Histology Core Publications

Below are selected publications from Histology Core users representing each of the major musculoskeletal tissue types handled by the core.

Bone

• Chakkalakal, SA; Uchibe, K; Convente, MR; Zhang, D; Economides, AN; Kaplan, FS; Pacifici, M; Iwamoto, M; Shore, EM, Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation. J Bone Miner Res 2016, 31 (9), 1666-75. PMC4992469.
• Knight, MN; Karuppaiah, K; Lowe, M; Mohanty, S; Zondervan, RL; Bell, S; Ahn, J; Hankenson, KD, R-spondin-2 is a Wnt agonist that regulates osteoblast activity and bone mass. Bone Res 2018, 6, 24. PMC6089978.
• Kegelman, CD; Coulombe, JC; Jordan, KM; Horan, DJ; Qin, L; Robling, AG; Ferguson, VL; Bellido, TM; Boerckel, JD, YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling. J Bone Miner Res 2020, 35 (1), 196-210. PMC7066596.
• Chandra, A; Lin, T; Young, T; Tong, W; Ma, X; Tseng, WJ; Kramer, I; Kneissel, M; Levine, MA; Zhang, Y; Cengel, K; Liu, XS; Qin, L, Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms. J Bone Miner Res 2017, 32 (2), 360-372. PMC5476363.
• Liu, Z; Yuan, X; Liu, M; Fernandes, G; Zhang, Y; Yang, S; Ionita, CN; Yang, S, Antimicrobial Peptide Combined with BMP2-Modified Mesenchymal Stem Cells Promotes Calvarial Repair in an Osteolytic Model. Mol Ther 2018, 26 (1), 199-207. PMC5762982.
• de Bakker, CM; Li, Y; Zhao, H; Leavitt, L; Tseng, WJ; Lin, T; Tong, W; Qin, L; Liu, XS, Structural Adaptations in the Rat Tibia Bone Induced by Pregnancy and Lactation Confer Protective Effects Against Future Estrogen Deficiency. J Bone Miner Res 2018, 33 (12), 2165-2176. PMC6464108.

Intervertebral Disc

• Zhang, C; Gullbrand, SE; Schaer, TP; Lau, YK; Jiang, Z; Dodge, GR; Elliott, DM; Mauck, RL; Malhotra, NR; Smith, LJ, Inflammatory cytokine and catabolic enzyme expression in a goat model of intervertebral disc degeneration. J Orthop Res 2020. PMC7483272.
• Gullbrand, SE; Ashinsky, BG; Bonnevie, ED; Kim, DH; Engiles, JB; Smith, LJ; Elliott, DM; Schaer, TP; Smith, HE; Mauck, RL, Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc. Sci Transl Med 2018, 10 (468). PMC7380504.
• Zhang, C; Gullbrand, S; Schaer, TP; Boorman, S; Elliott, DM; Chen, W; Dodge, GR; Mauck, RL; Malhotra, NR; Smith, LJ, Combined Hydrogel and Mesenchymal Stem Cell Therapy for Moderate Severity Disc Degeneration in Goats. Tissue Eng Part A 2020. PMCID in process.
• Gullbrand, SE; Malhotra, NR; Schaer, TP; Zawacki, Z; Martin, JT; Bendigo, JR; Milby, AH; Dodge, GR; Vresilovic, EJ; Elliott, DM; Mauck, RL; Smith, LJ, A large animal model that recapitulates the spectrum of human intervertebral disc degeneration. Osteoarthritis Cartilage 2017, 25 (1), 146-156. PMC5182186.
• Piazza, M; Peck, SH; Gullbrand, SE; Bendigo, JR; Arginteanu, T; Zhang, Y; Smith, HE; Malhotra, NR; Smith, LJ, Quantitative MRI correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration. J Orthop Res 2018, 36 (10), 2771-2779. PMC6200662.
• Ashinsky, BG; Gullbrand, SE; Bonnevie, ED; Mandalapu, SA; Wang, C; Elliott, DM; Han, L; Mauck, RL; Smith, HE, Multiscale and multimodal structure-function analysis of intervertebral disc degeneration in a rabbit model. Osteoarthritis Cartilage 2019, 27 (12), 1860-1869. PMC6875634.

