Microbiology, Virology, and Parasitology Faculty
All CAMB Faculty | CB Faculty | CPM Faculty | DSRB Faculty | G&E Faculty | GTV Faculty | MVP Faculty
The University of Pennsylvania has a very collaborative and integrated research program in microbiology involving approximately 75 faculty throughout the campus. The program provides the best graduate training available in the molecular and cellular biology of viral and bacterial pathogenesis and parasitology. Faculty throughout the Perelman School of Medicine, the School of Veterinary Medicine, the School of Dental Medicine, the School of Arts and Sciences, Children's Hospital, and the Wistar Institute participate.
Current Members
Microbiology, Virology and Parasitology
Click the faculty member's name to see more detailed information.
Faculty
|
Ileana Perez-Rodriguez
|
|
|
Flavia R Teles
|
|
|
Geelsu Hwang
|
|
The current research interests of the faculty in microbiology and virology encompass a broad range of disciplines including:
| Faculty | Brief Research Description |
|---|---|
| Michael Abt | Mucosal Immunology, intestinal homeostasis, host/pathogen interactions, microbiome, C. difficile |
| Jorge Alvarez | Research in the Alvarez lab is aiming to understand the biology of the Central Nervous System (CNS) barriers under homeostatic and inflammatory conditions. These barriers selectively restrict the molecular and cellular trafficking between the periphery and the CNS, but also serve as a signaling interface that actively regulates exchanges between both compartments. They are composed of the blood-brain barrier (BBB), the blood-meningeal barrier (BMB) and the blood cerebrospinal fluid barrier (BCB). |
| Dustin Brisson | Disease ecology, molecular evolution, microbial ecology/ evolution, host-pathogen interaction |
| Igor Brodsky | Host-pathogen interactions; bacterial pathogenesis; Yersinia; innate immunity |
| Frederic Bushman | Microbiome, gene therapy, HIV, integration, integrase, poxvirus, DNA modifying enzyme, virology, variola, resolvase |
| Ken Cadwell |
Gut microbes, autophagy, inflammatory bowel disease, virology, microbial pathogenesis, microbiota, helminths, mucosal immunity |
| Ronald Collman | Microbiome, respiratory tract, lung disease |
| Fevzi Daldal | Photosynthetic and respiratory electron transfer pathways and structure, function and biogenesis of cytochrome complexes |
| Cesar de la Fuente | Antibiotics, digital discovery, synthetic biology, antibiotic discovery, peptides The de la Fuente Lab focuses on combining experiments with computational tools for antibiotic discovery |
| Mark Goulian | Bacterial regulatory networks; two-component signaling; antimicrobial peptides |
| Elizabeth Grice | microbial genomics, metagenomics, wound healing, innate immunity, microbiome of skin in health and disease |
| Audrey Odom John | Staphylococcus aureus, microbiome, metabolism, antimicrobial development |
| Rahul Kohli | Antimicrobial resistance; SOS pathway |
| Hyun (Michel) Koo | Assembly principles and the virulence determinants of oral biofilms, as well as developing novel therapeutic approaches to prevent biofilm-dependent oral infectious diseases such as dental caries |
| Nicole Marino |
Molecular antagonism between bacteria and phage, CRISPR-Cas biology and applications |
| Michael S. Marks | Cell biology of host-pathogen interactions; innate immunity; phagocytosis; dendritic cell responses to bacteria; primary immunodeficiency disorders |
| Paul Planet | Microbial Evolution, Phylogenetics, Bioinformatics, Genomics, Microbial Genetics, Mucosal and Epithelial Immunity, Antimicrobial Resistance, Global Molecular Epidemiology, Microbiomics, Respiratory Pathogens, Staphylococcus aureus, Prevotella, Kingella, Aggregatibacter, Pseudomonas aeruginosa, nontuberculous mycobacteria, SARS-CoV-2 |
| Mechthild Pohlschroder | Archaea, bacteria, cell surface biogenesis, glycoproteomics, biofilm, cell shape, type IV pili, flagella |
| Phillip Scott | T helper cell subsets; IL-12; T cell memory; Leishmania |
| Sunny Shin | Immunnity against bacterial pathogens; bacterial pathogenesis; Legionella pneumophila |
| Joseph St. Geme, III | Molecular and cellular determinants of bacterial pathogenicity, with a particular focus on Haemophilus influenzae and Kingella kingae |
