Genetics and Epigenetics Faculty

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Genetics and Epigenetics Members

Current Members

Genetics and Epigenetics

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Faculty


Faculty areas of research in G&E can be broken up into the following categories:

Human Genetics

G&E Faculty Brief Research Description
Naiara Aquizu Lopez Our research interest is to better understand human brain complexity in health and disease, with the ultimate goal to uncover therapeutic targets for neurological disorders.
Ben Black Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes
Christopher Brown Our research focuses on how genotypes produce phenotypes and how they vary and evolve
Maja Bucan Genetic dissection of complex behaviors in mice; Functional genomics
Alice Chen-Plotkin I am interested in neurodegenerative diseases; my research approach uses genomic-scale screens to identify leads for downstream mechanistic follow-up in cell culture systems.
Gideon Dreyfuss RNA-binding proteins, nuclear transport of proteins and mRNAs, RNA processing, neurodegenerative disease, high throughput approaches to drug discovery.
Struan Grant Utilizing high-throughput genotyping and sequencing technologies, combined with statistical and bioinformatic approaches, my goals include unraveling genomic puzzles related to childhood obesity, pediatric bone strength determination, early onset diabetes and cancer.
Casey Greene Our overarching goal is to transform how we understand complex biological systems by developing and applying computational algorithms that effectively model processes by integrating multiple types of big data from diverse experiments.
Hakon Hakonarson Genetics of common and rare human diseases, using high-throughput sequencing and genotyping approaches
Jennifer Kalish Understanding and improving detection of epigenetics and mosaicism in human disease
Nina Luning Prak mobile DNA, rearrangement of immunoglobulin genes, regulation of L1 retrotransposition
Aimee Payne Genetic and functional characterization of human autoantibody repertoires; Targeted therapy for pemphigus ; Regulation of desmosome assembly and disassembly
J. Eric Russell Control and function of human embryonic globin genes.
Eileen M. Shore Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes.
Nancy Spinner Human Genetics, Notch signaling in human disease, Alagille syndrome, human disease gene identifcation by mapping deletions.
Kai Tan Model gene regulatory networks in development and disease
Sarah Tishkoff Human Genetics, complex disease, human evolution, infectious disease, malaria, evolutionary biology, natural selection, adaptation.
Golnaz Vahedi Epigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning
Benjamin Voight Using statistical genetics, population genetics, and computational biology toward understanding the biological underpinnings and evolutionary history of human phenotypes
Other CAMB Faculty Brief Research Description
Daniel Rader Genetic regulation of lipid and lipoprotein metabolism and molecular relationship to atherosclerosis.
Dwight Stambolian Gene discovery of complex and monogenic disorders.

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Genetics of Model Organisms - C elegans

G&E Faculty Brief Research Description
Nancy Bonini Molecular genetics of neurodegenerative disease.
Brian Gregory RNA silencing, RNA degradation, RNA stability, microRNAs, small RNAs
John Murray  Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging
David Raizen The regulation and purpose of sleep-like behavior in C. elegans.
Arjun Raj RNA systems biology, particular as related to non-coding RNAs and cancer biology.
Meera Sundaram Regulation and targets of Ras/ERK signaling in C. elegans
Other CAMB Faculty Brief Research Description
Meera Sundaram Regulation and targets of Ras/ERK signaling in C. elegans

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Genetics of Model Organisms - Drosophila

G&E Faculty Brief Research Description
Michael Atchison Control of Gene Expression, development, and oncogenesis.
Thomas Jongens Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Eric Joyce Form and function of nuclear compartments and chromosome positioning
Shawn Little Transcription dynamics; Cell fate specification; RNA production, processing, transport, localization
Amita Sehgal Molecular basis of behavior
Other CAMB Faculty Brief Research Description
Greg Bashaw Signaling mechanisms that function during attractive and repulsive axon guidance.
Sara Cherry Genetic and mechanistic studies of viral-host interactions.
Steve Dinardo Stem cell function; developmental patterning.
Greg Guild Shaping Drosophila cells with the actin cytoskeleton.

