Cell Biology, Physiology, and Metabolism Faculty

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The Program in Cell Biology, Physiology, and Metabolism is dedicated to training graduate students in the diversity of medical science that defines modern cell biology, as well as providing ample time and resources for specializations.

Current Members

Cell Biology, Physiology and Metabolism

Click the faculty member's name to see more detailed information.

Faculty

Charles S. Abrams, M.D.	Virginia Man-Yee Lee, Ph.D.
Zoltan Pierre Arany, MD, PhD	Robert J. Lee, Ph.D.
Yair Argon, Ph.D.	Elizabeth M Lennon, DVM, PhD, DACVIM
Joseph A. Baur, PhD	Krithika Lingappan, MD MS PhD
Erfei Bi, Ph.D.	Fange Liu, Ph.D
Lawrence F. Brass, MD, PhD	Damaris Lorenzo, MSc, PhD
Janis K. Burkhardt, Ph.D.	Zhe Lu, MD, PhD
Natali L Chanaday, PhD	Francis Luca, PhD
Qi N. Cui, MD, PhD	David R. Lynch, MD, PhD
Andrew Dancis, M.D.	Minghong Ma, Ph.D.
Carol J. Deutsch, Ph.D.	Sandra Lynn Maday, Ph.D.
Dennis E. Discher, Ph.D.	Kenneth B. Margulies, M.D.
Roberto Dominguez, Ph.D.	Michael S. Marks, Ph.D.
Joshua L. Dunaief, MD, PhD	David M Merrick, MD, PhD
Aron B. Fisher, M.D.	Claire H. Mitchell, Ph.D.
J. Kevin Foskett, PhD	Michael Ostap, Ph.D.
Yale E. Goldman, MD, PhD	Benjamin L. Prosser, Ph.D
Matthew C Good, Ph.D.	Akhilesh Basi Reddy, MA MB BChir PhD
Ekaterina L. Grishchuk, Ph.D.	Dejian Ren, Ph.D.
Marie A Guerraty, MD, PhD	Jeffrey David Roizen, M.D., Ph.D.
Wei Guo, Ph.D.	Brian M. Salzberg, Ph.D.
Jorge Henao-Mejia, M.D., Ph.D.	Amita Sehgal, Ph.D.
David A. Hill, MD, PhD, FAAP, FACAAI, FAAAAI	John T. Seykora, M.D., Ph.D
Erika L.F. Holzbaur, Ph.D.	James Shorter, M.A., Ph.D.
Paul A. Janmey, Ph.D.	Tatyana M. Svitkina, Ph.D.
Mark L. Kahn, M.D.	Christopher Thom, MD, PhD
Anna Kashina, Ph.D.	Paul M. Titchenell, Ph.D.
Daniel P Kelly, MD	Phong Tran, Ph.D.
Tejvir S. Khurana, MD, PhD	Andrew van Eps, BVSc, PhD
Vera P. Krymskaya, PhD, MBA, FCPP	John W. Weisel, Ph.D.
Melike Lakadamyali, Ph.D.	Rebecca G. Wells, MD
Michael Lampson	Gary D. Wu, MD
Edward B Lee, MD, PhD

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Laboratories in this program conduct research in a wide variety of areas that encompass, but are not limited to, five overlapping areas of research:

• Cellular Metabolism
• Cell Motility, The Cytoskeleton, and Muscle Physiology
• Intracellular Trafficking and Organelle Function
• Membrane Transport
• Signal Transduction

Cellular Metabolism

Faculty	Brief Research Description
Zoltan Pierre Arany	Cardiovascular metabolism
Joseph A. Baur	Molecular mechanisms of aging
Joshua Dunaief	Retinal iron trafficking and its role in retinal disease
J. Kevin Foskett	Ion channels, calcium signaling, cystic fibrosis.
Daniel Kelly	Transcriptional and epigenetic control of mitochondrial function; nuclear receptor signaling in the developing and diseased heart; molecular mechanisms controlling muscle metabolic fitness.
Mitchell Lazar	Regulation of gene expression and metabolism by nuclear hormone receptors.
Robert Lee	Epithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis
Virginia Lee	Tau, a-synuclein and amyloid beta precursor protein (APP), and their roles in the pathobiology of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson’s disease (PD), and frontotemporal dementias (FTD).
Benjamin L. Prosser	cardiac electrophysiology; excitation-contraction coupling; calcium signaling; mechanotransduction; redox signaling
Paul Titchenell	Molecular mechanisms of insulin signaling and insulin resistance

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Cell Motility, The Cytoskeleton, and Muscle Physiology

