Schipani Lab

Welcome to the Schipani Laboratory

The Schipani Laboratory has a long-standing interest in the study of cartilage and bone development. Over the years, we have used cartilage and bone tissues as models to establish essential principles in the broader fields of G-protein coupled receptors and hypoxia biology.

Early in her career, Dr. Schipani cloned the human PTH/PTHrP receptor (PTHR1) and its gene, and discovered that gain-of-function mutations of PTHR1 cause Jansen Metaphyseal Chondrodysplasia (JMC), a severe form of short-limbed dwarfism associated to hypercalcemia. JMC has been one of the first examples in the literature of a human disease being caused by a constitutively active G-protein coupled receptor. Analysis of mutant mice I generated using those mutations have contributed to shape up our current understanding of the role of osteoblastic PTHR1 in skeletal development and homeostasis, and hematopoiesis.

She next pioneered the notion that gradients of oxygen control tissue morphogenesis during skeletal development). Oxygen is not only an essential metabolic substrate in numerous enzymatic reactions, including mitochondrial respiration, but also a regulatory signal. The Schipani laboratory studies the role of hypoxia-driven pathways in skeletal development with the overall goal of unveiling both novel aspects of the cellular adaptation to hypoxia and new avenues for the treatment of cartilage and bone diseases. We use genetically modified mice as a model organism and we analyze their phenotypes with a variety of in vivo, ex-vivo and in vitro assays.

 

Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival; Genes Dev. 2001 Nov 1;15(21):2865-76

 

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News

Welcome to the Schipani Lab, Lorenzo Arboit!
July 15, 2021
Lorenzo is a visiting medical student from St. Anna School of Advanced Studies in Pisa Italy. He hopes to expand his knowledge of bone biology while working on a project with the Schipani Lab!

Welcome to the Schipani Lab, Dian Wang!
July 01, 2021
Dian Wang joins the Schipani Lab as a histology technician!

Welcome Perry!
February 22, 2021
Perry Bruder just arrived from Michigan to work in the Schipani Lab! Unfortunately, he brought a lot of snow with him :(

The Schipani Lab Joins McKay Orthopedic Research Laboratory!!!
November 01, 2020
Dr. Ernestina (Stina) Schipani has joined the University of Pennsylvania Perelman School of Medicine as the William Wikoff Smith Professor of Orthopaedic Surgery. She is located within the McKay Orthopedic Research Labs and over the years she has used cartilage and bone tissues as models to establish important principles in the broader fields of G-protein coupled receptors and hypoxia biology. She brings post doc Mohd Parvez Khan, Ph.D. with her and hired Brittany Laslow, M.S. as the lab's new lab manager!

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