Tony Barnitz, PhD
TCR2 Therapeutics Inc.
Cambridge, MA, USA
BS Biology, Wake Forest University, USA
PhD Immunology, University of Pennsylvania, 2010 (Mentor: Dr. Michael Lenardo; NIAID)
Tony examined the mechanism of HIV-1 induced cytopathicity of CD4+ T cells by investigating the role of HIV-1 Vpr protein in cell cycle arrest and cell death.
Publications From Graduate Work
- Barnitz RA, Chaigne-Delalande B, Bolton DL, Lenardo MJ. Exposed hydrophobic residues in human immunodeficiency virus type 1 Vpr helix-1 are important for cell cycle arrest and cell death. PLoS One. 6(9): e24924. 2011.
- Sakai K, Barnitz RA, Chaigne-Delalande B, Bidère N, Lenardo MJ. Human immunodeficiency virus type 1 Vif causes dysfunction of Cdk1 and CyclinB1: implications for cell cycle arrest. Virol J. 8:219. 2011.
- Barnitz RA, Wan F, Tripuraneni V, Bolton DL, Lenardo MJ. Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection. J Virol. 84(13):6410-24. 2010.
- Bolton DL, Barnitz RA, Sakai K, Lenardo MJ. 14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr. Biol Direct. 3:17. 2008.
- Wan F, Anderson DE, Barnitz RA, Snow A, Bidere N, Zheng L, Hegde V, Lam LT, Staudt LM, Levens D, Deutsch WA, Lenardo MJ. Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation. Cell. 131(5):927-939. 2007.