Cartilage

• Friedman, JM; Sennett, ML; Bonadio, MB; Orji, KO; Neuwirth, AL; Keah, N; Carey, JL; Moutos, FT; Estes, BT; Guilak, F; Madry, H; Mauck, RL; Dodge, GR, Comparison of Fixation Techniques of 3D-Woven Poly(-Caprolactone) Scaffolds for Cartilage Repair in a Weightbearing Porcine Large Animal Model. Cartilage 2018, 9 (4), 428-437. PMC6139593.
• Sambamurthy, N; Nguyen, V; Smalley, R; Xiao, R; Hankenson, K; Gan, J; Miller, RE; Malfait, AM; Dodge, GR; Scanzello, CR, Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis. J Orthop Res 2018, 36 (3), 864-875. PMC5920778.
• Chery, DR; Han, B; Li, Q; Zhou, Y; Heo, SJ; Kwok, B; Chandrasekaran, P; Wang, C; Qin, L; Lu, XL; Kong, D; Enomoto-Iwamoto, M; Mauck, RL; Han, L, Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis. Acta Biomater. 2020, 111, 267-278. PMC7321882
• Karchner, JP; Querido, W; Kandel, S; Pleshko, N, Spatial correlation of native and engineered cartilage components at micron resolution. Ann N Y Acad Sci 2019, 1442 (1), 104-117. PMC6351229.
• Pfeifer, CG; Fisher, MB; Saxena, V; Kim, M; Henning, EA; Steinberg, DA; Dodge, GR; Mauck, RL, Age-Dependent Subchondral Bone Remodeling and Cartilage Repair in a Minipig Defect Model. Tissue Eng Part C Methods 2017, 23 (11), 745-753. PMC5689111.
• Jia, H; Ma, X; Tong, W; Doyran, B; Sun, Z; Wang, L; Zhang, X; Zhou, Y; Badar, F; Chandra, A; Lu, XL; Xia, Y; Han, L; Enomoto-Iwamoto, M; Qin, L, EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation. Proc Natl Acad Sci U S A. 2016, 113 (50), 14360-14365. PMC5167216

Meniscus

• Han, WM; Heo, SJ; Driscoll, TP; Delucca, JF; McLeod, CM; Smith, LJ; Duncan, RL; Mauck, RL; Elliott, DM, Microstructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage. Nat Mater 2016, 15 (4), 477-84. PMC4805445.
• Bansal, S; Miller, LM; Patel, JM; Meadows, KD; Eby, MR; Saleh, KS; Martin, AR; Stoeckl, BD; Hast, MW; Elliott, DM; Zgonis, MH; Mauck, RL, Transection of the medial meniscus anterior horn results in cartilage degeneration and meniscus remodeling in a large animal model. J Orthop Res 2020. PMCID in process.
• Bansal, S; Peloquin, JM; Keah, NM; O'Reilly, OC; Elliott, DM; Mauck, RL; Zgonis, MH, Structure, function, and defect tolerance with maturation of the radial tie fiber network in the knee meniscus. J Orthop Res 2020. PMCID in process.

Tendon

• Riggin, CN; Chen, M; Gordon, JA; Schultz, SM; Soslowsky, LJ; Khoury, V, Ultrasound-Guided Dry Needling of the Healthy Rat Supraspinatus Tendon Elicits Early Healing Without Causing Permanent Damage. J Orthop Res 2019, 37 (9), 2035-2042. PMC6688919.
• Robinson, KA; Sun, M; Barnum, CE; Weiss, SN; Huegel, J; Shetye, SS; Lin, L; Saez, D; Adams, SM; Iozzo, RV; Soslowsky, LJ; Birk, DE, Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons. Matrix Biol 2017, 64, 81-93. PMC5705405.
• Freedman, BR; Fryhofer, GW; Salka, NS; Raja, HA; Hillin, CD; Nuss, CA; Farber, DC; Soslowsky, LJ, Mechanical, histological, and functional properties remain inferior in conservatively treated Achilles tendons in rodents: Long term evaluation. J Biomech 2017, 56, 55-60. PMC5393933.
• Tucker, JJ; Soslowsky, LJ, Effect of simvastatin on rat supraspinatus tendon mechanical and histological properties in a diet-induced hypercholesterolemia model. J Orthop Res 2016, 34 (11), 2009-2015. PMC5349294.
• Hagiwara, Y; Dyrna, F; Kuntz, AF; Adams, DJ; Dyment, NA, Cells from a GDF5 origin produce zonal tendon-to-bone attachments following anterior cruciate ligament reconstruction. Ann N Y Acad Sci 2020, 1460 (1), 57-67. PMC6992521.
• Taylor, BL; Kim, DH; Huegel, J; Raja, HA; Burkholder, SJ; Weiss, SN; Nuss, CA; Soslowsky, LJ; Mauck, RL; Kuntz, AF; Bernstein, J, Localized delivery of ibuprofen via a bilayer delivery system (BiLDS) for supraspinatus tendon healing in a rat model. J Orthop Res 2020. PMCID in process.

Muscle

• Sharifi-Sanjani, M; Meeker, AK; Mourkioti, F, Evaluation of telomere length in human cardiac tissues using cardiac quantitative FISH. Nat Protoc 2017, 12 (9), 1855-1870. PMCID in process.
• Sharifi-Sanjani, M; Oyster, NM; Tichy, ED; Bedi, KC, Jr.; Harel, O; Margulies, KB; Mourkioti, F, Cardiomyocyte-Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans. J Am Heart Assoc 2017, 6 (9). PMC5634248.
• Tichy, ED; Sidibe, DK; Greer, CD; Oyster, NM; Rompolas, P; Rosenthal, NA; Blau, HM; Mourkioti, F, A robust Pax7EGFP mouse that enables the visualization of dynamic behaviors of muscle stem cells. Skelet Muscle 2018, 8 (1), 27. PMC6107960.
• Song, Y; Rosenblum, ST; Morales, L; Petrov, M; Greer, C; Globerman, S; Stedman, HH, Suite of clinically relevant functional assays to address therapeutic efficacy and disease mechanism in the dystrophic mdx mouse. J Appl Physiol (1985) 2017, 122 (3), 593-602. PMC5401958.