Jacob Paiano, PhD

Post-doctoral Fellow
Norbert Perrimon Laboratory
Harvard Medical School


BA, Biology, Chemistry, Case Western Reserve University, USA

PhD Immunology, University of Pennsylvania, 2020 (Mentor: Dr. Andre Nussenzweig, Ph.D, NCI/CCR)


During Jacob's doctoral studies, he studied DNA repair mechanisms responsible for maintaining genomic stability during mitosis and meiosis

Publications From Graduate Work

  • Paiano J, Zolnerowich N, Wu W, Pavani R, Wang C, Li H, Zheng L, Shen B, Sleckman BP, Chen BR, Nussenzweig A. Role of 53BP1 in end protection and DNA synthesis at DNA breaks. Genes & Development 35(19-20): 1356-1367. 2021

  • Wu W*, Hill SE*, Nathan WJ*, Paiano J, Callen E, Wang D, Shinoda K, van Wietmarschen N, Col√≥n-Mercado JM, Zong D, De Pace R, Shih HY, Coon S, Parsadanian M, Pavani R, Hanzlikova H, Park S, Jung SK, McHugh PJ, Canela A, Chen C, Casellas R, Caldecott KW, Ward ME, Nussenzweig A. Neuronal enhancers are hotspots for DNA single-strand break repair. Nature. 2021 Mar 25. doi: 10.1038/s41586-021-03468-5. PMID: 33767446.
  • Mahgoub M*, Paiano J*, Bruno M, Wu W, Pathuri S, Zhang X, Ralls S, Cheng X, Nussenzweig A, Macfarlan T. Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks. eLife 9:e53360. 2020
  • Paiano J, Nussenzweig A. Burning bridges in cancer genomes. Science 368(6488): 240-241. 2020
  • Paiano J*, Wu W*, Yamada S, Sciascia N, Callen E, Cotrim AP, Deshpande RA, Maman Y, Day A, Paull TT, Nussenzweig A. ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis. Nature Communications 11(1):857. 2020
  • Paiano J*, Harland M*, Strainic MG, Nedrud J, Hussain W, Medof ME. Follicular B2 cell activation and class switch recombination depend on autocrine C3ar1/C5ar1 signaling in B2 cells. J. Immunol. 203(2):379-388. 2019
  • Paiano JJ, Johnson JL, Vahedi G. Enhancing our understanding of enhancers in T helper cells. European Journal of Immunology 45(11): 2998-3001. 2015
Learn more about Dr. Paiano here.