| Cornelius Taabazuing | Host-pathogen interactions, innate immunity, molecular mechanisms of pyroptosis and apoptosis |
| Christoph Thaiss | Host-microbiome communication in aging, cancer, infectious, inflammatory, cardiovascular, and neurodegenerative diseases |
| Joseph Zackular | Bacterial pathogenesis, host-pathogen interactions, polymicrobial interactions, microbial ecology, bacterial genomics, vaccine development, Clostridioides difficile, enterococci |
| Jun (Jay) Zhu | Quorum sensing; bacterial pathogenesis; Vibrio cholerae and virulence gene regulation; biofilms |
| Faculty | Brief Research Description |
|---|---|
| Michael Abt | Mucosal Immunology, intestinal homeostasis, host/pathogen interactions, microbiome, C. difficile |
| Raiees Andrabi | Rational Design of Vaccines against Infectious Diseases, Directed Evolution, Protein Engineering, B cell Immunology to Infection and Vaccination, Antibody Discovery and Engineering, Glycans |
| Paul Bates | Ebola virus; hepatitis C; SARS |
| Daniel Beiting | Microbiome, Bioinformatics, Host-microbe interactions |
| Dustin Brisson | Disease ecology, molecular evolution, microbial ecology/ evolution, host-pathogen interaction |
| Frederic Bushman | Microbiome, gene therapy, HIV, integration, integrase, poxvirus, DNA modifying enzyme, virology, variola, resolvase |
| Sara Cherry | West Nile Virus; Dengue Virus; Rift Valley Fever Virus; Venezuealan Equine Encephalitis virus; Poxvirus |
| Gary Cohen | Smallpox glycoproteins; vaccinia virus |
| Amelia Escolano | HIV-1 vaccines, antibody responses, sequential immunization, B cell biology, germinal center responses, mouse models, NHP models |
| Laurence Eisenlohr | Antigen Processing and Presentation, T cell responses and memory, Immune evasion and subversion, Immunopeptidomics, Influenza, Ectromelia, HIV, Salmonella |
| Ronald Harty | Filoviruses, Rhabdoviruses, Arenaviruses, Ebola, Marburg, virus-host interactions, virus budding, antiviral therapeutics |
| Scott Hensley | Influenza virus, SARS-CoV-2, COVID-19, vaccines, mRNA vaccines, viral pathogenesis, antibodies, immune responses |
| Christopher Hunter | Innate and adaptive immunity to infection; immune pathology; cytokine biology; cell biology of intracellular parasites; neuroimmunology |
| Stuart Isaacs | Vaccinia virus, recombinant orthopoxvirus vaccines, poxvirus , pathogenesis, smallpox, monkeypox, orthopoxvirus therapeutics |
| Kellie Ann Jurado | Focused on delineating disease pathogenesis of emerging viruses in order to uncover mechanisms of immune control |
| Jonathan Miner | Zika virus, West Nile virus, chikungunya virus, Mayaro virus, La Crosse virus, Powassan virus |
| Louise Moncla | Using tools from phylodynamics, virology, and population genetics to understand how viruses evolve within individuals, between populations, and across time, space, and population groups |
| Paul Planet | Microbial Evolution, Phylogenetics, Bioinformatics, Genomics, Microbial Genetics, Mucosal and Epithelial Immunity, Antimicrobial Resistance, Global Molecular Epidemiology, Microbiomics, Respiratory Pathogens, Staphylococcus aureus, Prevotella, Kingella, Aggregatibacter, Pseudomonas aeruginosa, nontuberculous mycobacteria, SARS-CoV-2 |
| Robert Ricciardi | Smallpox and vaccinia processivity factors |
| Erle Robertson | oncogenesis, viruses and cancer, viral oncology, Tumor Virology, Gene therapy, Kaposi's Sarcoma, Epstein-Barr Virus, Lymphoproliferative disease, Lymphomas |
| David Roos | Molecular parasitology, drug resistance, organellar targeting, eukaryotic evolution, pathogen genomics, database mining, computational biology, Toxoplasma, Plasmodium, malaria |
| Phillip Scott | Parasites, Leishmania, T cells, memory T cells, skin microbiome |
| Joseph St. Geme, III | Molecular and cellular determinants of bacterial pathogenicity, with a particular focus on Haemophilus influenzae and Kingella kingae |
| Laura Su | CD4+ T cells, pre-existing memory, vaccine, autoimmunity, microbiome, host-microbe interaction |
| Sarah Tishkoff | We combine field work, laboratory work, and computational approaches to address fundamental questions about modern human evolutionary history and the genetic architecture of traits related to adaptation and disease risk in Africa. |
