Developmental, Stem Cell, and Regenerative Biology Faculty
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Current Members
Developmental, Stem Cell and Regenerative Biology
Click the faculty member's name to see more detailed information.
Faculty
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Aman Yebio Husbands
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Kyle Vining
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Faculty areas of research in DSRB can be broken up into the following eight categories:
| Faculty | Brief Research Description |
|---|---|
| Marisa Bartolomei | The research in my laboratory focuses on the study of genomic imprinting and X inactivation in mice. |
| Colin Conine | The functions of small RNAs in fertility, inheritance, and development. |
| Stephen DiNardo | Stem Cells, Niche, Epithelial Morphogenesis, Cell Polarity |
| Christopher Lengner | Interested in the mechanisms by which both somatic and embryonic stem cells acquire and maintain developmental potency. We are also exploring how deregulation of these mechanisms can contribute to oncogenic transformation and tumorigenesis, and how we can learn to manipulate these mechanisms for application in disease modeling and regenerative medicine |
| Mary Mullins | BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates. |
| P. Jeremy Wang | Regulation of meiosis, piRNA biogenesis, DNA recombination, chromosome segregation, DNA double-strand break repair, chromosome synapsis, male infertility in humans. |
| Faculty | Brief Research Description |
|---|---|
| Montserrat C Anguera | Roles of long noncoding RNAs during early development and how their misregulation results in disease |
| Elizabeth Bhoj | Our lab works in translational genetics to improve diagnosis and treatment through the discovery, mechanistic understanding, and targeted treatment of novel human syndromes. |
| Colin Conine | The functions of small RNAs in fertility, inheritance, and development. |
| E. Bryan Crenshaw | Analysis of the role of developmental regulatory factors during mouse embryogenesis |
| Jonathan Epstein | Transcriptional regulation of cardiac development and function using mouse models |
| Robert Heuckeroth | Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development |
| Peter Klein | Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3) |
| Andrew Modzelewski | Investigating the role and regulation of retrotransposons in development and disease |
| Edward Morrisey | Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors |
| Mary Mullins | BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates |
| John Murray | Developmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans |
| Michael Pack | Research interests: Research in my laboratory is geared towards studying medically relevant aspects of digestive organ development |
| Jonathan Raper | Developmental neurobiology, especially axon guidance |
| Patrick Seale | Stem Cells, Embryonic development, Adipocyte progenitors, Brown adipose tissue, White adipose tissue, PRDM16, PPARgamma |
| Nancy Speck | Hematopoietic stem cells and leukemia using mouse models |
| Meera Sundaram | Tubulogenesis and Epithelial matrix biology in C. elegans |
| Wei Tong | Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication |
| Julia Warren |
Hematopoietic stem cell biology, granulopoiesis, genetics of bone marrow failure syndromes especially severe congenital neutropenia, mitochondria function and proteostasis in hematopoiesis, leukemia |
| Faculty | Brief Research Description |
|---|---|
| Greg Bashaw | Axon guidance, developmental neuroscience, Slit, Robo, Netrin. |
| Steve DiNardo | Migration and polarization of niche cells |
| Michael Granato | Axonal guidance, nerve regeneration and learning behaviors in zebrafish |
| Robert Heuckeroth | Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development |
| Olena Jacenko | Molecular mechanisms of skeletal development and blood cell differentiation. |
| Mary Mullins | BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates. |
| John Murray | Developmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans |
| Michael Pack | Zebrafish and mouse genetics, developmental biology, cancer, chemical genetics |
| Richard Poethig | miRNA, siRNA, RNAi, developmental genetics, developmental timing, plants. |
| Jonathan Raper | axon guidance, developmental neurobiology, Molecular biology; tissue culture; Protein biochemistry; Videomicroscopy, expression cloning; mouse, chick, zebrafish. |
| Arndt Siekmann |
Development of the vascular system with a focus on investigating the mechanisms leading to arterial-venous malformations |
| Meera Sundaram | Tubulogenesis and Epithelial matrix biology in C. elegans |
| Faculty | Brief Research Description |
|---|---|
| Stewart A Anderson | GABAergic interneurons of the cerebral cortex in development and in disease (epilepsy, schizophrenia, autism) |
| Greg Bashaw | - Molecular mechanisms of axon growth and guidance during nervous system development. - How axon guidance receptors specify attractive and repulsive signals and transmit these signals to the navigating growth cone. - Formation of Neural Circuits at the Midline |
| Elizabeth Bhoj | Our lab works in translational genetics to improve diagnosis and treatment through the discovery, mechanistic understanding, and targeted treatment of novel human syndromes. |
| Michael Granato | Axonal guidance, nerve regeneration and learning behaviors in zebrafish |
