Developmental, Stem Cell, and Regenerative Biology Faculty

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Current Members

Developmental, Stem Cell and Regenerative Biology

Click the faculty member's name to see more detailed information.

Faculty

Michael C. Abt, PhD	Fanxin Long, Ph.D.
Juan R Alvarez, PhD	Wenqin Luo, M.D, Ph.D
Stewart A Anderson, MD	Robert L Mauck, PhD
Montserrat C Anguera, PhD	Mustafa Mir, Ph.D.
Naiara Aquizu Lopez, Ph.D.	Andrew J Modzelewski, PhD
Michael L. Atchison, PhD	Edward E. Morrisey, Ph.D.
Marisa S. Bartolomei, Ph.D.	Foteini Mourkioti, PhD
Greg J. Bashaw, Ph.D.	Mary C. Mullins, Ph.D.
Maria Ciocca Basil, MD PhD	John Isaac Murray, Ph.D.
Elizabeth Bhoj, M.D., Ph.D.	Xilma R Ortiz-Gonzalez, MD PhD
Stella T Chou, M.D.	Kyla Ortved, DVM, PhD, DACVS, DACVSMR
Kimberly M Christian, Ph.D.	Michael A. Pack, MD
Colin Conine, PhD	Michael S. Parmacek, M.D.
George Cotsarelis, M.D.	Jennifer E. Phillips-Cremins, Ph.D.
Stephen (He, Him) DiNardo, Ph.D.	Richard Scott Poethig, Ph.D.
Theodore G. Drivas, MD PhD	Ling Qin, Ph.D.
Jonathan A. Epstein, M.D.	Bushra Raj, Ph.D.
Douglas J. Epstein, Ph.D.	Jonathan A. Raper, Ph.D.
David B. Frank, MD, PhD	Panteleimon Rompolas, M.B.A., Ph.D.
Marc V Fuccillo, M.D., Ph.D.	Kotaro Sasaki, MD, PhD
Paul J Gadue, PhD	Patrick Seale, Ph.D.
Kimberly L Gallagher	Shaon Sengupta, MBBS, MPH, FAAP
Matthew C Good, Ph.D.	Eileen M. Shore, Ph.D.
Riccardo Gottardi, PhD	Arndt Siekmann, Ph.D.
Michael Granato, Ph.D.	Hongjun Song, Ph.D.
Judith B. Grinspan, Ph.D.	Yuanquan Song, Ph.D.
Kathryn (Kate) Hamilton, PhD	Nancy A. Speck, Ph.D.
Robert O. Heuckeroth, M.D. Ph.D.	Meera V. Sundaram, Ph.D
Alex J Hughes	Natalie A Terry, M.D., Ph.D.
Aman Yebio Husbands	Wei Tong, PhD
Olena Jacenko	Katherine Uyhazi, MD, PhD
Rajan Jain, MD	Andrew E Vaughan
Kyu Sang Joeng, Ph.D.	Doris Wagner, PhD
Yana G. Kamberov, Ph.D.	P. Jeremy Wang, MD, PhD
Daniel S. Kessler, Ph.D.	Xiaowei Xu, MD, PhD
Peter S. Klein, MD, PhD	Xiaolu Yang, Ph.D.
Peter Kurre, MD	Shuying Yang
Christopher Joachim Lengner, Ph.D.	Kenneth S. Zaret, PhD
Thomas H. Leung, M.D., Ph.D.	Jarod A. Zepp, PhD
Chien-Wei Eric Liao, M.D., Ph.D	Zhaolan (Joe) Zhou, Ph.D.
Krithika Lingappan, MD MS PhD

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Faculty areas of research in DSRB can be broken up into the following eight categories:

Gametogenesis

Faculty	Brief Research Description
Marisa Bartolomei	The research in my laboratory focuses on the study of genomic imprinting and X inactivation in mice.
Colin Conine	The functions of small RNAs in fertility, inheritance, and development.
Stephen DiNardo	Stem Cells, Niche, Epithelial Morphogenesis, Cell Polarity
George Gerton	Spermatogenesis, Acrosome, Spermatid, Flagellum, Acrosomal matrix, Preimplantation, Embryo, Trophoblast.
Christopher Lengner	Interested in the mechanisms by which both somatic and embryonic stem cells acquire and maintain developmental potency. We are also exploring how deregulation of these mechanisms can contribute to oncogenic transformation and tumorigenesis, and how we can learn to manipulate these mechanisms for application in disease modeling and regenerative medicine
Mary Mullins	BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates.
P. Jeremy Wang	Regulation of meiosis, piRNA biogenesis, DNA recombination, chromosome segregation, DNA double-strand break repair, chromosome synapsis, male infertility in humans.

