Developmental, Stem Cell, and Regenerative Biology Faculty

Developmental, Stem Cell and Regenerative Biology Members

Current Members

Developmental, Stem Cell and Regenerative Biology

Click the faculty member's name to see more detailed information.

Faculty

Stewart A Anderson, MD	Peter S. Klein, MD, PhD
Montserrat C Anguera, PhD	Christopher Joachim Lengner, Ph.D.
Greg J. Bashaw, Ph.D.	Thomas H. Leung, M.D., Ph.D.
Jason A. Burdick	Fanxin Long, Ph.D.
Maya Capelson, PhD	Wenqin Luo, M.D, Ph.D
Stella T Chou, M.D.	Robert L Mauck, PhD
George Cotsarelis, M.D.	Edward E. Morrisey, Ph.D.
E. Bryan Crenshaw III, Ph.D.	Foteini Mourkioti, PhD
Stephen DiNardo, Ph.D.	Mary C. Mullins, Ph.D.
Michal A. Elovitz, M.D.	Kyla Ortved, DVM, PhD, DACVS, DACVSMR
Jonathan A. Epstein, M.D.	Michael A. Pack, MD
David B. Frank, MD, PhD	Michael S. Parmacek, M.D.
Marc V Fuccillo, M.D., Ph.D.	Richard Scott Poethig, Ph.D.
Paul J Gadue, PhD	Ling Qin, Ph.D.
Kimberly L Gallagher	Jonathan A. Raper, Ph.D.
John D. Gearhart, Ph.D.	Panteleimon Rompolas, M.B.A., Ph.D.
George L. Gerton, PhD	Kotaro Sasaki, MD, PhD
Michael Granato, Ph.D.	Patrick Seale, Ph.D.
Judith B. Grinspan, Ph.D.	Arndt Siekmann, Ph.D.
Gregory M. Guild, Ph.D.	Yuanquan Song, Ph.D.
Robert O. Heuckeroth, M.D. Ph.D.	Hongjun Song, Ph.D.
Alex J Hughes	Nancy A. Speck, Ph.D.
Olena Jacenko	Diana Elena Stanescu, MD
Rajan Jain, MD	Meera V. Sundaram, Ph.D
Kyu Sang Joeng, Ph.D.	Natalie A Terry, M.D., Ph.D.
Yana G. Kamberov, Ph.D.	Andrew E Vaughan
Daniel S. Kessler, Ph.D.	P. Jeremy Wang, MD, PhD

Faculty areas of research in DSRB can be broken up into the following eight categories:

Gametogenesis

Faculty	Brief Research Description
Marisa Bartolomei	The research in my laboratory focuses on the study of genomic imprinting and X inactivation in mice.
Stephen DiNardo	Stem Cells, Niche, Epithelial Morphogenesis, Cell Polarity
George Gerton	Spermatogenesis, Acrosome, Spermatid, Flagellum, Acrosomal matrix, Preimplantation, Embryo, Trophoblast.
Christopher Lengner	Interested in the mechanisms by which both somatic and embryonic stem cells acquire and maintain developmental potency. We are also exploring how deregulation of these mechanisms can contribute to oncogenic transformation and tumorigenesis, and how we can learn to manipulate these mechanisms for application in disease modeling and regenerative medicine
Mary Mullins	BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates.
P. Jeremy Wang	Regulation of meiosis, piRNA biogenesis, DNA recombination, chromosome segregation, DNA double-strand break repair, chromosome synapsis, male infertility in humans.

Embryo & Fetal Development

Faculty	Brief Research Description
Montserrat C Anguera	Roles of long noncoding RNAs during early development and how their misregulation results in disease
Maya Capelson	* Nuclear structure and its role in gene regulation * Spatial organization of the genome * Epigenetic memory of gene expression states
E. Bryan Crenshaw	Analysis of the role of developmental regulatory factors during mouse embryogenesis
Jonathan Epstein	Transcriptional regulation of cardiac development and function using mouse models
Robert Heuckeroth	Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development
Daniel Kessler	* Establishment and organization of the primary germ layers * Formation and function of the Spemann organizer in axial development * Signaling and transcriptional networks in the vertebrate gastrula
Peter Klein	Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3)
Edward Morrisey	Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Mary Mullins	BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates
Michael Pack	Research interests: Research in my laboratory is geared towards studying medically relevant aspects of digestive organ development
Jonathan Raper	Developmental neurobiology, especially axon guidance
Patrick Seale	Stem Cells, Embryonic development, Adipocyte progenitors, Brown adipose tissue, White adipose tissue, PRDM16, PPARgamma
Nancy Speck	Hematopoietic stem cells and leukemia using mouse models

Cell Migration, Polarity, and Morphogenesis

Faculty	Brief Research Description
Greg Bashaw	Axon guidance, developmental neuroscience, Slit, Robo, Netrin.
Steve DiNardo	Stem Cell Function; developmental patterning.
Michael Granato	Axonal guidance, nerve regeneration and learning behaviors in zebrafish
Robert Heuckeroth	Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development
Olena Jacenko	Molecular mechanisms of skeletal development and blood cell differentiation.
Mary Mullins	BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates.
Michael Pack	Zebrafish and mouse genetics, developmental biology, cancer, chemical genetics
Richard Poethig	miRNA, siRNA, RNAi, developmental genetics, developmental timing, plants.
Jonathan Raper	axon guidance, developmental neurobiology, Molecular biology; tissue culture; Protein biochemistry; Videomicroscopy, expression cloning; mouse, chick, zebrafish.