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Genetics of Model Organisms - Mouse

G&E Faculty Brief Research Description
Michael Atchison Control of Gene Expression, development, and oncogenesis.
Marisa Bartolomei  Genomic imprinting and X inactivation in mice.
Ben Black Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes
Edward S. Brodkin Genetic analysis of social behaviors (aggressive and affiliative behaviors) and related brain phenotypes in mouse models relevant to autism and schizophrenia.
Douglas Epstein Regulation of Sonic hedgehog signaling in development and disease
David L. Gasser Genes that affect the immune response
Eric Joyce Form and function of nuclear compartments and chromosome positioning
Yana Kamberov Evolution of human specific traits; Genetics of skin appendage development and evolution; Mouse models to understand the functional significance of adaptive genetic changes;identification and functional testing of regulatory elements driving human evolution
Brett Kaufman The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission.
Frank Lee Molecular mechanisms of the hypoxic response.
Nina Luning Prak mobile DNA, rearrangement of immunoglobulin genes, regulation of L1 retrotransposition
Kazuko Nishikura RNA metabolism/processing. RNA editing, RNAi mechanism, apoptosis, cell cycle regulation.
Aimee Payne *Genetic and functional characterization of human autoantibody repertoires
*Targeted therapy for pemphigus
*Regulation of desmosome assembly and disassembly
John R. Pehrson Role of histone variants in regulating chromatin structure and function
J. Eric Russell Control and function of human embryonic globin genes.
Doris Stoffers Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Katalin Susztak Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development
Kenneth Zaret Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan (Joe) Zhou Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease
Other CAMB Faculty Brief Research Description
Lewis Chodosh Genetically engineered mouse models for breast cancer; Cancer stem cells; Molecular therapeutics; Genomics; Non-invasive imaging.
E. Bryan Crenshaw Analysis of the role of developmental regulatory factors during mouse embryogenesis.
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models.
Xianxin Hua The critical role of the tumor suppressor Menin in regulation of cell proliferation, apoptosis, and genome stability.
Signal transduction mediated by transforming growth factor beta (TGF-b).
Olena Jacenko Molecular mechanisms of skeletal development and blood cell differentiation.
Brad Johnson Molecular biology of aging, Werner syndrome, telomeres, recombination.
Anna Kashina Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis.
Klaus Kaestner Dr. Kaestner’s lab is employing modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Sarah Millar Intercellular signals regulating the development of hair follicles, teeth and mammary glands and postnatal hair growth.
Ed Morrisey Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors.
Michael Parmacek Transcriptional programs that regulate cardiovascular development.
Daniel Rader Genetic regulation of lipid and lipoprotein metabolism and molecular relationship to atherosclerosis.
Anil Rustgi Oncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI).
Richard Schultz Egg activation and gene expression in mouse embryos.
Celeste Simon Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.
Nancy Speck Hematopoietic stem cells and leukemia using mouse models
Ben Stanger Organogenesis, Stem Cells, Pancreatic Cancer, Regulation of Organ Size.

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Genetics of Model Organisms - Plants

G&E Faculty Brief Research Description
Brian Gregory RNA silencing, RNA degradation, RNA stability, microRNAs, small RNAs
Doris Wagner Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.
Other CAMB Faculty Brief Research Description
Scott Poethig  Regulation of developmental timing and organ polarity in plants.

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Genetics of Model Organisms - S. cerevisiae

G&E Faculty Brief Research Description
Shelley Berger Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection.
Other CAMB Faculty Brief Research Description
Erfei Bi  Development of cell polarity and control of cytokinesis in budding yeast.
Andrew Dancis Iron transport into mitochondria, Heme sythesis, Fe-S cluster biogenesis, Yeast genetics, and Sideroblastic anemia
Wei Guo The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis.
Brad Johnson Molecular biology of aging, Werner syndrome, telomeres, recombination.
Frank Luca Yeast and mammalian cell cycle regulation; Cytokinesis.
Daughter cell-specific gene expression; Polarized growth
Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM).

