Stanley Adoro, PhD
Principal Investigator
Experimental Immunology Branch, National Cancer Institute
Education
BSc Biochemistry and MSc Cellular Parasitology, University of Ibadan, Nigeria
PhD Immunology, University of Pennsylvania, 2009 (Mentor: Dr. Alfred Singer, NCI)
Thesis
Stanley established that the genetic loci encoding CD4 and CD8 co-receptor proteins dictated T-cell lineage fate during T cell development in the thymus.
Publications From Graduate Work
- Adoro S, Park JH and Singer A. Coreceptor gene imprinting”: a genetic solution to a developmental dilemma in T cells. Cell Cycle 11:833-834. 2012.
- Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park JH, Tai X, Kimura M, Wang L, Grinberg A, Kubo M, Bosselut R, Love P and Singer A. Coreceptor gene imprinting governs thymocyte lineage fate. EMBO Journal 31:366-377. 2012.
- Park JH, Adoro S, Guinter T, Erman B, Alag AS, Catalfamo M, Kimura MY, Cui Y, Lucas PJ, Gress RE, Kubo M, Hennighausen L, Feigenbaum L and Singer A. Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic lineage T cells. Nature Immunology 11:257-264. 2010.
- Singer A, Adoro S and Park JH. Lineage fate and intense debate: myths, models and mechanisms of CD4/CD8 lineage choice. Nature Reviews Immunology 8:788-801. 2008.
- Adoro S, Erman B, Sarafova S, Van Laethem F, Park JH, Feigenbaum L and Singer A. Targeting CD4 coreceptor expression to post-selection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic. Journal of Immunology 181:6975-6983. 2008.
- Park JH, Adoro S, Lucas PJ, Sarafova SD, Alag SA, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L and Singer A. Coreceptor tuning’: cytokine signals transcriptionally tailor CD8 coreceptor expression in CD8 T cells to the self-specificity of their TCR. Nature Immunology 8:1049-1059. 2007.