Developmental, Stem Cell, and Regenerative Biology Faculty

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Developmental, Stem Cell and Regenerative Biology Members

Current Members

Developmental, Stem Cell and Regenerative Biology

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Faculty

Aman Yebio Husbands


Faculty areas of research in DSRB can be broken up into the following eight categories:

Faculty Brief Research Description
Marisa Bartolomei  The research in my laboratory focuses on the study of genomic imprinting and X inactivation in mice.
Colin Conine The functions of small RNAs in fertility, inheritance, and development.
Stephen DiNardo Stem Cells, Niche, Epithelial Morphogenesis, Cell Polarity
Christopher Lengner  Interested in the mechanisms by which both somatic and embryonic stem cells acquire and maintain developmental potency. We are also exploring how deregulation of these mechanisms can contribute to oncogenic transformation and tumorigenesis, and how we can learn to manipulate these mechanisms for application in disease modeling and regenerative medicine
Mary Mullins  BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates.
P. Jeremy Wang  Regulation of meiosis, piRNA biogenesis, DNA recombination, chromosome segregation, DNA double-strand break repair, chromosome synapsis, male infertility in humans.

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Faculty Brief Research Description
Montserrat C Anguera Roles of long noncoding RNAs during early development and how their misregulation results in disease
Elizabeth Bhoj Our lab works in translational genetics to improve diagnosis and treatment through the discovery, mechanistic understanding, and targeted treatment of novel human syndromes.
Colin Conine The functions of small RNAs in fertility, inheritance, and development.
E. Bryan Crenshaw Analysis of the role of developmental regulatory factors during mouse embryogenesis
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models
Robert Heuckeroth Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development
Peter Klein Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3)
Andrew Modzelewski Investigating the role and regulation of retrotransposons in development and disease
Edward Morrisey Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Mary Mullins  BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates
John Murray Developmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans
Michael Pack Research interests: Research in my laboratory is geared towards studying medically relevant aspects of digestive organ development
Jonathan Raper Developmental neurobiology, especially axon guidance
Patrick Seale Stem Cells, Embryonic development, Adipocyte progenitors, Brown adipose tissue, White adipose tissue, PRDM16, PPARgamma
Nancy Speck Hematopoietic stem cells and leukemia using mouse models
Meera Sundaram Tubulogenesis and Epithelial matrix biology in C. elegans
Wei Tong Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication
Julia Warren

Hematopoietic stem cell biology, granulopoiesis, genetics of bone marrow failure syndromes especially severe congenital neutropenia, mitochondria function and proteostasis in hematopoiesis, leukemia

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Faculty Brief Research Description
Greg Bashaw Axon guidance, developmental neuroscience, Slit, Robo, Netrin.
Steve DiNardo Migration and polarization of niche cells
Michael Granato Axonal guidance, nerve regeneration and learning behaviors in zebrafish
Robert Heuckeroth Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development
Olena Jacenko Molecular mechanisms of skeletal development and blood cell differentiation.
Mary Mullins BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates.
John Murray Developmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans
Michael Pack  Zebrafish and mouse genetics, developmental biology, cancer, chemical genetics
Richard Poethig  miRNA, siRNA, RNAi, developmental genetics, developmental timing, plants.
Jonathan Raper axon guidance, developmental neurobiology, Molecular biology; tissue culture; Protein biochemistry; Videomicroscopy, expression cloning; mouse, chick, zebrafish.
Arndt Siekmann

Development of the vascular system with a focus on investigating the mechanisms leading to arterial-venous malformations

Meera Sundaram Tubulogenesis and Epithelial matrix biology in C. elegans

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Faculty Brief Research Description
Stewart A Anderson GABAergic interneurons of the cerebral cortex in development and in disease (epilepsy, schizophrenia, autism)
Greg Bashaw - Molecular mechanisms of axon growth and guidance during nervous system development.
- How axon guidance receptors specify attractive and repulsive signals and transmit these signals to the navigating growth cone.
- Formation of Neural Circuits at the Midline
Elizabeth Bhoj Our lab works in translational genetics to improve diagnosis and treatment through the discovery, mechanistic understanding, and targeted treatment of novel human syndromes.
Michael Granato  Axonal guidance, nerve regeneration and learning behaviors in zebrafish
Judith Grinspan  Our lab studies the controls of the development of oligodendrocytes, the myelinating cells of the central nervous system, from stem cells through to myelination.
Robert Heuckeroth Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development.
Peter Klein  Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3).
Xilma Ortiz-Gonzalez

