Genetics and Epigenetics Faculty

Genetics and Epigenetics Members

Current Members

Genetics and Epigenetics

Click the faculty member's name to see more detailed information.

Faculty

Rebecca Ahrens-Nicklas, MD, PhD	Edward B Lee, MD, PhD
Naiara Akizu, Ph.D.	Frank S. Lee, MD, PhD
Defne Amado, MD, PhD	Veronique M Lefebvre, PhD
Hajera Amatullah, PhD	Mia Tauna Levine, PhD
Montserrat C Anguera, PhD	Qin Li, PhD
Irfan A Asangani, Ph.D.	Lan Lin, Ph.D.
Michael L. Atchison, PhD	Glennis Logsdon, Ph.D.
Yoseph Barash, Ph.D.	Eline Tjetske Luning Prak, MD, PhD
Marisa S. Bartolomei, Ph.D.	Kristen W. Lynch, PhD
Maria Ciocca Basil, MD PhD	Nicole D. Marino, PhD
Craig H. Bassing, Ph.D.	Ronen Marmorstein, Ph.D.
Shelley L. Berger, Ph.D.	Iain Mathieson, Ph.D.
Kara Anne Bernstein, Ph.D.	Kara N Maxwell, MD, PhD
Elizabeth Bhoj, M.D., Ph.D.	Andrew J Modzelewski, PhD
Ben E. Black, Ph.D.	Edward E. Morrisey, Ph.D.
M. Andres Blanco, PhD	Zissimos Mourelatos, M.D.
Kahlilia Blanco	Foteini Mourkioti, PhD
Gerd A. Blobel, MD, PhD	Mary C. Mullins, Ph.D.
Roberto Bonasio, Ph.D.	Maureen E. Murphy, Ph.D.
Nancy M. Bonini, Ph.D.	John Isaac Murray, Ph.D.
Edward Stuart Brodkin, M.D.	Vikram R Paralkar, MD
Maja Bucan, Ph.D.	Aimee S. Payne, MD,PhD
Luca Busino, Ph.D.	Liming Pei, Ph.D.
Brian C Capell, M.D., Ph.D.	Richard Edmund Phillips, MD PhD
Alice S. Chen-Plotkin, MD	Jennifer E. Phillips-Cremins, Ph.D.
Yuyan Cheng, Ph.D.	Alexander M Price, Ph.D.
Alessandra Chesi, PhD	Daniel J Rader, MD
Lewis A. Chodosh, M.D., Ph.D.	David M. Raizen, MD, PhD
Peter S. Choi, Ph.D.	Arjun Raj, PhD
Shinjae Chung, Ph.D.	Bushra Raj, Ph.D.
Colin Conine, PhD	Marylyn D Ritchie, PhD
Crystal S. Conn, PhD	Melanie Ruffner, MD, PhD
Ana G Cristancho, MD, PhD	J. Eric Russell, M.D.
Pablo G Cámara, PhD	Kavitha Sarma, Ph.D.
Sharlene M. Day, MD	Sydney M Shaffer, M.D., Ph.D.
Yanxiang Deng, PhD	Ophir Shalem, Ph.D.
Gideon Dreyfuss, Ph.D.	Junwei Shi, Ph.D.
Theodore G. Drivas, MD PhD	Eileen M. Shore, Ph.D.
Andrew C. Edmondson, MD, PhD	Rebecca A. Simmons, M.D.
Douglas J. Epstein, Ph.D.	Priya Sivaramakrishnan, MSc., PhD.
Robert Babak Faryabi, Ph.D.	Yuanquan Song, Ph.D.
David M. Feldser, Ph.D.	Hongjun Song, Ph.D.
Michael J. Gandal, MD, Ph.D.	Nancy B. Spinner, Ph.D.
Ziyue Gao, PhD	Avi Srivastava, Ph.D.
Louis Ghanem, MD, PhD	Doris A. Stoffers, M.D., Ph.D
Struan F.A. Grant, PhD	Alanna Strong, MD, PhD
Roger A. Greenberg, MD, PhD	Meera V. Sundaram, Ph.D
Brian Gregory	Katalin Susztak, MD, PhD
Hakon Hakonarson, MD, PhD	Andrei Thomas-Tikhonenko, Ph.D.
Kathryn (Kate) Hamilton, PhD	Bin Tian, PhD
Michael S. Haney, Ph.D.	Sarah A. Tishkoff, Ph.D.
Michael P Hart, PhD	Golnaz Vahedi, Ph.D.
Elizabeth A Heller, PhD	Adeline Vanderver, M.D.
Sarah Henrickson, M.D., Ph.D.	Shefali Setia Verma, Ph.D.
Rajan Jain, MD	Benjamin Franklin Voight, Ph.D.
Thomas A. Jongens, Ph.D.	Doris Wagner, PhD
Eric F. Joyce, Ph.D.	Liling Wan, PhD
Klaus H. Kaestner, Ph.D.	P. Jeremy Wang, MD, PhD
Jennifer M. Kalish, MD, PhD	Li-San Wang, Ph.D.
Yana G. Kamberov, Ph.D.	Kai Wang, Ph.D.
Bryson W. Katona, MD, PhD	Franz Weber, Ph.D.
Jonathan P. Katz, MD	Matthew D. Weitzman, Ph.D.
Matthew S Kayser, MD, PhD	Andrew D. Wells, Ph.D.
Rachel L. Kember, M.Sc., Ph.D.	Hao Wu, Ph.D.
Eugene Khandros, MD, PhD	Yi Xing, Ph.D.
Rahul M. Kohli, M.D., Ph.D	Kenneth S. Zaret, PhD
Erica Korb, PhD	Lijun Zhou, PhD
Melike Lakadamyali, Ph.D.	Wanding Zhou, Ph.D.
Mitchell A. Lazar, MD, PhD	Zhaolan (Joe) Zhou, Ph.D.

