Current Students
Developmental, Stem Cell, and Regenerative Biology
Degree: PhD
Matriculation Year: 2020
Advisor(s):
- Emily Partridge
Developmental, Stem Cell, and Regenerative Biology
Degree: PhD
Matriculation Year: 2020
Developmental, Stem Cell, and Regenerative Biology
Degree: PhD
Matriculation Year: 2020
Microbiology, Virology, and Parasitology
Degree: PhD
Matriculation Year: 2020
Developmental, Stem Cell, and Regenerative Biology
Degree: PhD
Matriculation Year: 2020
Developmental, Stem Cell, and Regenerative Biology
Degree: PhD
Matriculation Year: 2020
Developmental, Stem Cell, and Regenerative Biology
Degree: PhD
Matriculation Year: 2020
Microbiology, Virology, and Parasitology
Degree: MD/PhD
Matriculation Year: 2019
Rotations:
- Rahul Kohli
Microbiology, Virology, and Parasitology
Degree: VMD/PhD
Matriculation Year: 2008
Advisor(s):
- Alice Chen-Plotkin
Rotations:
- Susan Weiss
- Alice Chen-Plotkin
- David Artis
- Aaron Gitler
In the vast majority of cases of amyotrophic lateral sclerosis and ~50% of the cases of frontotemporal lobar degeneration, pathology is characterized by mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43) in neurons and glia. Research has emphasized TDP-43’s role as an RNA binding protein and despite in vitro characterization of TDP-43’s ability to bind DNA, a genome-wide DNA binding map has yet to be defined. Therefore, I am studying the DNA binding characteristics of TDP-43 in human cells via ChIP-Seq and subsequent biochemical analysis.
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Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2017
Project Title: Genome Wide CRISPR/Cas9 Knockout Screen Identifies Host Genes Important for Cryptosporidium parvum Infection
Advisor(s):
- Boris Striepen
Cancer Biology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Zachary Schug
Rotations:
- Kathryn Wellen
- Peter Choi
- Zachary Schug
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2019
Rotations:
- Edward Morrisey
- Alex Hughes
- Paula Oliver
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2019
Rotations:
- Elizabeth Bhoj
- Paula Oliver
- Kelly Jordan-Sciutto
Cancer Biology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Marco Ruella
Rotations:
- Andrei Thomas-Tikhonenko
- Marco Ruella
- Patrick Grohar
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Igor Brodsky
Rotations:
- Maayan Levy
- Igor Brodsky
- Sara Cherry
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Audrey John
Rotations:
- Harvey Friedman
- Audrey John
- Paul Bates
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2019
Rotations:
- Marisa Bartolomei
- Greg Bashaw
- Amita Sehgal
Cancer Biology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Gregory Beatty
Rotations:
- Ben Stanger
- Celeste Simon
- Gregory Beatty
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Igor Brodsky
Rotations:
- Igor Brodsky
- Elizabeth White
- Sunny Shin
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Daniel Beiting
Rotations:
- Michael Silverman
- Daniel Beiting
- Kyle Bittinger
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Christopher Hunter
Rotations:
- Sunny Shin
- Christopher Hunter
- Joseph Zackular
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Stephen Dinardo
Rotations:
- Jeremy Wang
- Marisa Bartolomei
- Paul Gadue
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Joseph St Geme
- Paul Planet
Rotations:
- Joseph St Geme
- Paul Planet
- Audrey John
Cancer Biology
Degree: PhD
Matriculation Year: 2019
Rotations:
- Maureen Murphy
- Malay Haldar
- Peter Choi
- Irfan Asangani
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Matthew Weitzman
Rotations:
- Scott Hensley
- Matthew Weitzman
- Daniel Beiting
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2019
Rotations:
- Mia Levine
- Alessandro Gardini
- Junwei Shi
Cancer Biology
Degree: PhD
Matriculation Year: 2019
Rotations:
- Thomas DeRaedt
- Yael Mosse
- Celeste Simon
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Daniel Kulp
Rotations:
- Daniel Kulp
- Norbert Pardi
- Mike Farwell
Cancer Biology
Degree: PhD
Matriculation Year: 2019
Rotations:
- Andy Minn
- Maayan Levy
- John Wherry
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Christopher Lengner
Rotations:
- Panteleimon Rompolas
- Andrew Vaughan
- Christopher Lengner
Cancer Biology
Degree: PhD
Matriculation Year: 2019
Rotations:
- Dmitry Gabrilovich
- Ben Stanger
- Chengcheng Jin
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Joseph Fraietta
Rotations:
- Hamid Bassiri
- Hansell Stedman
- Joseph Fraietta
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Joseph St Geme
Rotations:
- Scott Hensley
- Joseph Zackular
- Joseph St Geme
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Daniel Kulp
- George Shaw
Rotations:
- Daniel Kulp
- George Shaw
- Scott Hensley
Cancer Biology
Degree: PhD
Matriculation Year: 2019
Rotations:
- Constantinos Koumenis
- Patrick Grohar
- Lewis Chodosh
- Ronny Drapkin
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Susan Weiss
Rotations:
- Kellie Jurado
- Paul Bates
- Susan Weiss
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Laurence Eisenlohr
Rotations:
- Laurence Eisenlohr
- Sara Cherry
- Boris Striepen
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Andres Blanco
Rotations:
- Montserrat Anguera
- Andres Blanco
- Brian Capell
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2019
Rotations:
- Naiara Aquizu Lopez
- Greg Bashaw
- Thomas Jongens
Cancer Biology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Patrick Grohar
Rotations:
- Bradley Johnson
- Paul Lieberman
- Patrick Grohar
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2018
Rotations:
- Ivan Maillard
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Jianxin You
Rotations:
- Jianxin You
- Ronald Collman
- Dennis Kolson
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2017
Project Title: Role of KLRG1 signaling on CD8+ T-cells during chronic HIV infection
Advisor(s):
- Michael Betts
Rotations:
- Frederic Bushman
- Michael Betts
- Elizabeth Grice
Microbiology, Virology and Parasitology
Degree: MD/PhD
Matriculation Year: 2017
Advisor(s):
- Elizabeth Grice
Rotations:
- Elizabeth Grice
- Michael Silverman
Microbiology, Virology and Parasitology
Degree: MD/PhD
Matriculation Year: 2017
Advisor(s):
- Elizabeth Grice
Rotations:
- Matthew Weitzman
- Kai Tan
- Elizabeth Grice
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2015
Project Title: Replication and tropism of Redondoviridae, a new family of DNA viruses of the human oro-respiratory tract
Advisor(s):
- Frederic Bushman
Rotations:
- Frederic Bushman
- Paula Oliver
- Matthew Weitzman
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2017
Project Title: Defining the proteins responsible for establishing C. parvum infection
Advisor(s):
- Boris Striepen
Rotations:
- Carolina Lopez
- Boris Striepen
- David Weiner
Microbiology, Virology and Parasitology
Degree: VMD/PhD
Matriculation Year: 2014
Advisor(s):
- Michael Povelones
Rotations:
- Matthew Hayes
- Michael Povelones
- De'Broski Herbert
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Joseph Zackular
Rotations:
- James Riley
- Joseph Zackular
- Michael Silverman
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2016
Advisor(s):
- Sunny Shin
Rotations:
- Scott Hensley
- Sunny Shin
- Paul Planet
I am studying how the human immune system recognizes Salmonella, which causes diarrheal disease. Salmonella initially invades and replicates within intestinal epithelial cells by using type III secretion systems (T3SSs) to inject proteins into host cells. I am studying the role of a cytosolic sensor called human NAIP (hNAIP) during Salmonella infection. I will determine which T3SS components are sensed by hNAIP, what response hNAIP mounts, and whether these responses control bacterial infection.