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Genetics of Microbes and Viruses

Other CAMB Faculty Brief Research Description
Frederic Bushman Virology, HIV, Poxviruses, DNA modifying enzymes, Lateral DNA transfer.
Sara Cherry Genetic and mechanistic studies of viral-host interactions.
Mark Goulian Bacterial regulatory circuits and signal transduction
Elizabeth Grice Genomic approaches to understand host-microbe interactions at the cutaneous surface in health and disease.
Paul Lieberman Genome maintenance and gene expression; Gammaherpesviruses and oncogenesis; Telomere Biology, Chromatin structure and genome stability; Transcription regulation.
Mechthild Pohlschroder Prokaryotic Protein Translocation across Hydrophobic Membranes and Their Substrates.
David Roos Molecular parasitology, host-pathogen interactions, drug targets & resistance mechanisms, evolution of eukaryotic cells & organellar function, genome databases & database mining, comparative genomics, computational biology, Toxoplasma gondii, Plasmodium falciparum.
Matthew Weitzman Virology, Virus Replication, DNA Damage and Repair, Genome Instability, Viral Vectors
Jun Zhu Quorum Sensing, Bacterial pathogenesis, Biofilms, Vibrio cholerae.

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Developmental Genetics

G&E Faculty Brief Research Description
Naiara Aquizu Lopez Our research interest is to better understand human brain complexity in health and disease, with the ultimate goal to uncover therapeutic targets for neurological disorders.
Michael Atchison Control of Gene Expression, development, and oncogenesis.
Roberto Bonasio Epigenetics, chromatin, noncoding RNAs, ants
Gerd Blobel Hematopoiesis, gene expression, transcription factors, chromatin
Brian Capell Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Jennifer Cremins The Cremins lab investigates the link between three-dimensional organization of genomes and the establishment and maintenance of cellular function.
Douglas Epstein Regulation of Sonic hedgehog signaling in development and disease
Thomas Jongens Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Eric Joyce Form and function of nuclear compartments and chromosome positioning
Yana Kamberov Evolution of human specific traits; Genetics of skin appendage development and evolution; Mouse models to understand the functional significance of adaptive genetic changes;identification and functional testing of regulatory elements driving human evolution
Shawn Little Transcription dynamics; Cell fate specification; RNA production, processing, transport, localization
John Murray  Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging
Kazuko Nishikura RNA metabolism/processing. RNA editing, RNAi mechanism, apoptosis, cell cycle regulation.
Aimee Payne *Genetic and functional characterization of human autoantibody repertoires
*Targeted therapy for pemphigus
*Regulation of desmosome assembly and disassembly
Nancy Spinner Human Genetics, Notch signaling in human disease, Alagille syndrome, human disease gene identifcation by mapping deletions.
Eileen M. Shore Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes.
Doris Stoffers Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Katalin Susztak Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development.
Kai Tan Model gene regulatory networks in development and disease
Doris Wagner Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.
Mitchell Weiss Developmental Hematopoiesis concentrating on red blood cell and megakaryocyte lineages.
Kenneth Zaret Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan (Joe) Zhou Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease
Other CAMB Faculty Brief Research Description
Greg Bashaw Signaling mechanisms that function during attractive and repulsive axon guidance.
E. Bryan Crenshaw Analysis of the role of developmental regulatory factors during mouse embryogenesis.
Steve DiNardo Stem Cell Function; developmental patterning.
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models.
Amin Ghabrial How cells make and shape tubular organs
Michael Granato Axonal guidance and motor behavior regulation in the zebrafish.
Greg Guild Shaping Drosophila cells with the actin cytoskeleton.
Olena Jacenko Molecular mechanisms of skeletal development and blood cell differentiation.
Brian Keith How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.
Sarah Millar Intercellular signals regulating the development of hair follicles, teeth and mammary glands and postnatal hair growth.
Ed Morrisey Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors.
Mary Mullins BMP signal transduction; molecular mechanisms of cell specification establishment of the vertebrate body plan via maternal control mechanisms.
Michael Pack Genetic analysis of vertebrate digestive organ development using the zebrafish.
Micahel Parmacek Transcriptional programs that regulate cardiovascular development.
Scott Poethig Regulation of developmental timing and organ polarity in plants.
Patrick Seale Transcriptional control of adipocyte formation and function
Richard Schultz Egg activation and gene expression in mouse embryos.
Celeste Simon Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.
Nancy Speck Hematopoietic stem cells and leukemia using mouse models
Ben Stanger Organogenesis, Stem Cells, Pancreatic Cancer, Regulation of Organ Size.
Meera Sundaram Regulation and targets of Ras/ERK signaling in C. elegans

