi-Chamber Tissue Culture Device for Load-Dependent Parallel Evaluation of Tendon Explants. BMC Musculoskeletal Disorders. 2019. PMID: 31739778
Haak AJ, Kostallari E, Sicard D, Ligresti G, Choi KM, Caporarello N, Jones DL, Tan Q, Meridew J, Diaz Espinosa AM, Aravamudhan A, Maiers JL, Britt R, Roden AC, Pabelick CM, Prakash YS, Nouraie SM, Li X, Zhang Y, Kass DJ, Lagares D, Tager AM, Varelax X, Shah VH, Tschumperlin DJ. Selective YAP/TAZ Inhibition in Fibroblasts via Dopamine Receptor D1 Agonism Reverses Fibrosis. Science Translational Medicine. 2019. PMID: 31666402
Jones DL, Haak AJ, Caporarello N, Choi KM, Ye Z, Yan H, Varelas X, Ordog T, Ligresti G, Tschumperlin DJ. TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression. Journal of Cell Science. 2019. PMID: 31527052
Caporarello N, Meridew JA, Jones DL, Tan Q, Haak AJ, Manlove LJ, Prakash YS, Tschumperlin DJ, Ligresti G. PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state. Thorax. 2019. PMID: 31182654
Ligresti G, Caporarello N, Meridew JA, Jones DL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, Prakash YS, Lomberk G, Urrutia RA, Tschumperlin DJ. CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis. JCI Insight. 2019. PMID: 31095524
Tan Q, Ma XY, Liu W, Meridew JA, Jones DL, Haak AJ, Sicard D, Ligresti G, Tschumperlin DJ. Nascent Lung Organoids Reveal Epithelium- and BMP- Mediated Suppression of Fibroblast Activation. American Journal of Respiratory Cell and Molecular Biology. 2019. PMID: 31050552
Jones DL, Ligresti, G. Survivin IPF: Targeting Cellular Metabolism to Promote Apoptosis in IPF fibroblasts. American Journal of Respiratory Cell and Molecular Biology. 2019. PMID: 30211627.
Riester SM, Denbeigh JM, Lin Y, Jones DL, De Mooij T, Lewallen EA, Nie H. Paradise CR, Radel DJ, Dudakovic A, Camilleri ET, Larson DR, Qu W, Krych AJ, Frick MA, Im H-J, Dietz AB, Smith J, van Wijnen AJ. Safety Studies for Use of Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells in a Rabbit Model for Osteoarthritis to Support a Phase I Clinical Trial. Stem Cells Translational Medicine. 2017. PMID: 27798372
Lin Y, Lewallen EA, Camilleri ET, Bonin CA, Jones DL, Dudakovic A, Galeano-Garces C, Wang W, Karperien MJ, Larson AN, Dahm DL, Stuart MJ, Levy BA, Ryssman DB, Smith J, Westendorf JJ, Im H-J, van Wijnen AJ, Riester SM, Krych AJ. RNA-seq analysis of clinical-grade osteochondral allografts reveals activation of early response genes. Journal of Orthopaedic Research. 2016. PMID: 26909883
Onishi K*, Jones DL*, Riester SM, Lewallen EA, Lewallen DG, Sellon JL, Dietz AB, Qu W, van Wijnen AJ, Smith J. Human Adipose-Derived Mesenchymal Stem Cells Retain Metabolic Activity, Viability, and Behavior Following Clinical-Grade Needle Injection. Physical Medicine and Rehabilitation. 2016. PMID: 26826615 . * designates co-first author
Lewallen EA, Jones DL, Dudakovic A, Thaler R, Paradise C, Kremers HM, Abdel MP, Dietz AB, Cohen RC, Lewallen DG, van Wijnen AJ. Osteogenic potential of human adipose-tissue-derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium. Gene. 2016. PMID: 26774799
Getzlaf MA, Lewallen EA, Kremers HM, Jones DL, Bonin CA, Dudakovic A, Thaler R, Cohen RC, Lewallen DG, van Wijnen AJ. Multi-disciplinary antimicrobial strategies for improving orthopedic implants to prevent prosthetic joint infections in hip and knee. Journal of Orthopaedic Research. 2015. PMID: 26449208
Seacrist T, Locey CM, Mathews EA, Jones DL, Balasubramanian S, Maltese MR, Arbogast KB. Evaluation of Pediatric ATD Biofidelity as Compared to Child Volunteers in Low-Speed Far-Side Oblique and Lateral Impacts. Traffic Injury Prevention. 2014. PMID: 25307388
Conference Abstracts
Oral Presentations:
Jones DL, Meridew JA, Caporarello N, Tan Q, Ye Z, Yan H, Ordog T, Ligresti G, Tschumperlin DJ. Identification of ZNF416 as a Novel Mechanoregulator of Lung Fibroblast Activation. Biomedical Engineering Society Annual Meeting. Philadelphia, Pennsylvania. October 16-19, 2019.
