Microbiology, Virology, and Parasitology Faculty

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The University of Pennsylvania has a very collaborative and integrated research program in microbiology involving approximately 75 faculty throughout the campus. The program provides the best graduate training available in the molecular and cellular biology of viral and bacterial pathogenesis and parasitology. Faculty throughout the Perelman School of Medicine, the School of Veterinary Medicine, the School of Dental Medicine, the School of Arts and Sciences, Children's Hospital, and the Wistar Institute participate.

Microbiology, Virology and Parasitology Members

Current Members

Microbiology, Virology and Parasitology

Click the faculty member's name to see more detailed information.

Faculty

Ileana Perez-Rodriguez
Flavia R Teles


The current research interests of the faculty in microbiology and virology encompass a broad range of disciplines including:

Faculty Brief Research Description
Michael Abt Mucosal Immunology, intestinal homeostasis, host/pathogen interactions, microbiome, C. difficile
Jorge Alvarez Research in the Alvarez lab is aiming to understand the biology of the Central Nervous System (CNS) barriers under homeostatic and inflammatory conditions. These barriers selectively restrict the molecular and cellular trafficking between the periphery and the CNS, but also serve as a signaling interface that actively regulates exchanges between both compartments. They are composed of the blood-brain barrier (BBB), the blood-meningeal barrier (BMB) and the blood cerebrospinal fluid barrier (BCB).
Dustin Brisson Disease ecology, molecular evolution, microbial ecology/ evolution, host-pathogen interaction
Igor Brodsky Host-pathogen interactions; bacterial pathogenesis; Yersinia; innate immunity
Frederic Bushman Microbiome, gene therapy, HIV, integration, integrase, poxvirus, DNA modifying enzyme, virology, variola, resolvase
Ken Cadwell

Gut microbes, autophagy, inflammatory bowel disease, virology, microbial pathogenesis, microbiota, helminths, mucosal immunity

Ronald Collman Microbiome, respiratory tract, lung disease
Fevzi Daldal Photosynthetic and respiratory electron transfer pathways and structure, function and biogenesis of cytochrome complexes
Cesar de la Fuente Antibiotics, digital discovery, synthetic biology, antibiotic discovery, peptides
The de la Fuente Lab focuses on combining experiments with computational tools for antibiotic discovery
Mark Goulian Bacterial regulatory networks; two-component signaling; antimicrobial peptides
Elizabeth Grice microbial genomics, metagenomics, wound healing, innate immunity, microbiome of skin in health and disease
Audrey Odom John Staphylococcus aureus, microbiome, metabolism, antimicrobial development
Rahul Kohli Antimicrobial resistance; SOS pathway
Hyun (Michel) Koo Assembly principles and the virulence determinants of oral biofilms, as well as developing novel therapeutic approaches to prevent biofilm-dependent oral infectious diseases such as dental caries
Michael S. Marks Cell biology of host-pathogen interactions; innate immunity; phagocytosis; dendritic cell responses to bacteria; primary immunodeficiency disorders
Paul Planet Microbial Evolution, Phylogenetics, Bioinformatics, Genomics, Microbial Genetics, Mucosal and Epithelial Immunity, Antimicrobial Resistance, Global Molecular Epidemiology, Microbiomics, Respiratory Pathogens, Staphylococcus aureus, Prevotella, Kingella, Aggregatibacter, Pseudomonas aeruginosa, nontuberculous mycobacteria, SARS-CoV-2
Mechthild Pohlschroder Archaea, bacteria, cell surface biogenesis, glycoproteomics, biofilm, cell shape, type IV pili, flagella
Phillip Scott T helper cell subsets; IL-12; T cell memory; Leishmania
Sunny Shin Immunnity against bacterial pathogens; bacterial pathogenesis; Legionella pneumophila
Joseph St. Geme, III Molecular and cellular determinants of bacterial pathogenicity, with a particular focus on Haemophilus influenzae and Kingella kingae
Cornelius Taabazuing Host-pathogen interactions, innate immunity, molecular mechanisms of pyroptosis and apoptosis
Christoph Thaiss Host-microbiome communication in aging, cancer, infectious, inflammatory, cardiovascular, and neurodegenerative diseases
Joseph Zackular Bacterial pathogenesis, host-pathogen interactions, polymicrobial interactions, microbial ecology, bacterial genomics, vaccine development, Clostridioides difficile, enterococci
Jun (Jay) Zhu Quorum sensing; bacterial pathogenesis; Vibrio cholerae and virulence gene regulation; biofilms