Faculty areas of research in G&E can be broken up into the following categories:

G&E Faculty	Brief Research Description
Montserrat Anguera	Epigenetic mechanisms of X-Chromosome Inactivation in immune cells & immune-related diseases
Naiara Aquizu Lopez	Our research interest is to better understand human brain complexity in health and disease, with the ultimate goal to uncover therapeutic targets for neurological disorders.
Ben Black	Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes
Kahlilia Blanco	Epigenetics, noncoding RNAs, and mitochondrial function in neuroprotection and stroke and cerebrovascular disease pathology
Maja Bucan	Genetic dissection of complex behaviors in mice; Functional genomics
Alice Chen-Plotkin	I am interested in neurodegenerative diseases; my research approach uses genomic-scale screens to identify leads for downstream mechanistic follow-up in cell culture systems.
Gideon Dreyfuss	RNA-binding proteins, nuclear transport of proteins and mRNAs, RNA processing, neurodegenerative disease, high throughput approaches to drug discovery.
Michael Gandal	The Gandal Lab has three main areas of focus: (1) gene discovery for neurodevelopmental, psychiatric disorders in large-scale biobanks; (2) developing statistical genetic tools and constructing large-scale functional genomic resources using human brain tissue samples to prioritize GWAS mechanisms; (3) using single-cell and long-read sequencing technology to characterize transcript-isoform diversity during human brain development and disease.
Struan Grant	Utilizing high-throughput genotyping and sequencing technologies, combined with statistical and bioinformatic approaches, my goals include unraveling genomic puzzles related to childhood obesity, pediatric bone strength determination, early onset diabetes and cancer.
Hakon Hakonarson	Genetics of common and rare human diseases, using high-throughput sequencing and genotyping approaches
Michael Haney	Functional genomics of neuroimmune interactions in neurodegenerative disease and brain aging
Jennifer Kalish	Understanding and improving detection of epigenetics and mosaicism in human disease
Bryson Katona	Understanding cancer risks, prevention strategies, and therapeutic mechanisms for hereditary gastrointestinal cancer and polyposis predisposition syndromes
Rachel Kember	The lab seeks to identify the complex phenotypic and genomic interactions that lead to substance use and psychiatric disease, using computational genetics methods in electronic health record datasets linked to biobanks.
Edward Lee	Neurogenerative disease pathology, genetics and epigenetics, RNA misprocessing, and human tissue transcriptomics
Qin Li	Genetic basis of self/non-self RNA discrimination in innate immunity and disease
Glennis Logsdon	Genetic and epigenetic variation of complex repeat regions among the human population and throughout evolution using long-read sequencing technologies and synthetic biology approaches
Vikram Paralkar	Epigenetics, Transcription, Ribosomal DNA/RNA, Bioinformatics, Hematopoiesis, Leukemia
Nina Luning Prak	Mobile DNA, rearrangement of immunoglobulin genes, regulation of L1 retrotransposition
Andrew Modzelewski	Investigating the role and regulation of retrotransposons in development and disease
Aimee Payne	Genetic and functional characterization of human autoantibody repertoires; Targeted therapy for pemphigus ; Regulation of desmosome assembly and disassembly
Daniel Rader	Genetic regulation of lipid and lipoprotein metabolism and molecular relationship to atherosclerosis.
J. Eric Russell	Control and function of human embryonic globin genes.
Eileen M. Shore	Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes.
Nancy Spinner	Human Genetics, Notch signaling in human disease, Alagille syndrome, human disease gene identifcation by mapping deletions.
Avi Srivastava	The Srivastava Lab focuses on research in three key areas. (1), we design innovative single-cell technologies to explore cellular heterogeneity. (2), we develop high-throughput probabilistic models to quantify single-cell measurements accurately. (3), we apply novel methods to study alternative splicing and chromatin dynamics in hematopoietic disruption.
Alanna Strong	Gene discovery, hepatobiliary disease, cystic kidney disease, ciliopathy syndromes, tubulogenesis
Kai Tan	Model gene regulatory networks in development and disease
Sarah Tishkoff	Human Genetics, complex disease, human evolution, infectious disease, malaria, evolutionary biology, natural selection, adaptation.
Golnaz Vahedi	Epigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning
Benjamin Voight	Using statistical genetics, population genetics, and computational biology toward understanding the biological underpinnings and evolutionary history of human phenotypes
Kai Wang	We develop genomics and bioinformatics methods to understand the genetic basis of human diseases, with specific focus on the use of long-read sequencing techniques and the integration of multimodal data from electronic health records

Other CAMB Faculty	Brief Research Description
Dwight Stambolian	Gene discovery of complex and monogenic disorders.

G&E Faculty	Brief Research Description
Nancy Bonini	Molecular genetics of neurodegenerative disease.
Brian Gregory	RNA silencing, RNA degradation, RNA stability, microRNAs, small RNAs
John Murray	Developmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans
David Raizen	The regulation and purpose of sleep-like behavior in C. elegans.
Arjun Raj	RNA systems biology, particular as related to non-coding RNAs and cancer biology.
Priya Sivaramakrishnan	Regulation of fundamental cellular processes (transcription, DNA replication and repair) during embryonic cell fate programming.
Meera Sundaram	Tubulogenesis and Epithelial matrix biology in C. elegans

G&E Faculty	Brief Research Description
Michael Atchison	Control of Gene Expression, development, and oncogenesis.
Thomas Jongens	Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Eric Joyce	Form and function of nuclear compartments and chromosome positioning
Amita Sehgal	Molecular basis of behavior

Other CAMB Faculty	Brief Research Description
Greg Bashaw	Signaling mechanisms that function during attractive and repulsive axon guidance.
Sara Cherry	Genetic and mechanistic studies of viral-host interactions.
Steve Dinardo	Stem cell function; developmental patterning.