Jones DL, Ligresti G, Tschumperlin DJ. Substrate Elasticity Governs Epigenetic Repression of Anti-Fibrotic Gene Activity in Lung Fibroblasts. Biomedical Engineering Society Annual Meeting. Phoenix, Arizona. October 11-14, 2017.
Jones DL, Seacrist T, Arbogast KB. Evaluation of Pediatric ATD Biofidelity as Compared to Child Volunteers in Low-Speed Far-Side Oblique and Lateral Impacts. Injury Biomechanics Symposium. Ohio State University, Columbus, OH. May, 2014.
Poster Presentations:
Jones DL, Meridew JA, Caporarello N, Tan Q, Ye Z, Yan H, Ordog T, Ligresti G, Tschumperlin DJ. Identification of ZNF416 as a Novel Mechanoregulator of Lung Fibroblast Activation. International Workshop on Scleroderma Research. Cambridge, England. July 27-31, 2019.
Jones DL, Haak AJ, Caporarello N, Ligresti G, Tschumperlin DJ. TGFβ-induced fibroblast activation requires HDAC-mediated epigenetic suppression of anti-fibrotic genes. American Thoracic Society. San Diego, California. May 18-23, 2018.
Jones DL, Ligresti G, Tschumperlin DJ. Substrate rigidity promotes fibroblast activation by epigenetic repression of an anti-fibrotic gene program. Mechanical Forces in Biology. Heidelberg, Germany. July 12-15, 2017
Ligresti G, Jones DL, Haak AJ, Choi KM, Tan Q, Sicard DG, Lomberk GA, Urrutia RA Tschumperlin DJ. Role of CBX5/G9a-Mediated Epigenetic Silencing in Lung Fibroblast Activation. American Thoracic Society. Washington D.C., May 19-24, 2017.
Lewallen E, Jones DL, Thaler R, Dudakovic A, Denbeigh J, Paradise C, Gluscevic M, Soreide E, Kremers H, Abdel M, Cohen R, Lewallen D, van Wijnen A. Surface roughness of metal orthopedic implants alters the biology of human mesenchymal stromal cells. Biomedical Engineering Society Annual Meeting. Minneapolis, MN, October 5-8, 2016.
Lewallen EA, Jones DL, Dudakovic A, Bonin CA, Getzlaf MA, Thaler R, Riester SM, Camilleri ET, Westendorf JJ, Dietz AB, Cohen RC, Lewallen DG, van Wijnen AJ. Mesenchymal cell-based biological enhancement of porous titanium orthopedic implants. The American Society for Bone and Mineral Research. Seattle, WA, October 8-12, 2015.
Thaler R, Schreiner M, Lewallen EA, Jones DL, Deyle DR, Dietz AB, Lewallen DG, van Wijnen AJ. Modulation of the extracellular matrix environment and epigenetic DNA methylation improves osteogenicity of human mesenchymal stromal cells. The American Society for Bone and Mineral Research. Seattle, WA, October 8-12, 2015.
Lewallen EA, Riester SM, Lin Y, Bonin CA, Jones DL, Camilleri ET, Galeano-Garces C, Qu W, Smith J, Larson AN, Karperien MJ, Stuart MJ, Westendorf JJ, Kakar S, Im H-J, Krych A, van Wijnen AJ. Molecular approaches to the screening and optimization of osteochondral allograft cartilage. International Cartilage Repair Society. Chicago, IL, May 8-11, 2015.
Jones DL, Brasch ME, Baker RM, Manning ML, Henderson JH. Subpopulation Identification During Cell-Material Interactions Via Neural Network Clustering of Motility Metrics. Society for Biomaterials. Denver, CO. April 16-19, 2014.
Jones DL, Baker RM, Mather PT, and Henderson JH. Tuning Recovery Kinetics of a Shape Memory Polymer for Active Cell Culture. Biomedical Engineering Society Annual Meeting. Hartford, CT, October 12 – 15, 2011.