Developmental, Stem Cell, and Regenerative Biology Faculty

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Developmental, Stem Cell and Regenerative Biology Members

Current Members

Developmental, Stem Cell and Regenerative Biology

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Faculty


Faculty areas of research in DSRB can be broken up into the following eight categories:

Gametogenesis

Faculty Brief Research Description
Marisa Bartolomei  The research in my laboratory focuses on the study of genomic imprinting and X inactivation in mice.
Stephen DiNardo Stem Cells, Niche, Epithelial Morphogenesis, Cell Polarity
George Gerton  Spermatogenesis, Acrosome, Spermatid, Flagellum, Acrosomal matrix, Preimplantation, Embryo, Trophoblast.
Christopher Lengner  Interested in the mechanisms by which both somatic and embryonic stem cells acquire and maintain developmental potency. We are also exploring how deregulation of these mechanisms can contribute to oncogenic transformation and tumorigenesis, and how we can learn to manipulate these mechanisms for application in disease modeling and regenerative medicine
Mary Mullins  BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates.
P. Jeremy Wang  Regulation of meiosis, piRNA biogenesis, DNA recombination, chromosome segregation, DNA double-strand break repair, chromosome synapsis, male infertility in humans.

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Embryo & Fetal Development

Faculty Brief Research Description
Montserrat C Anguera Roles of long noncoding RNAs during early development and how their misregulation results in disease
Maya Capelson * Nuclear structure and its role in gene regulation
* Spatial organization of the genome
* Epigenetic memory of gene expression states
E. Bryan Crenshaw Analysis of the role of developmental regulatory factors during mouse embryogenesis
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models
Robert Heuckeroth Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development
Daniel Kessler * Establishment and organization of the primary germ layers
* Formation and function of the Spemann organizer in axial development
* Signaling and transcriptional networks in the vertebrate gastrula
Peter Klein Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3)
Edward Morrisey Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Mary Mullins  BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates
Michael Pack Research interests: Research in my laboratory is geared towards studying medically relevant aspects of digestive organ development
Jonathan Raper Developmental neurobiology, especially axon guidance
Patrick Seale Stem Cells, Embryonic development, Adipocyte progenitors, Brown adipose tissue, White adipose tissue, PRDM16, PPARgamma
Nancy Speck Hematopoietic stem cells and leukemia using mouse models

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Cell Migration, Polarity, and Morphogenesis

Faculty Brief Research Description
Greg Bashaw Axon guidance, developmental neuroscience, Slit, Robo, Netrin.
Steve DiNardo Stem Cell Function; developmental patterning.
Michael Granato Axonal guidance, nerve regeneration and learning behaviors in zebrafish
Robert Heuckeroth Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development
Olena Jacenko Molecular mechanisms of skeletal development and blood cell differentiation.
Mary Mullins BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates.
Michael Pack  Zebrafish and mouse genetics, developmental biology, cancer, chemical genetics
Richard Poethig  miRNA, siRNA, RNAi, developmental genetics, developmental timing, plants.
Jonathan Raper axon guidance, developmental neurobiology, Molecular biology; tissue culture; Protein biochemistry; Videomicroscopy, expression cloning; mouse, chick, zebrafish.

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Neurogenesis and Axonogenesis

Faculty Brief Research Description
Stewart A Anderson GABAergic interneurons of the cerebral cortex in development and in disease (epilepsy, schizophrenia, autism)
Greg Bashaw - Molecular mechanisms of axon growth and guidance during nervous system development.
- How axon guidance receptors specify attractive and repulsive signals and transmit these signals to the navigating growth cone.
- Formation of Neural Circuits at the Midline
Michael Granato  Axonal guidance, nerve regeneration and learning behaviors in zebrafish
Judith Grinspan  Our lab studies the controls of the development of oligodendrocytes, the myelinating cells of the central nervous system, from stem cells through to myelination.
Robert Heuckeroth Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development.
Peter Klein  Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3).
Jonathan Raper  developmental neurobiology, especially axon guidance
Wenqin Luo  Development and Function of Mammalian Mechanosensory Dorsal Root Ganglion (DRG) Neurons