G&E Faculty	Brief Research Description
Montserrat Anguera	Epigenetic mechanisms of X-Chromosome Inactivation in immune cells & immune-related diseases
Michael Atchison	Control of Gene Expression, development, and oncogenesis.
Marisa Bartolomei	Genomic imprinting and X inactivation in mice.
Craig Bassing	My lab uses mice as a model to elucidate genetic, epigenetic, and signaling mechanisms by which organisms establish genetic diversity of lymphocyte antigen receptor genes while suppressing inherent hazards of autoimmunity and lymphoid malignancies
Ben Black	Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes
Kahlilia Blanco	Epigenetics, noncoding RNAs, and mitochondrial function in neuroprotection and stroke and cerebrovascular disease pathology
Edward S. Brodkin	Genetic analysis of social behaviors (aggressive and affiliative behaviors) and related brain phenotypes in mouse models relevant to autism and schizophrenia.
Lewis Chodosh	Genetically engineered mouse models for breast cancer; Cancer stem cells; Molecular therapeutics; Genomics; Non-invasive imaging.
Douglas Epstein	Regulation of Sonic hedgehog signaling in development and disease
Jonathan Epstein	Transcriptional regulation of cardiac development and function using mouse models.
Michael Haney	Functional genomics of neuroimmune interactions in neurodegenerative disease and brain aging
Xianxin Hua	The critical role of the tumor suppressor Menin in regulation of cell proliferation, apoptosis, and genome stability. Signal transduction mediated by transforming growth factor beta (TGF-b).
Olena Jacenko	Molecular mechanisms of skeletal development and blood cell differentiation.
Brad Johnson	Molecular biology of aging, Werner syndrome, telomeres, recombination.
Eric Joyce	Form and function of nuclear compartments and chromosome positioning
Klaus Kaestner	Dr. Kaestner’s lab is employing modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Yana Kamberov	Evolution of human specific traits; Genetics of skin appendage development and evolution; Mouse models to understand the functional significance of adaptive genetic changes;identification and functional testing of regulatory elements driving human evolution
Anna Kashina	Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis.
Jonathan Katz	Transcriptional regulation, epithelial homeostasis, gastrointestinal carcinogenesis
Frank Lee	Molecular mechanisms of the hypoxic response.
Andrew Modzelewski	Investigating the role and regulation of retrotransposons in development and disease
Ed Morrisey	Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors.
Kazuko Nishikura	RNA metabolism/processing. RNA editing, RNAi mechanism, apoptosis, cell cycle regulation.
Vikram Paralkar	Epigenetics, Transcription, Ribosomal DNA/RNA, Bioinformatics, Hematopoiesis, Leukemia
Michael Parmacek	Transcriptional programs that regulate cardiovascular development.
Aimee Payne	Genetic and functional characterization of human autoantibody repertoires Targeted therapy for pemphigus *Regulation of desmosome assembly and disassembly
Nina Luning Prak	mobile DNA, rearrangement of immunoglobulin genes, regulation of L1 retrotransposition
Daniel Rader	Genetic regulation of lipid and lipoprotein metabolism and molecular relationship to atherosclerosis.
J. Eric Russell	Control and function of human embryonic globin genes.
Celeste Simon	Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.
Nancy Speck	Hematopoietic stem cells and leukemia using mouse models
Avi Srivastava	The Srivastava Lab focuses on research in three key areas. (1), we design innovative single-cell technologies to explore cellular heterogeneity. (2), we develop high-throughput probabilistic models to quantify single-cell measurements accurately. (3), we apply novel methods to study alternative splicing and chromatin dynamics in hematopoietic disruption.
Ben Stanger	Organogenesis, Stem Cells, Pancreatic Cancer, Regulation of Organ Size.
Doris Stoffers	Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Katalin Susztak	Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development
Kenneth Zaret	Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan (Joe) Zhou	Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease

G&E Faculty	Brief Research Description
Brian Gregory	RNA silencing, RNA degradation, RNA stability, microRNAs, small RNAs
Doris Wagner	Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.

Other CAMB Faculty	Brief Research Description
Scott Poethig	Regulation of developmental timing and organ polarity in plants.

G&E Faculty	Brief Research Description
Shelley Berger	Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection.
Kara Bernstein	Regulation of DNA repair, recombination, and replication in cancer
Erfei Bi	Development of cell polarity and control of cytokinesis in budding yeast.
Andrew Dancis	Iron transport into mitochondria, Heme synthesis, Fe-S cluster biogenesis, Yeast genetics, and Sideroblastic anemia
Wei Guo	The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis.
Brad Johnson	Molecular biology of aging, Werner syndrome, telomeres, recombination.
Frank Luca	Yeast and mammalian cell cycle regulation; Cytokinesis. Daughter cell-specific gene expression; Polarized growth Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM).

Other CAMB Faculty	Brief Research Description
Frederic Bushman	Virology, HIV, Poxviruses, DNA modifying enzymes, Lateral DNA transfer.
Sara Cherry	Genetic and mechanistic studies of viral-host interactions.
Mark Goulian	Bacterial regulatory circuits and signal transduction
Elizabeth Grice	Genomic approaches to understand host-microbe interactions at the cutaneous surface in health and disease.
Paul Lieberman	Genome maintenance and gene expression; Gammaherpesviruses and oncogenesis; Telomere Biology, Chromatin structure and genome stability; Transcription regulation.
Nicole Marino	Molecular antagonism between bacteria and phage, CRISPR-Cas biology and applications
Mechthild Pohlschroder	Prokaryotic Protein Translocation across Hydrophobic Membranes and Their Substrates.
Alexander Price	Molecular biology of DNA viruses and tumor viruses, innate immunity by nucleic acid sensing , viral and cellular RNA transcription and processing, and viral-host interactions
David Roos	Molecular parasitology, host-pathogen interactions, drug targets & resistance mechanisms, evolution of eukaryotic cells & organellar function, genome databases & database mining, comparative genomics, computational biology, Toxoplasma gondii, Plasmodium falciparum.
Matthew Weitzman	Virology, Virus Replication, DNA Damage and Repair, Genome Instability, Viral Vectors
Jun Zhu	Quorum Sensing, Bacterial pathogenesis, Biofilms, Vibrio cholerae.