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Behavioral Genetics and Neurobiology

G&E Faculty Brief Research Description
Roberto Bonasio Epigenetics, chromatin, noncoding RNAs, ants
Nancy Bonini Molecular genetics of neurodegenerative disease.
Edward S. Brodkin Genetic analysis of social behaviors (aggressive and affiliative behaviors) and related brain phenotypes in mouse models relevant to autism and schizophrenia.
Maja Bucan Genetic dissection of complex behaviors in mice; Functional genomics
Alice Chen-Plotkin I am interested in neurodegenerative diseases; my research approach uses genomic-scale screens to identify leads for downstream mechanistic follow-up in cell culture systems.
Douglas Epstein Regulation of Sonic hedgehog signaling in development and disease
Thomas Jongens Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Erica Korb Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders
Kazuko Nishikura RNA metabolism/processing. RNA editing, RNAi mechanism, apoptosis, cell cycle regulation.
David Raizen The regulation and purpose of sleep-like behavior in C. elegans
Amita Sehgal Molecular basis of behavior
Franz Weber We employ a multidisciplinary approach to study the regulation and function of REM sleep and seek to mechanistically understand how this brain state influences our emotions and behavior in health and disease.
Zhaolan (Joe) Zhou Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease
Other CAMB Faculty Brief Research Description
Greg Bashaw  Signaling mechanisms that function during attractive and repulsive axon guidance.
Michael Granato Axonal guidance and motor behavior regulation in the zebrafish.

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Cancer Genetics and Signal Transduction

G&E Faculty Brief Research Description
Andres Blanco I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Gerd Blobel Hematopoiesis, gene expression, transcription factors, chromatin
Russ Carstens Study of the molecular mechanisms of alternative splicing.
Brian Capell Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Douglas Epstein Regulation of Sonic hedgehog signaling in development and disease
Robert Faryabi Develop analytical methods for precision cancer genomics.
Donna L. George Our research interests are focused broadly on the molecular pathways governing cellular growth control and their disruption during the initiation and progression of human cancers.
Jennifer Kalish Understanding and improvingdetection of epigenetics and mosaicismin human disease
Maureen Murphy p53 tumor suppressor, HSP70 chaperone, autophagy, programmed cell death. Keywords: Cancer Genetics and Signal Transduction, Genetics of diabetes and metabolism, Animal modeling of human disease
Doris Stoffers Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Kai Tan Model gene regulatory networks in development and disease
Doris Wagner Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.
Other CAMB Faculty Brief Research Description
Craig Bassing  Elucidation of molecular mechanisms which regulate the initiation and proper repair of DNA double strand breaks during chromosomal V(D)J recombination.
Garrett Brodeur Molecular biology and genetics of childhood cancer, especially neuroblastoma.
Lewis Chodosh Genetically engineered mouse models for breast cancer; Cancer stem cells; Molecular therapeutics; Genomics; Non-invasive imaging.
David Feldser Mechanisms of tumor-suppressor gene action; Role of the immune system in tumor suppression; Genome engineering in the mouse; Chemical genetic strategies to modulate tumor suppression
Brian Keith How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.
Warren Pear Processes that control normal development and malignant transformation.
Anil Rustgi Oncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI).
Celeste Simon Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.
Ben Stanger Organogenesis, Stem Cells, Pancreatic Cancer, Regulation of Organ Size.
Meera Sundaram Regulation and targets of Ras/ERK signaling in C. elegans

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Genetics of Diabetes and Metabolism