My laboratory studies mechanism underlying neurodegeneration using ultra-rare pediatric monogenic disorders as disease models

Bushra Raj Gene regulatory code and dynamics of neural development
Jonathan Raper  developmental neurobiology, especially axon guidance
Wenqin Luo  Development and Function of Mammalian Mechanosensory Dorsal Root Ganglion (DRG) Neurons
Katherine Uyhazi Visual system disorders, photoreceptor development, cell-based therapies for retinal regeneration

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Faculty Brief Research Description
Elizabeth Bhoj Our lab works in translational genetics to improve diagnosis and treatment through the discovery, mechanistic understanding, and targeted treatment of novel human syndromes.
Maya Capelson Nuclear structure and its role in gene regulation
Spatial organization of the genome
Epigenetic memory of gene expression states
Stephen DiNardo  We study how organs place and organize their niches.
Robert Heuckeroth Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development.
Olena Jacenko  molecular mechanisms of skeletal development and blood cell differentiation.
Rajan Jain Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Fanxin Long We study the formation and maintenance of skeletal tissues.
Foteini Mourkioti Muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting.
Mary Mullins  BMP signal transduction; molecular mechanisms of cell specification and maternal control in vertebrates.
Michael Pack  Research in my laboratory is geared towards studying medically relevant aspects of digestive organ development.
Michael Parmacek Transcriptional programs that regulate cardiovascular development
R. Scott Poethig  Genetic regulation of the juvenile-to-adult transition in plants
The developmental function of RNAi in plants
Ling Qin  Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction
Bushra Raj Gene regulatory code and dynamics of neural development
Jonathan Raper  developmental neurobiology, especially axon guidance
Panteleimon Rompolas Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration
Nancy Speck  Hematopoietic stem cells and leukemia using mouse models
Patrick Seale Obesity is the predominant risk factor for an expanding array of diseases including: type 2 diabetes, heart disease, stroke and cancer. Our lab investigates the transcriptional pathways that control the development, differentiation and function of adipose cells in normal development and in obesity.
Meera Sundaram Tubulogenesis and Epithelial matrix biology in C. elegans
Wei Tong Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication
Julia Warren

Hematopoietic stem cell biology, granulopoiesis, genetics of bone marrow failure syndromes especially severe congenital neutropenia, mitochondria function and proteostasis in hematopoiesis, leukemia

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Faculty Brief Research Description
George Cotsarelis Stem cells; Hair follicle; Wounding; Aging; Skin cancer
Stephen DiNardo Live-imaging to study stem cell behavior in real-time
Paul Gadue My laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using mouse and human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells.
Judith Grinspan Our lab studies the controls of the development of oligodendrocytes, the myelinating cells of the central nervous system, from stem cells through to myelination.
Robert Heuckeroth Our research is focused on the molecular and cellular mechanisms that control enteric nervous system development.
Olena Jacenko molecular mechanisms of skeletal development and blood cell differentiation.
Rajan Jain Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Peter Klein Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3).
Kang Ko

Epithelial-immune and mesenchymal-immune interactions in periodontitis (oral inflammatory disease) and wound healing process

Peter Kurre

The Kurre Lab is interested in the bidirectional crosstalk between hematopoietic stem and progenitor cells and components of the healthy bone marrow niche as well as leukemic blasts of the leukemic niche. Emphasis for our work is on the specific role of nanoscale sized extracellular vesicles.

Christopher Lengner The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis.
Fanxin Long We study mesenchymal stem/progenitor cells and their interactions with other cell ipopulations n either the bone marrow or the periosteal niche.
Edward Morrisey Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Foteini Mourkioti muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting.
Xilma Ortiz-Gonzalez

My laboratory studies mechanism underlying neurodegeneration using ultra-rare pediatric monogenic disorders as disease models

Panteleimon Rompolas Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration
Nancy Speck Hematopoietic stem cells and leukemia using mouse models
Ling Qin Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction
Wei Tong

Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication

Julia Warren

Hematopoietic stem cell biology, granulopoiesis, genetics of bone marrow failure syndromes especially severe congenital neutropenia, mitochondria function and proteostasis in hematopoiesis, leukemia

