Matthew B. Fisher, Ph.D.
Post-Doctoral Fellow
University of Pennsylvania
Hometown
Pittsburg, PA
Education
Ph.D. Bioengineering, 2010, University of Pittsburgh
B.S. Biomedical Engineering, 2005, Columbia University
Areas of Special Interest
Matt joined the group as a post-doctoral researcher in January 2011 after receiving his Ph.D. from the University of Pittsburgh at the Musculoskeletal Research Center under the direction of Dr. Savio L-Y. Woo. Matt's research is focused on tissue engineering of the injured knee meniscus and articular cartilage. A particular focus is the development of appropriate animal models to evaluate the performance of tissue engineered constructs in-vivo as a first step toward their clinical translation. Matt is a Pittsburgh native, and thus, is a fan of the Steelers, Penguins, and alas, Pirates. He also enjoys the occasional round of golf, traveling with his wife, and competitive games of all varieties.
Publications
Fisher, M.B., Henning, E.A, Soegaard, N., Esterhai, J.L., Mauck, R.L. Functional Maturation of Mesenchymal Stem Cell Laden Nanofibrous Scaffolds with Anatomic Organization for Replacement of the Knee Meniscus. In preparation.
Fisher, M.B., Henning, E.A, Soegaard, N., Burdick, J.A., Mauck, R.L. Development of Trajectory-Based Tissue Engineering for Repair of Articular Cartilage. In preparation.
Belkin, N.S.*, Fisher, M.B.*, Henning, E.A., Kim, M., Bian, L., Burdick, J.A., Steinberg, D.R., Mauck, R.L.. Hyaluronic Acid Hydrogels for Articular Cartilage Defect Repair in a Large Animal Model. In preparation. *Contributed equally.
Schenker, M.L., Huang, K., Fisher, M.B., Bonilla, A., Ionescu, L.C., Esterhai, J.L., Schaer, T.P., Mauck, R.L. In Vivo Evaluation of Dynamic Nanofibrous Scaffolds for Meniscus Tissue Engineering. In preparation.
Qu, F., Lin, J-M.G., Esterhai, J.L., Fisher, M.B., Mauck, R.L. Improved Meniscus Integration via Controlled Degradation of the Wound Interface. In preparation.
Farrell, M.J., Fisher, M.B., Soegaard, N., Farrell, K.M., Mauck, R.L. Mesenchymal Stem Cell-Based Cartilage is Unstable in Long Term In-Vitro Culture. In preparation.
Fisher, M.B., Henning, E.A, Soegaard, N., Esterhai, J.L., Mauck, R.L. Organized Nanofibrous Scaffolds That Mimic the Macroscopic and Microscopic Architecture of the Knee Meniscus. Acta Biomaterialia, 9 (1):4496-504, 2012.
Ionescu, L.C., Fisher, M.B., Schenker, M.L., Huang, K.L., Esterhai, J.L., and Mauck, R.L. Enhanced Vascularization of Electrospun Scaffolds for Fibrous Tissue Repair via VEGF Delivery from Sacrificial Fibers and Entrapped Microspheres. Submitted to European Journal of Cells and Materials, in revision, May, 2012.
Fisher, M.B., Woo, S.L-Y., Zamarra, G., Jung, H-J., Almarza, A.J., Liang, R., and McMahon, P.J. Potential of Healing a Transected Anterior Cruciate Ligament with Genetically-Modified Extracellular Matrix Bioscaffolds in a Goat Model. Knee Surgery, Sports Traumatology, Arthroscopy, 20: 1357-1365, 2012.
Jung, H-J., Vangipuram, G., Fisher, M.B., Yang, G., Hsu, S., and Woo, S.L-Y. The Effects of Multiple Freeze-Thaw Cycles on the Biomechanical Properties of the Human Bone-Patellar Tendon-Bone Graft. Journal of Orthopaedic Research, 29(8): 1193-1198, 2011.