G&E Faculty	Brief Research Description
Naiara Aquizu Lopez	Our research interest is to better understand human brain complexity in health and disease, with the ultimate goal to uncover therapeutic targets for neurological disorders.
Michael Atchison	Control of Gene Expression, development, and oncogenesis.
Craig Bassing	My lab uses mice as a model to elucidate genetic, epigenetic, and signaling mechanisms by which organisms establish genetic diversity of lymphocyte antigen receptor genes while suppressing inherent hazards of autoimmunity and lymphoid malignancies
Roberto Bonasio	Epigenetics, chromatin, noncoding RNAs, ants
Gerd Blobel	Hematopoiesis, gene expression, transcription factors, chromatin
Brian Capell	Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Jennifer Cremins	The Cremins lab investigates the link between three-dimensional organization of genomes and the establishment and maintenance of cellular function.
Douglas Epstein	Regulation of Sonic hedgehog signaling in development and disease
Michael Gandal	The Gandal Lab has three main areas of focus: (1) gene discovery for neurodevelopmental, psychiatric disorders in large-scale biobanks; (2) developing statistical genetic tools and constructing large-scale functional genomic resources using human brain tissue samples to prioritize GWAS mechanisms; (3) using single-cell and long-read sequencing technology to characterize transcript-isoform diversity during human brain development and disease.
Thomas Jongens	Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Eric Joyce	Form and function of nuclear compartments and chromosome positioning
Yana Kamberov	Evolution of human specific traits; Genetics of skin appendage development and evolution; Mouse models to understand the functional significance of adaptive genetic changes;identification and functional testing of regulatory elements driving human evolution
Andrew Modzelewski	Investigating the role and regulation of retrotransposons in development and disease
Ed Morrisey	Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors.
Mary Mullins	BMP signal transduction; molecular mechanisms of cell specification establishment of the vertebrate body plan via maternal control mechanisms.
John Murray	Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging
Kazuko Nishikura	RNA metabolism/processing. RNA editing, RNAi mechanism, apoptosis, cell cycle regulation.
Aimee Payne	Genetic and functional characterization of human autoantibody repertoires Targeted therapy for pemphigus *Regulation of desmosome assembly and disassembly
Priya Sivaramakrishnan	Studying fundamental gene regulatory principles that drive robust cellular decision-making during embryonic development.
Nancy Spinner	Human Genetics, Notch signaling in human disease, Alagille syndrome, human disease gene identifcation by mapping deletions.
Eileen M. Shore	Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes.
Doris Stoffers	Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Alanna Strong	Gene discovery, hepatobiliary disease, cystic kidney disease, ciliopathy syndromes, tubulogenesis
Meera Sundaram	Tubulogenesis and Epithelial matrix biology in C. elegans
Katalin Susztak	Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development.
Kai Tan	Model gene regulatory networks in development and disease
Doris Wagner	Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.
Kenneth Zaret	Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan (Joe) Zhou	Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease

Other CAMB Faculty	Brief Research Description
Greg Bashaw	Signaling mechanisms that function during attractive and repulsive axon guidance.
Steve DiNardo	Stem Cell Function; developmental patterning.
Jonathan Epstein	Transcriptional regulation of cardiac development and function using mouse models.
Michael Granato	Axonal guidance and motor behavior regulation in the zebrafish.
Olena Jacenko	Molecular mechanisms of skeletal development and blood cell differentiation.
Brian Keith	How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.
Michael Pack	Genetic analysis of vertebrate digestive organ development using the zebrafish.
Micahel Parmacek	Transcriptional programs that regulate cardiovascular development.
Scott Poethig	Regulation of developmental timing and organ polarity in plants.
Patrick Seale	Transcriptional control of adipocyte formation and function
Celeste Simon	Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.
Nancy Speck	Hematopoietic stem cells and leukemia using mouse models
Ben Stanger	Organogenesis, Stem Cells, Pancreatic Cancer, Regulation of Organ Size.

G&E Faculty	Brief Research Description
Kahlilia Blanco	Epigenetics, noncoding RNAs, and mitochondrial function in neuroprotection and stroke and cerebrovascular disease pathology
Roberto Bonasio	Epigenetics, chromatin, noncoding RNAs, ants
Nancy Bonini	Molecular genetics of neurodegenerative disease.
Edward S. Brodkin	Genetic analysis of social behaviors (aggressive and affiliative behaviors) and related brain phenotypes in mouse models relevant to autism and schizophrenia.
Maja Bucan	Genetic dissection of complex behaviors in mice; Functional genomics
Alice Chen-Plotkin	I am interested in neurodegenerative diseases; my research approach uses genomic-scale screens to identify leads for downstream mechanistic follow-up in cell culture systems.
Douglas Epstein	Regulation of Sonic hedgehog signaling in development and disease
Michael Gandal	The Gandal Lab has three main areas of focus: (1) gene discovery for neurodevelopmental, psychiatric disorders in large-scale biobanks; (2) developing statistical genetic tools and constructing large-scale functional genomic resources using human brain tissue samples to prioritize GWAS mechanisms; (3) using single-cell and long-read sequencing technology to characterize transcript-isoform diversity during human brain development and disease.
Michael Haney	Functional genomics of neuroimmune interactions in neurodegenerative disease and brain aging
Thomas Jongens	Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Rachel Kember	The lab seeks to identify the complex phenotypic and genomic interactions that lead to substance use and psychiatric disease, using computational genetics methods in electronic health record datasets linked to biobanks.
Erica Korb	Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders
Edward Lee	Neurogenerative disease pathology, genetics and epigenetics, RNA misprocessing, and human tissue transcriptomics
Kazuko Nishikura	RNA metabolism/processing. RNA editing, RNAi mechanism, apoptosis, cell cycle regulation.
David Raizen	The regulation and purpose of sleep-like behavior in C. elegans
Amita Sehgal	Molecular basis of behavior
Franz Weber	We employ a multidisciplinary approach to study the regulation and function of REM sleep and seek to mechanistically understand how this brain state influences our emotions and behavior in health and disease.
Zhaolan (Joe) Zhou	Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease

Other CAMB Faculty	Brief Research Description
Greg Bashaw	Signaling mechanisms that function during attractive and repulsive axon guidance.
Michael Granato	Axonal guidance and motor behavior regulation in the zebrafish.