Close

Faculty Brief Research Description
George Cotsarelis  Stem cells; Hair follicle; Wounding; Aging; Skin cancer
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models
Michael Granato Axonal guidance, nerve regeneration and learning behaviors in zebrafish
Robert Heuckeroth Enteric nervous system precursor differentiation, migration, proliferation, axon guidance, and stem cell biology
Rajan Jain Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Kang Ko  Investigating the mechanisms by which fibroblasts from the oral cavity and skin differ at the functional and molecular level that can explain superior wound healing in the gingiva/gum tissue
Christopher Lengner The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis.
Thomas Leung We seek to improve our understanding of mammalian tissue regeneration and to develop novel therapeutics for regenerative medicine.
Fanxin Long

We study the biology of both bone remodeling, a continuous regenerative process necessary for maintaining bone integrity, and also bone regeneration during fracture repair.

Andrew Modzelewski Investigating the role and regulation of retrotransposons in development and disease
Edward Morrisey Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
Foteini Mourkioti Muscle disorders, NF-kB signaling, M2 macrophages, muscle regeneration, stem cells, muscular dystrophy, telomeres, cardiomyopathy, mitochondria, oxidative stress, muscle atrophy, muscle wasting.
Panteleimon Rompolas Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration.
Yuanquan Song Neural degeneration, Neural regeneration, Neurodegenerative diesases, Drosophila, Spinal cord injury, Tumorigenesis
Wei Tong Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication
Katherine Uyhazi Visual system disorders, photoreceptor development, cell-based therapies for retinal regeneration

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Faculty Brief Research Description
Montserrat Anguera

Epigenetic mechanisms of X-Chromosome Inactivation in immune cells & immune-related diseases

Marisa Bartolomei The research in my laboratory focuses on the study of genomic imprinting and X inactivation in mice.
Elizabeth Bhoj Our lab works in translational genetics to improve diagnosis and treatment through the discovery, mechanistic understanding, and targeted treatment of novel human syndromes.
Colin Conine The functions of small RNAs in fertility, inheritance, and development.
E. Bryan Crenshaw Analysis of the role of developmental regulatory factors during mouse embryogenesis.
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models
Paul Gadue My laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using mouse and human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells.
Rajan Jain Nuclear architecture, nuclear lamina, chromatin, epigenetics, genome organization, heart development, stem cell biology
Peter Klein Early vertebrate development and pattern formation, Wnt signaling, chromatin and epigenetic regulation of early development, hematopoietic stem cell biology, neural stem cells and neurogenesis, neuropharmacology of bipolar disorder, lithium and glycogen synthase kinase-3 (GSK-3).
Christopher Lengner The overarching goal of my research program is to gain an understanding of the molecular mechanisms that govern stem cell potency and how dysregulation of these mechanisms can contribute to disease onset and progression, including oncogenesis.
Fanxin Long We study the metabolomic and epigenetic regulation of skeletal cell differentiation.
Andrew Modzelewski Investigating the role and regulation of retrotransposons in development and disease
Edward Morrisey lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors
John Murray Developmental regulatory networks, dynamics of embryonic gene expression, and single-cell methods in C. elegans
Michael Parmacek Transcriptional programs that regulate cardiovascular development
Ling Qin Bone metabolism, stem cell biology, growth plate development, cancer bone metastasis, and signal transduction
Panteleimon Rompolas Mechanisms of epithelial stem cell fate and plasticity in skin morphogenesis and regeneration.
Patrick Seale Our lab investigates the transcriptional pathways that control the development, differentiation and function of adipose cells in normal development and in obesity.
Nancy Speck Hematopoietic stem cells and leukemia using mouse models
Wei Tong Stem cell biology and regenerative medicine, leukemia, signal transduction and gene regulation, ribosome biogenesis, DNA replication
Jeremy Wang Regulation of meiosis, silencing of transposable elements, piRNA biogenesis, DNA recombination, chromosome segregation, DNA double-strand break repair, chromosome synapsis, male infertility in humans.
Julia Warren

Hematopoietic stem cell biology, granulopoiesis, genetics of bone marrow failure syndromes especially severe congenital neutropenia, mitochondria function and proteostasis in hematopoiesis, leukemia

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