Fisher, M.B., Jung, H-J., Kim, K.E., McMahon, P.J., and Woo, S.L-Y. Evaluation of Suture Techniques to Restore Initial Joint Stability after ACL Injury. Journal of Biomechanics, 44(8): 1530-1535, 2011.
Liang, R., Fisher, M.B., Yang, G., and Woo, S.L-Y. Morphological, Biochemical, and Biomechanical Characterization of Extracellular Matrix Derived from Genetically-Modified Pigs. Acta Biomaterialia, 7 (4): 1719-1727, 2011.
Fisher, M.B., Jung, H-J., McMahon P.J., and Woo, S.L-Y. Evaluation of Bone Tunnel Placement for Suture Augmentation of an Injured Anterior Cruciate Ligament: Effects on Joint Stability in a Goat Model. Journal of Orthopaedic Research, 28(10): 1373-1379, 2010.
Zamarra, G. Fisher, M.B., Cerulli G., and Woo, S.L-Y. Biomechanical Evaluation Using One Hamstrings Tendon for ACL Reconstruction: A Human Cadaveric Study. Knee Surgery, Sports Traumatology, Arthroscopy, 18: 11-19, 2010.
Woo S.L-Y., Liang, R., and Fisher, M.B. Future of Orthopaedic Sports Medicine and Soft Tissue Healing: the Important Role of Engineering. Cellular and Molecular Bioengineering, 2(3): 448-461, 2009.
Jung, H-J., Woo S.L-Y., and Fisher, M.B. Role of Biomechanics in the Understanding of Normal, Injured, and Healing Ligaments and Tendons. Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology, 1(9), 2009.
Woo S.L-Y. and Fisher, M.B. Evaluation of Knee Stability Using a Robotic System. Journal of Bone and Joint Surgery, 91(Supp. 1): 78-84, 2009.
Kelly, T. N., Fisher, M.B., Oswald, E.S., Tai, T., Mauck, R.L., Ateshian, G.A., and Hung, C.T. Low-Serum Media and Dynamic Deformational Loading in Tissue Engineering of Articular Cartilage. Annals of Biomedical Engineering, 36(5): 769-779, 2008.
Woo S.L-Y., Fisher, M.B., Feola, A.J. Contribution of Biomechanics to Management of Ligament and Tendon Injuries. Molecular and Cellular Biomechanics, 5(1): 49-68, 2008.
Karaoglu S., Fisher, M.B., Woo S.L-Y., Fu Y.C., Liang R., Abramowitch S.D.. Use of a bioscaffold to improve healing of the patellar tendon defect after graft harvest for ACL reconstruction: A study in rabbits. Journal of Orthopaedic Research, 26(2): 255-263, 2008.
Zhang, X., Fisher, M.B., Woo, S.L-Y., Jiang, G., Abramowitch, S.D.: The Assumption of a Negligible Preload on the Determination of Viscoelastic Properties Based on the Quasi-linear Viscoelastic (QLV) Theory. 2007 IEEE/ICME International Conference on Complex Medical Engineering, Beijing, China: 1645-1648, 2007.
Book Chapters
Fisher, M.B. and Mauck, R.L. Mechanics of Fiber-Reinforced Scaffolds and Tissues Formed From Organized Electrospun Assemblies in Tissue Engineering and Regenerative Medicine: A Nano Approach. Ed. M. Ramalingam, P. Vallittu, U. Ripamonti, and W-J Li, CRC Press, In Press, December 2011.
Woo, S.L-Y., Almarza, A.J., Karaoglu, S., Liang, R., Fisher, M.B.: Functional Tissue Engineering of Ligament and Tendon Injuries in Principles of Regenerative Medicine, Second Edition. Eds. A. Atala and R. Lanza, Elsevier, Inc., Chapter 7, Submitted January 2010.
