Stefan Muljo, PhD

Chief, Integrative Immunobiology Section

muljoWe are broadly interested in understanding the gene expression programs that control how cells in the immune system develop and function. We are particularly enamored by the post-transcriptional control of these programs and whether they can be manipulated to reprogram cell fate. I am excited to get this valuable opportunity to collaborate with Penn IGG. We have already established collaborations with Will Bailis and Craig Bassing.

Selected references:

  • Yuan, J., Nguyen, C. K., Liu, X., Kanellopoulou, C. and S. A. Muljo.  Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. Science 335: 1195-200, 2012.
  • Escobar, T. M., Kanellopoulou, C., Kugler, D. G., Kilaru, G., Nguyen, C. K., Nagarajan, V., Bhairavabhotla, R., Northrup, D., Zahr, R., Burr, P., Liu, X., Zhao, K., Sher, A., Jankovic, D., Zhu, J. and S. A. Muljo. miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve Polycomb-mediated repression. Immunity, 40: 865–79, 2014.
  • Wang, S., Chim, B., Su, Y., Khil, P., Wong, M., Wang, X., Foroushani, A., Smith, P. T., Liu, X., Li, R., Ganesan, S., Kanellopoulou, C., Hafner, M. and S. A. Muljo. Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3. Genes & Development, 33: 1048-1068, 2019
  • Foroushani, A., Chim, B., Wong, M., Rastegar, A., Smith, P. T., Wang, S., Barbian, K., Martens, C., Hafner, M. and S. A. Muljo. Post-transcriptional regulation of human endogenous retroviruses by RNA-Binding Motif Protein 4, RBM4. PNAS, 117: 26520-26530, 2020.

Suggested Penn mentors: Craig H. Bassing, Will Bailis