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Faculty Brief Research Description
Michael Abt Mucosal Immunology, intestinal homeostasis, host/pathogen interactions, microbiome, C. difficile
Raiees Andrabi Rational Design of Vaccines against Infectious Diseases, Directed Evolution, Protein Engineering, B cell Immunology to Infection and Vaccination, Antibody Discovery and Engineering, Glycans
Paul Bates Ebola virus; hepatitis C; SARS
Daniel Beiting Microbiome, Bioinformatics, Host-microbe interactions
Dustin Brisson Disease ecology, molecular evolution, microbial ecology/ evolution, host-pathogen interaction
Frederic Bushman Microbiome, gene therapy, HIV, integration, integrase, poxvirus, DNA modifying enzyme, virology, variola, resolvase
Sara Cherry West Nile Virus; Dengue Virus; Rift Valley Fever Virus; Venezuealan Equine Encephalitis virus; Poxvirus
Gary Cohen Smallpox glycoproteins; vaccinia virus
Amelia Escolano HIV-1 vaccines, antibody responses, sequential immunization, B cell biology, germinal center responses, mouse models, NHP models
Laurence Eisenlohr Antigen Processing and Presentation, T cell responses and memory, Immune evasion and subversion, Immunopeptidomics, Influenza, Ectromelia, HIV, Salmonella
Ronald Harty Filoviruses, Rhabdoviruses, Arenaviruses, Ebola, Marburg, virus-host interactions, virus budding, antiviral therapeutics
Scott Hensley Influenza virus, SARS-CoV-2, COVID-19, vaccines, mRNA vaccines, viral pathogenesis, antibodies, immune responses
Christopher Hunter Innate and adaptive immunity to infection; immune pathology; cytokine biology; cell biology of intracellular parasites; neuroimmunology
Stuart Isaacs Vaccinia virus, recombinant orthopoxvirus vaccines, poxvirus , pathogenesis, smallpox, monkeypox, orthopoxvirus therapeutics
Kellie Ann Jurado Focused on delineating disease pathogenesis of emerging viruses in order to uncover mechanisms of immune control
Jonathan Miner Zika virus, West Nile virus, chikungunya virus, Mayaro virus, La Crosse virus, Powassan virus
Louise Moncla Using tools from phylodynamics, virology, and population genetics to understand how viruses evolve within individuals, between populations, and across time, space, and population groups
Paul Planet Microbial Evolution, Phylogenetics, Bioinformatics, Genomics, Microbial Genetics, Mucosal and Epithelial Immunity, Antimicrobial Resistance, Global Molecular Epidemiology, Microbiomics, Respiratory Pathogens, Staphylococcus aureus, Prevotella, Kingella, Aggregatibacter, Pseudomonas aeruginosa, nontuberculous mycobacteria, SARS-CoV-2
Robert Ricciardi Smallpox and vaccinia processivity factors
Erle Robertson oncogenesis, viruses and cancer, viral oncology, Tumor Virology, Gene therapy, Kaposi's Sarcoma, Epstein-Barr Virus, Lymphoproliferative disease, Lymphomas
David Roos Molecular parasitology, drug resistance, organellar targeting, eukaryotic evolution, pathogen genomics, database mining, computational biology, Toxoplasma, Plasmodium, malaria
Phillip Scott Parasites, Leishmania, T cells, memory T cells, skin microbiome
Joseph St. Geme, III Molecular and cellular determinants of bacterial pathogenicity, with a particular focus on Haemophilus influenzae and Kingella kingae
Laura Su CD4+ T cells, pre-existing memory, vaccine, autoimmunity, microbiome, host-microbe interaction
Sarah Tishkoff We combine field work, laboratory work, and computational approaches to address fundamental questions about modern human evolutionary history and the genetic architecture of traits related to adaptation and disease risk in Africa.
David Weiner DNA Vaccines, HIV, Viral Protein R., Vaccines
Susan Weiss murine coronavirus, SARS associated coronavirus, viral pathogenesis
James Wilson adenovirus, adeno-associated virus (AAV), gene therapy, gene transfer, lentivirus
Jun (Jay) Zhu Genomics, Genetics, host-pathogen interaction, cell-cell signaling.