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Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Elizabeth Grice
Rotations:
- Elizabeth Grice
- David Weiner
- Carolina Lopez
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2015
Advisor(s):
- Joseph St Geme
Rotations:
- Joseph St Geme
- Frederic Bushman
- Ronald Collman
Microbiology, Virology and Parasitology
Degree: VMD/PhD
Matriculation Year: 2016
Project Title: The role of retrograde trafficking during cellular entry by severe fever with thrombocytopenia syndrome virus
Advisor(s):
- Paul Bates
Rotations:
- Ronald Harty
- Paul Bates
- Elizabeth White
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Igor Brodsky
Rotations:
- Joseph St Geme
- Igor Brodsky
- Christoph Thaiss
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2017
Project Title: Innate immunity in primary neurons: specialized responses to viral infection
Advisor(s):
- Sara Cherry
Rotations:
- Scott Hensley
- Paul Bates
- Sara Cherry
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2017
Project Title: The Blood Meningeal Barrier Orchestrates the Development of Autoimmune Neuroinflammatory Responses
Advisor(s):
- Jorge Alvarez
Rotations:
- Jorge Alvarez
- Paul Lieberman
- Katharine Bar
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2017
Project Title: Cryptosporidium exports proteins to the cytoplasm of the epithelial host cell
Advisor(s):
- Boris Striepen
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2017
Advisor(s):
- Scott Hensley
Rotations:
- George Shaw
- Scott Hensley
- David Allman
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2015
Project Title: Elucidating the mechanisms underlying noncanonical inflammasome responses to Legionella pneumophila
Advisor(s):
- Sunny Shin
Rotations:
- Michael Povelones
- Sunny Shin
- Sara Cherry
Microbiology, Virology and Parasitology
Degree: MD/PhD
Matriculation Year: 2016
Project Title: Defining the Interaction between LPS and Caspase-11 in the Non-Canonical Inflammasome
Advisor(s):
- Igor Brodsky
Rotations:
- Igor Brodsky
- Jianxin You
- Michael Granato
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2015
Advisor(s):
- Laurence Eisenlohr
Rotations:
- Beatrice Hahn
- Michael Betts
- Laurence Eisenlohr
Despite HIV's significant global health importance, there is still much to learn about the ways in which the immune system detects and responds to this virus. Robust HIV-specific CD4+ T cell responses are associated with decreased viral load and a slower progression to AIDS, and will likely be essential for generating protective HIV vaccine responses. However, CD4+ T cells must be activated before they can contribute to the immune response.
This activation requires the binding of T cell receptors on the surface of the CD4+ T cell to antigen-derived peptides (epitopes) displayed in complex with MHCII molecules (MHCII) on the surface of an antigen presenting cell (APC). Thus, understanding the cellular pathways responsible for the presentation of these pathogen-derived epitopes on MHCII is absolutely vital.
It was long thought that a single, classical pathway is responsible for MHCII antigen presentation. In this pathway, internalized antigens are catabolized and loaded onto MHCII in late endosomal compartments. However, this pathway is likely inadequate for the presentation of both cytosolic antigens and antigens derived from proteins that are not carried within the pathogen, such as certain viral accessory proteins. Notably, a non-canonical, endogenous processing pathway has also been shown to play a significant role in the presentation of pathogen-derived epitopes.
Endogenous processing occurs when virally-derived antigens synthesized within infected APCs are proteolyzed and loaded onto MHCII via a complex network of intracellular pathways. This pathway is better suited for the presentation of cytosolic and newly synthesized viral antigens.
Current literature addressing the cellular pathways used by APCs to activate
CD4+ T cells in response to HIV-1 is sparse and conflicting. While some
HIV-1 epitopes can be presented from inactivated virus, two HIV-1 epitopes have been shown to be presented exclusively endogenously. Thus, the relative contributions of the classical and endogenous pathways in HIV-1 antigen presentation are not known. Additionally, our understanding of the cell types that act as APCs during HIV-1 infection is incomplete, as it is unknown if CD4+ T cells themselves act as APCs during an HIV-1 infection.
In this study, I will determine the ability of human dendritic cells, macrophages, and CD4+ T cells to present HIV-1 epitopes from infectious and inactivated virus. I will also elucidate the cellular pathways used by dendritic cells to present the two endogenously produced HIV-1 peptides referenced above. These studies will shed light on the cellular pathways used by dendritic cells and macrophages to process and present HIV-1 epitopes, and will interrogate the antigen presenting capabilities of CD4+ T cells during HIV infection. I anticipate that data obtained from this project will reveal key insights regarding HIV host-pathogen interplay and may inform rational vaccine design.
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Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2017
Project Title: Notch-dependent reorganization of enhancer-promoter interactions in triple-negative breast cancer
Advisor(s):
- Robert Faryabi
- Warren Pear
Rotations:
- Warren Pear
- Robert Faryabi
- Golnaz Vahedi
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2016
Advisor(s):
- Rebecca Simmons
Rotations:
- Peter Klein
- Gerd Blobel
- Rebecca Simmons
- Roger Greenberg
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Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2016
Advisor(s):
- Shelley Berger
Rotations:
- Shelley Berger
- Aimee Payne
- Guo-Li Ming
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2015
Project Title: Determining how axon guidance molecules regulate tissue homeostasis in the Drosophila intestinal epithelium
Advisor(s):
- Greg Bashaw
Rotations:
- Greg Bashaw
- Christopher Brown
- Roberto Bonasio
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2017
Advisor(s):
- Christopher Brown
Rotations:
- Christopher Brown
- Raymond Soccio
- Zhaolan Zhou
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Stephen Dinardo
Rotations:
- Stephen Dinardo
- Mary Mullins
- Yana Kamberov
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2016
Advisor(s):
- Gerd Blobel
Rotations:
- Gerd Blobel
- Mitchell Lazar
- Edward Morrisey
Increased levels of fetal hemoglobin (HbF) alleviates symptoms of beta hemoglobinopathies such as sickle cell disease. Therefore, it has been a long-standing interest in the hematopoiesis field to uncover underlying mechanisms of HbF regulation. From a screen, I have identified several hnRNPs that upregulate HbF expression when knocked down. Thus, I am interested in studying the role of these hnRNPs in the post-transcriptional regulation of HbF expression.