G&E Faculty	Brief Research Description
Yoseph Barash	The lab develops machine learning algorithms that integrate high-throughput data (RNASeq, CLIPSeq , PIPSeq, etc.) to infer RNA biogenesis and function, followed by experimental verifications of inferred mechanisms.
Craig Bassing	My lab uses mice as a model to elucidate genetic, epigenetic, and signaling mechanisms by which organisms establish genetic diversity of lymphocyte antigen receptor genes while suppressing inherent hazards of autoimmunity and lymphoid malignancies
Kara Bernstein	Regulation of DNA repair, recombination, and replication in cancer
Andres Blanco	I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Gerd Blobel	Hematopoiesis, gene expression, transcription factors, chromatin
Garrett Brodeur	Molecular biology and genetics of childhood cancer, especially neuroblastoma.
Brian Capell	Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Lewis Chodosh	Genetically engineered mouse models for breast cancer; Cancer stem cells; Molecular therapeutics; Genomics; Non-invasive imaging.
Douglas Epstein	Regulation of Sonic hedgehog signaling in development and disease
Robert Faryabi	Develop analytical methods for precision cancer genomics.
David Feldser	Mechanisms of tumor-suppressor gene action; Role of the immune system in tumor suppression; Genome engineering in the mouse; Chemical genetic strategies to modulate tumor suppression
Pablo Gonzalez-Camara	The focus of the Camara lab is the application and development of computational methods to study cellular heterogeneity and its role in cancer progression
Jennifer Kalish	Understanding and improvingdetection of epigenetics and mosaicismin human disease
Bryson Katona	Understanding cancer risks, prevention strategies, and therapeutic mechanisms for hereditary gastrointestinal cancer and polyposis predisposition syndromes
Jonathan Katz	Transcriptional regulation, epithelial homeostasis, gastrointestinal carcinogenesis
Brian Keith	How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.
Maureen Murphy	p53 tumor suppressor, HSP70 chaperone, autophagy, programmed cell death. Keywords: Cancer Genetics and Signal Transduction, Genetics of diabetes and metabolism, Animal modeling of human disease
Warren Pear	Processes that control normal development and malignant transformation.
Anil Rustgi	Oncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI).
Sydney Shaffer	Systems biology, genomics, lineage tracing, and spatial transcriptomics applied to tissues and cancer
Junwei Shi	CRISPR genome editing, cancer functional genomics, transcriptional and epigenetic regulation
Celeste Simon	Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.
Ben Stanger	Organogenesis, Stem Cells, Pancreatic Cancer, Regulation of Organ Size.
Doris Stoffers	Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Meera Sundaram	Regulation and targets of Ras/ERK signaling in C. elegans
Kai Tan	Model gene regulatory networks in development and disease
Doris Wagner	Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.

G&E Faculty	Brief Research Description
Xianxin Hua	Elucidating the critical role of the tumor suppressor Menin in regulation of cell proliferation, leukemia and diabetes; investigating signal transduction and epigenetics co-regulated by transforming growth factor beta (TGF-ß) and Menin.
Klaus Kaestner	Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Mitchell Lazar	Regulation of gene expression and metabolism by nuclear hormone receptors.
Qin Li	Genetic basis of self/non-self RNA discrimination in innate immunity and disease
Michael Pack	* Development of the vertebrate digestive system * Biology and physiology of digestive epithelia and cancers * High throughput small molecule drug screens
Liming Pei	The goal of our research is to understand metabolism and metabolic regulation in both normal physiology and disease states and apply this knowledge to human health and medicine.
Daniel Rader	Genetic regulation of lipid and lipoprotein metabolism and molecular relationship to atherosclerosis.
Patrick Seale	We are particularly interested in early determination and specification events; this involves the commitment of mesenchymal stem cells to a preadipose cell fate. We are also exploring pathways that determine the fate (and thus the function) of different types of fat cells.
Raymond Soccio	Nuclear receptors, transcription factors, lipid metabolism, genetic variation, Fatty liver disease, metabolic syndrome, obesity, diabetes
Doris Stoffers	Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Katherine Wellen	My lab is studying cellular metabolism, particularly how metabolic pathways regulate signal transduction and gene expression in cancer and metabolic disease.

G&E Faculty	Brief Research Description
Montserrat Anguera	Epigenetic mechanisms of X-Chromosome Inactivation in immune cells & immune-related diseases
Naiara Aquizu Lopez	Our research interest is to better understand human brain complexity in health and disease, with the ultimate goal to uncover therapeutic targets for neurological disorders.
Andres Blanco	I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Kahlilia Blanco	Epigenetics, noncoding RNAs, and mitochondrial function in neuroprotection and stroke and cerebrovascular disease pathology
Nancy Bonini	Molecular genetics of neurodegenerative disease.
Edward S. Brodkin	Genetic analysis of social behaviors (aggressive and affiliative behaviors) and related brain phenotypes in mouse models relevant to autism and schizophrenia.
Maja Bucan	Genetic dissection of complex behaviors in mice; functional genomics.
Brian Capell	Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Lewis Chodosh	Genetically engineered mouse models for breast cancer; Cancer stem cells; Molecular therapeutics; Genomics; Non-invasive imaging.
Gideon Dreyfuss	RNA-binding proteins, nuclear transport of proteins and mRNAs, RNA processing, neurodegenerative disease, high throughput approaches to drug discovery.
Douglas Epstein	Regulation of Sonic hedgehog signaling in development and disease
David Feldser	Mechanisms of tumor-suppressor gene action; Role of the immune system in tumor suppression; Genome engineering in the mouse; Chemical genetic strategies to modulate tumor suppression
Michael Haney	Functional genomics of neuroimmune interactions in neurodegenerative disease and brain aging
Thomas Jongens	Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Klaus Kaestner	Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Yana Kamberov	Evolution of human specific traits; Genetics of skin appendage development and evolution; Mouse models to understand the functional significance of adaptive genetic changes;identification and functional testing of regulatory elements driving human evolution
Bryson Katona	Using mouse models of hereditary gastrointestinal cancer and polyposis predisposition syndromes to understand cancer risks, prevention strategies, and therapeutic mechanisms for these syndromes
Jonathan Katz	Transcriptional regulation, epithelial homeostasis, gastrointestinal carcinogenesis
Erica Korb	Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders
Mitchell Lazar	* Regulation of gene expression and metabolism by nuclear hormone receptors * Mechanism of obesity-associated insulin resistance and diabetes
Aimee Payne	Genetic and functional characterization of human autoantibody repertoires Targeted therapy for pemphigus *Regulation of desmosome assembly and disassembly
Nina Luning Prak	Mobile DNA, rearrangement of immunoglobulin genes, regulation of L1 retrotransposition
J. Eric Russell	Control and function of human embryonic globin genes.
Priya Sivaramakrishnan	Generation of humanized worms to examine the molecular basis of variable expressivity and penetrance in transcription-associated developmental disorders.
Eileen M. Shore	Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes.
Raymond Soccio	Nuclear receptors, transcription factors, lipid metabolism, genetic variation, fatty liver disease, metabolic syndrome, obesity, diabetes
Doris Stoffers	Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Meera Sundaram	Tubulogenesis and Epithelial matrix biology in C. elegans
Katalin Susztak	Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development
Zhaolan (Joe) Zhou	Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease