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Tissue & Organ Formation

Faculty Brief Research Description
Maya Capelson Nuclear structure and its role in gene regulation
Spatial organization of the genome
Epigenetic memory of gene expression states
Stephen DiNardo  - Stem Cell-Niche Interactions
- Epithelial Morphogenesis
Robert Heuckeroth Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development.
Olena Jacenko  molecular mechanisms of skeletal development and blood cell differentiation.
Rajan Jain Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Daniel Kessler  * Establishment and organization of the primary germ layers
* Formation and function of the Spemann organizer in axial development
* Signaling and transcriptional networks in the vertebrate gastrula
Mary Mullins  BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates.
Michael Pack  Research in my laboratory is geared towards studying medically relevant aspects of digestive organ development.
Michael Parmacek Transcriptional programs that regulate cardiovascular development
R. Scott Poethig  Genetic regulation of the juvenile-to-adult transition in plants
The developmental function of RNAi in plants
Ling Qin  Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction
Jonathan Raper  developmental neurobiology, especially axon guidance
Panteleimon Rompolas Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration
Nancy Speck  Hematopoietic stem cells and leukemia using mouse models
Patrick Seale Obesity is the predominant risk factor for an expanding array of diseases including: type 2 diabetes, heart disease, stroke and cancer. Our lab investigates the transcriptional pathways that control the development, differentiation and function of adipose cells in normal development and in obesity.

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Stem Cell/Niche Interactions

Faculty Brief Research Description
George Cotsarelis Stem cells; Hair follicle; Wounding; Aging; Skin cancer
Stephen DiNardo - Stem Cell-Niche Interactions
- Epithelial Morphogenesis
Paul Gadue My laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using mouse and human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells.
Judith Grinspan Our lab studies the controls of the development of oligodendrocytes, the myelinating cells of the central nervous system, from stem cells through to myelination.
Robert Heuckeroth Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development.
Olena Jacenko molecular mechanisms of skeletal development and blood cell differentiation.
Rajan Jain Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Peter Klein Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3).
Christopher Lengner The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis.
Edward Morrisey Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Foteini Mourkioti muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting.
Panteleimon Rompolas Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration
Nancy Speck Hematopoietic stem cells and leukemia using mouse models
Ling Qin Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction

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Regenerative Biology

Faculty Brief Research Description
George Cotsarelis  Stem cells; Hair follicle; Wounding; Aging; Skin cancer
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models
Michael Granato Axonal guidance, nerve regeneration and learning behaviors in zebrafish
Robert Heuckeroth Enteric nervous system precursor differentiation, migration, proliferation, axon guidance, and stem cell biology
Rajan Jain Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Christopher Lengner The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis.
Thomas Leung We seek to improve our understanding of mammalian tissue regeneration and to develop novel therapeutics for regenerative medicine.
Edward Morrisey Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Foteini Mourkioti Muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting.
Panteleimon Rompolas Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration.
Yuanquan Song Neural degeneration, Neural regeneration, Neurodegenerative diesases, Drosophila, Spinal cord injury, Tumorigenesis

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Epigenetics, Gene Regulatory Networks, & Signal Integration

Faculty Brief Research Description
Montserrat Anguera Roles of long noncoding RNAs during early development and how their misregulation contributes to disease
Marisa Bartolomei The research in my laboratory focuses on the study of genomic imprinting and X inactivation in mice.
Maya Capelson Nuclear structure and its role in gene regulation; Spatial organization of the genome; Epigenetic memory of gene expression states
E. Bryan Crenshaw Analysis of the role of developmental regulatory factors during mouse embryogenesis.
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models
Paul Gadue My laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using mouse and human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells.
Rajan Jain Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Peter Klein Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neural stem cells and neurogenesis, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3).
Christopher Lengner The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis.
Edward Morrisey lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Michael Parmacek Transcriptional programs that regulate cardiovascular development
Ling Qin Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction
Panteleimon Rompolas Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration.
Patrick Seale Our lab investigates the transcriptional pathways that control the development, differentiation and function of adipose cells in normal development and in obesity.
Nancy Speck Hematopoietic stem cells and leukemia using mouse models
Jeremy Wang Regulation of meiosis, silencing of transposable elements, piRNA biogenesis, DNA recombination, chromosome segregation, DNA double-strand break repair, chromosome synapsis, male infertility in humans.

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For information on how to apply for CAMB Faculty membership, please see the CAMB Bylaws.