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Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Stephen Dinardo
Rotations:
- Meera Sundaram
- Greg Bashaw
- Stephen Dinardo
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Montserrat Anguera
Rotations:
- Montserrat Anguera
- Marisa Bartolomei
- Irfan Asangani
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2013
Project Title: Understanding the transcriptional regulation of enteric neuron subtype specification and differentiation
Advisor(s):
- Robert Heuckeroth
Rotations:
- Alice Chen-Plotkin
- Robert Heuckeroth
- Marcella Devoto
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2018
Project Title: Characterizing the METTL3-m6A epitranscriptome in epidermal homeostasis and carcinogenesis
Advisor(s):
- Brian Capell
Rotations:
- Brian Capell
- Melike Lakadamyali
- Fange Liu
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2016
Project Title: Elucidating the role of chromatin architecture in the pathophysiology of Cornelia de Lange Syndrome
Advisor(s):
- Eric Joyce
Rotations:
- Alice Chen-Plotkin
- Jennifer Phillips-Cremins
- Eric Joyce
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2014
Advisor(s):
- Gerd Blobel
Rotations:
- Paul Lieberman
- Kenneth Zaret
- Gerd Blobel
My thesis topic involves dissecting the roles and mechanisms of transcriptional pausing, and understanding the dynamics and mechanisms of chromatin organization during erythropoiesis.
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Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Struan Grant
Rotations:
- Struan Grant
- Ophir Shalem
- Maja Bucan
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2017
Advisor(s):
- Eric Joyce
Rotations:
- Maya Capelson
- Eric Joyce
- Andres Blanco
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Sydney Shaffer
Rotations:
- Sydney Shaffer
- Golnaz Vahedi
- Lukasz Bugaj
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2017
Project Title: Probing the three-dimensional organization of enhancer-promoter communication
Advisor(s):
- Douglas Epstein
- Eric Joyce
Rotations:
- Kenneth Zaret
- Douglas Epstein
- Eric Joyce
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2015
Advisor(s):
- Doris Stoffers
Rotations:
- Doris Stoffers
- Gerd Blobel
- David Raizen
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2017
Advisor(s):
- Kathryn Hamilton
Rotations:
- Andy Minn
- Kathryn Hamilton
- Alessandro Gardini
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2016
Project Title: The Role of PAQR8 in Breast Cancer Metastasis and Therapy Resistance
Advisor(s):
- Lewis Chodosh
Rotations:
- Mitchell Lazar
- Lewis Chodosh
- Mark Kahn
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2016
Project Title: Roles of RNA-binding proteins and epigenetic regulators in acute myeloid leukemia
Advisor(s):
- Junwei Shi
Rotations:
- Jennifer Phillips-Cremins
- Gerd Blobel
- Junwei Shi
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2015
Project Title: Investigating the roles of active DNA demethylation pathways in epigenetic reprogramming
Advisor(s):
- Marisa Bartolomei
Rotations:
- Marisa Bartolomei
- Thomas Jongens
- Mary Mullins
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Struan Grant
- Christopher Brown
Rotations:
- Christopher Brown
- Klaus Kaestner
- Sarah Tishkoff
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2014
Project Title: Gnas inactivation alters adipose tissue properties during progression to heterotopic ossification
Advisor(s):
- Eileen Shore
Rotations:
- Katherine Nathanson
- Eileen Shore
- Benjamin Voight
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2017
Advisor(s):
- Zoltan Arany
Rotations:
- Rahul Kohli
- Zoltan Arany
- Joe Baur
Developmental, Stem Cell, and Regenerative Biology
Degree: PhD
Matriculation Year: 2017
Advisor(s):
- Montserrat Anguera
Rotations:
- Montserrat Anguera
- Mary Mullins
- Foteini Mourkioti
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2014
Advisor(s):
- Patrick Seale
Rotations:
- Patrick Seale
- Mitchell Lazar
- Harry Ischiropoulos
I will utilize mouse genetics and metabolic assays to determine how BAT blood flow is regulated uponcold exposure. In particular, I will focus on the role of two novel targets in regulating BAT blood flow and how the thermogenic program regulates their expression. I hypothesize that these factors are required for BAT to increase blood flow and oxygen consumption following cold exposure. My thesis project will utilize classical mouse genetics and epigenomic techniques to determine the mechanisms regulating brown adipose blood flow.
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Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2017
Project Title: Uncovering the role of CD38 in Acute Myeloid Leukemia
Advisor(s):
- Saar Gill
Rotations:
- Benjamin Prosser
- Carl June
- Saar Gill
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2017
Project Title: Functional Analysis of Triglyceride Regulator ApoA-V Using Naturally- Occurring Human Genetic Variants
Advisor(s):
- Daniel Rader
Rotations:
- Foteini Mourkioti
- Daniel Rader
- Kiran Musunuru
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2017
Project Title: Combining IAP Inhibitors with CAR-T Cell Therapy to Treat Glioblastoma
Advisor(s):
- Michael Milone
Rotations:
- Youhai Chen
- Michael Milone
- Nicola Mason
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2014
Project Title: CRISPR-Cas9 Gene Editing Strategies of ATXN2 for the Treatment of Spinocerebellar Ataxia Type 2
Advisor(s):
- Beverly Davidson
Rotations:
- Jean Bennett
- Matthew Weitzman
- Beverly Davidson
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2012
Project Title: Re-directing cytomegalovirus specific chimeric antigen receptor T cells for glioblastoma multiforme cancer immunotherapy.
Advisor(s):
- Carl June
- Laura Johnson
Rotations:
- Valder Arruda
- Matthew Weitzman
- Nicola Mason
- Gregory Beatty
- Carl June
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2015
Project Title: Ontogeny of HIV-1 V2 apex broadly neutralizing antibodies in SHIV-infected rhesus macaques
Advisor(s):
- George Shaw
Rotations:
- Luis Montaner
- George Shaw
- Erica Stone
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2016
Project Title: Patient-derived HCV-like particle expressed by a lipid nanoparticle-encapsulated nucleoside-modified mRNA vaccine for HCV prophylaxis via bNAb elicitation
Advisor(s):
- Drew Weissman
- Katharine Bar
Rotations:
- David Weiner
- Drew Weissman
- Katharine Bar
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Naiara Aquizu Lopez
Rotations:
- Naiara Aquizu Lopez
- Kiran Musunuru
- Beverly Davidson
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2014
Project Title: Assessing the Safety and Efficacy of a Gene Transfer Approach for Duchenne Muscular Dystrophy
Advisor(s):
- Hansell Stedman
- Jean Bennett
Rotations:
- Valder Arruda
- Hansell Stedman
- Jean Bennett
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- James Wilson
Rotations:
- Kiran Musunuru
- Stefano Rivella
- James Wilson
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2016
Project Title: Lentiviral Vectors as Therapeutic Options for the Treatment of Alpha-Thalassemia
Advisor(s):
- Stefano Rivella
Rotations:
- Valder Arruda
- Stefano Rivella
- John Wolfe
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Beatriz Carreno
- Gerald Linette
Rotations:
- Katharine Bar
- Jan Melenhorst
- Gerald Linette
- Beatriz Carreno
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2017
Project Title: Determining the role of H3K9me2S10 phosphorylation in peripheral heterochromatin localization
Advisor(s):
- Jonathan Epstein
Rotations:
- Jonathan Epstein
- Mark Kahn
- Melike Lakadamyali
Developmental, Stem Cell and Regenerative Biology
Degree: VMD/PhD
Matriculation Year: 2014
Advisor(s):
- Edward Morrisey
Rotations:
- Ben Stanger
- Edward Morrisey
- Christopher Lengner
My thesis is focused on studying the developmental ontogeny and maturation process of alveolar type one cells in the lung.