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Faculty Brief Research Description
Michael Abt Mucosal Immunology, intestinal homeostasis, host/pathogen interactions, microbiome, C. difficile
Raiees Andrabi Rational Design of Vaccines against Infectious Diseases, Directed Evolution, Protein Engineering, B cell Immunology to Infection and Vaccination, Antibody Discovery and Engineering, Glycans
Will Bailis Immune cell metabolism
Katharine Bar HIV, SIV, antibody responses, broadly neutralizing antibodies, vaccines, cure, nonhuman primate models, viral rebound, broadly neutralizing antibodies
Daniel Beiting Microbiome, Bioinformatics, Host-microbe interactions
Michael Betts HIV; T cell; Immune Response
Igor Brodsky  Host-pathogen interactions; bacterial pathogenesis; Yersinia; innate immunity
Frederic Bushman Microbiome, gene therapy, HIV, integration, integrase, poxvirus, DNA modifying enzyme, virology, variola, resolvase
Ken Cadwell

Gut microbes, autophagy, inflammatory bowel disease, virology, microbial pathogenesis, microbiota, helminths, mucosal immunity

Kyong-Mi Chang HCV, HBV, liver disease, HIV/HCV coinfection, alcohol, viral pathogenesis, viral persistence, immune regulation, T cell exhaustion, transplant tolerance, epitope mapping, immunogenetics
Sara Cherry Virus, genomics, RNAi, genetics, Drosophila, innate, immunity
Daniel Claiborne HIV, HIV pathogenesis, CAR T cell therapy, T cell exhaustion, humanized mice
Ahmed Diab HPV, Tumor Virology, Cancer Immunotherapy, Viral Oncogenesis, and Tumor Microenvironment
Laurence Eisenlohr Antigen Processing and Presentation, T cell responses and memory, Immune evasion and subversion, Immunopeptidomics, Influenza, Ectromelia, HIV, Salmonella
Hildegund Ertl HIV Vaccine, HPV vaccines, Rabies Virus vaccines
Amelia Escolano HIV-1 vaccines, antibody responses, sequential immunization, B cell biology, germinal center responses, mouse models, NHP models
Harvey Friedman HSV immune evasion, glycoprotein gC, glycoprotein gE, complement, pathogenesis.
Glen Gaulton Lymphocyte Development, Retrovirus Pathology, HIV-1, Imaging, Diagnostics
Elizabeth Grice  microbial genomics, metagenomics, wound healing, innate immunity, microbiome of skin in health and disease
Scott Hensley Influenza virus, SARS-CoV-2, COVID-19, vaccines, mRNA vaccines, viral pathogenesis, antibodies, immune responses
Sarah Henrickson

Impact of chronic inflammation (obesity and primary immune deficiencies) on T cell function

De'Broski Herbert Neurons, helminths, Type 2 immunity
David Hill Causes of allergy and obesity, as well as the immunometabolic overlap between these two highly prevalent conditions.
James Hoxie AIDS, CD4, chemokine receptors, HIV, SIV, envelope glycoproteins, viral entry, neutralization, vaccine
Christopher Hunter Innate and adaptive immunity to infection; immune pathology; cytokine biology; cell biology of intracellular parasites; neuroimmunology
Stuart Isaacs Vaccinia virus, Recombinant vaccines, poxvirus , pathogenesis, smallpox, smallpox therapeutics
Chengcheng Jin Understanding how immune responses are initiated and evolve over time as tumors arise de novo and progress in the native TME; Defining the molecular and cellular mechanisms by which the immune system senses and responds to microbiota-derived or tumor-intrinsic signals in the TME to regulate tumor growth and responses to therapies.
Kelly Jordan-Sciutto

Impact of neuroinflammation on viability, differentiation and function of oligodendrocytes and neurons in the context of neurodegeneration
Role of organellar stress in cellular response to neuroinflammation in cells of the CNS
Use of induced pluripotent stem cells and 3-D organoids to model neuroinflammation induced CNS effects