| David Weiner | DNA Vaccines, HIV, Viral Protein R., Vaccines |
| Susan Weiss | murine coronavirus, SARS associated coronavirus, viral pathogenesis |
| James Wilson | adenovirus, adeno-associated virus (AAV), gene therapy, gene transfer, lentivirus |
| Jun (Jay) Zhu | Genomics, Genetics, host-pathogen interaction, cell-cell signaling. |
| Faculty | Brief Research Description |
|---|---|
| Michael Abt | Mucosal Immunology, intestinal homeostasis, host/pathogen interactions, microbiome, C. difficile |
| Raiees Andrabi | Rational Design of Vaccines against Infectious Diseases, Directed Evolution, Protein Engineering, B cell Immunology to Infection and Vaccination, Antibody Discovery and Engineering, Glycans |
| Will Bailis | Immune cell metabolism |
| Katharine Bar | HIV, SIV, antibody responses, broadly neutralizing antibodies, vaccines, cure, nonhuman primate models, viral rebound, broadly neutralizing antibodies |
| Daniel Beiting | Microbiome, Bioinformatics, Host-microbe interactions |
| Michael Betts | HIV; T cell; Immune Response |
| Igor Brodsky | Host-pathogen interactions; bacterial pathogenesis; Yersinia; innate immunity |
| Frederic Bushman | Microbiome, gene therapy, HIV, integration, integrase, poxvirus, DNA modifying enzyme, virology, variola, resolvase |
| Ken Cadwell |
Gut microbes, autophagy, inflammatory bowel disease, virology, microbial pathogenesis, microbiota, helminths, mucosal immunity |
| Kyong-Mi Chang | HCV, HBV, liver disease, HIV/HCV coinfection, alcohol, viral pathogenesis, viral persistence, immune regulation, T cell exhaustion, transplant tolerance, epitope mapping, immunogenetics |
| Sara Cherry | Virus, genomics, RNAi, genetics, Drosophila, innate, immunity |
| Daniel Claiborne | HIV, HIV pathogenesis, CAR T cell therapy, T cell exhaustion, humanized mice |
| Ahmed Diab | HPV, Tumor Virology, Cancer Immunotherapy, Viral Oncogenesis, and Tumor Microenvironment |
| Laurence Eisenlohr | Antigen Processing and Presentation, T cell responses and memory, Immune evasion and subversion, Immunopeptidomics, Influenza, Ectromelia, HIV, Salmonella |
| Hildegund Ertl | HIV Vaccine, HPV vaccines, Rabies Virus vaccines |
| Amelia Escolano | HIV-1 vaccines, antibody responses, sequential immunization, B cell biology, germinal center responses, mouse models, NHP models |
| Harvey Friedman | HSV immune evasion, glycoprotein gC, glycoprotein gE, complement, pathogenesis. |
| Glen Gaulton | Lymphocyte Development, Retrovirus Pathology, HIV-1, Imaging, Diagnostics |
| Elizabeth Grice | microbial genomics, metagenomics, wound healing, innate immunity, microbiome of skin in health and disease |
| Scott Hensley | Influenza virus, SARS-CoV-2, COVID-19, vaccines, mRNA vaccines, viral pathogenesis, antibodies, immune responses |
| Sarah Henrickson |
Impact of chronic inflammation (obesity and primary immune deficiencies) on T cell function |
| De'Broski Herbert | Neurons, helminths, Type 2 immunity |
| David Hill | Causes of allergy and obesity, as well as the immunometabolic overlap between these two highly prevalent conditions. |
| James Hoxie | AIDS, CD4, chemokine receptors, HIV, SIV, envelope glycoproteins, viral entry, neutralization, vaccine |
| Christopher Hunter | Innate and adaptive immunity to infection; immune pathology; cytokine biology; cell biology of intracellular parasites; neuroimmunology |
| Stuart Isaacs | Vaccinia virus, Recombinant vaccines, poxvirus , pathogenesis, smallpox, smallpox therapeutics |
| Chengcheng Jin | Understanding how immune responses are initiated and evolve over time as tumors arise de novo and progress in the native TME; Defining the molecular and cellular mechanisms by which the immune system senses and responds to microbiota-derived or tumor-intrinsic signals in the TME to regulate tumor growth and responses to therapies. |
| Kelly Jordan-Sciutto |
Impact of neuroinflammation on viability, differentiation and function of oligodendrocytes and neurons in the context of neurodegeneration |
| Carl June | T cells, human, gene therapy, genetic engineering, signal transduction |
| Kellie Ann Jurado | Focused on delineating disease pathogenesis of emerging viruses in order to uncover mechanisms of immune control |
| Edward (Ted) Kreider | mRNA vaccines, mRNA gene therapy, HIV cure, HIV vaccines, Infectious Diseases, Immunotherapy |