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Developmental, Stem Cell and Regenerative Biology
Degree: MD/PhD
Matriculation Year: 2016
Advisor(s):
- Hongjun Song
Rotations:
- Rajan Jain
- Hongjun Song
- Guo-Li Ming
- D. Kacy Cullen
- Jonathan Epstein
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2016
Advisor(s):
- Robert Heuckeroth
Rotations:
- Montserrat Anguera
- Robert Heuckeroth
- Mia Levine
I'm studying the role of microRNAs in the development of the enteric nervous system.
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Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2013
Project Title: Investigating the Role of TBX3 in Human Endoderm Development
Advisor(s):
- Paul Gadue
Rotations:
- Paul Gadue
- John Murray
- Warren Pear
Developmental, Stem Cell and Regenerative Biology
Degree: MD/PhD
Matriculation Year: 2015
Advisor(s):
- Christopher Lengner
Rotations:
- Thomas Leung
- Katalin Susztak
- Rebecca Wells
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2012
Advisor(s):
- Mary Mullins
Rotations:
- Erfei Bi
- Mary Mullins
- Edward Morrisey
The Balbiani body (Bb) is a transient aggregate found within the oocytes of many species, conserved form insects to humans. It shares structural similarities with amyloid plaques that cause degenerative disease. Understanding the Bb will provide insight how amyloid networks form and disassemble in a non-disease context, but few components of the Bb have been characterized. I am using proteomics, live imaging and gene editing to identify novel components of the Bb and discover their function.
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Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2016
Project Title: Identifying necessary chromatin states and targets for hemogenic specification and reprogramming by the transcription factor Runx1
Advisor(s):
- Nancy Speck
Rotations:
- Peter Klein
- Nancy Speck
- Klaus Kaestner
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2014
Project Title: Comparative phylogenetics of the dystrophin associated protein complex protein families and implications for Adeno-associated virus (AAV)-mediated gene therapy in Duchenne muscular dystrophy.
Advisor(s):
- Hansell Stedman
Rotations:
- Jonathan Epstein
- Foteini Mourkioti
- Jason Burdick
- Hansell Stedman
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2014
Project Title: Interpretation of the BMP morphogen gradient patterning the dorsal-ventral axis of the zebrafish embryo
Advisor(s):
- Mary Mullins
Rotations:
- Patrick Seale
- Mary Mullins
- Greg Bashaw
A gradient of BMP signaling activity patterns the dorsoventral embryonic axis of all vertebrates. My project seeks the mechanism by which cells interpret different levels of BMP signaling to specify different ventral cell fates.
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Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Erika Holzbaur
Rotations:
- Erika Holzbaur
- Greg Bashaw
- Matthew Good
Cell Biology, Physiology and Metabolism
Degree: PhD
Matriculation Year: 2017
Advisor(s):
- Zoltan Arany
Rotations:
- Elizabeth Grice
- Zoltan Arany
- Raymond Soccio
Cell Biology, Physiology and Metabolism
Degree: PhD
Matriculation Year: 2016
Advisor(s):
- Edward Lee
Rotations:
- Kelly Jordan-Sciutto
- Edward Lee
- Robert Kalb
Cell Biology, Physiology and Metabolism
Degree: MD/PhD
Matriculation Year: 2014
Advisor(s):
- Zoltan Arany
Rotations:
- Zoltan Arany
- Hao Wu
- Adam Resnick
Cell Biology, Physiology and Metabolism
Degree: PhD
Matriculation Year: 2015
Advisor(s):
- Zoltan Arany
Rotations:
- Michael Marks
- Benjamin Prosser
- Zoltan Arany
Cell Biology, Physiology and Metabolism
Degree: PhD
Matriculation Year: 2017
Project Title: Enhancing antitumor cytotoxicity of natural killer cells by increasing their intracellular pH
Advisor(s):
- Chi Dang
Rotations:
- Chi Dang
- Mitchell Lazar
- Celeste Simon
Cell Biology, Physiology and Metabolism
Degree: PhD
Matriculation Year: 2015
Advisor(s):
- Yale Goldman
Rotations:
- Marc Vermulst
- Rugang Zhang
- Edward Lee
- Ronen Marmorstein
Cell Biology, Physiology and Metabolism
Degree: PhD
Matriculation Year: 2017
Advisor(s):
- Zoltan Arany
Rotations:
- Zoltan Arany
- Benjamin Prosser
- Kenneth Margulies
Cell Biology, Physiology and Metabolism
Degree: PhD
Matriculation Year: 2014
Project Title: Targeting MCU-mediated Calcium Uptake by Mitochondria for the Development of New Chemotherapies
Advisor(s):
- Kevin Foskett
Rotations:
- Kevin Foskett
- Erika Holzbaur
- Robert Kalb
As a dissertation student my thesis project aims to understand how genetic and pharmacological inhibition of calcium influx into mitochondria, as well as inhibition of calcium transfer from the endoplasmic reticulum (ER) to mitochondria affects the survival of cancer cells in vitro and in vivo. Cancer is characterized by accelerated growth and division of unhealthy cells. While mitochondria are the main organelles that supply the energetic needs of cells through oxidative phosphorylation, the most prominent feature of cancer cells is a remodeled cell metabolism based on constitutive aerobic glycolysis. It is then reasonably assumed that the biological function of mitochondria as the “powerhouse of the cell” is diminished in cancer cells.
On the other hand, the unexpected finding from our lab published by Cardenas et al., (2016), revealed that constitutive influx of calcium into mitochondria is indispensable for survival of cancer cells. Therefore, I propose that calcium signaling from the ER to mitochondria, as well as calcium influx to mitochondria can be independently targeted for the development of novel chemotherapeutics to selectively damage and kill cancer cells. While the Foskett lab is recognized by the international scientific community as a significant contributor in many research areas, such as calcium signaling, the development of my project in cancer biology will enrich the expertise of the lab. Furthermore, I expect that the knowledge gained from my research will be employed to optimize and increase current chemotherapies.