Woo, S.L-Y., Jung, H-J., Fisher, M.B.: Biomechanical Variation of Double-Bundle Anterior Cruciate Ligament Reconstruction in Sports Injuries - Prevention, Diagnosis, Treatment and Rehabilitation. Ed. M.N. Doral, Springer-Verlag, Heidelberg, Germany, pp. 355-361, 2011.
Woo, S.L-Y., Almarza, A.J., Liang, R. and Fisher, M.B.: Functional Tissue Engineering of Ligament and Tendon Injuries in Translational Approaches in Tissue Engineering and Regenerative Medicine. Eds. J. Mao, G. Vunjak-Novakovic, A. Mikos and A. Atala, Artech House, Norwood, Massachusetts, Chapter 9, pp. 163-179, 2008.
Abstracts and Conference Proceedings
Fisher, M.B., Henning, E., Esterhai, J.L., and Mauck, R.L. Fabrication of Organized Nanofibrous Scaffolds to Mimic the Macroscopic Curvature of the Meniscus: Structure and Mechanics. ASME Summer Bioengineering Conference. Fajardo, Puerto Rico, June 2012.
Fisher, M.B., Henning, E., Esterhai, J.L., and Mauck, R.L. Organized Nanofibrous Scaffolds to Mimic the Macroscopic Curvature of the Meniscus. Northeast Bioengineering Conference. Philadelphia, PA, March 2012.
Schenker, M.L., Huang, K.L., Bonilla, A., Fisher, M.B., Shah R.P., Ionescu, L.C., Qu, F., Esterhai, J.L., Schaer, T.P., and Mauck, R.L. Dynamic Nanofibrous Scaffolds Improve In Vivo Colonization and Implant Fixation in a Meniscus Defect Model. 58th Annual Meeting of the Orthopaedic Research Society. San Francisco, CA, February 2012.
Ionescu, L.C., Fisher, M.B., Schenker, M.L., Esterhai, J.L., and Mauck, R.L. VEGF Delivery from Electrospun Composites Increases Vascular Density In Vivo. 58th Annual Meeting of the Orthopaedic Research Society. San Francisco, CA, February 2012.
Fisher, M.B., Henning, E., and Mauck, R.L. Novel Design of Organized Nanofibrous Scaffolds to Mimic the Macroscopic Curvature of Native Meniscus. 58th Annual Meeting of the Orthopaedic Research Society. San Francisco, CA, February 2012.
Liang, R., Fisher, M.B., Yang, G., Hall, C., and Woo, S.L-Y. Characterization of ?Gal(-) ECM Bioscaffolds: An Indication for Application in Tissue Engineering. ASME Summer Bioengineering Conference. Farmington, PA, June 2011.
Fisher, M.B., Jung, H-J., Kim, K.E., McMahon, P.J., and Woo, S.L-Y. Extracellular Matrix Bioscaffolds to Enhance ACL Healing: Impact on the Contribution of the MCL to Joint Stability. ASME Summer Bioengineering Conference. Farmington, PA, June 2011.
Kim, K.E., Hsu, S., Fisher, M.B., and Woo, S.L-Y. The Effect of Patellar Orientation on the Stiffness of the Porcine Femur-Medial Patellofemoral Ligament-Patella Complex. ASME Summer Bioengineering Conference. Farmington, PA, June 2011.
Fisher, M.B., Kim, K.E., Jung, H-J., McMahon, P.J., and Woo, S.L-Y. Mechanical Augmentation Using Sutures to Stimulate Healing of the ACL in the Goat Model. Accepted to International Symposium on Ligaments and Tendons XI. Long Beach, CA, January, 2010.
Fisher, M.B., Jung, H-J., Liang, R., Kim, K.E., McMahon, P.J., and Woo, S. L-Y. Use of Extracellular Matrix Bioscaffolds to Enhance ACL Healing: A Multidisciplinary Approach in a Goat Model. ASME Summer Bioengineering Conference. Naples, FL, June 2010.
