Cell Biology, Physiology, and Metabolism Faculty

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The Program in Cell Biology, Physiology, and Metabolism is dedicated to training graduate students in the diversity of medical science that defines modern cell biology, as well as providing ample time and resources for specializations.

Current Members

Cell Biology, Physiology and Metabolism

Click the faculty member's name to see more detailed information.

Faculty

Charles S. Abrams, M.D.	Edward B Lee, MD, PhD
Juan R Alvarez, PhD	Robert J. Lee, Ph.D.
Zoltan Pierre Arany, MD, PhD	Krithika Lingappan, MD MS PhD
Yair Argon, Ph.D.	Fange Liu, Ph.D
Will Bailis, Ph.D.	Fanxin Long, Ph.D.
Joseph A. Baur, PhD	Damaris Lorenzo, MSc, PhD
Erfei Bi, Ph.D.	Zhe Lu, MD, PhD
Ben E. Black, Ph.D.	Francis Luca, PhD
Kahlilia Blanco	David R. Lynch, MD, PhD
Donita C. Brady, Ph.D.	Minghong Ma, Ph.D.
Lawrence F. Brass, MD, PhD	Sandra Maday, Ph.D.
Janis K. Burkhardt, Ph.D.	Kenneth B. Margulies, M.D.
Natali L Chanaday, PhD	Michael S. Marks, Ph.D.
Qi N. Cui, MD, PhD	David M Merrick, MD, PhD
Andrew Dancis, M.D.	Claire H. Mitchell, Ph.D.
Sharlene M. Day, MD	Guilherme P.F. Nader, Ph.D.
Carol J. Deutsch, Ph.D.	Roddy O'Connor, B.Sc., M.S., Ph.D.
Dennis E. Discher, Ph.D.	Xilma R Ortiz-Gonzalez, MD PhD
Roberto Dominguez, Ph.D.	Michael Ostap, Ph.D.
Joshua L. Dunaief, MD, PhD	Liming Pei, Ph.D.
Aron B. Fisher, M.D.	Dipti Pitta, MVSc, PhD
J. Kevin Foskett, PhD	Mechthild Pohlschroder
Aime T. Franco, Ph.D.	Benjamin L. Prosser, Ph.D
David B. Frank, MD, PhD	David M. Raizen, MD, PhD
Yale E. Goldman, MD, PhD	Akhilesh Basi Reddy, MA MB BChir PhD
Matthew C Good, Ph.D.	Dejian Ren, Ph.D.
Ekaterina L. Grishchuk, Ph.D.	Stefano B Rivella, PhD
Marie A Guerraty, MD, PhD	Jeffrey David Roizen, M.D., Ph.D.
Wei Guo, Ph.D.	Brian M. Salzberg, Ph.D.
Malay Haldar, MBBS, PhD	Kotaro Sasaki, MD, PhD
Jorge Henao-Mejia, M.D., Ph.D.	Patrick Seale, Ph.D.
Robert O. Heuckeroth, M.D. Ph.D.	Amita Sehgal, Ph.D.
David A. Hill, MD, PhD, FAAP, FAAAAI	John T. Seykora, M.D., Ph.D
Erika L.F. Holzbaur, Ph.D.	James Shorter, M.A., Ph.D.
Paul A. Janmey, Ph.D.	Arndt Siekmann, Ph.D.
Thomas A. Jongens, Ph.D.	Katalin Susztak, MD, PhD
Kelly L Jordan-Sciutto, PhD	Tatyana M. Svitkina, Ph.D.
Mark L. Kahn, M.D.	Christoph A. Thaiss, Ph.D.
Anna Kashina, Ph.D.	Christopher Thom, MD, PhD
Daniel P Kelly, MD	Paul M. Titchenell, Ph.D.
Tejvir S. Khurana, MD, PhD	Phong Tran, Ph.D.
Vera P. Krymskaya, PhD, MBA, FCPP	Andrew van Eps, BVSc, PhD
Melike Lakadamyali, Ph.D.	John W. Weisel, Ph.D.
Michael Lampson	Kathryn E. Wellen, Ph.D.
Vivian Lee, MD	Rebecca G. Wells, MD
Virginia Man-Yee Lee, Ph.D.	Gary D. Wu, MD

