Matthew Wolf, PhD
Stadtman Investigator
Cancer Innovation Laboratory
Scaffold Assisted Cancer Immunotherapy. Biomaterial scaffolds are used for precise localized drug delivery. Biomaterials also have the ability to initiate and regulate inflammation in ways that depend on its physical and chemical composition, providing a natural synergy with cancer immunotherapy. We aim to integrate immunomodulatory biomaterials in surgical immune oncology – the study of the immune system’s role in recognizing and fighting cancer during surgical intervention. Decoding the cellular and molecular processes at the biomaterial-tissue interface enables us to control immunity for more effective cancer immunotherapy such as checkpoint blockade immunotherapy and cancer vaccines.