Other CAMB Faculty	Brief Research Description
Jonathan Epstein	Transcriptional regulation of cardiac development and function using mouse models.
Brad Johnson	Molecular biology of aging, Werner syndrome, telomeres, recombination.
Brian Keith	How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.
Warren Pear	Processes that control normal development and malignant transformation.
Celeste Simon	Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.

G&E Faculty	Brief Research Description
Montserrat Anguera	Epigenetic mechanisms of X-Chromosome Inactivation in immune cells & immune-related diseases
Michael Atchison	Control of Gene Expression, development, and oncogenesis.
Marisa Bartolomei	Genomic imprinting and X inactivation in mice.
Craig Bassing	My lab uses mice as a model to elucidate genetic, epigenetic, and signaling mechanisms by which organisms establish genetic diversity of lymphocyte antigen receptor genes while suppressing inherent hazards of autoimmunity and lymphoid malignancies
Shelley Berger	Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection.
Andres Blanco	I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Kahlilia Blanco	Epigenetics, noncoding RNAs, and mitochondrial function in neuroprotection and stroke and cerebrovascular disease pathology
Gerd Blobel	hematopoiesis, gene expression, transcription factors, chromatin
Roberto Bonasio	Molecular mechanisms of epigenetic memory, Noncoding RNAs, Chromatin biochemistry
Brian Capell	Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Douglas Epstein	Regulation of Sonic hedgehog signaling in development and disease
Jonathan Epstein	Transcriptional regulation of cardiac development and function using mouse models.
Robert Faryabi	Model interplay between mutated transcriptional regulators and epigenetic dysregulation in cancer
Michael Gandal	The Gandal Lab has three main areas of focus: (1) gene discovery for neurodevelopmental, psychiatric disorders in large-scale biobanks; (2) developing statistical genetic tools and constructing large-scale functional genomic resources using human brain tissue samples to prioritize GWAS mechanisms; (3) using single-cell and long-read sequencing technology to characterize transcript-isoform diversity during human brain development and disease.
Alessandro Gardini	The Gardini lab investigates how global transcription is regulated during cell differentiation and oncogenesis using a variety of genomics and biochemistry approaches.
Eric Joyce	Form and function of nuclear compartments and chromosome positioning
Klaus Kaestner	Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Jonathan Katz	Transcriptional regulation, epithelial homeostasis, gastrointestinal carcinogenesis
Erica Korb	Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders
Melike Lakadamyali	Super-resolution imaging of chromatin structure and epigenetic regulation of gene activity
Mitchell Lazar	Regulation of gene expression and metabolism by nuclear hormone receptors.
Frank Lee	Molecular mechanisms of the hypoxic response.
Ronen Marmorstein	Biochemical, biophysical and X-ray crystallographic techniques are employed to study the posttranslational modification of histones and other proteins and the misregulation of such modifications in cancer and metabolic disorders.
Andrew Modzelewski	Investigating the role and regulation of retrotransposons in development and disease
John Murray	Developmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans
Vikram Paralkar	Epigenetics, Transcription, Ribosomal DNA/RNA, Bioinformatics, Hematopoiesis, Leukemia
Jennifer Phillips-Cremins	Epigenetics \| Genomics \| Systems and Synthetic Bioengineering \| Experimental Neuroscience \| Molecular and Cellular Engineering
Alexander Price	Molecular biology of DNA viruses and tumor viruses, innate immunity by nucleic acid sensing , viral and cellular RNA transcription and processing, and viral-host interactions
Kavitha Sarma	RNA interactions in epigenetic gene regulation and genome organization
Sydney Shaffer	Systems biology, genomics, lineage tracing, and spatial transcriptomics applied to tissues and cancer
Junwei Shi	CRISPR genome editing, cancer functional genomics, transcriptional and epigenetic regulation
Eileen M. Shore	Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes.
Rebecca Simmons	Developmental programming of adult disease (diabetes, obesity); ß-cell development; role of epigenetics in fetal programming and early embryo/placenta development
Priya Sivaramakrishnan	Developing omics and imaging tools to capture and visualize gene regulatory phenomenon at high-resolution.
Avi Srivastava	The Srivastava Lab focuses on research in three key areas. (1), we design innovative single-cell technologies to explore cellular heterogeneity. (2), we develop high-throughput probabilistic models to quantify single-cell measurements accurately. (3), we apply novel methods to study alternative splicing and chromatin dynamics in hematopoietic disruption.
Alanna Strong	Gene discovery, hepatobiliary disease, cystic kidney disease, ciliopathy syndromes, tubulogenesis
Meera Sundaram	Regulation and targets of Ras/ERK signaling in C. elegans
Kai Tan	Model gene regulatory networks in development and disease
Golnaz Vahedi	Epigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning
Doris Wagner	Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.
Kenneth Zaret	Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan (Joe) Zhou	Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease

Other CAMB Faculty	Brief Research Description
Brian Keith	How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.
Michael Parmacek	Transcriptional programs that regulate cardiovascular development.
Celeste Simon	Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.