| Rahul Kohli | Antibody diversity; innate immune retroviral restriction resistance |
| Elizabeth Lennon | Gastrointestinal mucosal immunology, inflammatory bowel disease, innate immunity, mast cells, comparative host response to viral infection. |
| Leyuan Ma | Genetic, chemistry, engineering, and computational tools to decode the molecular and cellular crosstalk between immune cells and their microenvironment. Engineering novel biomaterials, protein, and cell-based precision immunotherapies. |
| Nicole Maloney | Mucosal immunology, helminths, immune regulation, inflammatory bowel disease |
| Michael S. Marks | Cell biology of host-pathogen interactions; innate immunity; phagocytosis; dendritic cell responses to bacteria; primary immunodeficiency disorders |
| Jonathan Miner | host-pathogen interactions, interferon, innate immunity, STING, cGAS, TREX1, RIG-I, nucleic acid sensors |
| Luis Montaner | HIV immunopathogenesis; innate immunity; cytokines |
| Paula Oliver | Innate and adaptive immunity, mucosal immunology, mechanisms of cell function and disease |
| Yvonne Paterson | Immune regulation, antigen design, vaccine development, cancer immunotherapy, HIV, HPV |
| Warren Pear | Tumor Biology, Development, Stem Cells, Hematopoiesis, Immune Function |
| Paul Planet | Microbial Evolution, Phylogenetics, Bioinformatics, Genomics, Microbial Genetics, Mucosal and Epithelial Immunity, Antimicrobial Resistance, Global Molecular Epidemiology, Microbiomics, Respiratory Pathogens, Staphylococcus aureus, Prevotella, Kingella, Aggregatibacter, Pseudomonas aeruginosa, nontuberculous mycobacteria, SARS-CoV-2 |
| Michael Povelones | Mosquito immunity to malaria parasites; Innate recognition of pathogens; Regulation of the immune response |
| Alexander Price |
Molecular biology of DNA viruses and tumor viruses, innate immunity by nucleic acid sensing , viral and cellular RNA transcription and processing, and viral-host interactions |
| Robert Ricciardi | Adenovirus; Human Kaposi’s Sarcoma Virus; immune escape |
| James Riley | T cell activation, Tumor Specific T cells, HIV specific T cells, expression profiles |
| David Roos | Molecular parasitology, drug resistance, organellar targeting, eukaryotic evolution, pathogen genomics, database mining, computational biology, Toxoplasma, Plasmodium, malaria |
| Phillip Scott | Parasites, Leishmania, T cells, memory T cells, skin microbiome |
| Shaon Sengupta | circadian regulation of the Host-pathogen interaction, tissue clocks, circadian rhythms, influenza, neonatal lung, lung inflammation, NK cells |
| Sunny Shin | Immunity against bacterial pathogens; bacterial pathogenesis; Legionella pneumophila |
| Michael Silverman | Microbiome, Immunology, HLA, MHC, antibiotics, intestinal immune system, autoimmune (type I) diabetes, IgA deficiency, Early life immune system development |
| Laura Su | CD4+ T cells, pre-existing memory, vaccine, autoimmunity, microbiome, host-microbe interaction |
| Cornelius Taabazuing | Host-pathogen interactions, innate immunity, molecular mechanisms of pyroptosis and apoptosis |
| Christoph Thaiss | Host-microbiome communication in aging, cancer, infectious, inflammatory, cardiovascular, and neurodegenerative diseases |
| Sarah Tishkoff | We combine field work, laboratory work, and computational approaches to address fundamental questions about modern human evolutionary history and the genetic architecture of traits related to adaptation and disease risk in Africa. |
| David Weiner | DNA Vaccines, HIV, Viral Protein R., Vaccines |
| Susan Weiss | murine coronavirus, SARS associated coronavirus, viral pathogenesis |
| Drew Weissman | HIV, Immunopathogenesis, RNAi, DMBT1, dendritic cell, siRNA, antigen presentation |
| E. John Wherry | Immunological memory, T cell memory, Chronic infection, T cell dysfunction, Memory T cell differentiation |
| Elizabeth White | Human Papillomavirus, tumor virus, cancer virology, transformation, carcinogenesis, innate immunity, HPV, epithelial biology, tissue models |
| James Wilson | adenovirus, adeno-associated virus (AAV), gene therapy, gene transfer, lentivirus |
| Joseph Zackular | Bacterial pathogenesis, host-pathogen interactions, polymicrobial interactions, microbial ecology, bacterial genomics, vaccine development, Clostridioides difficile, enterococci |