Carl June T cells, human, gene therapy, genetic engineering, signal transduction
Kellie Ann Jurado Focused on delineating disease pathogenesis of emerging viruses in order to uncover mechanisms of immune control
Rahul Kohli Antibody diversity; innate immune retroviral restriction resistance
Elizabeth Lennon Gastrointestinal mucosal immunology, inflammatory bowel disease, innate immunity, mast cells, comparative host response to viral infection.
Leyuan Ma Genetic, chemistry, engineering, and computational tools to decode the molecular and cellular crosstalk between immune cells and their microenvironment. Engineering novel biomaterials, protein, and cell-based precision immunotherapies.
Nicole Maloney Mucosal immunology, helminths, immune regulation, inflammatory bowel disease
Michael S. Marks Cell biology of host-pathogen interactions; innate immunity; phagocytosis; dendritic cell responses to bacteria; primary immunodeficiency disorders
Jonathan Miner host-pathogen interactions, interferon, innate immunity, STING, cGAS, TREX1, RIG-I, nucleic acid sensors
Luis Montaner HIV immunopathogenesis; innate immunity; cytokines
Paula Oliver Innate and adaptive immunity, mucosal immunology, mechanisms of cell function and disease
Yvonne Paterson Immune regulation, antigen design, vaccine development, cancer immunotherapy, HIV, HPV
Warren Pear Tumor Biology, Development, Stem Cells, Hematopoiesis, Immune Function
Paul Planet Microbial Evolution, Phylogenetics, Bioinformatics, Genomics, Microbial Genetics, Mucosal and Epithelial Immunity, Antimicrobial Resistance, Global Molecular Epidemiology, Microbiomics, Respiratory Pathogens, Staphylococcus aureus, Prevotella, Kingella, Aggregatibacter, Pseudomonas aeruginosa, nontuberculous mycobacteria, SARS-CoV-2
Michael Povelones Mosquito immunity to malaria parasites; Innate recognition of pathogens; Regulation of the immune response
Alexander Price

Molecular biology of DNA viruses and tumor viruses, innate immunity by nucleic acid sensing , viral and cellular RNA transcription and processing, and viral-host interactions

Robert Ricciardi Adenovirus; Human Kaposi’s Sarcoma Virus; immune escape
James Riley T cell activation, Tumor Specific T cells, HIV specific T cells, expression profiles
David Roos Molecular parasitology, drug resistance, organellar targeting, eukaryotic evolution, pathogen genomics, database mining, computational biology, Toxoplasma, Plasmodium, malaria
Phillip Scott Parasites, Leishmania, T cells, memory T cells, skin microbiome
Shaon Sengupta circadian regulation of the Host-pathogen interaction, tissue clocks, circadian rhythms, influenza, neonatal lung, lung inflammation, NK cells 
Sunny Shin  Immunity against bacterial pathogens; bacterial pathogenesis; Legionella pneumophila
Michael Silverman Microbiome, Immunology, HLA, MHC, antibiotics, intestinal immune system, autoimmune (type I) diabetes, IgA deficiency, Early life immune system development
Laura Su CD4+ T cells, pre-existing memory, vaccine, autoimmunity, microbiome, host-microbe interaction
Cornelius Taabazuing Host-pathogen interactions, innate immunity, molecular mechanisms of pyroptosis and apoptosis
Christoph Thaiss Host-microbiome communication in aging, cancer, infectious, inflammatory, cardiovascular, and neurodegenerative diseases
Sarah Tishkoff We combine field work, laboratory work, and computational approaches to address fundamental questions about modern human evolutionary history and the genetic architecture of traits related to adaptation and disease risk in Africa.
David Weiner DNA Vaccines, HIV, Viral Protein R., Vaccines
Susan Weiss murine coronavirus, SARS associated coronavirus, viral pathogenesis
Drew Weissman HIV, Immunopathogenesis, RNAi, DMBT1, dendritic cell, siRNA, antigen presentation
E. John Wherry Immunological memory, T cell memory, Chronic infection, T cell dysfunction, Memory T cell differentiation
Elizabeth White Human Papillomavirus, tumor virus, cancer virology, transformation, carcinogenesis, innate immunity, HPV, epithelial biology, tissue models
James Wilson adenovirus, adeno-associated virus (AAV), gene therapy, gene transfer, lentivirus
Joseph Zackular Bacterial pathogenesis, host-pathogen interactions, polymicrobial interactions, microbial ecology, bacterial genomics, vaccine development, Clostridioides difficile, enterococci

