Alex Leney-Greene, PhD
Post-doctoral Fellow
Aviv Regev Laboratory
Broad Institute
Education
BS, Microbiology & Immunology, McGill University, Montreal, Quebec, Canada
PhD Immunology, University of Pennsylvania, 2019 (Mentors: Drs. Helen Su and Michael Lenardo, NIAID)
Thesis
Alex studied genetic susceptibility to autoimmunity. He identified that mutations in Gimap5, a small GTPase expressed in T, NK and endothelial cells, were responsible for a novel recessive Mendelian disease of immune dysregulation, characterized by severe lymphopenia, splenomegaly, thrombocytopenia and liver failure.
Publications From Graduate Work
- Leney-Greene MA, Boddapati AK, Su HC, Cantor JR, Lenardo MJ. Human Plasma-like Medium Improves T Lymphocyte Activation. iScience. 23(1):100759. 2020.
- Liu Y, Gordesky-Gold B, Leney-Greene M, Weinbren NL, Tudor M, Cherry S. Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain. Cell Host Microbe. 24(1):57-68.e3. 2018.
- Dupont CD, Christian DA, Selleck EM, Pepper M, Leney-Greene M, Harms Pritchard G, Koshy AA, Wagage S, Reuter MA, Sibley LD, Betts MR, Hunter CA. Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii. PLoS Pathog. 10(4):e1004047. 2014.
- Caignard G, Leiva-Torres GA, Leney-Greene M, Charbonneau B, Dumaine A, Fodil-Cornu N, Pyzik M, Cingolani P, Schwartzentruber J, Dupaul-Chicoine J, Guo H, Saleh M, Veillette A, Lathrop M, Blanchette M, Majewski J, Pearson A, Vidal SM. Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1. PLoS Pathog. 9(9):e1003637. 2013.