G&E Faculty Brief Research Description
Klaus Kaestner Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Mitchell Lazar Regulation of gene expression and metabolism by nuclear hormone receptors.
Liming Pei The goal of our research is to understand metabolism and metabolic regulation in both normal physiology and disease states and apply this knowledge to human health and medicine.
Raymond Soccio Nuclear receptors, transcription factors, lipid metabolism, genetic variation, Fatty liver disease, metabolic syndrome, obesity, diabetes
Doris Stoffers Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Other CAMB Faculty Brief Research Description
Rex Ahima Neuroendocrine regulation of body weight and glucose.
Xianxin Hua Elucidating the critical role of the tumor suppressor Menin in regulation of cell proliferation, leukemia and diabetes; investigating signal transduction and epigenetics co-regulated by transforming growth factor beta (TGF-ß) and Menin.
Michael Pack * Development of the vertebrate digestive system
* Biology and physiology of digestive epithelia and cancers
* High throughput small molecule drug screens
Daniel Rader Genetic regulation of lipid and lipoprotein metabolism and molecular relationship to atherosclerosis.
Patrick Seale We are particularly interested in early determination and specification events; this involves the commitment of mesenchymal stem cells to a preadipose cell fate. We are also exploring pathways that determine the fate (and thus the function) of different types of fat cells.
Katherine Wellen My lab is studying cellular metabolism, particularly how metabolic pathways regulate signal transduction and gene expression in cancer and metabolic disease.
Bryan Wolf Signaling mechanisms of insulin secretion. Cytokines and diabetes.

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Animal Modeling of Human Disease 

G&E Faculty Brief Research Description
Naiara Aquizu Lopez Our research interest is to better understand human brain complexity in health and disease, with the ultimate goal to uncover therapeutic targets for neurological disorders.
Andres Blanco I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Nancy Bonini Molecular genetics of neurodegenerative disease.
Edward S. Brodkin Genetic analysis of social behaviors (aggressive and affiliative behaviors) and related brain phenotypes in mouse models relevant to autism and schizophrenia.
Maja Bucan Genetic dissection of complex behaviors in mice; functional genomics.
Brian Capell Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Nancy Cooke The role of chromatin structure in eukaryotic gene regulation.
Gideon Dreyfuss RNA-binding proteins, nuclear transport of proteins and mRNAs, RNA processing, neurodegenerative disease, high throughput approaches to drug discovery.
Douglas Epstein Regulation of Sonic hedgehog signaling in development and disease
David L. Gasser Genes that affect the immune response
Donna L. George Our research interests are focused broadly on the molecular pathways governing cellular growth control and their disruption during the initiation and progression of human cancers.
Thomas Jongens Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Klaus Kaestner Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Yana Kamberov Evolution of human specific traits; Genetics of skin appendage development and evolution; Mouse models to understand the functional significance of adaptive genetic changes;identification and functional testing of regulatory elements driving human evolution
Brett Kauffman The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission.
Erica Korb Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders
Mitchell Lazar * Regulation of gene expression and metabolism by nuclear hormone receptors
* Mechanism of obesity-associated insulin resistance and diabetes
Aimee Payne *Genetic and functional characterization of human autoantibody repertoires
*Targeted therapy for pemphigus
*Regulation of desmosome assembly and disassembly
Nina Luning Prak Mobile DNA, rearrangement of immunoglobulin genes, regulation of L1 retrotransposition
J. Eric Russell Control and function of human embryonic globin genes.
Eileen M. Shore Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes.
Raymond Soccio Nuclear receptors, transcription factors, lipid metabolism, genetic variation, fatty liver disease, metabolic syndrome, obesity, diabetes
Doris Stoffers Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Katalin Susztak Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development
Zhaolan (Joe) Zhou Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease
Other CAMB Faculty Brief Research Description
Lewis Chodosh Genetically engineered mouse models for breast cancer; Cancer stem cells; Molecular therapeutics; Genomics; Non-invasive imaging.
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models.
David Feldser Mechanisms of tumor-suppressor gene action; Role of the immune system in tumor suppression; Genome engineering in the mouse; Chemical genetic strategies to modulate tumor suppression
Brad Johnson Molecular biology of aging, Werner syndrome, telomeres, recombination.
Brian Keith How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.
Sarah Millar Intercellular signals regulating the development of hair follicles, teeth and mammary glands and postnatal hair growth.
Warren Pear Processes that control normal development and malignant transformation.
Anil Rustgi Oncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI).
Celeste Simon Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.