Neurogenesis and Axonogenesis

Faculty	Brief Research Description
Stewart A Anderson	GABAergic interneurons of the cerebral cortex in development and in disease (epilepsy, schizophrenia, autism)
Greg Bashaw	- Molecular mechanisms of axon growth and guidance during nervous system development. - How axon guidance receptors specify attractive and repulsive signals and transmit these signals to the navigating growth cone. - Formation of Neural Circuits at the Midline
Michael Granato	Axonal guidance, nerve regeneration and learning behaviors in zebrafish
Judith Grinspan	Our lab studies the controls of the development of oligodendrocytes, the myelinating cells of the central nervous system, from stem cells through to myelination.
Robert Heuckeroth	Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development.
Peter Klein	Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3).
Jonathan Raper	developmental neurobiology, especially axon guidance
Wenqin Luo	Development and Function of Mammalian Mechanosensory Dorsal Root Ganglion (DRG) Neurons

Tissue & Organ Formation

Faculty	Brief Research Description
Maya Capelson	Nuclear structure and its role in gene regulation Spatial organization of the genome Epigenetic memory of gene expression states
Stephen DiNardo	- Stem Cell-Niche Interactions - Epithelial Morphogenesis
Robert Heuckeroth	Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development.
Olena Jacenko	molecular mechanisms of skeletal development and blood cell differentiation.
Rajan Jain	Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Daniel Kessler	* Establishment and organization of the primary germ layers * Formation and function of the Spemann organizer in axial development * Signaling and transcriptional networks in the vertebrate gastrula
Mary Mullins	BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates.
Michael Pack	Research in my laboratory is geared towards studying medically relevant aspects of digestive organ development.
Michael Parmacek	Transcriptional programs that regulate cardiovascular development
R. Scott Poethig	Genetic regulation of the juvenile-to-adult transition in plants The developmental function of RNAi in plants
Ling Qin	Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction
Jonathan Raper	developmental neurobiology, especially axon guidance
Panteleimon Rompolas	Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration
Nancy Speck	Hematopoietic stem cells and leukemia using mouse models
Patrick Seale	Obesity is the predominant risk factor for an expanding array of diseases including: type 2 diabetes, heart disease, stroke and cancer. Our lab investigates the transcriptional pathways that control the development, differentiation and function of adipose cells in normal development and in obesity.

Stem Cell/Niche Interactions

Faculty	Brief Research Description
George Cotsarelis	Stem cells; Hair follicle; Wounding; Aging; Skin cancer
Stephen DiNardo	- Stem Cell-Niche Interactions - Epithelial Morphogenesis
Paul Gadue	My laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using mouse and human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells.
Judith Grinspan	Our lab studies the controls of the development of oligodendrocytes, the myelinating cells of the central nervous system, from stem cells through to myelination.
Robert Heuckeroth	Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development.
Olena Jacenko	molecular mechanisms of skeletal development and blood cell differentiation.
Rajan Jain	Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Peter Klein	Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3).
Christopher Lengner	The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis.
Edward Morrisey	Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Foteini Mourkioti	muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting.
Panteleimon Rompolas	Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration
Nancy Speck	Hematopoietic stem cells and leukemia using mouse models
Ling Qin	Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction

Regenerative Biology

Faculty	Brief Research Description
George Cotsarelis	Stem cells; Hair follicle; Wounding; Aging; Skin cancer
Jonathan Epstein	Transcriptional regulation of cardiac development and function using mouse models
Michael Granato	Axonal guidance, nerve regeneration and learning behaviors in zebrafish
Robert Heuckeroth	Enteric nervous system precursor differentiation, migration, proliferation, axon guidance, and stem cell biology
Rajan Jain	Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Christopher Lengner	The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis.
Thomas Leung	We seek to improve our understanding of mammalian tissue regeneration and to develop novel therapeutics for regenerative medicine.
Edward Morrisey	Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Foteini Mourkioti	Muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting.
Panteleimon Rompolas	Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration.
Yuanquan Song	Neural degeneration, Neural regeneration, Neurodegenerative diesases, Drosophila, Spinal cord injury, Tumorigenesis

Epigenetics, Gene Regulatory Networks, & Signal Integration

Faculty	Brief Research Description
Montserrat Anguera	Roles of long noncoding RNAs during early development and how their misregulation contributes to disease
Marisa Bartolomei	The research in my laboratory focuses on the study of genomic imprinting and X inactivation in mice.
Maya Capelson	Nuclear structure and its role in gene regulation; Spatial organization of the genome; Epigenetic memory of gene expression states
E. Bryan Crenshaw	Analysis of the role of developmental regulatory factors during mouse embryogenesis.
Jonathan Epstein	Transcriptional regulation of cardiac development and function using mouse models
Paul Gadue	My laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using mouse and human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells.
Rajan Jain	Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Peter Klein	Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neural stem cells and neurogenesis, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3).
Christopher Lengner	The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis.
Edward Morrisey	lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Michael Parmacek	Transcriptional programs that regulate cardiovascular development
Ling Qin	Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction
Panteleimon Rompolas	Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration.
Patrick Seale	Our lab investigates the transcriptional pathways that control the development, differentiation and function of adipose cells in normal development and in obesity.
Nancy Speck	Hematopoietic stem cells and leukemia using mouse models
Jeremy Wang	Regulation of meiosis, silencing of transposable elements, piRNA biogenesis, DNA recombination, chromosome segregation, DNA double-strand break repair, chromosome synapsis, male infertility in humans.

For information on how to apply for CAMB Faculty membership, please see the CAMB Bylaws.