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Faculty Brief Research Description
Daniel Beiting Microbiome, Bioinformatics, Host-microbe interactions
Dustin Brisson I am interested in the interactions between pathogenic microbes and their hosts and how specifically those interactions shape the ecology and evolution of both the microbe and the host populations. Additionally, I am interested in the causes and consequences of molecular evolution and population genetics of pathogens. Methods from field ecology (including chicken-wire and cargo pants!), advanced molecular techniques, mathematical modeling, and computational analysis are commonly used in my lab to address relevant hypotheses.
Frederic Bushman Microbiome, gene therapy, HIV, integration, integrase, poxvirus, DNA modifying enzyme, virology, variola, resolvase
Sara Cherry Virus, genomics, RNAi, genetics, Drosophila, innate, immunity
M. Fevzi Daldal Rhodobacter, cytochrome
Cesar de la Fuente Antibiotics, digital discovery, synthetic biology, antibiotic discovery, peptides
The de la Fuente Lab focuses on combining experiments with computational tools for antibiotic discovery
Elizabeth Grice  microbial genomics, metagenomics, wound healing, innate immunity, microbiome of skin in health and disease
Scott Hensley Influenza virus, antigenic drift, viral pathogenesis, viral receptors, antibody specificity, vaccine
Chengcheng Jin Understanding how immune responses are initiated and evolve over time as tumors arise de novo and progress in the native TME; Defining the molecular and cellular mechanisms by which the immune system senses and responds to microbiota-derived or tumor-intrinsic signals in the TME to regulate tumor growth and responses to therapies.
Rahul Kohli Our laboratory focuses on the enzymatic generation of genomic diversity. We utilize a broad array of approaches, including biochemical characterization of enzyme mechanisms, chemical synthesis of enzyme probes, and biological assays spanning immunology and virology to study this central tactic in the constant battle between our immune system and pathogens.
Louise Moncla Using tools from phylodynamics, virology, and population genetics to understand how viruses evolve within individuals, between populations, and across time, space, and population groups
Paul Planet Microbial Evolution, Phylogenetics, Bioinformatics, Genomics, Microbial Genetics, Mucosal and Epithelial Immunity, Antimicrobial Resistance, Global Molecular Epidemiology, Microbiomics, Respiratory Pathogens, Staphylococcus aureus, Prevotella, Kingella, Aggregatibacter, Pseudomonas aeruginosa, nontuberculous mycobacteria, SARS-CoV-2
Joshua Plotkin I am broadly interested in molecular population genetics and evolution. My research is based largely on computation and mathematical theory. A primary goal is to develop statistical methods for inferring the action of natural selection from intra-specific polymorphism data and from inter-specific sequence variation. Of particular interest are applications to the genomes of pathogens, whose proteins experience a wide range of selective pressures determined by interactions with their hosts.
Mechthild Pohlschroder Archaea, bacteria, cell surface biogenesis, glycoproteomics, biofilm, cell shape, type IV pili, flagella
David Roos Molecular parasitology, drug resistance, organellar targeting, eukaryotic evolution, pathogen genomics, database mining, computational biology, Toxoplasma, Plasmodium, malaria
Joseph St. Geme, III Molecular and cellular determinants of bacterial pathogenicity, with a particular focus on Haemophilus influenzae and Kingella kingae
Christoph Thaiss Host-microbiome communication in aging, cancer, infectious, inflammatory, cardiovascular, and neurodegenerative diseases
Sarah Tishkoff We combine field work, laboratory work, and computational approaches to address fundamental questions about modern human evolutionary history and the genetic architecture of traits related to adaptation and disease risk in Africa.
Joseph Zackular Bacterial pathogenesis, host-pathogen interactions, polymicrobial interactions, microbial ecology, bacterial genomics, vaccine development, Clostridioides difficile, enterococci
Jun (Jay) Zhu Genomics, Genetics, host-pathogen interaction, cell-cell signaling.