Fisher, M.B., Jung, H-J., Woo, S.L-Y. Suture Techniques for ACL Healing: Initial Knee Stability and Impact on the Medial Meniscus in the Goat. 56th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA, March 2010.
Fisher, M.B., Liang R., Jung H-J., McMahon, P.J., and Woo S.L-Y. A Novel Extracellular Matrix Bioscaffold Can Enhance ACL Healing. International Symposium on Ligaments and Tendons X. Hong Kong, China, February, 2010.
Jung H-J., Vangipuram G., Fisher, M.B., Yang G., Hsu S., and Woo S.L-Y. Will Multiple Freeze/Thaw Cycles Change the Tensile Properties of Human Patellar Tendons? International Symposium on Ligaments and Tendons X. Hong Kong, China, February, 2010.
Fisher, M.B. and Woo S.L-Y. Mechanical Properties of Extracellular Matrix Bioscaffolds Derived from Genetically-Modified Pigs. Biomedical Engineering Society Annual Meeting. Pittsburgh, PA, October 2009.
Fisher, M.B., Liang, R., Jung, H., McMahon, P.J., and Woo S.L-Y. Use of a Novel Extracellular Matrix Bioscaffold to Enhance Anterior Cruciate Ligament Healing. Biomedical Engineering Society Annual Meeting. Pittsburgh, PA, October 2009.
Fisher, M.B., Jung, H., McMahon, P.J., and Woo, S. L-Y. Effects of Tunnel Location for Suture Augmentation Following Anterior Cruciate Ligament Injury. ASME Summer Bioengineering Conference. Lake Tahoe, CA, June 2009.
Liang, R., Fisher, M.B., and Woo, S.L-Y. ECM Bioscaffold Improves Healing of the Anterior Cruciate Ligament in Goat. 2009 Midwestern Tissue Engineering Consortium. Pittsburgh, PA, April 2009.
Liang, R., Fisher, M.B., Yang, G., and Woo, S.L-Y. Expression of Fibronectin and TGF-beta in UBM Derived from Genetically-Modified Pigs. 2009 Midwestern Tissue Engineering Consortium. Pittsburgh, PA, April 2009.
Fisher, M.B. and Woo, S.L-Y. Mechanical Properties of Extracellular Matrix Bioscaffolds Derived from Genetically-Modified Pigs. 2009 Midwestern Tissue Engineering Consortium. Pittsburgh, PA, April 2009.
Liang, R., Ferderber, M., Fisher, M.B., Woo, S. L-Y. The Expressions of Fibronectin and TGF-beta in the Gal Knockout ECM Bioscaffold. 55th Annual Meeting of the Orthopaedic Research Society. Las Vegas, NV, February 2009.
Fisher, M.B., Zamarra, G., Cirillo, A., Liang, R., Almarza, A.J., McMahon, P.J., Woo, S.L-Y. Improved Healing of the Anterior Cruciate Ligament Following Genetically-Engineered Bioscaffold Treatment in the Goat Model. 55th Annual Meeting of the Orthopaedic Research Society. Las Vegas, NV, February 2009.
Fisher, M.B., Jung, H., McMahon, P.J., Woo, S. L-Y. In-vitro Evaluation of Suture Augmentation Techniques After ACL Injury. International Symposium on Ligaments and Tendons IX. Las Vegas, NV, February, 2009.
Zamarra G., Fisher, M.B., Woo, S. L-Y., Cerulli, G. Utilization of Only One Hamstrings Tendon for ACL. 5th Meeting of the European Federation of National Associates of Orthopaedic Sports Traumatology. November 2008.
Woo, S.L-Y., Liang, R., Fisher, M.B. Biomedical Engineering and its Important Role to the Healing, Repair, and Regeneration of Ligaments and Tendons. 10th Shanghai Round Table on Biomedical Engineering. November 2008.