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Transcriptional Gene Regulation

G&E Faculty Brief Research Description
Michael Atchison Control of Gene Expression, development, and oncogenesis.
Marisa Bartolomei Genomic imprinting and X inactivation in mice.
Shelley Berger Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection.
Andres Blanco I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Gerd Blobel hematopoiesis, gene expression, transcription factors, chromatin
Roberto Bonasio Molecular mechanisms of epigenetic memory, Noncoding RNAs, Chromatin biochemistry
Christopher Brown We are currently focused on massively parallelizing assays that interrogate non-coding DNA function and applying these approaches to the fine-mapping of the causal variants underlying human disease.
Brian Capell Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Russ Carstens Study of the molecular mechanisms of alternative splicing.
Douglas Epstein Regulation of Sonic hedgehog signaling in development and disease
Hua-Ying Fan  Chromatin structure regulation by ATP-dependent chromatin remodelers and its impact on disease; Mechanisms of transcription memory.
Robert Faryabi Model interplay between mutated transcriptional regulators and epigenetic dysregulation in cancer
Benjamin Garcia Quantitative Mass Spectrometry Based Proteomics for Characterizing Modified Proteins and Proteomes
Alessandro Gardini The Gardini lab investigates how global transcription is regulated during cell differentiation and oncogenesis using a variety of genomics and biochemistry approaches.
Donna L. George Our research interests are focused broadly on the molecular pathways governing cellular growth control and their disruption during the initiation and progression of human cancers.
Casey Greene Our overarching goal is to transform how we understand complex biological systems by developing and applying computational algorithms that effectively model processes by integrating multiple types of big data from diverse experiments.
Eric Joyce Form and function of nuclear compartments and chromosome positioning
Klaus Kaestner Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Brett Kaufman The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission.
Erica Korb Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders
Mitchell Lazar Regulation of gene expression and metabolism by nuclear hormone receptors.
Frank Lee Molecular mechanisms of the hypoxic response.
Stephen Liebhaber Roles of chromatin structure and epigenetic controls in eucaryotic gene activation; Roles of mRNA-protein interactions in control of eucarytic mRNA stability and expression.
Shawn Little Transcription dynamics; cell fate specification; RNA production, processing, transport, localization
Ronen Marmorstein Biochemical, biophysical and X-ray crystallographic techniques are employed to study the posttranslational modification of histones and other proteins and the misregulation of such modifications in cancer and metabolic disorders.
John Murray  Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging
John R. Pehrson Role of histone variants in regulating chromatin structure and function
Jennifer Phillips-Cremins Epigenetics | Genomics | Systems and Synthetic Bioengineering | Experimental Neuroscience | Molecular and Cellular Engineering
Kavitha Sarma RNA interactions in epigenetic gene regulation and genome organization
Eileen M. Shore Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes.
Rebecca Simmons Developmental programming of adult disease (diabetes, obesity); ß-cell development; role of epigenetics in fetal programming and early embryo/placenta development
Raymond Soccio Nuclear receptors, transcription factors, lipid metabolism, genetic variation, fatty liver disease, metabolic syndrome, obesity, diabetes
Kai Tan Model gene regulatory networks in development and disease
Golnaz Vahedi Epigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning
Doris Wagner Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.
Kenneth Zaret Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan (Joe) Zhou Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease
Other CAMB Faculty Brief Research Description
Frederic Barr Rhabdomyosarcoma (a cancer of the muscle lineage), chromosomal translocations, paired box transcription factors.
Maya Capelson *Nuclear structure and its role in gene regulation
*Spatial organization of the genome
*Epigenetic memory of gene expression states
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models.
Brian Keith How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.
Melike Lakadamyali Super-resolution imaging of chromatin structure and epigenetic regulation of gene activity
Mike May  NF-kB signaling in inflammation and cancer.
Michael Parmacek Transcriptional programs that regulate cardiovascular development.
Celeste Simon Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.
Meera Sundaram Regulation and targets of Ras/ERK signaling in C. elegans

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Post-Transcriptional Gene Regulation