| Faculty | Brief Research Description |
|---|---|
| Daniel Beiting | Microbiome, Bioinformatics, Host-microbe interactions |
| Dustin Brisson | I am interested in the interactions between pathogenic microbes and their hosts and how specifically those interactions shape the ecology and evolution of both the microbe and the host populations. Additionally, I am interested in the causes and consequences of molecular evolution and population genetics of pathogens. Methods from field ecology (including chicken-wire and cargo pants!), advanced molecular techniques, mathematical modeling, and computational analysis are commonly used in my lab to address relevant hypotheses. |
| Frederic Bushman | Microbiome, gene therapy, HIV, integration, integrase, poxvirus, DNA modifying enzyme, virology, variola, resolvase |
| Sara Cherry | Virus, genomics, RNAi, genetics, Drosophila, innate, immunity |
| M. Fevzi Daldal | Rhodobacter, cytochrome |
| Cesar de la Fuente | Antibiotics, digital discovery, synthetic biology, antibiotic discovery, peptides The de la Fuente Lab focuses on combining experiments with computational tools for antibiotic discovery |
| Elizabeth Grice | microbial genomics, metagenomics, wound healing, innate immunity, microbiome of skin in health and disease |
| Scott Hensley | Influenza virus, antigenic drift, viral pathogenesis, viral receptors, antibody specificity, vaccine |
| Chengcheng Jin | Understanding how immune responses are initiated and evolve over time as tumors arise de novo and progress in the native TME; Defining the molecular and cellular mechanisms by which the immune system senses and responds to microbiota-derived or tumor-intrinsic signals in the TME to regulate tumor growth and responses to therapies. |
| Rahul Kohli | Our laboratory focuses on the enzymatic generation of genomic diversity. We utilize a broad array of approaches, including biochemical characterization of enzyme mechanisms, chemical synthesis of enzyme probes, and biological assays spanning immunology and virology to study this central tactic in the constant battle between our immune system and pathogens. |
| Louise Moncla | Using tools from phylodynamics, virology, and population genetics to understand how viruses evolve within individuals, between populations, and across time, space, and population groups |
| Paul Planet | Microbial Evolution, Phylogenetics, Bioinformatics, Genomics, Microbial Genetics, Mucosal and Epithelial Immunity, Antimicrobial Resistance, Global Molecular Epidemiology, Microbiomics, Respiratory Pathogens, Staphylococcus aureus, Prevotella, Kingella, Aggregatibacter, Pseudomonas aeruginosa, nontuberculous mycobacteria, SARS-CoV-2 |
| Joshua Plotkin | I am broadly interested in molecular population genetics and evolution. My research is based largely on computation and mathematical theory. A primary goal is to develop statistical methods for inferring the action of natural selection from intra-specific polymorphism data and from inter-specific sequence variation. Of particular interest are applications to the genomes of pathogens, whose proteins experience a wide range of selective pressures determined by interactions with their hosts. |
| Mechthild Pohlschroder | Archaea, bacteria, cell surface biogenesis, glycoproteomics, biofilm, cell shape, type IV pili, flagella |
| David Roos | Molecular parasitology, drug resistance, organellar targeting, eukaryotic evolution, pathogen genomics, database mining, computational biology, Toxoplasma, Plasmodium, malaria |
| Joseph St. Geme, III | Molecular and cellular determinants of bacterial pathogenicity, with a particular focus on Haemophilus influenzae and Kingella kingae |
| Christoph Thaiss | Host-microbiome communication in aging, cancer, infectious, inflammatory, cardiovascular, and neurodegenerative diseases |
| Sarah Tishkoff | We combine field work, laboratory work, and computational approaches to address fundamental questions about modern human evolutionary history and the genetic architecture of traits related to adaptation and disease risk in Africa. |
| Joseph Zackular | Bacterial pathogenesis, host-pathogen interactions, polymicrobial interactions, microbial ecology, bacterial genomics, vaccine development, Clostridioides difficile, enterococci |