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Cell Biology, Physiology and Metabolism
Degree: PhD
Matriculation Year: 2013
Project Title: Tumor RIPK1 Signaling Mediates Intrinsic and Extrinsic Mechanisms of Resistance to Immune Checkpoint Blockade Therapy
Advisor(s):
- Andy Minn
Rotations:
- Kathryn Wellen
- Mitchell Lazar
- Andy Minn
- Dwight Gilliland
Cell Biology, Physiology and Metabolism
Degree: PhD
Matriculation Year: 2017
Project Title: A mechanistic investigation into F-actin assembly on mitochondria as a wave
Advisor(s):
- Erika Holzbaur
Rotations:
- Erika Holzbaur
- Michael Ostap
- James Shorter
Cell Biology, Physiology and Metabolism
Degree: PhD
Matriculation Year: 2017
Project Title: Cyclin B3 is an essential factor in female fertility and embryonic development
Advisor(s):
- Jeremy Wang
Rotations:
- Jeremy Wang
- Yana Kamberov
- Marisa Bartolomei
Cancer Biology
Degree: PhD
Matriculation Year: 2014
Advisor(s):
- Xiaolu Yang
Rotations:
- Shelley Berger
- Xiaolu Yang
- Gerd Blobel
Cancer Biology
Degree: PhD
Matriculation Year: 2017
Project Title: Pattern recognition receptor signaling in immune checkpoint blockade resistance
Advisor(s):
- Andy Minn
Rotations:
- Andy Minn
- Junwei Shi
- Shelley Berger
Cancer Biology
Degree: PhD
Matriculation Year: 2017
Project Title: The role of Epigenetic Regulators in Restricting LSD1i-Mediated Differentiation in Acute Myeloid Leukemia
Advisor(s):
- Andres Blanco
Rotations:
- Ben Stanger
- David Feldser
- Andres Blanco
Cancer Biology
Degree: PhD
Matriculation Year: 2016
Project Title: Paradoxical YAP activation as an emergent limitation to Cu chelation therapy in BRAFV600E-driven melanoma
Advisor(s):
- Donita Brady
Rotations:
- Donita Brady
- Kathryn Wellen
- Constantinos Koumenis
Cancer Biology
Degree: PhD
Matriculation Year: 2014
Project Title: Investigating tumor cell-intrinsic factors regulating immune infiltration in pancreatic cancer
Advisor(s):
- Ben Stanger
Rotations:
- Ben Stanger
- Lewis Chodosh
- Kathryn Wellen
Cancer Biology
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Gregory Beatty
Rotations:
- John Maris
- Saar Gill
- Gregory Beatty
Cancer Biology
Degree: PhD
Matriculation Year: 2017
Project Title: Understanding and Overcoming Melanoma Resistance to GPCR-based Therapy
Advisor(s):
- Todd Ridky
Rotations:
- David Feldser
- Todd Ridky
- Gerald Linette
Cancer Biology
Degree: PhD
Matriculation Year: 2017
Project Title: Investigating the Roles of Activation-Induced Cytidine Deaminase in theMalignant Progression of Chronic Lymphocytic Leukemia
Advisor(s):
- Andrew Hu
Rotations:
- Tzipora Sarah Karin Eisinger
- Andrew Hu
- Oliver Garden
Cancer Biology
Degree: PhD
Matriculation Year: 2014
Project Title: Investigating the mechanisms underlying melanosome biogenesis and maturation
Advisor(s):
- Michael Marks
Rotations:
- Andrei Thomas-Tikhonenko
- Rugang Zhang
- Michael Marks
- Patrick Viatour
Cancer Biology
Degree: PhD
Matriculation Year: 2014
Advisor(s):
- Andrei Thomas-Tikhonenko
Rotations:
- Andrei Thomas-Tikhonenko
- Nancy Speck
- Xianxin Hua
Cancer Biology
Degree: MD/PhD
Matriculation Year: 2011
Project Title: Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy
Advisor(s):
- Douglas Wallace
Rotations:
- Jean Bennett
- Douglas Wallace
- Shelley Berger
Cancer Biology
Degree: PhD
Matriculation Year: 2015
Project Title: Investigating the immunometabolism and anti-tumor properties of invariant natural killer T (iNKT) cells in neuroblastoma
Advisor(s):
- Hamid Bassiri
Rotations:
- Roger Greenberg
- Maureen Murphy
- Hamid Bassiri
Cancer Biology
Degree: PhD
Matriculation Year: 2014
Advisor(s):
- Celeste Simon
Rotations:
- Warren Pear
- Mitchell Lazar
- Celeste Simon
My thesis topic is investigating the role of urea cycle enzymes in clear cell renal cell carcinoma (ccRCC) progression. We observe reduction in the levels of urea cycle enzymes in ccRCC tumors when compared to the normal kidney. Re-expression of these enzymes slows cancer cell growth while loss promotes proliferation. Based on these data we hypothesize that urea cycle enzymes may act as potential tumor suppressors in ccRCC.
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Cancer Biology
Degree: PhD
Matriculation Year: 2017
Advisor(s):
- Margaret Chou
Rotations:
- Andy Minn
- Saar Gill
- Dmitry Gabrilovich
- Gregory Beatty
Cancer Biology
Degree: PhD
Matriculation Year: 2017
Project Title: Investigating the role of ACLY and acetyl-CoA metabolism in hepatocellular carcinoma
Advisor(s):
- Kathryn Wellen
Rotations:
- Kathryn Wellen
- Wei Tong
- Martin Carroll
Cancer Biology
Degree: PhD
Matriculation Year: 2017
Project Title: Role of HMG-box transcription factor TOX in maintaining CD8 T cell exhaustion
Advisor(s):
- John Wherry
Rotations:
- Dmitry Gabrilovich
- Jorge Henao-Mejia
- John Wherry
Cancer Biology
Degree: PhD
Matriculation Year: 2017
Project Title: Defining the Mechanism and Function of DNA Double Strand Break Induced Inhibition of V(D)J Recombination
Advisor(s):
- Craig Bassing
Rotations:
- John Maris
- Ronny Drapkin
- Craig Bassing
Cancer Biology
Degree: PhD
Matriculation Year: 2016
Project Title: The Role of the Endothelin B Receptor in Macrophage Function
Advisor(s):
- Malay Haldar
Rotations:
- Ben Stanger
- Anil Rustgi
- Malay Haldar
Cancer Biology
Degree: PhD
Matriculation Year: 2014
Project Title: Elucidating mechanisms of cancer therapy resistance due to alterations in endoplasmic reticulum-mitochondria contact sites
Advisor(s):
- Michael Hogarty
Rotations:
- Vera Krymskaya
- Michael Hogarty
- Rugang Zhang
Cancer Biology
Degree: PhD
Matriculation Year: 2014
Project Title: Dissecting transcriptional network during CD8+ T cell response
Advisor(s):
- John Wherry
Rotations:
- David Feldser
- John Wherry
- Mitchell Lazar
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Cancer Biology
Degree: PhD
Matriculation Year: 2014
Advisor(s):
- Kathryn Wellen
Rotations:
- Kathryn Wellen
- Celeste Simon
- Shelley Berger
My thesis is focused on understanding the functional impacts of changes in flux through the hexosamine biosynthesis pathway in pancreatic cancer.
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Cancer Biology
Degree: PhD
Matriculation Year: 2015
Advisor(s):
- Chi Dang
Rotations:
- Donita Brady
- Celeste Simon
- Chi Dang
I am currently working on determining the function of a previously uncharacterized circadian oscillating long noncoding RNA (lncRNA) that may modulate the degradation of an important chromatin modifying complex. In addition to normal physiology, this interaction may also play a role in clear cell renal carcinoma (ccRCC) progression.
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Cancer Biology
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Lewis Chodosh
Rotations:
- Wei Tong
- Todd Ridky
- Lewis Chodosh
Cancer Biology
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- David Feldser
Rotations:
- Sandra Ryeom
- Ben Stanger
- David Feldser
Cancer Biology
Degree: PhD
Matriculation Year: 2016
Advisor(s):
- David Feldser
Rotations:
- David Feldser
- Kristen Lynch
- Donita Brady
The tumor suppressor p53 can transactivate genes that mediate cytostatic and cytotoxic anti-tumor responses in a context-dependent manner. However, it is not known exactly how p53 mediates its pleiotropic effects. My thesis project incorporates the usage of established mouse models of lung cancer and cancer cell lines to dissect the mechanisms behind the pleiotropic tumor suppressive programs mediated by p53.