Research Topics

Cellular Metabolism

Faculty	Brief Research Description
Zoltan Pierre Arany	Cardiovascular metabolism
Will Bailis	Immune Cell Metabolism
Joseph A. Baur	Molecular mechanisms of aging
Joshua Dunaief	Retinal iron trafficking and its role in retinal disease
J. Kevin Foskett	Ion channels, calcium signaling, cystic fibrosis.
David Frank	Cellular and molecular mechanism of pulmonary vascular growth, disease, and homeostasis
Thomas Jongens	Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Daniel Kelly	Transcriptional and epigenetic control of mitochondrial function; nuclear receptor signaling in the developing and diseased heart; molecular mechanisms controlling muscle metabolic fitness.
Mitchell Lazar	Regulation of gene expression and metabolism by nuclear hormone receptors.
Robert Lee	Epithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis
Virginia Lee	Tau, a-synuclein and amyloid beta precursor protein (APP), and their roles in the pathobiology of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson’s disease (PD), and frontotemporal dementias (FTD).
Fanxin Long	Energy metabolism in skeletal cell types under normal or pathological conditions
Damaris Lorenzo	Cytoskeleton and membrane adaptors in metabolic processes using cell and mouse models.
Benjamin L. Prosser	Cardiac electrophysiology; excitation-contraction coupling; calcium signaling; mechanotransduction; redox signaling
Christoph Thaiss	Body-brain communication in aging, cancer, inflammatory, cardiovascular, and neurodegenerative diseases
Paul Titchenell	Molecular mechanisms of insulin signaling and insulin resistance

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Cell Motility, The Cytoskeleton, and Muscle Physiology

Faculty	Brief Research Description
Erfei Bi	Development of cell polarity and control of cytokinesis in budding yeast.
Janis Burkhardt	Cytoskeletal control of immune cell function, leukocyte adhesion and motility, cell mechanics, membrane-cortex attachment, TCR and integrin signaling.
Dennis Discher	Cell and nuclear membrane structure-function; Adhesion mechanisms and responses of cells; Phagocyte recognition processes; Membrane skeleton and cytoskeleton; Diseases ranging from muscular dystrophy to anemias to athersclerosis; Drug delivery.
Yale Goldman	Relating the structural changes to enzymatic reactions and mechanical steps of the energy transduction mechanism by mapping the real-time domain motions of the motor proteins and ribosomal elongation factors.
Ekaterina L. Grishchuk	Mechanisms that drive and control chromosome motions in mitosis
Wei Guo	The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis.
Erika L. Holzbaur	Microtubule-based motility.
Paul Janmey	Cytoskeleton, phosphoinositide signalling, cell mechanics.
Thomas Jongens	Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Anna S. Kashina	Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis.
Michael Lampson	Cell division, selfish centromeres and centromere evolution, germline epigenetic inheritance
Damaris Lorenzo	Cytoskeleton and membrane adaptors in cellular and organism metabolism.
Frank Luca	Yeast and mammalian cell cycle regulation; Cytokinesis. Daughter cell-specific gene expression; Polarized growth. Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM).
Guilherme Nader	Nuclear mechanosensing pathways during cell migration and invasion
Michael Ostap	Molecular mechanisms of cell motility.
Benjamin Prosser	Mechano-signaling in heart
Arndt Siekmann	Development of the vascular system with a focus on investigating the mechanisms leading to arterial-venous malformations
Tatyana Svitkina	Roles of the cytoskeleton in cell motility.
Phong Tran	The cytoskeleton and cellular pattern formation.
John W. Weisel	Intermolecular and cellular interactions in blood clotting, fibrinolysis, and atherosclerosis studied by molecular biophysical methods.

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Intracellular Trafficking and Organelle Function