G&E Faculty	Brief Research Description
Naiara Aquizu Lopez	Our research interest is to better understand human brain complexity in health and disease, with the ultimate goal to uncover therapeutic targets for neurological disorders.
Michael Atchison	Control of Gene Expression, development, and oncogenesis.
Yoseph Barash	The lab develops machine learning algorithms that integrate high-throughput data (RNASeq, CLIPSeq, PIPSeq, etc.) to infer RNA biogenesis and function, followed by experimental verifications of inferred mechanisms.
Kahlilia Blanco	Epigenetics, noncoding RNAs, and mitochondrial function in neuroprotection and stroke and cerebrovascular disease pathology
Gideon Dreyfuss	RNA-binding proteins, nuclear transport of proteins and mRNAs, RNA processing, neurodegenerative disease, high throughput approaches to drug discovery.
Brian Gregory	RNA silencing, RNA degradation, RNA stability, microRNAs, small RNAs
Thomas Jongens	Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Eric Joyce	Form and function of nuclear compartments and chromosome positioning
Mitchell Lazar	Regulation of gene expression and metabolism by nuclear hormone receptors.
Frank Lee	Molecular mechanisms of the hypoxic response
Qin Li	Genetic basis of self/non-self RNA discrimination in innate immunity and disease
Kristin Lynch	Mechanisms and consequences of alternative pre-mRNA splicing, in particular, how splicing patterns change in T cells during an immune response to alter cellular function.
Zissimos Mourelatos	MicroRNAs, RNA interference.
John Murray	Developmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans
Alexander Price	Molecular biology of DNA viruses and tumor viruses, innate immunity by nucleic acid sensing, viral and cellular RNA transcription and processing, and viral-host interactions
Doris Stoffers	Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Kazuko Nishikura	RNA metabolism/processing. RNA editing, RNAi mechanism, apoptosis, cell cycle regulation.
J. Eric Russell	Control and function of human embryonic globin genes.
Zhaolan (Joe) Zhou	Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease

Other CAMB Faculty	Brief Research Description
Constantinos Koumenis	Tumor hypoxia, Unfolded Protein Response, translational regulation of gene expression.

G&E Faculty	Brief Research Description
Montserrat Anguera	Epigenetic mechanisms of X-Chromosome Inactivation in immune cells & immune-related diseases
Michael Atchison	Control of Gene Expression, development, and oncogenesis.
Marisa Bartolomei	Genomic imprinting and X inactivation in mice.
Craig Bassing	My lab uses mice as a model to elucidate genetic, epigenetic, and signaling mechanisms by which organisms establish genetic diversity of lymphocyte antigen receptor genes while suppressing inherent hazards of autoimmunity and lymphoid malignancies
Shelley Berger	Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection.
Kara Bernstein	Regulation of DNA repair, recombination, and replication in cancer
Ben Black	Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes
Andres Blanco	I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Kahlilia Blanco	Epigenetics, noncoding RNAs, and mitochondrial function in neuroprotection and stroke and cerebrovascular disease pathology
Gerd Blobel	Hematopoiesis, gene expression, transcription factors, chromatin
Roberto Bonasio	Molecular mechanisms of epigenetic memory, Noncoding RNAs, Chromatin biochemistry
Brian Capell	Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Maya Capelson	Nuclear structure and its role in gene regulation Spatial organization of the genome *Epigenetic memory of gene expression states
Jennifer Cremins	The Cremins lab investigates the link between three-dimensional organization of genomes and the establishment and maintenance of cellular function.
Jonathan Epstein	Transcriptional regulation of cardiac development and function using mouse models.
Robert Faryabi	Model interplay between mutated transcriptional regulators and epigenetic dysregulation in cancer
David Feldser	Mechanisms of tumor-suppressor gene action; Role of the immune system in tumor suppression; Genome engineering in the mouse; Chemical genetic strategies to modulate tumor suppression
Alessandro Gardini	The Gardini lab investigates how global transcription is regulated during cell differentiation and oncogenesis using a variety of genomics and biochemistry approaches
Eric Joyce	Form and function of nuclear compartments and chromosome positioning
Klaus Kaestner	Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Jennifer Kalish	Understanding and improving detection of epigenetics and mosaicism in human disease
Brett Kaufman	The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission.
Peter Klein	Early vertebrate development, Wnt signal transduction, neuropharmacology of lithium action
Erica Korb	Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders
Melike Lakadamyali	The Lakadamyali lab uses high resolution, single cell imaging technologies to investigate the link between genome organization and gene function
Mitchell Lazar	Regulation of gene expression and metabolism by nuclear hormone receptors.
Edward Lee	Neurogenerative disease pathology, genetics and epigenetics, RNA misprocessing, and human tissue transcriptomics
Stephen Liebhaber	Roles of chromatin structure and epigenetic controls in eucaryotic gene activation; Roles of mRNA-protein interactions in control of eucarytic mRNA stability and expression.
Glennis Logsdon	Genetic and epigenetic variation of complex repeat regions among the human population and throughout evolution using long-read sequencing technologies and synthetic biology approaches
John Murray	Developmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans
Vikram Paralkar	Epigenetics, Transcription, Ribosomal DNA/RNA, Bioinformatics, Hematopoiesis, Leukemia
John R. Pehrson	Role of histone variants in regulating chromatin structure and function
Kavitha Sarma	RNA interactions in epigenetic gene regulation and genome organization
Richard Schultz	Egg activation and gene expression in mouse embryos.
Sydney Shaffer	Systems biology, genomics, lineage tracing, and spatial transcriptomics applied to tissues and cancer
Junwei Shi	CRISPR genome editing, cancer functional genomics, transcriptional and epigenetic regulation
Eileen M. Shore	Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes.
Rebecca Simmons	Developmental programming of adult disease (diabetes, obesity); ß-cell development; role of epigenetics in fetal programming and early embryo/placenta development
Raymond Soccio	Nuclear receptors, transcription factors, lipid metabolism, genetic variation, fatty liver disease, metabolic syndrome, obesity, diabetes
Avi Srivastava	The Srivastava Lab focuses on research in three key areas. (1), we design innovative single-cell technologies to explore cellular heterogeneity. (2), we develop high-throughput probabilistic models to quantify single-cell measurements accurately. (3), we apply novel methods to study alternative splicing and chromatin dynamics in hematopoietic disruption.
Doris Stoffers	Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Kai Tan	Model gene regulatory networks in development and disease
Golnaz Vahedi	Epigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning
Doris Wagner	Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.
Hao Wu	Epigenomics, DNA methylation and demethylation, Transcriptional control, Single cell analysis, Stem cell biology, Neural and cardiac lineage specification and maturation
Kenneth Zaret	Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan Zhou	Epigenetic Control of Genome Function in Brain Development and Disease