Faculty	Brief Research Description
Erfei Bi	Development of cell polarity and control of cytokinesis in budding yeast.
Janis Burkhardt	Regulation and function of the T cell cytoskeleton.
Peter Davies	Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Vascular Cell Communication, Cytoskeletal and membrane biophysics.
Horace M. DeLisser	Endothelial Cell Adhesion and Motility.
Dennis Discher	Cell and nuclear membrane structure-function; Adhesion mechanisms and responses of cells; Phagocyte recognition processes; Membrane skeleton and cytoskeleton; Diseases ranging from muscular dystrophy to anemias to athersclerosis; Drug delivery.
Yale Goldman	Relating the structural changes to enzymatic reactions and mechanical steps of the energy transduction mechanism by mapping the real-time domain motions of the motor proteins and ribosomal elongation factors.
Ekaterina L. Grishchuk	Mechanisms that drive and control chromosome motions in mitosis
Wei Guo	The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis.
Erika L. Holzbaur	Microtubule-based motility.
Paul Janmey	Cytoskeleton, phosphoinositide signalling, cell mechanics.
Anna S. Kashina	Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis.
Frank Luca	Yeast and mammalian cell cycle regulation; Cytokinesis. Daughter cell-specific gene expression; Polarized growth. Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM).
Michael Ostap	Molecular mechanisms of cell motility.
Benjamin Prosser	Mechano-signaling in heart
Tatyana Svitkina	Roles of the cytoskeleton in cell motility.
Phong Tran	The cytoskeleton and cellular pattern formation.
John W. Weisel	Intermolecular and cellular interactions in blood clotting, fibrinolysis, and atherosclerosis studied by molecular biophysical methods.

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Intracellular Trafficking and Organelle Function

Faculty	Brief Research Description
Zoltan Pierre Arany	cardiovascular metabolism
Yair Argon	Functions of molecular chaperones in the immune system - modulation of antigen receptors expression and of peptide presentation.
Joseph A. Baur	Molecular mechanisms of aging
Erfei Bi	Development of cell polarity and control of cytokinesis in budding yeast.
Natali Chanaday	Molecular mechanisms of neuronal communication
Margaret Chou	Mechanisms of malignant transformation; signaling by small GTPases; regulation of vesicular trafficking; ubiquitination.
Andy Dancis	Iron transport into mitochondria, Heme synthesis, Fe-S cluster biogenesis, Yeast genetics, and Sideroblastic anemia
Carol Deutsch	Function and assembly of potassium channels in human T lymphocytes.
Robert Doms	HIV; Emerging viral pathogens; Cell biology of Alzheimer's disease.
J. Kevin Foskett	Ion channels, calcium signaling, cystic fibrosis.
Claudio Giraudo	The research of the laboratory is mainly focused on understanding the membrane trafficking events and fusion machinery involved in cytotoxic immune response. Additionally, we also study the influence of membrane lipid composition on protein sorting.
Yale Goldman	Relating the structural changes to enzymatic reactions and mechanical steps of the energy transduction mechanism by mapping the real-time domain motions of the motor proteins and ribosomal elongation factors.
Wei Guo	The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis.
Erika L. Holzbaur	Microtubule-based motility.
Paul Janmey	Cytoskeleton, phosphoinositide signaling, cell mechanics.
Anna S. Kashina	Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis.
Frank Luca	Yeast and mammalian cell cycle regulation; Cytokinesis. Daughter cell-specific gene expression; Polarized growth. Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM).
Michael S. Marks	Regulation and diseases of intracellular protein transport and organelle biogenesis.
Michael Ostap	Molecular mechanisms of cell motility.
Mechthild Pohlschroder	Prokaryotic protein translocation across hydrophobic membranes.

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Membrane Transport

Faculty	Brief Research Description
Natali Chanaday	Molecular mechanisms of neuronal communication
Carol Deutsch	Function and assembly of potassium channels in human T lymphocytes.
Josuha Dunaief	Retinal iron trafficking and its role in retinal disease
J. Kevin Foskett	Ion channels, calcium signaling, cystic fibrosis.
Robert Lee	Epithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis
Zhe Lu	Molecular and biophysical mechanisms of ion channels.
Minghong Ma	Neurobiology of the sense of smell
Dejian Ren	Regulation of cellular excitability by ion channels and calcium signaling.

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Signal Transduction

Faculty	Brief Research Description
Yair Argon	Functions of molecular chaperones in the immune system - modulation of antigen receptors expression and of peptide presentation.
Lawrence F. Brass	Mechanisms of thrombosis.
Janis Burkhardt	Regulation and function of the T cell cytoskeleton.
Natali Chanaday	Molecular mechanisms of neuronal communication
Margaret Chou	Mechanisms of malignant transformation; signaling by small GTPases; regulation of vesicular trafficking; ubiquitination.
Dennis Discher	Cell and nuclear membrane structure-function; Adhesion mechanisms and responses of cells; Phagocyte recognition processes; Membrane skeleton and cytoskeleton; Diseases ranging from muscular dystrophy to anemias to athersclerosis; Drug delivery.
J. Kevin Foskett	Ion channels, calcium signaling, cystic fibrosis.
Paul Janmey	Cytoskeleton, phosphoinositide signalling, cell mechanics.
Mark Kahn	Signaling pathways in angiogenesis and hemostasis.
Michael Lampson	Mitotic kinase signaling, chromosome segregation in mitosis and meiosis, kinetochore function.
Robert Lee	Epithelial ion and fluid transport, calcium/cAMP/nitric oxide signaling, extra-oral taste receptors, respiratory mucociliary transport and innate immunity, respiratory physiology and pathophysiology, chronic rhinosinusitis, cystic fibrosis
Paul Titchenell	Molecular mechanisms of insulin signaling and insulin resistance
Rebecca Wells	TGF-ß receptor biology; Hepatic stellate cell function in liver fibrosis.

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For information on how to apply for CAMB Faculty membership, please see the CAMB Bylaws.