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Developmental, Stem Cell, and Regenerative Biology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Montserrat Anguera
Rotations:
- Zhaolan Zhou
- Lewis Chodosh
- Montserrat Anguera
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Paul Gadue
Rotations:
- Paul Gadue
- Stewart Anderson
- Stella Chou
Gene Therapy and Vaccines
Degree: MD/PhD
Matriculation Year: 2017
Advisor(s):
- James Wilson
Rotations:
- Kiran Musunuru
- James Wilson
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2018
Rotations:
- Kathryn Wellen
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2018
Advisor(s):
- Arjun Raj
Rotations:
- Mitchell Lazar
- Arjun Raj
Developmental, Stem Cell, and Regenerative Biology
Degree: VMD/PhD
Matriculation Year: 2018
Rotations:
- Robert Mauck
Cancer Biology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Peter Choi
Rotations:
- Andy Minn
- Marco Ruella
- Peter Choi
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Kenneth Zaret
Rotations:
- Gerd Blobel
- Kenneth Zaret
- Melike Lakadamyali
Cancer Biology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Celeste Simon
Rotations:
- Celeste Simon
- Ben Stanger
- Liling Wan
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Daniel Kulp
Rotations:
- Daniel Powell
- Michael Mitchell
- Daniel Kulp
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Matthew Weitzman
Rotations:
- Dieter Schifferli
- Matthew Weitzman
- Paul Lieberman
Microbiology, Virology, and Parasitology
Degree: MD/PhD
Matriculation Year: 2018
Rotations:
- Carolina Lopez
- Will Bailis
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2019
Rotations:
- Brian Capell
- Nancy Bonini
- David Feldser
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2019
Rotations:
- Bradley Johnson
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- De'Broski Herbert
Rotations:
- Sara Cherry
- Michaela Locci
- Frederic Bushman
Cancer Biology
Degree: PhD
Matriculation Year: 2019
Rotations:
- David Feldser
- Maureen Murphy
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Stefano Rivella
- Saar Gill
Rotations:
- Michael Milone
- Saar Gill
- Stefano Rivella
Cell Biology, Physiology, and Metabolism
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Melike Lakadamyali
Rotations:
- Meera Sundaram
- Melike Lakadamyali
- Tatyana Svitkina
Microbiology, Virology, and Parasitology
Degree: MD/PhD
Matriculation Year: 2018
Rotations:
- Scott Hensley
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2018
Rotations:
- Katalin Susztak
Cancer Biology
Degree: PhD
Matriculation Year: 2019
Rotations:
- Lewis Chodosh
- Todd Ridky
- George Burslem
Cell Biology, Physiology and Metabolism
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Melike Lakadamyali
Rotations:
- Melike Lakadamyali
- Erika Holzbaur
- Paul Janmey
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Paul Planet
Rotations:
- Paula Oliver
- Mark Goulian
- Paul Planet
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2017
Advisor(s):
- Arjun Raj
Rotations:
- Jennifer Phillips-Cremins
- Arjun Raj
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Gerd Blobel
Rotations:
- Junwei Shi
- Gerd Blobel
- Alessandro Gardini
Microbiology, Virology and Parasitology
Degree: MD/PhD
Matriculation Year: 2017
Advisor(s):
- Sunny Shin
- Igor Brodsky
Rotations:
- Sunny Shin
- Joseph Zackular
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Will Bailis
Rotations:
- Christopher Hunter
- Warren Pear
- Will Bailis
Microbiology, Virology and Parasitology
Degree: VMD/PhD
Matriculation Year: 2018
Project Title: The Ups and Downs of Host Regulation of Ebola Hemorrhagic Fever Virus Egress
Advisor(s):
- Ronald Harty
Rotations:
- Beatrice Hahn
- Matthew Weitzman
- Ronald Harty
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2016
Project Title: Investigating the Role of STING during enteric RNA virus infection in Drosophila
Advisor(s):
- Sara Cherry
Rotations:
- Sara Cherry
- Harvey Friedman
- Laurence Eisenlohr
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2016
Advisor(s):
- Paul Planet
Rotations:
- Paul Planet
- Dustin Brisson
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2014
Advisor(s):
- Beatrice Hahn
Rotations:
- Una O’Doherty
- George Shaw
- Beatrice Hahn
My thesis research is focused on the role of type 1 interferon on the evolution of HIV-1. This includes studying the ways in which SIVcpz adapted to the human interferon response following cross-species transmission, as well as studying the interferon resistance over time within HIV-1 infected individuals.
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Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Susan Weiss
Rotations:
- Matthew Weitzman
- Susan Weiss
- Kristen Lynch
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2015
Project Title: Determining the Mechanism of TNF-Mediated Defense Against Intracellular Legionella pneumophila Infection
Advisor(s):
- Sunny Shin
Rotations:
- Phillip Scott
- Michael Povelones
- Sunny Shin
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2015
Advisor(s):
- Joseph St Geme
Rotations:
- Joseph St Geme
- Kimberly Gallagher
- Mechthild Pohlschroder
Microbiology, Virology and Parasitology
Degree: VMD/PhD
Matriculation Year: 2015
Project Title: Investigating the innate immune antagonistic effects of the multifunctional C15 protein of Ectromelia virus
Advisor(s):
- Laurence Eisenlohr
Rotations:
- Matthew Weitzman
- Scott Hensley
- Laurence Eisenlohr
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2014
Project Title: Isolation and Characterization of Novel Adeno-associated Viruses from Mammalian Hosts; Development of Vectors for Gene Therapy
Advisor(s):
- James Wilson
Rotations:
- Luis Montaner
- James Wilson
- Matthew Weitzman
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- George Shaw
Rotations:
- George Shaw
- Katharine Bar
- Michael Betts
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2017
Project Title: Defining capsule and exopolysaccharide-independent complement resistance factors in Kingella kingae
Advisor(s):
- Joseph St Geme
Rotations:
- Elizabeth White
- Laurence Eisenlohr
- Joseph St Geme
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2017
Project Title: Role of Yersinia pseudotuberculosis virulence in granuloma formation during intestinal infection
Advisor(s):
- Igor Brodsky
Rotations:
- Igor Brodsky
- Boris Striepen
- Michael Abt
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2017
Advisor(s):
- Frederic Bushman
Rotations:
- Susan Weiss
- Sara Cherry
- Frederic Bushman
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2016
Project Title: Developing improved vaccine platforms against severe fever with thrombocytopenia syndrome virus
Advisor(s):
- Paul Bates
Rotations:
- Carolina Lopez
- Laurence Eisenlohr
- Paul Bates
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2016
Project Title: Evasion of Human Innate Immunity by Coxiella burnetii
Advisor(s):
- Sunny Shin
Rotations:
- Michael Betts
- Sunny Shin
- Paul Planet
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2016
Project Title: Dissecting the Immune Response to Merkel Cell Polyomavirus Infection
Advisor(s):
- Jianxin You
Rotations:
- Matthew Weitzman
- Jianxin You
- Igor Brodsky
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2017
Project Title: The role of PTPN14 inactivation by HPV E7 in the differentiation-dependent HPV life cycle
Advisor(s):
- Elizabeth White
Rotations:
- Carolina Lopez
- Elizabeth White
- Susan Weiss
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2017
Advisor(s):
- Frederic Bushman
Rotations:
- Frederic Bushman
- Elizabeth Grice
- Scott Hensley
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2015
Advisor(s):
- Carolina Lopez
Rotations:
- Hao Shen
- David Weiner
- Carolina Lopez
My project is examining the mechanism of recognition of defective viral genomes (DVGs) during paramyxovirus infections in vivo. Additionally, I will be examining the mechanism of action of DVG-derived oligonucleotides as vaccine adjuvants to understand how these adjuvants are able to induce type-I immune responses. All in all I am examining how immune responses capable of clearing intracellular pathogens are initiated.