G&E Faculty Brief Research Description
Naiara Aquizu Lopez Our research interest is to better understand human brain complexity in health and disease, with the ultimate goal to uncover therapeutic targets for neurological disorders.
Michael Atchison Control of Gene Expression, development, and oncogenesis.
Yoseph Barash The lab develops machine learning algorithms that integrate high-throughput data (RNASeq, CLIPSeq , PIPSeq, etc.) to infer RNA biogenesis and function, followed by experimental verifications of inferred mechanisms.
Russ Carstens Study of the molecular mechanisms of alternative splicing.
Gideon Dreyfuss RNA-binding proteins, nuclear transport of proteins and mRNAs, RNA processing, neurodegenerative disease, high throughput approaches to drug discovery.
Brian Gregory RNA silencing, RNA degradation, RNA stability, microRNAs, small RNAs
Thomas Jongens Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Eric Joyce Form and function of nuclear compartments and chromosome positioning
Brett Kaufman The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission.
Mitchell Lazar Regulation of gene expression and metabolism by nuclear hormone receptors.
Stephen Liebhaber Roles of chromatin structure and epigenetic controls in eucaryotic gene activation; Roles of mRNA-protein interactions in control of eucarytic mRNA stability and expression.
Frank Lee Molecular mechanisms of the hypoxic response
Kristin Lynch Mechanisms and consequences of alternative pre-mRNA splicing, in particular how splicing patterns change in T cells during an immune response to alter cellular function.
Zissimos Mourelatos MicroRNAs, RNA interference.
John Murray  Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging
Doris Stoffers Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Kazuko Nishikura RNA metabolism/processing. RNA editing, RNAi mechanism, apoptosis, cell cycle regulation.
J. Eric Russell Control and function of human embryonic globin genes.
Jeremy Wilusz Regulation of noncoding RNA biogenesis and function
Zhaolan (Joe) Zhou Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease
Other CAMB Faculty Brief Research Description
Constantinos Koumenis Tumor hypoxia, Unfolded Protein Response, translational regulation of gene expression.

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Epigenetics and Chromatin

G&E Faculty Brief Research Description
Michael Atchison Control of Gene Expression, development, and oncogenesis.
Marisa Bartolomei Genomic imprinting and X inactivation in mice.
Shelley Berger Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection.
Ben Black Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes
Andres Blanco I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Gerd Blobel Hematopoiesis, gene expression, transcription factors, chromatin
Roberto Bonasio Molecular mechanisms of epigenetic memory, Noncoding RNAs, Chromatin biochemistry
Christopher Brown We are currently focused on massively parallelizing assays that interrogate non-coding DNA function and applying these approaches to the fine-mapping of the causal variants underlying human disease.
Brian Capell Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Maya Capelson *Nuclear structure and its role in gene regulation
*Spatial organization of the genome
*Epigenetic memory of gene expression states
Jennifer Cremins The Cremins lab investigates the link between three-dimensional organization of genomes and the establishment and maintenance of cellular function.
Hua-Ying Fan  Chromatin structure regulation by ATP-dependent chromatin remodelers and its impact on disease; Mechanisms of transcription memory.
Robert Faryabi Model interplay between mutated transcriptional regulators and epigenetic dysregulation in cancer
Alessandro Gardini The Gardini lab investigates how global transcription is regulated during cell differentiation and oncogenesis using a variety of genomics and biochemistry approaches
Eric Joyce Form and function of nuclear compartments and chromosome positioning
Klaus Kaestner Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Jennifer Kalish Understanding and improving detection of epigenetics and mosaicism in human disease
Brett Kaufman The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission.
Erica Korb Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders
Mitchell Lazar Regulation of gene expression and metabolism by nuclear hormone receptors.
Stephen Liebhaber Roles of chromatin structure and epigenetic controls in eucaryotic gene activation; Roles of mRNA-protein interactions in control of eucarytic mRNA stability and expression.
John Murray  Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging
John R. Pehrson Role of histone variants in regulating chromatin structure and function
Kavitha Sarma RNA interactions in epigenetic gene regulation and genome organization
Eileen M. Shore Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes.
Rebecca Simmons Developmental programming of adult disease (diabetes, obesity); ß-cell development; role of epigenetics in fetal programming and early embryo/placenta development
Raymond Soccio Nuclear receptors, transcription factors, lipid metabolism, genetic variation, fatty liver disease, metabolic syndrome, obesity, diabetes
Doris Stoffers Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Kai Tan Model gene regulatory networks in development and disease
Golnaz Vahedi Epigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning
Doris Wagner Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.
Hao Wu Epigenomics, DNA methylation and demethylation, Transcriptional control, Single cell analysis, Stem cell biology, Neural and cardiac lineage specification and maturation
Kenneth Zaret Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan Zhou Epigenetic Control of Genome Function in Brain Development and Disease
Other CAMB Faculty Brief Research Description
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models.
David Feldser Mechanisms of tumor-suppressor gene action; Role of the immune system in tumor suppression; Genome engineering in the mouse; Chemical genetic strategies to modulate tumor suppression
Peter Klein Early vertebrate development, Wnt signal transduction, neuropharmacology of lithium action
Melike Lakadamyali Super-resolution imaging of chromatin structure and epigenetic regulation of gene activity
Richard Schultz Egg activation and gene expression in mouse embryos.