| Judith Grinspan | Our lab studies the controls of the development of oligodendrocytes, the myelinating cells of the central nervous system, from stem cells through to myelination. |
| Robert Heuckeroth | Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development. |
| Peter Klein | Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3). |
| Guo-Li Ming | Our research focuses on understanding brain development and developmental brain disorders using human genetics and patient-derived pluripotent stem cells (iPSCs)-based 2D and 3D organoid modes |
| Xilma Ortiz-Gonzalez |
My laboratory studies mechanism underlying neurodegeneration using ultra-rare pediatric monogenic disorders as disease models |
| Bushra Raj | Gene regulatory code and dynamics of neural development |
| Jonathan Raper | developmental neurobiology, especially axon guidance |
| Wenqin Luo | Development and Function of Mammalian Mechanosensory Dorsal Root Ganglion (DRG) Neurons |
| Katherine Uyhazi | Visual system disorders, photoreceptor development, cell-based therapies for retinal regeneration |
| Faculty | Brief Research Description |
|---|---|
| Elizabeth Bhoj | Our lab works in translational genetics to improve diagnosis and treatment through the discovery, mechanistic understanding, and targeted treatment of novel human syndromes. |
| Maya Capelson | Nuclear structure and its role in gene regulation Spatial organization of the genome Epigenetic memory of gene expression states |
| Stephen DiNardo | We study how organs place and organize their niches. |
| Robert Heuckeroth | Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development. |
| Olena Jacenko | molecular mechanisms of skeletal development and blood cell differentiation. |
| Rajan Jain | Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology |
| Fanxin Long | We study the formation and maintenance of skeletal tissues. |
| Foteini Mourkioti | Muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting. |
| Mary Mullins | BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates. |
| Michael Pack | Research in my laboratory is geared towards studying medically relevant aspects of digestive organ development. |
| Michael Parmacek | Transcriptional programs that regulate cardiovascular development |
| R. Scott Poethig | Genetic regulation of the juvenile-to-adult transition in plants The developmental function of RNAi in plants |
| Ling Qin | Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction |
| Bushra Raj | Gene regulatory code and dynamics of neural development |
| Jonathan Raper | developmental neurobiology, especially axon guidance |
| Panteleimon Rompolas | Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration |
| Nancy Speck | Hematopoietic stem cells and leukemia using mouse models |
| Patrick Seale | Obesity is the predominant risk factor for an expanding array of diseases including: type 2 diabetes, heart disease, stroke and cancer. Our lab investigates the transcriptional pathways that control the development, differentiation and function of adipose cells in normal development and in obesity. |
| Meera Sundaram | Tubulogenesis and Epithelial matrix biology in C. elegans |
| Wei Tong | Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication |
| Julia Warren |
Hematopoietic stem cell biology, granulopoiesis, genetics of bone marrow failure syndromes especially severe congenital neutropenia, mitochondria function and proteostasis in hematopoiesis, leukemia |
| Faculty | Brief Research Description |
|---|---|
| George Cotsarelis | Stem cells; Hair follicle; Wounding; Aging; Skin cancer |
| Stephen DiNardo | Live-imaging to study stem cell behavior in real-time |
| Paul Gadue | My laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using mouse and human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. |
| Judith Grinspan | Our lab studies the controls of the development of oligodendrocytes, the myelinating cells of the central nervous system, from stem cells through to myelination. |
| Robert Heuckeroth | Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development. |
| Olena Jacenko | molecular mechanisms of skeletal development and blood cell differentiation. |
| Rajan Jain | Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology |
| Peter Klein | Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3). |
| Kang Ko |
Epithelial-immune and mesenchymal-immune interactions in periodontitis (oral inflammatory disease) and wound healing process |
| Peter Kurre |
The Kurre Lab is interested in the bidirectional crosstalk between hematopoietic stem and progenitor cells and components of the healthy bone marrow niche as well as leukemic blasts of the leukemic niche. Emphasis for our work is on the specific role of nanoscale sized extracellular vesicles. |
| Christopher Lengner | The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis. |
| Fanxin Long | We study mesenchymal stem/progenitor cells and their interactions with other cell ipopulations n either the bone marrow or the periosteal niche. |
| Guo-Li Ming | Our research focuses on understanding brain development and developmental brain disorders using human genetics and patient-derived pluripotent stem cells (iPSCs)-based 2D and 3D organoid modes |
| Edward Morrisey | Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors |
| Foteini Mourkioti | muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting. |
| Xilma Ortiz-Gonzalez |