| Jun (Jay) Zhu | Genomics, Genetics, host-pathogen interaction, cell-cell signaling. |
| Faculty | Brief Research Description |
|---|---|
| Daniel Beiting | Microbiome, Bioinformatics, Host-microbe interactions |
| Dustin Brisson | Disease ecology, molecular evolution, microbial ecology/ evolution, host-pathogen interaction |
| Frederic Bushman | Microbiome, gene therapy, HIV, integration, integrase, poxvirus, DNA modifying enzyme, virology, variola, resolvase |
| Ken Cadwell |
Gut microbes, autophagy, inflammatory bowel disease, virology, microbial pathogenesis, microbiota, helminths, mucosal immunity |
| De'Broski Herbert | Neurons, helminths, Type 2 immunity |
| Christopher Hunter | Immunity to Toxoplasma gondii; innate immunity; immunopathology |
| Audrey Odom John | Malaria, Plasmodium falciparum, metabolism, antimalarial development, diagnostics |
| Paula Oliver | Innate and adaptive immunity, mucosal immunology, mechanisms of cell function and disease |
| Michael Povelones | Mosquito-parasite interactions; mosquito immunity; Plasmodium; malaria; lymphatic filariasis; Brugia; heartworm; Dirofilaria; kinetoplastid adhesion and differentiation |
| David Roos | Molecular parasitology, drug resistance, organellar targeting, eukaryotic evolution, pathogen genomics, database mining, computational biology, Toxoplasma, Plasmodium, malaria. |
| Phillip Scott | Parasites, Leishmania, T cells, memory T cells, skin microbiome |
| Sarah Tishkoff | We combine field work, laboratory work, and computational approaches to address fundamental questions about modern human evolutionary history and the genetic architecture of traits related to adaptation and disease risk in Africa. |
| Faculty | Brief Research Description |
|---|---|
| Paul Bates | Ebola, Virus entry, glycoproteins, viral assembly, SARS, retrovirus, gene therapy. |
| Frederic Bushman | Microbiome, gene therapy, HIV, integration, integrase, poxvirus, DNA modifying enzyme, virology, variola, resolvase |
| Kyong-Mi Chang | HCV immune pathogenesis, HCV persistence, Viral escape, Viral persistence, Epitope mapping, Liver disease, T cell suppression, HIV/HCV coinfection, Alcohol |
| Ronald Collman | HIV, virus, tropism, signal transduction, gp120, viral envelope, macrophage |
| Ahmed Diab | HPV, Tumor Virology, Cancer Immunotherapy, Viral Oncogenesis, and Tumor Microenvironment |
| Laurence Eisenlohr | Cell biology of MHC class I-restricted antigen processing and presentation, MHD class II-restricted antigen processing and presentation, "Cryptic" MHC Class I-Restricted Epitopes, Cancer immunotherapy and autoimmunity |
| Harvey Freidman | HSV immune evasion, glycoprotein gC, glycoprotein gE, complement, pathogenesis |
| Glen Gaulton | Lymphocyte Development, Retrovirus Pathology, HIV-1, Gene Therapy |
| James Hoxie | AIDS, CD4, chemokine receptors, HIV, SIV, envelope glycoproteins, viral entry, neutralization, vaccine |
| Dennis Kolson | Neuron, hippocampus, apoptosis, gene expression, single-cell mRNA, HIV, chemokine receptor, NMDA receptor |
| Chengyu Liang | Virus-host interaction, COVID19 |
| Paul Lieberman | Viral latency, chromatin, DNA replication, transcription, cancer |
| Ronen Marmorstein | Transcription, Chromatin regulation, Protein-DNA recognition, Posttranslational modification, Tumor Suppressors, Viral oncoproteins, X-ray Crystallography, Enzymology, Structure, Biophysics |
| Alexander Price |
Molecular biology of DNA viruses and tumor viruses, innate immunity by nucleic acid sensing , viral and cellular RNA transcription and processing, and viral-host interactions |
| Robert Ricciardi | Mechanisms by which oncogenic proteins of human viruses exploit cellular functions and regulate gene expression to produce disease and cancer |
| Erle Robertson | Oncogenesis, viruses and cancer, viral oncology, Tumor Virology, Gene therapy, Kaposi's Sarcoma, Epstein-Barr Virus, Lymphoproliferative disease, Lymphomas |
| Andrei Thomas-Tikhonenko | Myc, p53, microRNA, angiogenesis, colon cancer, B-lymphoma, interferons, infection |
| David Weiner | DNA Vaccines, HIV, Viral Protein R., Vaccines |
| Susan Weiss | Murine coronavirus, SARS associated coronavirus, viral pathogenesis |
