Cell Biology, Physiology, and Metabolism Faculty

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The Program in Cell Biology, Physiology, and Metabolism is dedicated to training graduate students in the diversity of medical science that defines modern cell biology, as well as providing ample time and resources for specializations.

Cell Biology, Physiology and Metabolism Members

Current Members

Cell Biology, Physiology and Metabolism

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Faculty


Laboratories in this program conduct research in a wide variety of areas that encompass, but are not limited to, five overlapping areas of research:

Cellular Metabolism

Faculty Brief Research Description
Zoltan Pierre Arany Cardiovascular metabolism
Joseph A. Baur Molecular mechanisms of aging
Joshua Dunaief Retinal iron trafficking and its role in retinal disease
J. Kevin Foskett Ion channels, calcium signaling, cystic fibrosis.
Daniel Kelly Transcriptional and epigenetic control of mitochondrial function; nuclear receptor signaling in the developing and diseased heart; molecular mechanisms controlling muscle metabolic fitness.
Mitchell Lazar Regulation of gene expression and metabolism by nuclear hormone receptors.
Robert Lee Epithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis
Virginia Lee Tau, a-synuclein and amyloid beta precursor protein (APP), and their roles in the pathobiology of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson’s disease (PD), and frontotemporal dementias (FTD).
Benjamin L. Prosser cardiac electrophysiology; excitation-contraction coupling; calcium signaling; mechanotransduction; redox signaling
Paul Titchenell Molecular mechanisms of insulin signaling and insulin resistance

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Cell Motility, The Cytoskeleton, and Muscle Physiology

Faculty Brief Research Description
Erfei Bi Development of cell polarity and control of cytokinesis in budding yeast.
Janis Burkhardt Regulation and function of the T cell cytoskeleton.
Peter Davies Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Vascular Cell Communication, Cytoskeletal and membrane biophysics.
Horace M. DeLisser Endothelial Cell Adhesion and Motility.
Dennis Discher Cell and nuclear membrane structure-function; Adhesion mechanisms and responses of cells; Phagocyte recognition processes; Membrane skeleton and cytoskeleton; Diseases ranging from muscular dystrophy to anemias to athersclerosis; Drug delivery.
Yale Goldman Relating the structural changes to enzymatic reactions and mechanical steps of the energy transduction mechanism by mapping the real-time domain motions of the motor proteins and ribosomal elongation factors.
Ekaterina L. Grishchuk Mechanisms that drive and control chromosome motions in mitosis
Wei Guo The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis.
Erika L. Holzbaur Microtubule-based motility.
Paul Janmey Cytoskeleton, phosphoinositide signalling, cell mechanics.
Anna S. Kashina Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis.
Frank Luca Yeast and mammalian cell cycle regulation; Cytokinesis. Daughter cell-specific gene expression; Polarized growth. Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM).
Michael Ostap Molecular mechanisms of cell motility.
Benjamin Prosser Mechano-signaling in heart
Tatyana Svitkina Roles of the cytoskeleton in cell motility.
Phong Tran The cytoskeleton and cellular pattern formation.
John W. Weisel Intermolecular and cellular interactions in blood clotting, fibrinolysis, and atherosclerosis studied by molecular biophysical methods.

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Intracellular Trafficking and Organelle Function

Faculty Brief Research Description
Zoltan Pierre Arany cardiovascular metabolism
Yair Argon Functions of molecular chaperones in the immune system - modulation of antigen receptors expression and of peptide presentation.
Joseph A. Baur Molecular mechanisms of aging
Erfei Bi Development of cell polarity and control of cytokinesis in budding yeast.
Margaret Chou Mechanisms of malignant transformation; signaling by small GTPases; regulation of vesicular trafficking; ubiquitination.
Andy Dancis Iron transport into mitochondria, Heme sythesis, Fe-S cluster biogenesis, Yeast genetics, and Sideroblastic anemia
Carol Deutsch Function and assembly of potassium channels in human T lymphocytes.
Robert Doms HIV; Emerging viral pathogens; Cell biology of Alzheimer's disease.
J. Kevin Foskett Ion channels, calcium signaling, cystic fibrosis.
Claudio Giraudo  The research of the laboratory is mainly focused on understanding the membrane trafficking events and fusion machinery involved in cytotoxic immune response. Additionally, we also study the influence of membrane lipid composition on protein sorting.
Yale Goldman Relating the structural changes to enzymatic reactions and mechanical steps of the energy transduction mechanism by mapping the real-time domain motions of the motor proteins and ribosomal elongation factors.
Wei Guo The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis.
Erika L. Holzbaur Microtubule-based motility.
Paul Janmey Cytoskeleton, phosphoinositide signalling, cell mechanics.
Anna S. Kashina Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis.
Frank Luca Yeast and mammalian cell cycle regulation; Cytokinesis. Daughter cell-specific gene expression; Polarized growth. Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM).
Michael S. Marks Regulation and diseases of intracellular protein transport and organelle biogenesis.
Michael Ostap Molecular mechanisms of cell motility.
Mechthild Pohlschroder Prokaryotic protein translocation across hydrophobic membranes.

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Membrane Transport

Faculty Brief Research Description
Carol Deutsch Function and assembly of potassium channels in human T lymphocytes.
Josuha Dunaief Retinal iron trafficking and its role in retinal disease
J. Kevin Foskett Ion channels, calcium signaling, cystic fibrosis.
Robert Lee Epithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis
Zhe Lu Molecular and biophysical mechanisms of ion channels.
Minghong Ma Neurobiology of the sense of smell
Dejian Ren Regulation of cellular excitability by ion channels and calcium signaling.

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Signal Transduction

Faculty Brief Research Description
Yair Argon Functions of molecular chaperones in the immune system - modulation of antigen receptors expression and of peptide presentation.
Lawrence F. Brass Mechanisms of thrombosis.
Janis Burkhardt Regulation and function of the T cell cytoskeleton.
Margaret Chou Mechanisms of malignant transformation; signaling by small GTPases; regulation of vesicular trafficking; ubiquitination.
Dennis Discher Cell and nuclear membrane structure-function; Adhesion mechanisms and responses of cells; Phagocyte recognition processes; Membrane skeleton and cytoskeleton; Diseases ranging from muscular dystrophy to anemias to athersclerosis; Drug delivery.
J. Kevin Foskett Ion channels, calcium signaling, cystic fibrosis.
Paul Janmey Cytoskeleton, phosphoinositide signalling, cell mechanics.
Mark Kahn Signaling pathways in angiogenesis and hemostasis.
Michael Lampson Mitotic kinase signaling, chromosome segregation in mitosis and meiosis, kinetochore function.
Robert Lee Epithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis
Paul Titchenell Molecular mechanisms of insulin signaling and insulin resistance
Rebecca Wells TGF-ß receptor biology; Hepatic stellate cell function in liver fibrosis.

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For information on how to apply for CAMB Faculty membership, please see the CAMB Bylaws.