Laura Chopp, PhD

Education

MD Student, University of Michigan Medicinal School

PhD Immunology, University of Pennsylvania (Advisor: Rémy Bosselut, MD, PhD), 2022

BS Biomedical Sciences, Minnesota State University, Mankato, 2015

Thesis

Integration of single cell transcriptomics and epigenomics to identify new regulators of T cell development and function

Publications from Graduate Work

  • Chopp LB, Zhu X, Gao Y, Nie J, Singh J, Kumar P, Young KZ, Patel S, Li C, Balmaceno-Criss M, Vacchio MS, Wang MM, Livak F, Merchant JL, Wang L, Kelly MC, Zhu J, Bosselut R. Zfp281 and Zfp148 control CD4+ T cell thymic development and TH2 functions. Science Immunology 2023 8(89):eadi9066. doi: 10.1126/sciimmunol.adi9066
  • Gao Y, Wang Y, Chauss D, Villarino AV, Link VM, Nagashima H, Spinner CA, Koparde VN, Bouladoux N, Abers MS, Break TJ, Chopp LB, Park JH, Zhu J, Wiest DL, Leonard WJ, Lionakis MS, O'Shea JJ, Afzali B, Belkaid Y, Lazarevic V. Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system. Nature Immunology 2023 8:1331-1344. doi: 10.1038/s41590-023-01553-7.
  • Georgiev H, Chopp LB, Hogquist KA. Ultrasound-guided intra-thymic cell injection. Methods Mol Biol. 2023 2580:283-292. doi: 10.1007/978-1-0716-2740-2_17
  • Carpenter AC, Chopp LB, Kim JK, Bosselut R. Purification of thymocyte and T cell subsets. Methods Mol Biol. 2023 2580:151-163. doi: 10.1007/978-1-0716-2740-2_8
  • Gao Y, Zamisch M, Vacchio M, Chopp LB, Ciucci T, Paine EL, Lyons GC, Nie J, Xiao Q, Zvezdova E, Love PE, Vinson CR, Jenkins LM, Bosselut R. NuRD complex recruitment to Thpok mediates CD4+ T cell lineage differentiation. Science Immunology 2022, 7(72):eabn5917. doi: 10.1126/sciimmunol.abn5917.
  • Nie J, Carpenter AC, Chopp LB, Chen T, Balmaceno-Criss M, Ciucci T, Xiao Q, Kelly MC, McGavern DB, Belkaid Y, Bosselut R. The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8αα+ intraepithelial lymphocyte precursors. Nature Immunology 2022 23(4):594-604. doi: 10.1038/s41590-022-01161-x.
  • Ciucci T, Vacchio MS, Chen T, Nie J, Chopp LB, McGavern DB, Kelly MC, Bosselut R. Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4+ T cells. Journal of Experimental Medicine 2022 219(1):e20202343. doi: 10.1084/jem.20202343.
  • Stamos DB, Clubb LM, Mitra A, Chopp LB, Nie J, Ding Y, Das A, Venkataganesh H, Lee J, El-Khoury D, Li L, Bhandoola A, Bosselut R, Love PE. The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development. Journal of Experimental Medicine 2021 218(12):e20202012. doi: 10.1084/jem.20202012.
  • Chopp LB, Gopalan V, Ciucci T, Ruchinskas A, Rae Z, Lagarde M, Gao Y, Li C, Bosticardo M, Pala F, Livak F, Kelly MC, Hannenhalli S, Bosselut R. An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development. Immunity 2020 53(6):1182-1201.e8. doi: 10.1016/j.immuni.2020.10.024.
  • Amir M, Chaudhari S, Wang R, Campbell S, Mosure SA, Chopp LB, Lu Q, Shang J, Pelletier OB, He Y, Doebelin C, Cameron MD, Kojetin DJ, Kamenecka TM, Solt LA. REV-ERBα Regulates Th17 Cell Development and Autoimmunity. Cell Reports 2018 25(13):3733-3749.e8. doi: 10.1016/j.celrep.2018.11.101.
  • Carpenter AC, Wohlfert E, Chopp LB, Vacchio MS, Nie J, Zhao Y, Shetty J, Xiao Q, Deng C, Tran B, Cam M, Gaida MM, Belkaid Y, Bosselut R. Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF. Journal of Immunology 2017 199(5):1716-1728. doi: 10.4049/jimmunol.1700181.
  • Reed BK*, Chopp LB*, Malo CS, Renner DN, Van Keulen VS, Girtman MA, Nevala WN, Pavelko KD, Gil D, Schrum AG, Johnson AJ, Pease LR. A Versatile Simple Capture Assay for Assessing the Structural Integrity of MHC Multimer Reagents. PLoS One 2015 10(9):e0137984. doi: 10.1371/journal.pone.0137984.