Cell Biology, Physiology, and Metabolism Faculty
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The Program in Cell Biology, Physiology, and Metabolism is dedicated to training graduate students in the diversity of medical science that defines modern cell biology, as well as providing ample time and resources for specializations.
Current Members
Cell Biology, Physiology and Metabolism
Click the faculty member's name to see more detailed information.
Faculty
Research Topics
| Faculty | Brief Research Description |
|---|---|
| Zoltan Pierre Arany | Cardiovascular metabolism |
| Will Bailis | Immune Cell Metabolism |
| Joseph A. Baur | Molecular mechanisms of aging |
| Joshua Dunaief | Retinal iron trafficking and its role in retinal disease |
| J. Kevin Foskett | Ion channels, calcium signaling, cystic fibrosis. |
| David Frank |
Cellular and molecular mechanism of pulmonary vascular growth, disease, and homeostasis |
| Thomas Jongens | Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification |
| Daniel Kelly | Transcriptional and epigenetic control of mitochondrial function; nuclear receptor signaling in the developing and diseased heart; molecular mechanisms controlling muscle metabolic fitness. |
| Mitchell Lazar | Regulation of gene expression and metabolism by nuclear hormone receptors. |
| Robert Lee | Epithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis |
| Virginia Lee | Tau, a-synuclein and amyloid beta precursor protein (APP), and their roles in the pathobiology of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson’s disease (PD), and frontotemporal dementias (FTD). |
| Fanxin Long | Energy metabolism in skeletal cell types under normal or pathological conditions |
| Damaris Lorenzo | Cytoskeleton and membrane adaptors in metabolic processes using cell and mouse models. |
| Benjamin L. Prosser | Cardiac electrophysiology; excitation-contraction coupling; calcium signaling; mechanotransduction; redox signaling |
| Christoph Thaiss |
Body-brain communication in aging, cancer, inflammatory, cardiovascular, and neurodegenerative diseases |
| Paul Titchenell | Molecular mechanisms of insulin signaling and insulin resistance |
| Faculty | Brief Research Description |
|---|---|
| Erfei Bi | Development of cell polarity and control of cytokinesis in budding yeast. |
| Janis Burkhardt | Cytoskeletal control of immune cell function, leukocyte adhesion and motility, cell mechanics, membrane-cortex attachment, TCR and integrin signaling. |
| Dennis Discher | Cell and nuclear membrane structure-function; Adhesion mechanisms and responses of cells; Phagocyte recognition processes; Membrane skeleton and cytoskeleton; Diseases ranging from muscular dystrophy to anemias to athersclerosis; Drug delivery. |
| Jonathan Edwards | Right ventricular heart failure, pediatric heart Failure, proteostasis |
| Yale Goldman | Relating the structural changes to enzymatic reactions and mechanical steps of the energy transduction mechanism by mapping the real-time domain motions of the motor proteins and ribosomal elongation factors. |
| Ekaterina L. Grishchuk | Mechanisms that drive and control chromosome motions in mitosis |
| Wei Guo | The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis. |
| Erika L. Holzbaur | Microtubule-based motility. |
| Paul Janmey | Cytoskeleton, phosphoinositide signalling, cell mechanics. |
| Thomas Jongens | Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification |
| Anna S. Kashina | Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis. |
| Michael Lampson | Cell division, selfish centromeres and centromere evolution, germline epigenetic inheritance |
| Damaris Lorenzo | Cytoskeleton and membrane adaptors in cellular and organism metabolism. |
| Frank Luca | Yeast and mammalian cell cycle regulation; Cytokinesis. Daughter cell-specific gene expression; Polarized growth. Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM). |
| Guilherme Nader | Nuclear mechanosensing pathways during cell migration and invasion |
| Michael Ostap | Molecular mechanisms of cell motility. |
| Benjamin Prosser | Mechano-signaling in heart |
| Arndt Siekmann |
Development of the vascular system with a focus on investigating the mechanisms leading to arterial-venous malformations |
| Tatyana Svitkina | Roles of the cytoskeleton in cell motility. |
| Phong Tran | The cytoskeleton and cellular pattern formation. |
| John W. Weisel | Intermolecular and cellular interactions in blood clotting, fibrinolysis, and atherosclerosis studied by molecular biophysical methods. |
| Faculty | Brief Research Description |
|---|---|
| Zoltan Pierre Arany | Cardiovascular metabolism |
| Yair Argon | Functions of molecular chaperones in the immune system - modulation of antigen receptors expression and of peptide presentation |
| Joseph A. Baur | Molecular mechanisms of aging |
| Erfei Bi | Development of cell polarity and control of cytokinesis in budding yeast |
| Janis Burkhardt | Cytoskeletal control of immune cell function, leukocyte adhesion and motility, cell mechanics, membrane-cortex attachment, TCR and integrin signaling |
