Ryan Locke, Ph.D
Post-Doctoral Fellow
University of Pennsylvania
Hometown
Mickleton, NJ
Education
Ph.D. Biomedical Engineering, University of Delaware, 2020
B.S. Biomedical Engineering, University of Delaware, 2015
Areas of Special Interest
Translational research, biomaterials, and prognostic biomarkers.
I am an enthusiast of all exercise especially tennis, running, biking, and circuit workouts. My dog, a miniature Dachshund named Macaroni and nicknamed 'Roni, is the best hands-down. I really enjoy the beach as well as cooking, which usually involves chicken parm, seafood, or homemade pizza.
I'm very passionate about helping others become involved with #orthoresearch through social media, outreach, and in-lab training. Anyone should feel free to reach out to discuss orthopaedics with me.
Awards
International:
2018 NSF I-CORP Sites
2018 Cover Photo for Connective Tissue Research v59, Issue 5
2018 Journal of Orthopaedic Research Early-Career Award (Awarded to Megan Killian)
I contributed to the manuscript that received this award, and I am the second co-author.
2019 ORS Scientific Photo Competition, 3rd Place
Institutional:
2013 First Step Award, College of Healthy Sciences
2014 First Step Award, College of Healthy Sciences
2014 Study Abroad, Marseilles, France
2015 First Step Award, College of Healthy Sciences
2017 INBRE Core Access Award
2018 Professional Development Award
2018 Art in Science, Meet the Artist, Top 50
2018-2019 Venture On
2019 Biomedical Engineering Rising Star Award
2019 Doctoral Fellowship Award
2020 Biomedical Engineering Distinguished Graduate Scholar Award
2020 Professional Development Award
Publications
1. David, M. A., Smith, M. K., Pilachowski, R. N., White, A. T., Locke, R. C., Price, C. Early, Focal Changes in Cartilage Cellularity and Structure Following Surgically Induced Meniscal Destabilization in the Mouse. Journal of Orthopaedic Research, 2016, 3(35):537-547.
2. Locke, R.C., Abraham, A.C., & Killian, M.L. Orthopaedic interface repair strategies based on native structural and mechanical features of the multiscale enthesis. ACS Biomaterials Science & Engineering, 2017, 3(11): 2633-2643. Review
3. Locke, R.C., Peloquin, J.M., Lemmon, E.A., Szostek, A., Elliott, D.M., & Killian, M.L. Strain distribution of intact rat rotator cuff tendon-to-bone attachments and attachments with defects. Journal of Biomechanical Engineering, 2017, 139(11):111007.
4. Lemmon, E.A., Locke, R.C., Szostek, A., Ganji, E., & Killian, M.L. Partial-width injuries of the rat rotator cuff heal with fibrosis. Connective Tissue Research, 2018, 59(5): 437-446. Selected as the Cover feature for special issue on Tendon Biology.
5. Killian, M.L., Locke, R.C., Atkins, P., James, M.G., Anderson, A.E., & Clohisy, J.C. Novel model for the induction of postnatal murine hip deformity. Journal of Orthopaedic Research, 2019, 37(1):151-160. Early Career Award.
6. Locke, R.C., Lemmon, E.A., Dudzinski, E., Kopa, S., Wayne, J., Soulas, J., De Taboada, L., & Killian, M.L. Photobiomodulation Does Not Influence Maturation and Mildly Improves Functional Healing of Mouse Achilles Tendons. Journal of Orthopaedic Research, 2020. Early View. DOI:10.1002/jor.24592.
7. Locke, R.C. & Ford, E., Silbernagel, K.G., Kloxin, A.M., Killian, M.L. Success Criteria and Preclinical Testing of Multifunctional Hydrogels for Tendon Regeneration. Tissue Eningeering Part C: Methods, 2020. DOI: 10.1089/ten.TEC.2020.0199.
8. Sullivan, AL., Locke, R.C., Klink, R.K., Leek, C.C., Killian, M.L. Mechanics and Differential Healing Outcomes of Small and Large Defect Injuries of the Tendon-Bone Attachment in the Rat Rotator Cuff. bioRxiv, 2020.
Conference Abstracts and Presentations
1. Locke, R.C., Peloquin, J., Lemmon, E.A., Szostek, A., Elliott, D.M., and Killian, M.L. Localized strain and Biomechanics of the Disrupted Tendon-Bone Attachment. Biomedical Engineering Society (BMES) Annual Meeting, Phoenix, AZ, October, 2017. Podium.
2. Locke, R.C., Peloquin, J., Lemmon, E.A., Szostek, A., Elliott, D.M., & Killian, M.L. Localized Strain and Biomechanics of the Disrupted Tendon-Bone Attachment. 64th Annual Orthopaedic Research Society (ORS) Meeting, New Orleans, LA. March, 2018. Podium.
3. Locke, R.C., Lemmon, E.A., Dudzinski, E., Kopa, S.C., Newman, H.R., Ganji, E., & Killian, M.L. Mitochondria Function and Histomechanical Outcomes after Exposure to Near-Infrared Light during Tendon Maturation and Adult Healing. ORS Annual meeting, Austin, TX. February, 2019. Podium.