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Microbiology, Virology and Parasitology
Degree: MD/PhD
Matriculation Year: 2014
Project Title: Structural Studies of Antiretroviral Drugs Targeting HIV Integrase
Advisor(s):
- Frederic Bushman
- Gregory Van Duyne
Rotations:
- Frederic Bushman
- Katharine Bar
- Gregory Van Duyne
I will be studying HIV integrase. Multimeric forms of integrase are the target of two classes of antiretroviral therapy, the strand transfer inhibitors and the allosteric inhibitors of integrase. My thesis topic is to characterize the multimeric forms of integrase that are relevant for understanding mechanisms of action and resistance to antiretroviral therapy.
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Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Sunny Shin
Rotations:
- Jun Zhu
- Sunny Shin
- Mark Goulian
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2017
Advisor(s):
- Michael Abt
Rotations:
- Michael Abt
- Gary Wu
- Jun Zhu
Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2015
Advisor(s):
- Susan Weiss
Rotations:
- Paul Bates
- Susan Weiss
- Carolina Lopez
My thesis project will focus on Middle East respiratory syndrome coronavirus (MERS-CoV) interactions with the human host innate immune system. MERS-CoV encodes a small, dsRNA binding protein, NS4a. I hypothesize that the role of NS4a during infection is to antagonize multiple antiviral dsRNA-induced pathways in the host cell.
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Microbiology, Virology and Parasitology
Degree: PhD
Matriculation Year: 2019
Rotations:
- Elizabeth White
- Scott Hensley
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2017
Project Title: Improved prediction modeling of complex genetic disease with multiomic data integration using knowledge-based variable selection
Advisor(s):
- Marylyn Ritchie
Rotations:
- Christopher Brown
- Rui Feng
- Marylyn Ritchie
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2016
Advisor(s):
- Ophir Shalem
Rotations:
- Sarah Tishkoff
- Golnaz Vahedi
- Ophir Shalem
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2013
Project Title: Regulation of anterior genes in the C. elegans embryo
Advisor(s):
- John Murray
Rotations:
- Dwight Stambolian
- Maya Capelson
- John Murray
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2015
Project Title: Alternative Splicing Variations in T cells and B-ALL
Advisor(s):
- Yoseph Barash
- Kristen Lynch
Rotations:
- Christopher Brown
- Benjamin Voight
- Kristen Lynch
- Yoseph Barash
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2017
Project Title: Regulation of Genome Activation and Contribution of a Spatial Pattern of Zygotic Transcription in Vertebrate Early Embryo Development
Advisor(s):
- Matthew Good
Rotations:
- Hao Wu
- Kenneth Zaret
- Gerd Blobel
- Melike Lakadamyali
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2015
Advisor(s):
- Benjamin Prosser
Rotations:
- Roger Greenberg
- Kenneth Zaret
- Gerd Blobel
- Jennifer Phillips-Cremins
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2016
Project Title: Dissecting the roles of Polycomb Repressive 2 accessory subunits during early developmental transitions
Advisor(s):
- Roberto Bonasio
Rotations:
- Hao Wu
- Roberto Bonasio
- Alessandro Gardini
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- John Murray
Rotations:
- John Murray
- Maya Capelson
- Doris Wagner
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2016
Project Title: Investigating the role of chromosome architecture in the pathophysiology of Cornelia de Lange Syndrome
Advisor(s):
- Eric Joyce
Rotations:
- Jennifer Phillips-Cremins
- Eric Joyce
- Edward Lee
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Brian Capell
Rotations:
- Brian Capell
- Golnaz Vahedi
- Elizabeth Heller
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Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2016
Advisor(s):
- Doris Stoffers
Rotations:
- Zhaolan Zhou
- Doris Stoffers
- Ophir Shalem
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2018
Project Title: Investigating the mechanism of RNA Polymerase II regulation by Phosphoprotein Phosphatase 2A
Advisor(s):
- Alessandro Gardini
Rotations:
- Alessandro Gardini
- John Murray
- Shawn Little
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2017
Project Title: Investigating Proteolytic Cleavage Events Using Genome-Wide CRISPR/Cas9 Knockout Screens
Advisor(s):
- Ophir Shalem
Rotations:
- Ophir Shalem
- Nancy Bonini
- Edward Lee
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2016
Advisor(s):
- Edward Behrens
Rotations:
- Todd Ridky
- Panteleimon Rompolas
- Thomas Leung
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2014
Advisor(s):
- Rajan Jain
- Jonathan Epstein
Rotations:
- Edward Lee
- Rajan Jain
- Ben Black
My work focuses on elucidating mechanisms by which multipotent cardiac progenitors make cell fate decisions during cardiac specification. More specifically, I am defining the role of the cardiac factor Hopx and its interplay with the spatial organization of chromatin in committing progenitors to the cardiomyogenic fate.
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Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2014
Project Title: Understanding the role of post-transcriptional gene regulation and long non-coding RNAs during plant stress and development
Advisor(s):
- Brian Gregory
Rotations:
- Montserrat Anguera
- Brian Gregory
- Jeremy Wilusz
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2016
Project Title: Role of Foxl1+ mesenchymal cell-derived Wnt5a during intestinal development
Advisor(s):
- Klaus Kaestner
Rotations:
- Zachary Schug
- Klaus Kaestner
- Katalin Susztak
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2016
Project Title: Inducing transcriptional reprogramming with targeted chemotherapy
Advisor(s):
- Arjun Raj
Rotations:
- Erika Holzbaur
- Arjun Raj
- Golnaz Vahedi
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2018
Project Title: Deciphering the Molecular Orchestrators of Heterochromatin-Lamina Interactions at the Nuclear Periphery
Advisor(s):
- Rajan Jain
Rotations:
- Rajan Jain
- Andres Blanco
- Eric Joyce
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2015
Project Title: Basis for specificity in heterochromatin establishment by zinc finger transcription factors
Advisor(s):
- Kenneth Zaret
Rotations:
- Kenneth Zaret
- Golnaz Vahedi
- Christopher Brown
My thesis project is about understanding the role that zinc finger proteins play in regulating cell type specific heterochromatin. This will be studied in the context of cellular reprogramming from human fibroblast to hepatic, neuronal, and iPSC lineages. The goal is to understand how perturbing specific zinc finger proteins can enhance reprogramming to different lineages.