My laboratory studies mechanism underlying neurodegeneration using ultra-rare pediatric monogenic disorders as disease models |
| Panteleimon Rompolas | Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration |
| Nancy Speck | Hematopoietic stem cells and leukemia using mouse models |
| Ling Qin | Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction |
| Wei Tong |
Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication |
| Julia Warren |
Hematopoietic stem cell biology, granulopoiesis, genetics of bone marrow failure syndromes especially severe congenital neutropenia, mitochondria function and proteostasis in hematopoiesis, leukemia |
| Faculty | Brief Research Description |
|---|---|
| George Cotsarelis | Stem cells; Hair follicle; Wounding; Aging; Skin cancer |
| Jonathan Epstein | Transcriptional regulation of cardiac development and function using mouse models |
| Michael Granato | Axonal guidance, nerve regeneration and learning behaviors in zebrafish |
| Robert Heuckeroth | Enteric nervous system precursor differentiation, migration, proliferation, axon guidance, and stem cell biology |
| Rajan Jain | Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology |
| Kang Ko | Investigating the mechanisms by which fibroblasts from the oral cavity and skin differ at the functional and molecular level that can explain superior wound healing in the gingiva/gum tissue |
| Christopher Lengner | The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis. |
| Thomas Leung | We seek to improve our understanding of mammalian tissue regeneration and to develop novel therapeutics for regenerative medicine. |
| Fanxin Long |
We study the biology of both bone remodeling, a continuous regenerative process necessary for maintaining bone integrity, and also bone regeneration during fracture repair. |
| Guo-Li Ming | Our research focuses on understanding brain development and developmental brain disorders using human genetics and patient-derived pluripotent stem cells (iPSCs)-based 2D and 3D organoid modes |
| Andrew Modzelewski | Investigating the role and regulation of retrotransposons in development and disease |
| Edward Morrisey | Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors |
| Foteini Mourkioti | Muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting. |
| Panteleimon Rompolas | Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration. |
| Yuanquan Song | Neural degeneration, Neural regeneration, Neurodegenerative diesases, Drosophila, Spinal cord injury, Tumorigenesis |
| Wei Tong | Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication |
| Katherine Uyhazi | Visual system disorders, photoreceptor development, cell-based therapies for retinal regeneration |
| Faculty | Brief Research Description |
|---|---|
| Montserrat Anguera |
Epigenetic mechanisms of X-Chromosome Inactivation in immune cells & immune-related diseases |
| Marisa Bartolomei | The research in my laboratory focuses on the study of genomic imprinting and X inactivation in mice. |
| Elizabeth Bhoj | Our lab works in translational genetics to improve diagnosis and treatment through the discovery, mechanistic understanding, and targeted treatment of novel human syndromes. |
| Colin Conine | The functions of small RNAs in fertility, inheritance, and development. |
| E. Bryan Crenshaw | Analysis of the role of developmental regulatory factors during mouse embryogenesis. |
| Jonathan Epstein | Transcriptional regulation of cardiac development and function using mouse models |
| Paul Gadue | My laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using mouse and human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. |
| Rajan Jain | Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology |
| Peter Klein | Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neural stem cells and neurogenesis, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3). |
| Christopher Lengner | The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis. |
| Fanxin Long | We study the metabolomic and epigenetic regulation of skeletal cell differentiation. |
| Andrew Modzelewski | Investigating the role and regulation of retrotransposons in development and disease |
| Edward Morrisey | lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors |
| John Murray | Developmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans |
| Michael Parmacek | Transcriptional programs that regulate cardiovascular development |
| Ling Qin | Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction |
| Panteleimon Rompolas | Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration. |
| Patrick Seale | Our lab investigates the transcriptional pathways that control the development, differentiation and function of adipose cells in normal development and in obesity. |
| Nancy Speck | Hematopoietic stem cells and leukemia using mouse models |
| Wei Tong | Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication |
| Jeremy Wang | Regulation of meiosis, silencing of transposable elements, piRNA biogenesis, DNA recombination, chromosome segregation, DNA double-strand break repair, chromosome synapsis, male infertility in humans. |
| Julia Warren |
Hematopoietic stem cell biology, granulopoiesis, genetics of bone marrow failure syndromes especially severe congenital neutropenia, mitochondria function and proteostasis in hematopoiesis, leukemia |
For information on how to apply for CAMB Faculty membership, please see the CAMB Bylaws.