Publications Utilizing the PCMD Biomechanics Core

Bone Mechanics

• Knight MN, Karuppaiah K, Lowe M, Mohanty S, Zondervan RL, Bell S, Ahn J, Hankenson KD. R-spondin-2 is a Wnt agonist that regulates osteoblast activity and bone mass. Bone Res. 2018 Aug 14;6:24. doi: 10.1038/s41413-018-0026-7. PMID: 30131881; PMCID: PMC6089978.
• de Bakker CMJ, Zhao H, Tseng WJ, Li Y, Altman-Singles AR, Liu Y, Leavitt L, Liu XS. Effects of reproduction on sexual dimorphisms in rat bone mechanics. J Biomech. 2018 Aug 22;77:40-47. doi: 10.1016/j.jbiomech.2018.06.023. Epub 2018 Jun 23. PMID: 29961584; PMCID: PMC6481170.
• Lu Y, Alharbi M, Zhang C, O'Connor JP, Graves DT. Deletion of FOXO1 in chondrocytes rescues the effect of diabetes on mechanical strength in fracture healing. Bone. 2019 Jun;123:159-167. doi: 10.1016/j.bone.2019.03.026. Epub 2019 Mar 21. PMID: 30904630; PMCID: PMC6491266.
• Wang L, Tower RJ, Chandra A, Yao L, Tong W, Xiong Z, Tang K, Zhang Y, Liu XS, Boerckel JD, Guo X, Ahn J, Qin L. Periosteal Mesenchymal Progenitor Dysfunction and Extraskeletally-Derived Fibrosis Contribute to Atrophic Fracture Nonunion. J Bone Miner Res. 2019 Mar;34(3):520-532. doi: 10.1002/jbmr.3626. Epub 2019 Jan 2. PMID: 30602062; PMCID: PMC6508876.

Uniaxial Tension of Musculoskeletal Tissues

• Freedman BR, Fryhofer GW, Salka NS, Raja HA, Hillin CD, Nuss CA, Farber DC, Soslowsky LJ. Mechanical, histological, and functional properties remain inferior in conservatively treated Achilles tendons in rodents: Long term evaluation. J Biomech. 2017 May 3;56:55-60. doi: 10.1016/j.jbiomech.2017.02.030. Epub 2017 Mar 4. PMID: 28366437; PMCID: PMC5393933.
• Rooney SI, Torino DJ, Baskin R, Vafa RP, Kuntz AF, Soslowsky LJ. Rat supraspinatus tendon responds acutely and chronically to exercise. J Appl Physiol (1985). 2017 Oct 1;123(4):757-763. doi: 10.1152/japplphysiol.00368.2017. Epub 2017 Jun 29. PMID: 28663377; PMCID: PMC5668451.
• Szczesny SE, Aeppli C, David A, Mauck RL. Fatigue loading of tendon results in collagen kinking and denaturation but does not change local tissue mechanics. J Biomech. 2018 Apr 11;71:251-256. doi: 10.1016/j.jbiomech.2018.02.014. Epub 2018 Feb 21. PMID: 29519673; PMCID: PMC6590695.
• Gaffey AC, Chen MH, Trubelja A, Venkataraman CM, Chen CW, Chung JJ, Schultz S, Sehgal CM, Burdick JA, Atluri P. Delivery of progenitor cells with injectable shear-thinning hydrogel maintains geometry and normalizes strain to stabilize cardiac function after ischemia. J Thorac Cardiovasc Surg. 2019 Apr;157(4):1479-1490. doi: 10.1016/j.jtcvs.2018.07.117. Epub 2018 Nov 14. PMID: 30579534.
• Bansal S, Peloquin JM, Keah NM, O'Reilly OC, Elliott DM, Mauck RL, Zgonis MH. Structure, function, and defect tolerance with maturation of the radial tie fiber network in the knee meniscus. J Orthop Res. 2020 Apr 17:10.1002/jor.24697. doi: 10.1002/jor.24697. Epub ahead of print. PMID: 32301519; PMCID: PMC7572531.

Uniaxial Compression of Musculoskeletal Tissues

• Kim M, Steinberg DR, Burdick JA, Mauck RL. Extracellular vesicles mediate improved functional outcomes in engineered cartilage produced from MSC/chondrocyte cocultures. Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1569-1578. doi: 10.1073/pnas.1815447116. Epub 2019 Jan 15. PMID: 30647113; PMCID: PMC6358691.
• Mohanraj B, Huang AH, Yeger-McKeever MJ, Schmidt MJ, Dodge GR, Mauck RL. Chondrocyte and mesenchymal stem cell derived engineered cartilage exhibits differential sensitivity to pro-inflammatory cytokines. J Orthop Res. 2018 Nov;36(11):2901-2910. doi: 10.1002/jor.24061. Epub 2018 Jul 13. PMID: 29809295.
• Gullbrand SE, Kim DH, Bonnevie E, Ashinsky BG, Smith LJ, Elliott DM, Mauck RL, Smith HE. Towards the scale up of tissue engineered intervertebral discs for clinical application. Acta Biomater. 2018 Apr 1;70:154-164. doi: 10.1016/j.actbio.2018.01.050. Epub 2018 Feb 8. PMID: 29427744.
• Kwon MY, Wang C, Galarraga JH, Puré E, Han L, Burdick JA. Influence of hyaluronic acid modification on CD44 binding towards the design of hydrogel biomaterials. Biomaterials. 2019 Nov;222:119451. doi: 10.1016/j.biomaterials.2019.119451. Epub 2019 Aug 23. PMID: 31480001; PMCID: PMC6746338.