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Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2017
Project Title: Investigating barriers to polygenic risk prediction across diverse populations
Advisor(s):
- Sarah Tishkoff
- Iain Mathieson
Rotations:
- Iain Mathieson
- Sarah Tishkoff
- Yana Kamberov
Genetics and Epigenetics
Degree: VMD/PhD
Matriculation Year: 2015
Project Title: The gut microbiota regulates the progression of obesity and white adipose tissue inflammation via a highly conserved family of microRNAs
Advisor(s):
- Jorge Henao-Mejia
Rotations:
- Montserrat Anguera
- Michael Silverman
- Jorge Henao-Mejia
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2015
Project Title: Revealing the “primed” cellular states underlying variability in directed differentiation fates
Advisor(s):
- Arjun Raj
Rotations:
- Klaus Kaestner
- Golnaz Vahedi
- Arjun Raj
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2016
Project Title: Lineage Analysis of Cellular States Predicting Reprogramming into iPSCs
Advisor(s):
- Arjun Raj
Rotations:
- Arjun Raj
- Daniel Rader
- John Murray
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Alessandro Gardini
Rotations:
- Alessandro Gardini
- Gerd Blobel
- Roberto Bonasio
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Naiara Aquizu Lopez
Rotations:
- Jennifer Kalish
- Naiara Aquizu Lopez
- Erica Korb
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2015
Project Title:
Advisor(s):
- Zoltan Arany
Rotations:
- Zoltan Arany
- Ben Stanger
- Jennifer Phillips-Cremins
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2015
Project Title: Evaluating the role of genetic variation in the development of cardiometabolic disease
Advisor(s):
- Christopher Brown
- Benjamin Voight
Rotations:
- Maja Bucan
- Benjamin Voight
- Christopher Brown
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2017
Advisor(s):
- Mitchell Lazar
Rotations:
- Andy Minn
- Zhaolan Zhou
- Eric Joyce
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2017
Project Title: Investigating the role of TRAK proteins as motor adaptors for mitochondrial transport in neurons
Advisor(s):
- Erika Holzbaur
- Thomas Jongens
Rotations:
- Roberto Bonasio
- Erika Holzbaur
- Thomas Jongens
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2016
Project Title: Multiplexing CRISPR/Cas9-based Continuous Evolution for Improved Epigenome Editing
Advisor(s):
- Junwei Shi
- Rahul Kohli
Rotations:
- Kiran Musunuru
- Rahul Kohli
- Junwei Shi
Genetics and Epigenetics
Degree: MD/PhD
Matriculation Year: 2016
Project Title: Dichotomous Engagement of HDAC3 Catalytic Activity Governs Inflammatory Responses
Advisor(s):
- Mitchell Lazar
Rotations:
- Andy Minn
- Mitchell Lazar
Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2016
Advisor(s):
- Shelley Berger
Rotations:
- Roberto Bonasio
- Shelley Berger
- Marisa Bartolomei
My research revolves around nuclear acetyl-CoA metabolism and its contributions to histone acetylation and gene transcription in neurons. I am particularly interested in how the metabolic enzyme ACSS2 is recruited to the chromatin and how this recruitment impacts learning and memory in mice.
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Genetics and Epigenetics
Degree: PhD
Matriculation Year: 2015
Project Title: Nuclear pore protein Megator attenuates dosage compensation of the male X chromosome
Advisor(s):
- Maya Capelson
Rotations:
- Maya Capelson
- David Raizen
- Mia Levine
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2015
Project Title: Characterizing the Physiological and Molecular Mechanism by Which hepatic Trib1 Regulates Plasma Lipids in Mice
Advisor(s):
- Daniel Rader
Rotations:
- Jean Bennett
- Daniel Rader
- Susan Weiss
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Drew Weissman
Rotations:
- John Wherry
- Drew Weissman
- Scott Hensley
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Elizabeth White
Rotations:
- Paul Bates
- Drew Weissman
- Elizabeth White
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2019
Advisor(s):
- Joseph Fraietta
Rotations:
- Michael Milone
- Joseph Fraietta
- James Riley
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2016
Project Title: Understanding the Mechanisms of PHP.B Transport Across the Murine Blood-Brain Barrier
Advisor(s):
- James Wilson
Rotations:
- Kiran Musunuru
- James Wilson
- Jeffrey Saven
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2015
Advisor(s):
- James Riley
Rotations:
- Michael Betts
- James Riley
- John Wherry
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2017
Project Title: The role of a gut microbiota-induced lncRNA in regulating intestinal epithelial cells
Advisor(s):
- Jorge Henao-Mejia
Rotations:
- Junwei Shi
- Aimee Payne
- Jorge Henao-Mejia
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2018
Project Title: Developing a safe utrophin-based gene therapy platform through design of novel synthetic muscle-specific promoters and a liver-detargeted Adeno-associated virus 9
Advisor(s):
- Hansell Stedman
Rotations:
- Joshua Dunaief
- Hansell Stedman
- Daniel Rader
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Joseph Fraietta
Rotations:
- Jan Melenhorst
- Joseph Fraietta
- Shelley Berger
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2017
Advisor(s):
- Beverly Davidson
Rotations:
- John Wolfe
- Beverly Davidson
- Stefano Rivella
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2016
Project Title: Understanding CAR T cell Dysfunction in Chronic Lymphocytic Leukemia
Advisor(s):
- Jan Melenhorst
Rotations:
- Constantinos Koumenis
- Jan Melenhorst
- Junwei Shi
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2017
Project Title: Assaying the potential cardioprotective effect of MTSS1 downregulation against dilated cardiomyopathy
Advisor(s):
- Kiran Musunuru
Rotations:
- Frederic Bushman
- Stefano Rivella
- Kiran Musunuru
Gene Therapy and Vaccines
Degree: PhD
Matriculation Year: 2016
Project Title: Investigating the role of cell-intrinsic checkpoint regulators PD1 and CTLA4 in Chimeric antigen receptor T cells
Advisor(s):
- Carl June
Rotations:
- Carolina Lopez
- Carl June
- Janis Burkhardt
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2016
Project Title: Crossing the Midline Requires Sequential Proteolysis of the Attractive Frazzled Axon Guidance Receptor
Advisor(s):
- Greg Bashaw
Rotations:
- Greg Bashaw
- Jonathan Raper
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2017
Project Title: The role of ΔNp63 in maladaptive regeneration and repair following severe pulmonary injury
Advisor(s):
- Andrew Vaughan
Rotations:
- Rajan Jain
- Andrew Vaughan
- Ling Qin
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2012
Advisor(s):
- Mary Mullins
Rotations:
- Mary Mullins
- Peter Klein
- Jonathan Raper
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2016
Advisor(s):
- Greg Bashaw
Rotations:
- Wenqin Luo
- Mary Mullins
- Greg Bashaw
Developmental, Stem Cell and Regenerative Biology
Degree: MD/PhD
Matriculation Year: 2014
Project Title: Single cell CRISPR lineage tracing of cancer metastasis
Advisor(s):
- Christopher Lengner
Rotations:
- Joe Baur
- Gerd Blobel
- Christopher Lengner
- John Murray
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2016
Project Title: Investigating the nuclear organization of the inactive X in female lymphocytes
Advisor(s):
- Montserrat Anguera
Rotations:
- Michael Granato
- Montserrat Anguera
- Marisa Bartolomei
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Sandra Maday
Rotations:
- Kelvin Luk
- Isaac Chen
- Sandra Maday
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2013
Project Title: The Frazzled receptor is required for oocyte development independently of its ligand Netrin
Advisor(s):
- Greg Bashaw
Rotations:
- Greg Bashaw
- Michael Granato
- Douglas Epstein
Developmental, Stem Cell and Regenerative Biology
Degree: PhD
Matriculation Year: 2018
Advisor(s):
- Jonathan Epstein
Rotations:
- Mark Kahn
- Jonathan Epstein
- Edward Morrisey