| Drew Weissman | HIV, Immunopathogenesis, RNAi, gp-340, dendritic cell, siRNA, antigen presentation, HIV vaccine |
| Matthew D. Weitzman | DNA Viruses, Virus Replication, DNA Damage and Repair, Genome Instability, Nuclear Reorganization, Host Restriction Factors, Viral Vectors, Proteomics |
| Elizabeth White | Human Papillomavirus, tumor virus, cancer virology, transformation, carcinogenesis, innate immunity, HPV, epithelial biology, tissue models |
| Jianxin You | STING activation, cancer immunotherapy, anti-viral immunotherapy, DNA tumor viruses, Viral oncogenesis, and Tumor virology |
| Faculty | Brief Research Description |
|---|---|
| Raiees Andrabi | Rational Design of Vaccines against Infectious Diseases, Directed Evolution, Protein Engineering, B cell Immunology to Infection and Vaccination, Antibody Discovery and Engineering, Glycans |
| Katharine Bar | HIV, SIV, antibody responses, broadly neutralizing antibodies, vaccines, cure, nonhuman primate models, viral rebound, broadly neutralizing antibodies |
| Paul Bates | Ebola, Virus entry, glycoproteins, viral assembly, SARS, retrovirus, gene therapy |
| Michael Betts | HIV; T cell; Immune Response |
| Frederic Bushman | Microbiome, gene therapy, HIV, integration, integrase, poxvirus, DNA modifying enzyme, virology, variola, resolvase |
| Ken Cadwell |
Gut microbes, autophagy, inflammatory bowel disease, virology, microbial pathogenesis, microbiota, helminths, mucosal immunity |
| Kyong-Mi Chang | HCV, HBV, liver disease, HIV/HCV coinfection, alcohol, viral pathogenesis, viral persistence, immune regulation, T cell exhaustion, transplant tolerance, epitope mapping, immunogenetics |
| Sara Cherry | Virus, genomics, RNAi, genetics, Drosophila, innate, immunity |
| Daniel Claiborne | HIV, HIV pathogenesis, CAR T cell therapy, T cell exhaustion, humanized mice |
| Gary Cohen | Herpes, HSV, virology, glycoproteins, virus entry |
| Ronald Collman | HIV-1, SIV, virus tropism, AIDS pathogenesis |
| Laurence Eisenlohr | Antigen Processing and Presentation, T cell responses and memory, Immune evasion and subversion, Immunopeptidomics, Influenza, Ectromelia, HIV, Salmonella |
| Amelia Escolano | HIV-1 vaccines, antibody responses, sequential immunization, B cell biology, germinal center responses, mouse models, NHP models |
| Harvey Friedman | HSV vaccine development, mRNA vaccines, genital herpes, prevention vaccine, therapeutic vaccine, HSV immune evasion, correlates of protection |
| Glen Gaulton | Lymphocyte Development, Retrovirus Pathology, HIV-1, Imaging, Diagnostics |
| Beatrice Hahn | HIV-1 transmission, ape Plasmodium infections, SIVcpz infection of wild chimpanzee, HIV vaccine development |
| Ronald Harty | Filoviruses, Rhabdoviruses, Arenaviruses, Ebola, Marburg, virus-host interactions, virus budding, antiviral therapeutics |
| Scott Hensley | Influenza virus, SARS-CoV-2, COVID-19, vaccines, mRNA vaccines, viral pathogenesis, antibodies, immune responses |
| James Hoxie | AIDS, CD4, chemokine receptors, HIV, SIV, envelope glycoproteins, viral entry, neutralization, vaccine |
| Stuart Isaacs | Vaccinia virus, recombinant orthopoxvirus vaccines, poxvirus , pathogenesis, smallpox, monkeypox, orthopoxvirus therapeutics |
| Kelly Jordan-Sciutto |
Impact of neuroinflammation on viability, differentiation and function of oligodendrocytes and neurons in the context of neurodegeneration |
| Kellie Ann Jurado | Focused on delineating disease pathogenesis of emerging viruses in order to uncover mechanisms of immune control |
| Rahul Kohli | Our laboratory focuses on the enzymatic generation of genomic diversity. We utilize a broad array of approaches, including biochemical characterization of enzyme mechanisms, chemical synthesis of enzyme probes, and biological assays spanning immunology and virology to study this central tactic in the constant battle between our immune system and pathogens. |
| Dennis Kolson | Neuron, hippocampus, apoptosis, gene expression, single-cell mRNA, HIV, chemokine receptor, NMDA receptor. |
| Edward (Ted) Kreider | mRNA vaccines, mRNA gene therapy, HIV cure, HIV vaccines, Infectious Diseases, Immunotherapy |
| Paul Lieberman | Viral latency, telomeres, chromatin, DNA replication, transcription regulation, herpesvirus. |