Faculty	Brief Research Description
Zoltan Pierre Arany	Cardiovascular metabolism
Yair Argon	Functions of molecular chaperones in the immune system - modulation of antigen receptors expression and of peptide presentation
Joseph A. Baur	Molecular mechanisms of aging
Erfei Bi	Development of cell polarity and control of cytokinesis in budding yeast
Janis Burkhardt	Cytoskeletal control of immune cell function, leukocyte adhesion and motility, cell mechanics, membrane-cortex attachment, TCR and integrin signaling
Natali Chanaday	Molecular mechanisms of neuronal communication
Margaret Chou	Mechanisms of malignant transformation; signaling by small GTPases; regulation of vesicular trafficking; ubiquitination
Andy Dancis	Iron transport into mitochondria, Heme synthesis, Fe-S cluster biogenesis, Yeast genetics, and Sideroblastic anemia
Carol Deutsch	Function and assembly of potassium channels in human T lymphocytes
Robert Doms	HIV; Emerging viral pathogens; Cell biology of Alzheimer's disease
J. Kevin Foskett	Ion channels, calcium signaling, cystic fibrosis.
Yale Goldman	Relating the structural changes to enzymatic reactions and mechanical steps of the energy transduction mechanism by mapping the real-time domain motions of the motor proteins and ribosomal elongation factors.
Wei Guo	The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis.
Erika L. Holzbaur	Microtubule-based motility.
Paul Janmey	Cytoskeleton, phosphoinositide signaling, cell mechanics.
Thomas Jongens	Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Anna S. Kashina	Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis.
Damaris Lorenzo	Cytoskeleton and membrane adaptors in cellular and organism metabolism.
Frank Luca	Yeast and mammalian cell cycle regulation; Cytokinesis. Daughter cell-specific gene expression; Polarized growth. Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM).
Michael S. Marks	Regulation and diseases of intracellular protein transport and organelle biogenesis.
Michael Ostap	Molecular mechanisms of cell motility.
Mechthild Pohlschroder	Prokaryotic protein translocation across hydrophobic membranes.

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Membrane Transport

Faculty	Brief Research Description
Natali Chanaday	Molecular mechanisms of neuronal communication
Carol Deutsch	Function and assembly of potassium channels in human T lymphocytes.
Josuha Dunaief	Retinal iron trafficking and its role in retinal disease
J. Kevin Foskett	Ion channels, calcium signaling, cystic fibrosis.
Robert Lee	Epithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis
Damaris Lorenzo	Cytoskeleton and membrane adaptors in cellular and organism metabolism.
Zhe Lu	Molecular and biophysical mechanisms of ion channels.
Minghong Ma	Neurobiology of the sense of smell
Dejian Ren	Regulation of cellular excitability by ion channels and calcium signaling.

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Signal Transduction

Faculty	Brief Research Description
Yair Argon	Functions of molecular chaperones in the immune system - modulation of antigen receptors expression and of peptide presentation.
Lawrence F. Brass	Mechanisms of thrombosis.
Janis Burkhardt	Cytoskeletal control of immune cell function, leukocyte adhesion and motility, cell mechanics, membrane-cortex attachment, TCR and integrin signaling
Natali Chanaday	Molecular mechanisms of neuronal communication
Margaret Chou	Mechanisms of malignant transformation; signaling by small GTPases; regulation of vesicular trafficking; ubiquitination.
Dennis Discher	Cell and nuclear membrane structure-function; Adhesion mechanisms and responses of cells; Phagocyte recognition processes; Membrane skeleton and cytoskeleton; Diseases ranging from muscular dystrophy to anemias to athersclerosis; Drug delivery.
J. Kevin Foskett	Ion channels, calcium signaling, cystic fibrosis.
David Frank	Cellular and molecular mechanism of pulmonary vascular growth, disease, and homeostasis
Paul Janmey	Cytoskeleton, phosphoinositide signalling, cell mechanics.
Thomas Jongens	Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Mark Kahn	Signaling pathways in angiogenesis and hemostasis.
Michael Lampson	Mitotic kinase signaling, chromosome segregation in mitosis and meiosis, kinetochore function.
Robert Lee	Epithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis
Fanxin Long	Metabolic reprogramming by growth factor signaling in skeletal cells.
Damaris Lorenzo	Cytoskeleton and membrane adaptors in cellular and organism metabolism.
Guilherme Nader	Nuclear mechanosensing pathways during cell migration and invasion
Christoph Thaiss	Body-brain communication in aging, cancer, inflammatory, cardiovascular, and neurodegenerative diseases
Paul Titchenell	Molecular mechanisms of insulin signaling and insulin resistance
Stefano Rivella	Molecular mechanisms that control erythropoiesis, iron metabolism and inflammation
Rebecca Wells	TGF-ß receptor biology; Hepatic stellate cell function in liver fibrosis.

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For information on how to apply for CAMB Faculty membership, please see the CAMB Bylaws.