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Faculty Brief Research Description
Daniel Beiting Microbiome, Bioinformatics, Host-microbe interactions
Dustin Brisson Disease ecology, molecular evolution, microbial ecology/ evolution, host-pathogen interaction
Frederic Bushman Microbiome, gene therapy, HIV, integration, integrase, poxvirus, DNA modifying enzyme, virology, variola, resolvase
Ken Cadwell

Gut microbes, autophagy, inflammatory bowel disease, virology, microbial pathogenesis, microbiota, helminths, mucosal immunity

De'Broski Herbert Neurons, helminths, Type 2 immunity
Christopher Hunter Immunity to Toxoplasma gondii; innate immunity; immunopathology
Audrey Odom John Malaria, Plasmodium falciparum, metabolism, antimalarial development, diagnostics
Paula Oliver Innate and adaptive immunity, mucosal immunology, mechanisms of cell function and disease
Michael Povelones Mosquito-parasite interactions; mosquito immunity; Plasmodium; malaria; lymphatic filariasis; Brugia; heartworm; Dirofilaria; kinetoplastid adhesion and differentiation
David Roos Molecular parasitology, drug resistance, organellar targeting, eukaryotic evolution, pathogen genomics, database mining, computational biology, Toxoplasma, Plasmodium, malaria.
Phillip Scott Parasites, Leishmania, T cells, memory T cells, skin microbiome
Sarah Tishkoff We combine field work, laboratory work, and computational approaches to address fundamental questions about modern human evolutionary history and the genetic architecture of traits related to adaptation and disease risk in Africa.

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Faculty Brief Research Description
Paul Bates Ebola, Virus entry, glycoproteins, viral assembly, SARS, retrovirus, gene therapy.
Frederic Bushman Microbiome, gene therapy, HIV, integration, integrase, poxvirus, DNA modifying enzyme, virology, variola, resolvase
Kyong-Mi Chang HCV immune pathogenesis, HCV persistence, Viral escape, Viral persistence, Epitope mapping, Liver disease, T cell suppression, HIV/HCV coinfection, Alcohol
Ronald Collman HIV, virus, tropism, signal transduction, gp120, viral envelope, macrophage
Ahmed Diab HPV, Tumor Virology, Cancer Immunotherapy, Viral Oncogenesis, and Tumor Microenvironment
Laurence Eisenlohr Cell biology of MHC class I-restricted antigen processing and presentation, MHD class II-restricted antigen processing and presentation, "Cryptic" MHC Class I-Restricted Epitopes, Cancer immunotherapy and autoimmunity
Harvey Freidman HSV immune evasion, glycoprotein gC, glycoprotein gE, complement, pathogenesis
Glen Gaulton Lymphocyte Development, Retrovirus Pathology, HIV-1, Gene Therapy
James Hoxie AIDS, CD4, chemokine receptors, HIV, SIV, envelope glycoproteins, viral entry, neutralization, vaccine
Dennis Kolson Neuron, hippocampus, apoptosis, gene expression, single-cell mRNA, HIV, chemokine receptor, NMDA receptor
Chengyu Liang Virus-host interaction, COVID19
Paul Lieberman Viral latency, chromatin, DNA replication, transcription, cancer
Ronen Marmorstein Transcription, Chromatin regulation, Protein-DNA recognition, Posttranslational modification, Tumor Suppressors, Viral oncoproteins, X-ray Crystallography, Enzymology, Structure, Biophysics
Alexander Price

Molecular biology of DNA viruses and tumor viruses, innate immunity by nucleic acid sensing , viral and cellular RNA transcription and processing, and viral-host interactions

Robert Ricciardi Mechanisms by which oncogenic proteins of human viruses exploit cellular functions and regulate gene expression to produce disease and cancer
Erle Robertson Oncogenesis, viruses and cancer, viral oncology, Tumor Virology, Gene therapy, Kaposi's Sarcoma, Epstein-Barr Virus, Lymphoproliferative disease, Lymphomas
Andrei Thomas-Tikhonenko Myc, p53, microRNA, angiogenesis, colon cancer, B-lymphoma, interferons, infection
David Weiner DNA Vaccines, HIV, Viral Protein R., Vaccines
Susan Weiss Murine coronavirus, SARS associated coronavirus, viral pathogenesis
Drew Weissman HIV, Immunopathogenesis, RNAi, gp-340, dendritic cell, siRNA, antigen presentation, HIV vaccine
Matthew D. Weitzman DNA Viruses, Virus Replication, DNA Damage and Repair, Genome Instability, Nuclear Reorganization, Host Restriction Factors, Viral Vectors, Proteomics
Elizabeth White Human Papillomavirus, tumor virus, cancer virology, transformation, carcinogenesis, innate immunity, HPV, epithelial biology, tissue models
Jianxin You STING activation, cancer immunotherapy, anti-viral immunotherapy, DNA tumor viruses, Viral oncogenesis, and Tumor virology