| Leyuan Ma | Using genetic, chemistry, engineering, and computational tools to decode the molecular and cellular crosstalk between immune cells and their microenvironment. Engineering novel biomaterials, protein, and cell-based precision immunotherapies. |
| Jonathan Miner | flavivirus, alphavirus, herpesvirus, bunyavirus, immune response, gene therapy, viral pathogenesis |
| Louise Moncla | Using tools from phylodynamics, virology, and population genetics to understand how viruses evolve within individuals, between populations, and across time, space, and population groups |
| Luis Montaner | Innate Immunity & HIV-1 Infection: Dendritic cells & Natural Killer Cells Direct or indirect interactions of viral particles with innate and specific adaptive immunity effector cells affects the cross talk between antigen presenting cells (APCs), NK cells and the antigen specific T and B-lymphocytes, and may contribute to regulate HIV disease progression. Specifically, we are pursuing analysis of the effects of HIV infection in macrophages, dendritic cells and Natural Killer cells |
| Una O'Doherty | HIV, latency, reservoirs, dendritic cells, viral pathogenesis, proviral integration, retrovirus, virology, T cell activation, resting T cells. |
| Paul Planet | Microbial Evolution, Phylogenetics, Bioinformatics, Genomics, Microbial Genetics, Mucosal and Epithelial Immunity, Antimicrobial Resistance, Global Molecular Epidemiology, Microbiomics, Respiratory Pathogens, Staphylococcus aureus, Prevotella, Kingella, Aggregatibacter, Pseudomonas aeruginosa, nontuberculous mycobacteria, SARS-CoV-2 |
| Alexander Price |
Molecular biology of DNA viruses and tumor viruses, innate immunity by nucleic acid sensing , viral and cellular RNA transcription and processing, and viral-host interactions |
| Robert Ricciardi | Our laboratory is interested in the mechanisms by which oncogenic proteins of human viruses exploit cellular functions and regulate gene expression to produce disease and cancer. |
| James Riley | T cell activation, Tumor Specific T cells, HIV specific T cells, expression profiles. |
| Erle Robertson | oncogenesis, viruses and cancer, viral oncology, Tumor Virology, Gene therapy, Kaposi's Sarcoma, Epstein-Barr Virus, Lymphoproliferative disease, Lymphomas. |
| Shaon Sengupta | circadian regulation of the Host-pathogen interaction, tissue clocks, circadian rhythms, influenza, neonatal lung, lung inflammation, NK cells |
| George Shaw | Molecular studies of HIV-1 transmission, persistence and pathogenesis, SIV transmission, persistence and pathogenesis, HCV transmission, persistence and pathogenesis |
| Laura Su | CD4+ T cells, pre-existing memory, vaccine, autoimmunity, microbiome, host-microbe interaction |
| Sarah Tishkoff | We combine field work, laboratory work, and computational approaches to address fundamental questions about modern human evolutionary history and the genetic architecture of traits related to adaptation and disease risk in Africa. |
| Andrew Vaughan |
Our research is focused on defining and understanding the relevant cell types and molecular mechanisms by which the mammalian lung is able to regenerate after severe injury. We are especially interested in lung repair after viral insults including influenza and SARS-CoV-2. |
| David Weiner | DNA Vaccines, HIV, Viral Protein R., Vaccines. |
| Susan Weiss | Murine coronavirus, SARS associated coronavirus, viral pathogenesis. |
| Drew Weissman | HIV, Immunopathogenesis, RNAi, DMBT1, dendritic cell, siRNA, antigen presentation. |
| Matthew D. Weitzman | DNA Viruses, Virus Replication, DNA Damage and Repair, Genome Instability, Nuclear Reorganization, Host Restriction Factors, Viral Vectors, Proteomics |
| E. John Wherry | Immunological memory, T cell memory, Chronic infection, T cell dysfunction, Memory T cell differentiation. |
| Elizabeth White | Human Papillomavirus, tumor virus, cancer virology, transformation, carcinogenesis, innate immunity, HPV, epithelial biology, tissue models |
| James Wilson | Adenovirus, adeno-associated virus (AAV), gene therapy, gene transfer, lentivirus. |
| Jianxin You | STING activation, cancer immunotherapy, anti-viral immunotherapy, DNA tumor viruses, Viral oncogenesis, and Tumor virology |
For information on how to apply for CAMB Faculty membership, please see the CAMB Bylaws.