Developmental, Stem Cell, and Regenerative Biology Faculty
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Developmental, Stem Cell and Regenerative Biology
Click the faculty member's name to see more detailed information.
Faculty
Faculty areas of research in DSRB can be broken up into the following eight categories:
- Gametogenesis
- Embryo & Fetal Development
- Cell Migration, Polarity, and Morphogenesis
- Neurogenesis and Axonogenesis
- Tissue & Organ Formation
- Stem Cell/Niche Interactions
- Regenerative Biology
- Epigenetics, Gene Regulatory Networks, & Signal Integration
Faculty | Brief Research Description |
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Marisa Bartolomei | The research in my laboratory focuses on the study of genomic imprinting and X inactivation in mice. |
Stephen DiNardo | Stem Cells, Niche, Epithelial Morphogenesis, Cell Polarity |
George Gerton | Spermatogenesis, Acrosome, Spermatid, Flagellum, Acrosomal matrix, Preimplantation, Embryo, Trophoblast. |
Christopher Lengner | Interested in the mechanisms by which both somatic and embryonic stem cells acquire and maintain developmental potency. We are also exploring how deregulation of these mechanisms can contribute to oncogenic transformation and tumorigenesis, and how we can learn to manipulate these mechanisms for application in disease modeling and regenerative medicine |
Mary Mullins | BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates. |
P. Jeremy Wang | Regulation of meiosis, piRNA biogenesis, DNA recombination, chromosome segregation, DNA double-strand break repair, chromosome synapsis, male infertility in humans. |
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Faculty | Brief Research Description |
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Montserrat C Anguera | Roles of long noncoding RNAs during early development and how their misregulation results in disease |
Maya Capelson | * Nuclear structure and its role in gene regulation * Spatial organization of the genome * Epigenetic memory of gene expression states |
E. Bryan Crenshaw | Analysis of the role of developmental regulatory factors during mouse embryogenesis |
Jonathan Epstein | Transcriptional regulation of cardiac development and function using mouse models |
Robert Heuckeroth | Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development |
Daniel Kessler | * Establishment and organization of the primary germ layers * Formation and function of the Spemann organizer in axial development * Signaling and transcriptional networks in the vertebrate gastrula |
Peter Klein | Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3) |
Edward Morrisey | Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors |
Mary Mullins | BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates |
Michael Pack | Research interests: Research in my laboratory is geared towards studying medically relevant aspects of digestive organ development |
Jonathan Raper | Developmental neurobiology, especially axon guidance |
Patrick Seale | Stem Cells, Embryonic development, Adipocyte progenitors, Brown adipose tissue, White adipose tissue, PRDM16, PPARgamma |
Nancy Speck | Hematopoietic stem cells and leukemia using mouse models |
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Faculty | Brief Research Description |
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Greg Bashaw | Axon guidance, developmental neuroscience, Slit, Robo, Netrin. |
Steve DiNardo | Stem Cell Function; developmental patterning. |
Michael Granato | Axonal guidance, nerve regeneration and learning behaviors in zebrafish |
Robert Heuckeroth | Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development |
Olena Jacenko | Molecular mechanisms of skeletal development and blood cell differentiation. |
Mary Mullins | BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates. |
Michael Pack | Zebrafish and mouse genetics, developmental biology, cancer, chemical genetics |
Richard Poethig | miRNA, siRNA, RNAi, developmental genetics, developmental timing, plants. |
Jonathan Raper | axon guidance, developmental neurobiology, Molecular biology; tissue culture; Protein biochemistry; Videomicroscopy, expression cloning; mouse, chick, zebrafish. |
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Faculty | Brief Research Description |
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Stewart A Anderson | GABAergic interneurons of the cerebral cortex in development and in disease (epilepsy, schizophrenia, autism) |
Greg Bashaw | - Molecular mechanisms of axon growth and guidance during nervous system development. - How axon guidance receptors specify attractive and repulsive signals and transmit these signals to the navigating growth cone. - Formation of Neural Circuits at the Midline |
Michael Granato | Axonal guidance, nerve regeneration and learning behaviors in zebrafish |
Judith Grinspan | Our lab studies the controls of the development of oligodendrocytes, the myelinating cells of the central nervous system, from stem cells through to myelination. |
Robert Heuckeroth | Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development. |
Peter Klein | Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3). |
Jonathan Raper | developmental neurobiology, especially axon guidance |
Wenqin Luo | Development and Function of Mammalian Mechanosensory Dorsal Root Ganglion (DRG) Neurons |
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Faculty | Brief Research Description |
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Maya Capelson | Nuclear structure and its role in gene regulation Spatial organization of the genome Epigenetic memory of gene expression states |
Stephen DiNardo | - Stem Cell-Niche Interactions - Epithelial Morphogenesis |
Robert Heuckeroth | Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development. |
Olena Jacenko | molecular mechanisms of skeletal development and blood cell differentiation. |
Rajan Jain | Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology |
Daniel Kessler | * Establishment and organization of the primary germ layers * Formation and function of the Spemann organizer in axial development * Signaling and transcriptional networks in the vertebrate gastrula |
Mary Mullins | BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates. |
Michael Pack | Research in my laboratory is geared towards studying medically relevant aspects of digestive organ development. |
Michael Parmacek | Transcriptional programs that regulate cardiovascular development |
R. Scott Poethig | Genetic regulation of the juvenile-to-adult transition in plants The developmental function of RNAi in plants |
Ling Qin | Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction |
Jonathan Raper | developmental neurobiology, especially axon guidance |
Panteleimon Rompolas | Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration |
Nancy Speck | Hematopoietic stem cells and leukemia using mouse models |
Patrick Seale | Obesity is the predominant risk factor for an expanding array of diseases including: type 2 diabetes, heart disease, stroke and cancer. Our lab investigates the transcriptional pathways that control the development, differentiation and function of adipose cells in normal development and in obesity. |
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Faculty | Brief Research Description |
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George Cotsarelis | Stem cells; Hair follicle; Wounding; Aging; Skin cancer |
Stephen DiNardo | - Stem Cell-Niche Interactions - Epithelial Morphogenesis |
Paul Gadue | My laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using mouse and human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. |
Judith Grinspan | Our lab studies the controls of the development of oligodendrocytes, the myelinating cells of the central nervous system, from stem cells through to myelination. |
Robert Heuckeroth | Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development. |
Olena Jacenko | molecular mechanisms of skeletal development and blood cell differentiation. |
Rajan Jain | Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology |
Peter Klein | Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3). |
Christopher Lengner | The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis. |
Edward Morrisey | Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors |
Foteini Mourkioti | muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting. |
Panteleimon Rompolas | Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration |
Nancy Speck | Hematopoietic stem cells and leukemia using mouse models |
Ling Qin | Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction |
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Faculty | Brief Research Description |
---|---|
George Cotsarelis | Stem cells; Hair follicle; Wounding; Aging; Skin cancer |
Jonathan Epstein | Transcriptional regulation of cardiac development and function using mouse models |
Michael Granato | Axonal guidance, nerve regeneration and learning behaviors in zebrafish |
Robert Heuckeroth | Enteric nervous system precursor differentiation, migration, proliferation, axon guidance, and stem cell biology |
Rajan Jain | Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology |
Christopher Lengner | The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis. |
Thomas Leung | We seek to improve our understanding of mammalian tissue regeneration and to develop novel therapeutics for regenerative medicine. |
Edward Morrisey | Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors |
Foteini Mourkioti | Muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting. |
Panteleimon Rompolas | Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration. |
Yuanquan Song | Neural degeneration, Neural regeneration, Neurodegenerative diesases, Drosophila, Spinal cord injury, Tumorigenesis |
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Faculty | Brief Research Description |
---|---|
Montserrat Anguera | Roles of long noncoding RNAs during early development and how their misregulation contributes to disease |
Marisa Bartolomei | The research in my laboratory focuses on the study of genomic imprinting and X inactivation in mice. |
Maya Capelson | Nuclear structure and its role in gene regulation; Spatial organization of the genome; Epigenetic memory of gene expression states |
E. Bryan Crenshaw | Analysis of the role of developmental regulatory factors during mouse embryogenesis. |
Jonathan Epstein | Transcriptional regulation of cardiac development and function using mouse models |
Paul Gadue | My laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using mouse and human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. |
Rajan Jain | Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology |
Peter Klein | Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neural stem cells and neurogenesis, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3). |
Christopher Lengner | The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis. |
Edward Morrisey | lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors |
Michael Parmacek | Transcriptional programs that regulate cardiovascular development |
Ling Qin | Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction |
Panteleimon Rompolas | Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration. |
Patrick Seale | Our lab investigates the transcriptional pathways that control the development, differentiation and function of adipose cells in normal development and in obesity. |
Nancy Speck | Hematopoietic stem cells and leukemia using mouse models |
Jeremy Wang | Regulation of meiosis, silencing of transposable elements, piRNA biogenesis, DNA recombination, chromosome segregation, DNA double-strand break repair, chromosome synapsis, male infertility in humans. |
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For information on how to apply for CAMB Faculty membership, please see the CAMB Bylaws.
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