G&E Faculty	Brief Research Description
Montserrat Anguera	Epigenetic mechanisms of X-Chromosome Inactivation in immune cells & immune-related diseases
Yoseph Barash	The lab develops machine learning algorithms that integrate high-throughput data (RNASeq, CLIPSeq , PIPSeq, etc.) to infer RNA biogenesis and function, followed by experimental verifications of inferred mechanisms.
Ben Black	Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes
Andres Blanco	I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Roberto Bonasio	Molecular mechanisms of epigenetic memory, Noncoding RNAs, Chromatin biochemistry
Maja Bucan	Genetic dissection of complex behaviors in mice; Functional genomics
Frederic Bushman	Virology, HIV, Poxviruses, DNA modifying enzymes, Lateral DNA transfer.
Brian Capell	Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Alice Chen-Plotkin	I am interested in neurogenerative diseases; my research approach uses genomic-scale screens to identify leads for downstream mechanistic follow-up in cell culture systems.
Sara Cherry	Genetic and mechanistic studies of viral-host interactions.
Robert Faryabi	Model interplay between mutated transcriptional regulators and epigenetic dysregulation in cancer
Michael Gandal	The Gandal Lab has three main areas of focus: (1) gene discovery for neurodevelopmental, psychiatric disorders in large-scale biobanks; (2) developing statistical genetic tools and constructing large-scale functional genomic resources using human brain tissue samples to prioritize GWAS mechanisms; (3) using single-cell and long-read sequencing technology to characterize transcript-isoform diversity during human brain development and disease.
Alessandro Gardini	The Gardini lab investigates how global transcription is regulated during cell differentiation and oncogenesis using a variety of genomics and biochemistry approaches
Pablo Gonzalez-Camara	The focus of the Camara lab is the application and development of computational methods to study cellular heterogeneity and its role in cancer progression
Struan Grant	My current work continues to primarily investigate disease genomics, with a specific focus on pediatrics
Hakon Hakonarson	Genetics of common and rare human diseases, using high-throughput sequencing and genotyping approaches.
Michael Haney	Functional genomics of neuroimmune interactions in neurodegenerative disease and brain aging
Eric Joyce	Form and function of nuclear compartments and chromosome positioning
Klaus Kaestner	Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Rachel Kember	The lab seeks to identify the complex phenotypic and genomic interactions that lead to substance use and psychiatric disease, using computational genetics methods in electronic health record datasets linked to biobanks.
Erica Korb	Neuroepigenetics, chromatin biology, learning and memory, neurodevelopmental disorders
Edward Lee	Neurogenerative disease pathology, genetics and epigenetics, RNA misprocessing, and human tissue transcriptomics
Qin Li	Genetic basis of self/non-self RNA discrimination in innate immunity and disease
Glennis Logsdon	Development of software to build complete, telomere-to-telomere human genome assemblies using long-read sequencing technologies and to characterize the variation of complex repeat regions among the human population and throughout evolution
John Murray	Developmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans
Vikram Paralkar	Epigenetics, Transcription, Ribosomal DNA/RNA, Bioinformatics, Hematopoiesis, Leukemia
Jennifer Phillips-Cremins	Epigenetics \| Genomics \| Systems and Synthetic Bioengineering \| Experimental Neuroscience \| Molecular and Cellular Engineering
David Roos	Molecular parasitology, host-pathogen interactions, drug targets & resistance mechanisms, evolution of eukaryotic cells & organellar function, genome databases & database mining, comparative genomics, computational biology, Toxoplasma gondii, Plasmodium falciparum.
Sydney Shaffer	Systems biology, genomics, lineage tracing, and spatial transcriptomics applied to tissues and cancer
Junwei Shi	CRISPR genome editing, cancer functional genomics, transcriptional and epigenetic regulation
Raymond Soccio	Nuclear receptors, transcription factors, lipid metabolism, genetic variation, fatty liver disease, metabolic syndrome, obesity, diabetes
Avi Srivastava	The Srivastava Lab focuses on research in three key areas. (1), we design innovative single-cell technologies to explore cellular heterogeneity. (2), we develop high-throughput probabilistic models to quantify single-cell measurements accurately. (3), we apply novel methods to study alternative splicing and chromatin dynamics in hematopoietic disruption.
Doris Stoffers	Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Kai Tan	Model gene regulatory networks in development and disease
Golnaz Vahedi	Epigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning
Benjamin Voight	Using statistical genetics, population genetics, and computational biology toward understanding the biological underpinnings and evolutionary history of human phenotypes
Doris Wagner	Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.
Kai Wang	We develop genomics and bioinformatics methods to understand the genetic basis of human diseases, with specific focus on the use of long-read sequencing techniques and the integration of multimodal data from electronic health records
Kenneth Zaret	Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan (Joe) Zhou	Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease
Jun Zhu	Quorum Sensing, Bacterial pathogenesis, Biofilms, Vibrio cholerae.

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Biomedical Graduate Studies

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Genetics and Epigenetics Faculty

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Genetics and Epigenetics

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