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Faculty Brief Research Description
Raiees Andrabi Rational Design of Vaccines against Infectious Diseases, Directed Evolution, Protein Engineering, B cell Immunology to Infection and Vaccination, Antibody Discovery and Engineering, Glycans
Katharine Bar HIV, SIV, antibody responses, broadly neutralizing antibodies, vaccines, cure, nonhuman primate models, viral rebound, broadly neutralizing antibodies
Paul Bates Ebola, Virus entry, glycoproteins, viral assembly, SARS, retrovirus, gene therapy
Michael Betts HIV; T cell; Immune Response
Frederic Bushman Microbiome, gene therapy, HIV, integration, integrase, poxvirus, DNA modifying enzyme, virology, variola, resolvase
Ken Cadwell

Gut microbes, autophagy, inflammatory bowel disease, virology, microbial pathogenesis, microbiota, helminths, mucosal immunity

Kyong-Mi Chang  HCV, HBV, liver disease, HIV/HCV coinfection, alcohol, viral pathogenesis, viral persistence, immune regulation, T cell exhaustion, transplant tolerance, epitope mapping, immunogenetics
Sara Cherry Virus, genomics, RNAi, genetics, Drosophila, innate, immunity
Daniel Claiborne HIV, HIV pathogenesis, CAR T cell therapy, T cell exhaustion, humanized mice
Gary Cohen Herpes, HSV, virology, glycoproteins, virus entry
Ronald Collman HIV-1, SIV, virus tropism, AIDS pathogenesis
Laurence Eisenlohr Antigen Processing and Presentation, T cell responses and memory, Immune evasion and subversion, Immunopeptidomics, Influenza, Ectromelia, HIV, Salmonella
Amelia Escolano HIV-1 vaccines, antibody responses, sequential immunization, B cell biology, germinal center responses, mouse models, NHP models
Harvey Friedman HSV vaccine development, mRNA vaccines, genital herpes, prevention vaccine, therapeutic vaccine, HSV immune evasion, correlates of protection
Glen Gaulton Lymphocyte Development, Retrovirus Pathology, HIV-1, Imaging, Diagnostics
Beatrice Hahn HIV-1 transmission, ape Plasmodium infections, SIVcpz infection of wild chimpanzee, HIV vaccine development
Ronald Harty Filoviruses, Rhabdoviruses, Arenaviruses, Ebola, Marburg, virus-host interactions, virus budding, antiviral therapeutics
Scott Hensley Influenza virus, SARS-CoV-2, COVID-19, vaccines, mRNA vaccines, viral pathogenesis, antibodies, immune responses
James Hoxie AIDS, CD4, chemokine receptors, HIV, SIV, envelope glycoproteins, viral entry, neutralization, vaccine
Stuart Isaacs Vaccinia virus, recombinant orthopoxvirus vaccines, poxvirus , pathogenesis, smallpox, monkeypox, orthopoxvirus therapeutics
Kelly Jordan-Sciutto

Impact of neuroinflammation on viability, differentiation and function of oligodendrocytes and neurons in the context of neurodegeneration
Role of organellar stress in cellular response to neuroinflammation in cells of the CNS
Use of induced pluripotent stem cells and 3-D organoids to model neuroinflammation induced CNS effects