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Embryo & Fetal Development

Faculty	Brief Research Description
Montserrat C Anguera	Roles of long noncoding RNAs during early development and how their misregulation results in disease
Elizabeth Bhoj	Our lab works in translational genetics to improve diagnosis and treatment through the discovery, mechanistic understanding, and targeted treatment of novel human syndromes.
Colin Conine	The functions of small RNAs in fertility, inheritance, and development.
E. Bryan Crenshaw	Analysis of the role of developmental regulatory factors during mouse embryogenesis
Jonathan Epstein	Transcriptional regulation of cardiac development and function using mouse models
Robert Heuckeroth	Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development
Peter Klein	Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3)
Andrew Modzelewski	Investigating the role and regulation of retrotransposons in development and disease
Edward Morrisey	Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Mary Mullins	BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates
John Murray	Developmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans
Michael Pack	Research interests: Research in my laboratory is geared towards studying medically relevant aspects of digestive organ development
Jonathan Raper	Developmental neurobiology, especially axon guidance
Patrick Seale	Stem Cells, Embryonic development, Adipocyte progenitors, Brown adipose tissue, White adipose tissue, PRDM16, PPARgamma
Nancy Speck	Hematopoietic stem cells and leukemia using mouse models
Meera Sundaram	Tubulogenesis and Epithelial matrix biology in C. elegans
Wei Tong	Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication

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Cell Migration, Polarity, and Morphogenesis

Faculty	Brief Research Description
Greg Bashaw	Axon guidance, developmental neuroscience, Slit, Robo, Netrin.
Steve DiNardo	Migration and polarization of niche cells
Michael Granato	Axonal guidance, nerve regeneration and learning behaviors in zebrafish
Robert Heuckeroth	Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development
Olena Jacenko	Molecular mechanisms of skeletal development and blood cell differentiation.
Mary Mullins	BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates.
John Murray	Developmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans
Michael Pack	Zebrafish and mouse genetics, developmental biology, cancer, chemical genetics
Richard Poethig	miRNA, siRNA, RNAi, developmental genetics, developmental timing, plants.
Jonathan Raper	axon guidance, developmental neurobiology, Molecular biology; tissue culture; Protein biochemistry; Videomicroscopy, expression cloning; mouse, chick, zebrafish.
Arndt Siekmann	Development of the vascular system with a focus on investigating the mechanisms leading to arterial-venous malformations
Meera Sundaram	Tubulogenesis and Epithelial matrix biology in C. elegans

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Neurogenesis and Axonogenesis

Faculty	Brief Research Description
Stewart A Anderson	GABAergic interneurons of the cerebral cortex in development and in disease (epilepsy, schizophrenia, autism)
Greg Bashaw	- Molecular mechanisms of axon growth and guidance during nervous system development. - How axon guidance receptors specify attractive and repulsive signals and transmit these signals to the navigating growth cone. - Formation of Neural Circuits at the Midline
Elizabeth Bhoj	Our lab works in translational genetics to improve diagnosis and treatment through the discovery, mechanistic understanding, and targeted treatment of novel human syndromes.
Michael Granato	Axonal guidance, nerve regeneration and learning behaviors in zebrafish
Judith Grinspan	Our lab studies the controls of the development of oligodendrocytes, the myelinating cells of the central nervous system, from stem cells through to myelination.
Robert Heuckeroth	Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development.
Peter Klein	Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3).
Xilma Ortiz-Gonzalez	My laboratory studies mechanism underlying neurodegeneration using ultra-rare pediatric monogenic disorders as disease models
Bushra Raj	Gene regulatory code and dynamics of neural development
Jonathan Raper	developmental neurobiology, especially axon guidance
Wenqin Luo	Development and Function of Mammalian Mechanosensory Dorsal Root Ganglion (DRG) Neurons

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Tissue & Organ Formation

Faculty	Brief Research Description
Elizabeth Bhoj	Our lab works in translational genetics to improve diagnosis and treatment through the discovery, mechanistic understanding, and targeted treatment of novel human syndromes.
Maya Capelson	Nuclear structure and its role in gene regulation Spatial organization of the genome Epigenetic memory of gene expression states
Stephen DiNardo	We study how organs place and organize their niches.
Robert Heuckeroth	Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development.
Olena Jacenko	molecular mechanisms of skeletal development and blood cell differentiation.
Rajan Jain	Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Fanxin Long	We study the formation and maintenance of skeletal tissues.
Foteini Mourkioti	Muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting.
Mary Mullins	BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates.
Michael Pack	Research in my laboratory is geared towards studying medically relevant aspects of digestive organ development.
Michael Parmacek	Transcriptional programs that regulate cardiovascular development
R. Scott Poethig	Genetic regulation of the juvenile-to-adult transition in plants The developmental function of RNAi in plants
Ling Qin	Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction
Bushra Raj	Gene regulatory code and dynamics of neural development
Jonathan Raper	developmental neurobiology, especially axon guidance
Panteleimon Rompolas	Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration
Nancy Speck	Hematopoietic stem cells and leukemia using mouse models
Patrick Seale	Obesity is the predominant risk factor for an expanding array of diseases including: type 2 diabetes, heart disease, stroke and cancer. Our lab investigates the transcriptional pathways that control the development, differentiation and function of adipose cells in normal development and in obesity.
Meera Sundaram	Tubulogenesis and Epithelial matrix biology in C. elegans
Wei Tong	Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication

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Stem Cell/Niche Interactions

Faculty	Brief Research Description
George Cotsarelis	Stem cells; Hair follicle; Wounding; Aging; Skin cancer
Stephen DiNardo	Live-imaging to study stem cell behavior in real-time
Paul Gadue	My laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using mouse and human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells.
Judith Grinspan	Our lab studies the controls of the development of oligodendrocytes, the myelinating cells of the central nervous system, from stem cells through to myelination.
Robert Heuckeroth	Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development.
Olena Jacenko	molecular mechanisms of skeletal development and blood cell differentiation.
Rajan Jain	Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Peter Klein	Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3).
Christopher Lengner	The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis.
Fanxin Long	We study mesenchymal stem/progenitor cells and their interactions with other cell ipopulations n either the bone marrow or the periosteal niche.
Edward Morrisey	Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Foteini Mourkioti	muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting.
Xilma Ortiz-Gonzalez	My laboratory studies mechanism underlying neurodegeneration using ultra-rare pediatric monogenic disorders as disease models
Panteleimon Rompolas	Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration
Nancy Speck	Hematopoietic stem cells and leukemia using mouse models
Ling Qin	Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction
Wei Tong	Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication

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Regenerative Biology

Faculty	Brief Research Description
George Cotsarelis	Stem cells; Hair follicle; Wounding; Aging; Skin cancer
Jonathan Epstein	Transcriptional regulation of cardiac development and function using mouse models
Michael Granato	Axonal guidance, nerve regeneration and learning behaviors in zebrafish
Robert Heuckeroth	Enteric nervous system precursor differentiation, migration, proliferation, axon guidance, and stem cell biology
Rajan Jain	Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Christopher Lengner	The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis.
Thomas Leung	We seek to improve our understanding of mammalian tissue regeneration and to develop novel therapeutics for regenerative medicine.
Fanxin Long	We study the biology of both bone remodeling, a continuous regenerative process necessary for maintaining bone integrity, and also bone regeneration during fracture repair.
Andrew Modzelewski	Investigating the role and regulation of retrotransposons in development and disease
Edward Morrisey	Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Foteini Mourkioti	Muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting.
Panteleimon Rompolas	Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration.
Yuanquan Song	Neural degeneration, Neural regeneration, Neurodegenerative diesases, Drosophila, Spinal cord injury, Tumorigenesis
Wei Tong	Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication

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Epigenetics, Gene Regulatory Networks, & Signal Integration

Faculty	Brief Research Description
Montserrat Anguera	Roles of long noncoding RNAs during early development and how their misregulation contributes to disease
Marisa Bartolomei	The research in my laboratory focuses on the study of genomic imprinting and X inactivation in mice.
Elizabeth Bhoj	Our lab works in translational genetics to improve diagnosis and treatment through the discovery, mechanistic understanding, and targeted treatment of novel human syndromes.
Colin Conine	The functions of small RNAs in fertility, inheritance, and development.
E. Bryan Crenshaw	Analysis of the role of developmental regulatory factors during mouse embryogenesis.
Jonathan Epstein	Transcriptional regulation of cardiac development and function using mouse models
Paul Gadue	My laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using mouse and human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells.
Rajan Jain	Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Peter Klein	Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neural stem cells and neurogenesis, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3).
Christopher Lengner	The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis.
Fanxin Long	We study the metabolomic and epigenetic regulation of skeletal cell differentiation.
Andrew Modzelewski	Investigating the role and regulation of retrotransposons in development and disease
Edward Morrisey	lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
John Murray	Developmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans
Michael Parmacek	Transcriptional programs that regulate cardiovascular development
Ling Qin	Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction
Panteleimon Rompolas	Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration.
Patrick Seale	Our lab investigates the transcriptional pathways that control the development, differentiation and function of adipose cells in normal development and in obesity.
Nancy Speck	Hematopoietic stem cells and leukemia using mouse models
Wei Tong	Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication
Jeremy Wang	Regulation of meiosis, silencing of transposable elements, piRNA biogenesis, DNA recombination, chromosome segregation, DNA double-strand break repair, chromosome synapsis, male infertility in humans.

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