| Natali Chanaday | Molecular mechanisms of neuronal communication |
| Margaret Chou | Mechanisms of malignant transformation; signaling by small GTPases; regulation of vesicular trafficking; ubiquitination |
| Andy Dancis | Iron transport into mitochondria, Heme synthesis, Fe-S cluster biogenesis, Yeast genetics, and Sideroblastic anemia |
| Carol Deutsch | Function and assembly of potassium channels in human T lymphocytes |
| Robert Doms | HIV; Emerging viral pathogens; Cell biology of Alzheimer's disease |
| J. Kevin Foskett | Ion channels, calcium signaling, cystic fibrosis. |
| Yale Goldman | Relating the structural changes to enzymatic reactions and mechanical steps of the energy transduction mechanism by mapping the real-time domain motions of the motor proteins and ribosomal elongation factors. |
| Wei Guo | The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis. |
| Erika L. Holzbaur | Microtubule-based motility. |
| Paul Janmey | Cytoskeleton, phosphoinositide signaling, cell mechanics. |
| Thomas Jongens | Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification |
| Kelly Jordan-Sciutto |
Impact of neuroinflammation on viability, differentiation and function of oligodendrocytes and neurons in the context of neurodegeneration |
| Anna S. Kashina | Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis. |
| Damaris Lorenzo | Cytoskeleton and membrane adaptors in cellular and organism metabolism. |
| Frank Luca | Yeast and mammalian cell cycle regulation; Cytokinesis. Daughter cell-specific gene expression; Polarized growth. Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM). |
| Michael S. Marks | Regulation and diseases of intracellular protein transport and organelle biogenesis. |
| Michael Ostap | Molecular mechanisms of cell motility. |
| Mechthild Pohlschroder | Prokaryotic protein translocation across hydrophobic membranes. |
| Faculty | Brief Research Description |
|---|---|
| Natali Chanaday |
Molecular mechanisms of neuronal communication |
| Carol Deutsch | Function and assembly of potassium channels in human T lymphocytes. |
| Josuha Dunaief | Retinal iron trafficking and its role in retinal disease |
| J. Kevin Foskett | Ion channels, calcium signaling, cystic fibrosis. |
| Robert Lee | Epithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis |
| Damaris Lorenzo | Cytoskeleton and membrane adaptors in cellular and organism metabolism. |
| Zhe Lu | Molecular and biophysical mechanisms of ion channels. |
| Minghong Ma | Neurobiology of the sense of smell |
| Dejian Ren | Regulation of cellular excitability by ion channels and calcium signaling. |
| Faculty | Brief Research Description |
|---|---|
| Yair Argon | Functions of molecular chaperones in the immune system - modulation of antigen receptors expression and of peptide presentation. |
| Lawrence F. Brass | Mechanisms of thrombosis. |
| Janis Burkhardt | Cytoskeletal control of immune cell function, leukocyte adhesion and motility, cell mechanics, membrane-cortex attachment, TCR and integrin signaling |
| Natali Chanaday |
Molecular mechanisms of neuronal communication |
| Margaret Chou | Mechanisms of malignant transformation; signaling by small GTPases; regulation of vesicular trafficking; ubiquitination. |
| Dennis Discher | Cell and nuclear membrane structure-function; Adhesion mechanisms and responses of cells; Phagocyte recognition processes; Membrane skeleton and cytoskeleton; Diseases ranging from muscular dystrophy to anemias to athersclerosis; Drug delivery. |
| Jonathan Edwards | Right ventricular heart failure, pediatric heart Failure, proteostasis |
| J. Kevin Foskett | Ion channels, calcium signaling, cystic fibrosis. |
| David Frank |
Cellular and molecular mechanism of pulmonary vascular growth, disease, and homeostasis |
| Paul Janmey | Cytoskeleton, phosphoinositide signalling, cell mechanics. |
| Thomas Jongens | Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification |
| Kelly Jordan-Sciutto |
Impact of neuroinflammation on viability, differentiation and function of oligodendrocytes and neurons in the context of neurodegeneration |
| Mark Kahn | Signaling pathways in angiogenesis and hemostasis. |
| Michael Lampson | Mitotic kinase signaling, chromosome segregation in mitosis and meiosis, kinetochore function. |
| Robert Lee | Epithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis |
| Fanxin Long |
Metabolic reprogramming by growth factor signaling in skeletal cells. |
| Damaris Lorenzo | Cytoskeleton and membrane adaptors in cellular and organism metabolism. |
| Guilherme Nader | Nuclear mechanosensing pathways during cell migration and invasion |
| Christoph Thaiss |
Body-brain communication in aging, cancer, inflammatory, cardiovascular, and neurodegenerative diseases |
| Paul Titchenell | Molecular mechanisms of insulin signaling and insulin resistance |
| Stefano Rivella | Molecular mechanisms that control erythropoiesis, iron metabolism and inflammation |
| Rebecca Wells | TGF-ß receptor biology; Hepatic stellate cell function in liver fibrosis. |
For information on how to apply for CAMB Faculty membership, please see the CAMB Bylaws.