Kellie Ann Jurado Focused on delineating disease pathogenesis of emerging viruses in order to uncover mechanisms of immune control
Rahul Kohli Our laboratory focuses on the enzymatic generation of genomic diversity. We utilize a broad array of approaches, including biochemical characterization of enzyme mechanisms, chemical synthesis of enzyme probes, and biological assays spanning immunology and virology to study this central tactic in the constant battle between our immune system and pathogens.
Dennis Kolson Neuron, hippocampus, apoptosis, gene expression, single-cell mRNA, HIV, chemokine receptor, NMDA receptor.
Paul Lieberman Viral latency, telomeres, chromatin, DNA replication, transcription regulation, herpesvirus.
Leyuan Ma Using genetic, chemistry, engineering, and computational tools to decode the molecular and cellular crosstalk between immune cells and their microenvironment. Engineering novel biomaterials, protein, and cell-based precision immunotherapies.
Jonathan Miner flavivirus, alphavirus, herpesvirus, bunyavirus, immune response, gene therapy, viral pathogenesis
Louise Moncla Using tools from phylodynamics, virology, and population genetics to understand how viruses evolve within individuals, between populations, and across time, space, and population groups
Luis Montaner Innate Immunity & HIV-1 Infection: Dendritic cells & Natural Killer Cells Direct or indirect interactions of viral particles with innate and specific adaptive immunity effector cells affects the cross talk between antigen presenting cells (APCs), NK cells and the antigen specific T and B-lymphocytes, and may contribute to regulate HIV disease progression. Specifically, we are pursuing analysis of the effects of HIV infection in macrophages, dendritic cells and Natural Killer cells
Una O'Doherty HIV, latency, reservoirs, dendritic cells, viral pathogenesis, proviral integration, retrovirus, virology, T cell activation, resting T cells.
Paul Planet Microbial Evolution, Phylogenetics, Bioinformatics, Genomics, Microbial Genetics, Mucosal and Epithelial Immunity, Antimicrobial Resistance, Global Molecular Epidemiology, Microbiomics, Respiratory Pathogens, Staphylococcus aureus, Prevotella, Kingella, Aggregatibacter, Pseudomonas aeruginosa, nontuberculous mycobacteria, SARS-CoV-2
Alexander Price

Molecular biology of DNA viruses and tumor viruses, innate immunity by nucleic acid sensing , viral and cellular RNA transcription and processing, and viral-host interactions

Robert Ricciardi Our laboratory is interested in the mechanisms by which oncogenic proteins of human viruses exploit cellular functions and regulate gene expression to produce disease and cancer.
James Riley T cell activation, Tumor Specific T cells, HIV specific T cells, expression profiles.
Erle Robertson oncogenesis, viruses and cancer, viral oncology, Tumor Virology, Gene therapy, Kaposi's Sarcoma, Epstein-Barr Virus, Lymphoproliferative disease, Lymphomas.
Shaon Sengupta circadian regulation of the Host-pathogen interaction, tissue clocks, circadian rhythms, influenza, neonatal lung, lung inflammation, NK cells 
George Shaw Molecular studies of HIV-1 transmission, persistence and pathogenesis, SIV transmission, persistence and pathogenesis, HCV transmission, persistence and pathogenesis
Laura Su CD4+ T cells, pre-existing memory, vaccine, autoimmunity, microbiome, host-microbe interaction
Sarah Tishkoff We combine field work, laboratory work, and computational approaches to address fundamental questions about modern human evolutionary history and the genetic architecture of traits related to adaptation and disease risk in Africa.
Andrew Vaughan

Our research is focused on defining and understanding the relevant cell types and molecular mechanisms by which the mammalian lung is able to regenerate after severe injury. We are especially interested in lung repair after viral insults including influenza and SARS-CoV-2.

David Weiner DNA Vaccines, HIV, Viral Protein R., Vaccines.
Susan Weiss Murine coronavirus, SARS associated coronavirus, viral pathogenesis.
Drew Weissman HIV, Immunopathogenesis, RNAi, DMBT1, dendritic cell, siRNA, antigen presentation.
Matthew D. Weitzman DNA Viruses, Virus Replication, DNA Damage and Repair, Genome Instability, Nuclear Reorganization, Host Restriction Factors, Viral Vectors, Proteomics
E. John Wherry Immunological memory, T cell memory, Chronic infection, T cell dysfunction, Memory T cell differentiation.
Elizabeth White Human Papillomavirus, tumor virus, cancer virology, transformation, carcinogenesis, innate immunity, HPV, epithelial biology, tissue models
James Wilson Adenovirus, adeno-associated virus (AAV), gene therapy, gene transfer, lentivirus.
Jianxin You STING activation, cancer immunotherapy, anti-viral immunotherapy, DNA tumor viruses, Viral oncogenesis, and Tumor virology

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