4. Locke, R.C.; Lemmon, E.A., Dudzinski, E., Kopa, S.C., Newman, H.R., Ganji, E., Killian, M.L. Mitochondria Function, Structural, and Mechanical Outcomes after Exposure to Near-Infrared Light during Tendon Maturation and Adult Healing. Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C) Meeting, Seven Springs, PA. 2019. Podium.
5. Wernlé, K.K., Sonnenfelt, M., Leek, C., Locke, R.C., Guzy, R., Ornitz, D.M., Killian, M.L. Regulating enthesis and bone structure/function by Fibroblast Growth Factor signaling. BMES Annual meeting, Philadelphia, PA. October, 2019. Invited Podium.
6. Soulas, J.M., Locke, R.C., Ganji, E., Ornitz, D.M., & Killian, M.L. The Role of Muscle-specific Fibroblast Growth Factor 9 (Fgf9) In Innervation and Bone Shape. ORS 2020 Annual Meeting, Phoenix, AZ, 2020. Podium.
7. Locke, R.C., Lemmon, B.A., Killian, M.L. Mitochondrial Genes Are Differentially Expressed in Mouse Achilles Tendons During Postnatal Growth and Followoing Injury. UD BME Seminar. Newark, DE, 2020. Podium.
8. Locke, R.C., Lemmon, B.A., Killian, M.L. Mitochondrial Genes Are Differentially Expressed in Mouse Achilles Tendons During Postnatal Growth and Following Injury. SB3C 2020 Annual Meeting, Virtual Conference, 2020. Recorded Podium.
14. Locke, R.C. and Killian, M.L. Morphometric changes following hip join instability in mice using micro-computed tomography. UD Center for Biomechanical Engineering Research. 2016. Poster.
15. Lemmon, E.A., Locke, R.C., Szostek, A., & Killian, M.L. Biomechanical strength and stiffness are impaired following acute partial-width, full-thickness tendon-bone injury in a rat rotator cuff defect model. 63rd Annual Orthopaedic Research Society Meeting, San Diego, CA, 2017. Poster.
16. Lemmon, E.A., Locke, R.C., Szostek, A., Ganji, E., & Killian, M.L. Partial-width injury of the tendon-bone attachment leads to spontaneous healing and diminished structural quality in the rat rotator cuff. 64th Annual Orthopaedic Research Society Meeting, New Orleans, LA. March, 2018. Poster.
17. Shuff, J., Ganji, E., Locke, R.C., & Killian, M.L. Age-Dependent Morphometric Changes of the Murine Deltoid Tuberosity. BMES Annual meeting, Philadelphia, PA. October, 2019. Poster.
18. Wayne, J., Locke, R.C., & Killian, M.L. Variability Analysis of Bilateral Achilles Tendons using Uniaxial Tensile Testing with 3D-Printed Fixture. BMES Annual meeting, Philadelphia, PA. October, 2019. Poster.
19. Klink, R., Sullivan, A.L., Locke, R.C., and Killian, M.L. Mechanics of Small and Large Partial-Width Defects of the Rat Rotator Cuff Tendon-to-Bone Attachment. BMES Annual meeting, Philadelphia, PA. October, 2019. Poster.
20. Locke, R.C., Dudzinski, E., Lemmon, E.A., Kopa, S., Wayne, J., & Killian, M.L. Photobiomodulation During Mouse Achilles Tendon Maturation and Healing. BMES Annual meeting, Philadelphia, PA. October, 2019. Poster.
21. Sullivan, A.L., Klink, R.K., Locke, R.C., & Killian, M.L. Differential Mechanics and Healing Outcomes of Small and Large Partial-Width Defects In The Tendon Attachment Of The Rat Rotator Cuff. 2019 Penn Center for Musculoskeletal Disorders Annual Symposium. Poster. 2nd Place Award.
22. Leek, C., Locke, R.C., Bhattacharya, I., Ornitz, D.M., & Killian, M.L. Global Knockout of Fgf9 Results in Enlarged Bone Ridges and Differential Gene Expression In Muscle But Not Bone. ORS 2020 Annual Meeting, Phoenix, AZ, 2020. Moderated Poster.
23. Klink, R.K., Locke, R.C., Sullivan, A.L., & Killian, M.L. Mechanical Consequences of Critical Defect Size in The Rat Rotator Cuff Attachment. Poster. ORS 2020 Annual Meeting, Phoenix, AZ, 2020. Poster.
24. Sullivan, A.L., Locke, R.C., & Killian, M.L. Differential Healing of Small and Large Partial-width Defects In The Tendon Attachment Of The Rat Rotator Cuff. ORS 2020 Annual Meeting, Phoenix, AZ, 2020. Poster.
25. Locke, R.C., Lemmon, B.A., Killian, M.L. Mitochondrial Genes Are Differentially Expressed in Mouse Achilles Tendons During Postnatal Growth and Following Injury. ORS 2020 Annual Meeting, Phoenix, AZ, 2020. Later Breaking Poster.