Micro and Nano-Scale Tissue Indentation

• Meloni GR, Fisher MB, Stoeckl BD, Dodge GR, Mauck RL. Biphasic Finite Element Modeling Reconciles Mechanical Properties of Tissue-Engineered Cartilage Constructs Across Testing Platforms. Tissue Eng Part A. 2017 Jul;23(13-14):663-674. doi: 10.1089/ten.tea.2016.0191. Epub 2017 Apr 14. PMID: 28414616; PMCID: PMC5549831.
• Qu F, Li Q, Wang X, Cao X, Zgonis MH, Esterhai JL, Shenoy VB, Han L, Mauck RL. Maturation State and Matrix Microstructure Regulate Interstitial Cell Migration in Dense Connective Tissues. Sci Rep. 2018 Feb 19;8(1):3295. doi: 10.1038/s41598-018-21212-4. PMID: 29459687; PMCID: PMC5818574.
• Li Q, Wang C, Han B, Qu F, Qi H, Li CY, Mauck RL, Han L. Impacts of maturation on the micromechanics of the meniscus extracellular matrix. J Biomech. 2018 Apr 27;72:252-257. doi: 10.1016/j.jbiomech.2018.02.037. Epub 2018 Mar 9. PMID: 29555076; PMCID: PMC5895496.
• Beach ZM, Tucker JJ, Thomas SJ, Reuther KE, Gray CF, Lee CS, Glaser DL, Soslowsky LJ. Biceps tenotomy in the presence of a supraspinatus tear alters the adjacent intact tendons and glenoid cartilage. J Biomech. 2017 Oct 3;63:151-157. doi: 10.1016/j.jbiomech.2017.08.021. Epub 2017 Aug 26. PMID: 28893394; PMCID: PMC5836471.
• Ashinsky BG, Bonnevie ED, Mandalapu SA, Pickup S, Wang C, Han L, Mauck RL, Smith HE, Gullbrand SE. Intervertebral Disc Degeneration Is Associated With Aberrant Endplate Remodeling and Reduced Small Molecule Transport. J Bone Miner Res. 2020 Aug;35(8):1572-1581. doi: 10.1002/jbmr.4009. Epub 2020 Apr 2. PMID: 32176817.

Fiber Alignment Assessment and Tracking

• Gorth DJ, Shapiro IM, Risbud MV. A New Understanding of the Role of IL-1 in Age-Related Intervertebral Disc Degeneration in a Murine Model. J Bone Miner Res. 2019 Aug;34(8):1531-1542. doi: 10.1002/jbmr.3714. Epub 2019 May 29. PMID: 30875127; PMCID: PMC6697204.
• Schmidt EC, Chin M, Aoyama JT, Ganley TJ, Shea KG, Hast MW. Mechanical and Microstructural Properties of Pediatric Anterior Cruciate Ligaments and Autograft Tendons Used for Reconstruction. Orthop J Sports Med. 2019 Jan 23;7(1):2325967118821667. doi: 10.1177/2325967118821667. PMID: 30719479; PMCID: PMC6348523.
• Connizzo BK, Han L, Birk DE, Soslowsky LJ. Collagen V-heterozygous and -null supraspinatus tendons exhibit altered dynamic mechanical behaviour at multiple hierarchical scales. Interface Focus. 2016 Feb 6;6(1):20150043. doi: 10.1098/rsfs.2015.0043. PMID: 26855746; PMCID: PMC4686235.
• Bonnevie ED, Gullbrand SE, Ashinsky BG, Tsinman TK, Elliott DM, Chao PG, Smith HE, Mauck RL. Aberrant mechanosensing in injured intervertebral discs as a result of boundary-constraint disruption and residual-strain loss. Nat Biomed Eng. 2019 Dec;3(12):998-1008. doi: 10.1038/s41551-019-0458-4. Epub 2019 Oct 14. PMID: 31611678; PMCID: PMC6899202.

Joint-Scale Biomechanics

• Bansal S, Miller LM, Patel JM, Meadows KD, Eby MR, Saleh KS, Martin AR, Stoeckl BD, Hast MW, Elliott DM, Zgonis MH, Mauck RL. Transection of the medial meniscus anterior horn results in cartilage degeneration and meniscus remodeling in a large animal model. J Orthop Res. 2020 Apr 14. doi: 10.1002/jor.24694. Epub ahead of print. PMID: 32285971.
• Kamalitdinov TB, Fujino K, Shetye SS, Jiang X, Ye Y, Rodriguez AB, Kuntz AF, Zgonis MH, Dyment NA. Amplifying Bone Marrow Progenitors Expressing α-Smooth Muscle Actin Produce Zonal Insertion Sites During Tendon-to-Bone Repair. J Orthop Res. 2020 Jan;38(1):105-116. doi: 10.1002/jor.24395. Epub 2019 Jul 11. PMID: 31228280; PMCID: PMC6917878.
• Rajapakse CS, Farid AR, Kargilis DC, Jones BC, Lee JS, Johncola AJ, Batzdorf AS, Shetye SS, Hast MW, Chang G. MRI-based assessment of proximal femur strength compared to mechanical testing. Bone. 2020 Apr;133:115227. doi: 10.1016/j.bone.2020.115227. Epub 2020 Jan 9. PMID: 31926345; PMCID: PMC7096175.
• Gullbrand SE, Ashinsky BG, Bonnevie ED, Kim DH, Engiles JB, Smith LJ, Elliott DM, Schaer TP, Smith HE, Mauck RL. Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc. Sci Transl Med. 2018 Nov 21;10(468):eaau0670. doi: 10.1126/scitranslmed.aau0670. PMID: 30463917; PMCID: PMC7380504.