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Bioinformatics and Genomics

G&E Faculty Brief Research Description
Yoseph Barash The lab develops machine learning algorithms that integrate high-throughput data (RNASeq, CLIPSeq , PIPSeq, etc.) to infer RNA biogenesis and function, followed by experimental verifications of inferred mechanisms.
Ben Black Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes
Andres Blanco I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Roberto Bonasio Molecular mechanisms of epigenetic memory, Noncoding RNAs, Chromatin biochemistry
Christopher Brown We are currently focused on massively parallelizing assays that interrogate non-coding DNA function and applying these approaches to the fine-mapping of the causal variants underlying human disease.
Maja Bucan Genetic dissection of complex behaviors in mice; Functional genomics
Brian Capell Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Russ Carstens Study of the molecular mechanisms of alternative splicing.
Alice Chen-Plotkin I am interested in neurogenerative diseases; my research approach uses genomic-scale screens to identify leads for downstream mechanistic follow-up in cell culture systems.
Jennifer Phillips-Cremins Epigenetics | Genomics | Systems and Synthetic Bioengineering | Experimental Neuroscience | Molecular and Cellular Engineering
Robert Faryabi Model interplay between mutated transcriptional regulators and epigenetic dysregulation in cancer
Alessandro Gardini The Gardini lab investigates how global transcription is regulated during cell differentiation and oncogenesis using a variety of genomics and biochemistry approaches
Struan Grant My current work continues to primarily investigate disease genomics, with a specific focus on pediatrics
Casey Greene big data, integrative genomics, precision medicine, bioinformatics, transcriptomics
Hakon Hakonarson Genetics of common and rare human diseases, using high-throughput sequencing and genotyping approaches.
Eric Joyce Form and function of nuclear compartments and chromosome positioning
Klaus Kaestner Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Erica Korb Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders
John Murray  Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging
Raymond Soccio Nuclear receptors, transcription factors, lipid metabolism, genetic variation, fatty liver disease, metabolic syndrome, obesity, diabetes
Doris Stoffers Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Kai Tan Model gene regulatory networks in development and disease
Golnaz Vahedi Epigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning
Benjamin Voight Using statistical genetics, population genetics, and computational biology toward understanding the biological underpinnings and evolutionary history of human phenotypes
Doris Wagner Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.
Jeremy Wilusz Regulation of noncoding RNA biogenesis and function
Kenneth Zaret Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan (Joe) Zhou Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease
Other CAMB Faculty Brief Research Description
Frederic Bushman Virology, HIV, Poxviruses, DNA modifying enzymes, Lateral DNA transfer.
Sara Cherry Genetic and mechanistic studies of viral-host interactions.
David Roos Molecular parasitology, host-pathogen interactions, drug targets & resistance mechanisms, evolution of eukaryotic cells & organellar function, genome databases & database mining, comparative genomics, computational biology, Toxoplasma gondii, Plasmodium falciparum.
Jun Zhu Quorum Sensing, Bacterial pathogenesis, Biofilms, Vibrio cholerae.

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For information on how to apply for CAMB Faculty membership, please see the CAMB Bylaws.