Woo, S.L-Y., Fisher, M.B., Almarza, A.J. Regeneration of Ligaments and Tendons by Application of Bioscaffolds. ASME International Mechanical Engineering Congress & Exposition. Boston, MA. October 2008.
Zamarra, G., Fisher, M.B., Cerulli, G., Woo, S.L-Y. Utilization of Only One Hamstrings Tendon for ACL Reconstruction: An "All-Inside" Technique. 16th International Conference on Mechanics in Medicine and Biology. Pittsburgh, PA. July 2008.
Debski, R.E., Fisher, M.B., Jolly, J.T., Woo, S.L-Y. Use of Robotic Technology at the Muscoluskeletal Research Center: Technical Challenges. International Symposium on Robotic Applications in Biomechanics. Banff, Canada. May 2008.
Woo S.L-Y. and Fisher, M.B. Evaluation of Knee Stability using a Robotic Testing System. AAOS/ORS Advanced Imaging and Computer Assisted Surgery of the Hip and Knee Research. Providence, RI. May 2008.
Woo, S.L-Y., Fisher, M.B., Liang, R. Biomechanical and Functional Assessment of ACL Reconstruction. International Symposium on Ligaments and Tendons - Hong Kong. Hong Kong, China. April 2008.
Woo, S.L-Y., Almarza, A.J., Fisher, M.B., Liang, R. Biologic Effects of ECM Bioscaffolds for Ligament and Tendon Healing and Regeneration. 5th Symposium on the use of extracellular matrix as a biological scaffold for tissue reconstruction. Scottsdale, Arizona. February 2008.
Abramowitch, SD; Fisher, M.B.; Karaoglu, S; Woo, SL-Y. The mechanical and viscoelastic properties of the healing rabbit patellar tendon. American Society of Mechanical Engineers Summer Bioengineering Conference, Keystone, Colorado. June 2007.
Karaoglu, S., Fisher, M.B., Liang, R., Fu, Y.C., Abramowitch, S.D., Woo, S. L-Y. A Bioscaffold to Improve Healing of a Patellar Tendon Defect After Graft Harvest for ACL Reconstruction. International Symposium on Ligaments and Tendons VII. San Diego, California. February 2007.
Liu, P.C., Liang, R., Karaoglu, S., Fisher, M.B., Almarza, A., Abramowitch, S.D., Woo, S.L-Y.: The Effect of a Bioscaffold on Patellar Tendon Harvest in ACL Reconstruction: Analysing the Risk Factors of Patellar Tendon Rupture in the Rabbit Flexed Knee Model. 10th Intl Conference on Orthopaedics, Biomechanics & Sports Rehabilitation, Assisi, Italy, December 2006.
Fisher, M.B., Abramowitch, S.D., Woo, S. L-Y. The Effect of Assuming a Negligible Preload on the Viscoelastic Properties of the Normal and Healing Rabbit Patellar Tendon. ASME Summer Bioengineering Conference. Amelia Island, Florida. June 2006.
Fu. Y.C., Fisher, M.B., Liang, R., Nguyen, T.D., Moon, D.K., Abramowitch, S.D., Woo, S. L-Y. Treatment with a Bioscaffold to Improve the Healing of a Patellar Tendon Defect: Short Term Results in the Rabbit Model. 52nd Annual Meeting of the Orthopaedic Research Society. Poster No. 1052. Transactions Vol. 31. Chicago, Illinois. March 2006.
Kelly, T.N., Chahine, N.O., Fisher, M.B., Ng, K.W., Tai, T., Ateshian, G.A., Hung, C.T. Tension-Compression Nonlinearity in Chondrocyte-Seeded Agarose Hydrogels. ASME Summer Bioengineering Conference. Vail, Colorado. June 2005.
Kelly, T.N., Fisher, M.B., Lima, E.G., Ateshian, G.A., Hung, C.T. Integrative Properties of Chondrocyte-Seeded Agarose Constructs. 51st Annual Meeting of the Orthopaedic Research Society. Washington, D.C. February 2005.